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Thyroid cancer, nonmedullary, 4(NMTC4)

MedGen UID:
907624
Concept ID:
C4225293
Neoplastic Process
Synonyms: NMTC4
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
 
Gene (location): FOXE1 (9q22.33)
OMIM®: 616534

Definition

Nonmedullary thyroid cancer (NMTC) refers to neoplasms originating from the thyroid follicular cells and represents 80 to 95% of all thyroid cancers. Approximately 5% of NMTC occurs on the background of a familial predisposition. Although papillary thyroid carcinoma (PTC) is usually the most frequent thyroid lesion in NMTC families, multinodular goiter (MNG) and follicular thyroid adenoma also occur (summary by Pereira et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from OMIM]

Clinical features

From HPO
Non-medullary thyroid carcinoma
MedGen UID:
502247
Concept ID:
C3501843
Neoplastic Process
Goiter
MedGen UID:
42270
Concept ID:
C0018021
Disease or Syndrome
An enlargement of the thyroid gland.
Non-medullary thyroid carcinoma
MedGen UID:
502247
Concept ID:
C3501843
Neoplastic Process

Recent clinical studies

Etiology

Beysel S, Eyerci N, Pinarli FA, Apaydin M, Kizilgul M, Caliskan M, Ozcelik O, Kan S, Cakal E
Tumour Biol 2018 Nov;40(11):1010428318811766. doi: 10.1177/1010428318811766. PMID: 30486759
Or K, Benbassat C, Koren S, Shteinshneider M, Koren R, Cantrell D, Kummer E, Muallem Kalmovich L
Eur Arch Otorhinolaryngol 2018 Nov;275(11):2851-2859. Epub 2018 Sep 18 doi: 10.1007/s00405-018-5126-x. PMID: 30229453
Llamas-Olier AE, Cuéllar DI, Buitrago G
Thyroid 2018 Oct;28(10):1311-1317. doi: 10.1089/thy.2017.0578. PMID: 30105948
Wagner M, Wuest M, Hamann I, Lopez-Campistrous A, McMullen TPW, Wuest F
Nucl Med Biol 2018 Mar;58:51-58. Epub 2017 Dec 27 doi: 10.1016/j.nucmedbio.2017.12.005. PMID: 29367096
Mazeh H, Benavidez J, Poehls JL, Youngwirth L, Chen H, Sippel RS
Thyroid 2012 Jan;22(1):3-8. Epub 2011 Dec 2 doi: 10.1089/thy.2011.0192. PMID: 22136209

Diagnosis

Or K, Benbassat C, Koren S, Shteinshneider M, Koren R, Cantrell D, Kummer E, Muallem Kalmovich L
Eur Arch Otorhinolaryngol 2018 Nov;275(11):2851-2859. Epub 2018 Sep 18 doi: 10.1007/s00405-018-5126-x. PMID: 30229453
Llamas-Olier AE, Cuéllar DI, Buitrago G
Thyroid 2018 Oct;28(10):1311-1317. doi: 10.1089/thy.2017.0578. PMID: 30105948
Adewuyi EE, Deschenes J, Lopez-Campistrous A, Kattar MM, Ghosh S, McMullen TPW
Hum Pathol 2018 May;75:146-153. Epub 2018 Feb 2 doi: 10.1016/j.humpath.2018.01.025. PMID: 29408504
Xie X, Shi X, Guan H, Guo Q, Fan C, Dong W, Wang G, Li F, Shan Z, Cao L, Teng W
Oncotarget 2017 Apr 11;8(15):24882-24891. doi: 10.18632/oncotarget.15079. PMID: 28178642Free PMC Article
Moses W, Weng J, Kebebew E
Thyroid 2011 Apr;21(4):367-71. Epub 2010 Dec 29 doi: 10.1089/thy.2010.0256. PMID: 21190444Free PMC Article

Therapy

Wei L, Bai L, Zhao L, Yu T, Ma Q, Ji B
World J Surg 2019 May;43(5):1256-1263. doi: 10.1007/s00268-019-04924-0. PMID: 30684002
Liu Y, Li L, Yu J, Fan YX, Lu XB
Cancer Biomark 2018;23(2):227-233. doi: 10.3233/CBM-181386. PMID: 30198867
Llamas-Olier AE, Cuéllar DI, Buitrago G
Thyroid 2018 Oct;28(10):1311-1317. doi: 10.1089/thy.2017.0578. PMID: 30105948
Sung TY, Cho JW, Lee YM, Lee YH, Kwon H, Jeon MJ, Kim WG, Choi YJ, Song DE, Chung KW, Yoon JH, Hong SJ
Thyroid 2017 Nov;27(11):1400-1407. Epub 2017 Oct 17 doi: 10.1089/thy.2017.0199. PMID: 28847226
Randle RW, Bushman NM, Orne J, Balentine CJ, Wendt E, Saucke M, Pitt SC, Macdonald CL, Connor NP, Sippel RS
Thyroid 2017 Jul;27(7):902-907. Epub 2017 Jun 12 doi: 10.1089/thy.2016.0632. PMID: 28510505Free PMC Article

Prognosis

Zarkesh M, Zadeh-Vakili A, Akbarzadeh M, Fanaei SA, Hedayati M, Azizi F
BMC Cancer 2018 Dec 3;18(1):1199. doi: 10.1186/s12885-018-5112-0. PMID: 30509240Free PMC Article
Beysel S, Eyerci N, Pinarli FA, Apaydin M, Kizilgul M, Caliskan M, Ozcelik O, Kan S, Cakal E
Tumour Biol 2018 Nov;40(11):1010428318811766. doi: 10.1177/1010428318811766. PMID: 30486759
Adewuyi EE, Deschenes J, Lopez-Campistrous A, Kattar MM, Ghosh S, McMullen TPW
Hum Pathol 2018 May;75:146-153. Epub 2018 Feb 2 doi: 10.1016/j.humpath.2018.01.025. PMID: 29408504
Wagner M, Wuest M, Hamann I, Lopez-Campistrous A, McMullen TPW, Wuest F
Nucl Med Biol 2018 Mar;58:51-58. Epub 2017 Dec 27 doi: 10.1016/j.nucmedbio.2017.12.005. PMID: 29367096
Pontius LN, Oyekunle TO, Thomas SM, Stang MT, Scheri RP, Roman SA, Sosa JA
Thyroid 2017 Nov;27(11):1408-1416. Epub 2017 Oct 5 doi: 10.1089/thy.2017.0306. PMID: 28891405Free PMC Article

Clinical prediction guides

Zarkesh M, Zadeh-Vakili A, Akbarzadeh M, Fanaei SA, Hedayati M, Azizi F
BMC Cancer 2018 Dec 3;18(1):1199. doi: 10.1186/s12885-018-5112-0. PMID: 30509240Free PMC Article
Llamas-Olier AE, Cuéllar DI, Buitrago G
Thyroid 2018 Oct;28(10):1311-1317. doi: 10.1089/thy.2017.0578. PMID: 30105948
Adewuyi EE, Deschenes J, Lopez-Campistrous A, Kattar MM, Ghosh S, McMullen TPW
Hum Pathol 2018 May;75:146-153. Epub 2018 Feb 2 doi: 10.1016/j.humpath.2018.01.025. PMID: 29408504
Wagner M, Wuest M, Hamann I, Lopez-Campistrous A, McMullen TPW, Wuest F
Nucl Med Biol 2018 Mar;58:51-58. Epub 2017 Dec 27 doi: 10.1016/j.nucmedbio.2017.12.005. PMID: 29367096
Pontius LN, Oyekunle TO, Thomas SM, Stang MT, Scheri RP, Roman SA, Sosa JA
Thyroid 2017 Nov;27(11):1408-1416. Epub 2017 Oct 5 doi: 10.1089/thy.2017.0306. PMID: 28891405Free PMC Article

Recent systematic reviews

Su H, Li Y
Zentralbl Chir 2018 Aug;143(4):373-379. Epub 2018 Aug 22 doi: 10.1055/a-0652-5651. PMID: 30134497
Gartland RM, Lubitz CC
Ann Surg Oncol 2018 Sep;25(9):2520-2525. Epub 2018 May 31 doi: 10.1245/s10434-018-6550-2. PMID: 29855833Free PMC Article
Hughes DT, Rosen JE, Evans DB, Grubbs E, Wang TS, Solórzano CC
Ann Surg Oncol 2018 Sep;25(9):2526-2534. Epub 2018 May 21 doi: 10.1245/s10434-018-6528-0. PMID: 29786126
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770
Fontenot TE, Deniwar A, Bhatia P, Al-Qurayshi Z, Randolph GW, Kandil E
JAMA Otolaryngol Head Neck Surg 2015 Jun;141(6):512-8. doi: 10.1001/jamaoto.2015.0596. PMID: 25928119

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