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Prednisolone response

MedGen UID:
881196
•Concept ID:
CN236771
•
Sign or Symptom
Drug:
prednisolone
MedGen UID:
10892
•Concept ID:
C0032950
•
Pharmacologic Substance
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04) [from NCI]
prednisolone

Professional guidelines

PubMed

EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update.
Hellmich B, Sanchez-Alamo B, Schirmer JH, Berti A, Blockmans D, Cid MC, Holle JU, Hollinger N, Karadag O, Kronbichler A, Little MA, Luqmani RA, Mahr A, Merkel PA, Mohammad AJ, Monti S, Mukhtyar CB, Musial J, Price-Kuehne F, Segelmark M, Teng YKO, Terrier B, Tomasson G, Vaglio A, Vassilopoulos D, Verhoeven P, Jayne D
Ann Rheum Dis 2024 Jan 2;83(1):30-47. doi: 10.1136/ard-2022-223764. PMID: 36927642
The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy.
Bartalena L, Kahaly GJ, Baldeschi L, Dayan CM, Eckstein A, Marcocci C, Marinò M, Vaidya B, Wiersinga WM; EUGOGO †
Eur J Endocrinol 2021 Aug 27;185(4):G43-G67. doi: 10.1530/EJE-21-0479. PMID: 34297684
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article

Curated

DailyMed Drug Label, prednisolone, 2007

Recent clinical studies

Etiology

Anthracycline-Free Protocol for Favorable-Risk Childhood ALL: A Noninferiority Comparison Between Malaysia-Singapore ALL 2003 and ALL 2010 Studies.
Ariffin H, Chiew EKH, Oh BLZ, Lee SHR, Lim EH, Kham SKY, Abdullah WA, Chan LL, Foo KM, Lam JCM, Chan YH, Lin HP, Quah TC, Tan AM, Yeoh AEJ
J Clin Oncol 2023 Jul 10;41(20):3642-3651. Epub 2023 Jun 5 doi: 10.1200/JCO.22.02347. PMID: 37276496
Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Assone T, Menezes SM, de Toledo Gonçalves F, Folgosi VA, da Silva Prates G, Dierckx T, Braz M, Smid J, Haziot ME, Marcusso RMN, Dahy FE, Vanderlinden E, Claes S, Schols D, Bruhn R, Murphy EL, Penalva de Oliveira AC, Daelemans D, Vercauteren J, Casseb J, Van Weyenbergh J
J Neuroinflammation 2022 Dec 8;19(1):293. doi: 10.1186/s12974-022-02658-w. PMID: 36482436Free PMC Article
Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India.
Das N, Banavali S, Bakhshi S, Trehan A, Radhakrishnan V, Seth R, Arora B, Narula G, Sinha S, Roy P, Gogoi MP, Chatterjee S, Abraham B, Das P, Saha V, Krishnan S
Trials 2022 Jan 31;23(1):102. doi: 10.1186/s13063-022-06033-1. PMID: 35101099Free PMC Article
Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.
Usami I, Imamura T, Takahashi Y, Suenobu SI, Hasegawa D, Hashii Y, Deguchi T, Hori T, Shimada A, Kato K, Ito E, Moriya-Saito A, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Sato A, Horibe K; Japan Association of Childhood Leukemia Study Group (JACLS)
Int J Hematol 2019 Apr;109(4):477-482. Epub 2019 Jan 28 doi: 10.1007/s12185-019-02599-w. PMID: 30689137

Diagnosis

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India.
Das N, Banavali S, Bakhshi S, Trehan A, Radhakrishnan V, Seth R, Arora B, Narula G, Sinha S, Roy P, Gogoi MP, Chatterjee S, Abraham B, Das P, Saha V, Krishnan S
Trials 2022 Jan 31;23(1):102. doi: 10.1186/s13063-022-06033-1. PMID: 35101099Free PMC Article
Minimal residual disease and outcome characteristics in infant KMT2A-germline acute lymphoblastic leukaemia treated on the Interfant-06 protocol.
Stutterheim J, de Lorenzo P, van der Sluis IM, Alten J, Ancliffe P, Attarbaschi A, Aversa L, Boer JM, Biondi A, Brethon B, Diaz P, Cazzaniga G, Escherich G, Ferster A, Kotecha RS, Lausen B, Leung AW, Locatelli F, Silverman L, Stary J, Szczepanski T, van der Velden VHJ, Vora A, Zuna J, Schrappe M, Valsecchi MG, Pieters R
Eur J Cancer 2022 Jan;160:72-79. Epub 2021 Nov 13 doi: 10.1016/j.ejca.2021.10.004. PMID: 34785111
Idiopathic sclerosing orbital inflammation.
Hsuan JD, Selva D, McNab AA, Sullivan TJ, Saeed P, O'Donnell BA
Arch Ophthalmol 2006 Sep;124(9):1244-50. doi: 10.1001/archopht.124.9.1244. PMID: 16966618
Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study.
Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA
Thorax 2003 Aug;58(8):654-8. doi: 10.1136/thorax.58.8.654. PMID: 12885977Free PMC Article

Therapy

Anthracycline-Free Protocol for Favorable-Risk Childhood ALL: A Noninferiority Comparison Between Malaysia-Singapore ALL 2003 and ALL 2010 Studies.
Ariffin H, Chiew EKH, Oh BLZ, Lee SHR, Lim EH, Kham SKY, Abdullah WA, Chan LL, Foo KM, Lam JCM, Chan YH, Lin HP, Quah TC, Tan AM, Yeoh AEJ
J Clin Oncol 2023 Jul 10;41(20):3642-3651. Epub 2023 Jun 5 doi: 10.1200/JCO.22.02347. PMID: 37276496
Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India.
Das N, Banavali S, Bakhshi S, Trehan A, Radhakrishnan V, Seth R, Arora B, Narula G, Sinha S, Roy P, Gogoi MP, Chatterjee S, Abraham B, Das P, Saha V, Krishnan S
Trials 2022 Jan 31;23(1):102. doi: 10.1186/s13063-022-06033-1. PMID: 35101099Free PMC Article
Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.
Usami I, Imamura T, Takahashi Y, Suenobu SI, Hasegawa D, Hashii Y, Deguchi T, Hori T, Shimada A, Kato K, Ito E, Moriya-Saito A, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Sato A, Horibe K; Japan Association of Childhood Leukemia Study Group (JACLS)
Int J Hematol 2019 Apr;109(4):477-482. Epub 2019 Jan 28 doi: 10.1007/s12185-019-02599-w. PMID: 30689137
Idiopathic sclerosing orbital inflammation.
Hsuan JD, Selva D, McNab AA, Sullivan TJ, Saeed P, O'Donnell BA
Arch Ophthalmol 2006 Sep;124(9):1244-50. doi: 10.1001/archopht.124.9.1244. PMID: 16966618

Prognosis

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Assone T, Menezes SM, de Toledo Gonçalves F, Folgosi VA, da Silva Prates G, Dierckx T, Braz M, Smid J, Haziot ME, Marcusso RMN, Dahy FE, Vanderlinden E, Claes S, Schols D, Bruhn R, Murphy EL, Penalva de Oliveira AC, Daelemans D, Vercauteren J, Casseb J, Van Weyenbergh J
J Neuroinflammation 2022 Dec 8;19(1):293. doi: 10.1186/s12974-022-02658-w. PMID: 36482436Free PMC Article
Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.
Usami I, Imamura T, Takahashi Y, Suenobu SI, Hasegawa D, Hashii Y, Deguchi T, Hori T, Shimada A, Kato K, Ito E, Moriya-Saito A, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Sato A, Horibe K; Japan Association of Childhood Leukemia Study Group (JACLS)
Int J Hematol 2019 Apr;109(4):477-482. Epub 2019 Jan 28 doi: 10.1007/s12185-019-02599-w. PMID: 30689137
Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol.
Bajel A, George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M
Pediatr Blood Cancer 2008 Nov;51(5):621-5. doi: 10.1002/pbc.21671. PMID: 18688848
Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study.
Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA
Thorax 2003 Aug;58(8):654-8. doi: 10.1136/thorax.58.8.654. PMID: 12885977Free PMC Article

Clinical prediction guides

Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Assone T, Menezes SM, de Toledo Gonçalves F, Folgosi VA, da Silva Prates G, Dierckx T, Braz M, Smid J, Haziot ME, Marcusso RMN, Dahy FE, Vanderlinden E, Claes S, Schols D, Bruhn R, Murphy EL, Penalva de Oliveira AC, Daelemans D, Vercauteren J, Casseb J, Van Weyenbergh J
J Neuroinflammation 2022 Dec 8;19(1):293. doi: 10.1186/s12974-022-02658-w. PMID: 36482436Free PMC Article
Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India.
Das N, Banavali S, Bakhshi S, Trehan A, Radhakrishnan V, Seth R, Arora B, Narula G, Sinha S, Roy P, Gogoi MP, Chatterjee S, Abraham B, Das P, Saha V, Krishnan S
Trials 2022 Jan 31;23(1):102. doi: 10.1186/s13063-022-06033-1. PMID: 35101099Free PMC Article
Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol.
Bajel A, George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M
Pediatr Blood Cancer 2008 Nov;51(5):621-5. doi: 10.1002/pbc.21671. PMID: 18688848
Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study.
Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA
Thorax 2003 Aug;58(8):654-8. doi: 10.1136/thorax.58.8.654. PMID: 12885977Free PMC Article
Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease.
Spencer CM, McTavish D
Drugs 1995 Nov;50(5):854-72. doi: 10.2165/00003495-199550050-00006. PMID: 8586030

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