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  • CN169279 has been replaced by C3554664, showing C3554664

Restless legs syndrome, susceptibility to, 8(RLS8)

MedGen UID:
767578
Concept ID:
C3554664
Finding
Synonyms: RLS8
 
Cytogenetic location: 5q31
OMIM®: 615197

Definition

Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). For additional information and a discussion of heterogeneity of restless legs syndrome, see RLS1 (102300). [from GHR]

Additional description

From OMIM
Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). For additional information and a discussion of heterogeneity of restless legs syndrome, see RLS1 (102300).  http://www.omim.org/entry/615197

Recent clinical studies

Etiology

Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, Dauvilliers Y, Stefani A, Högl B, Poewe W, Kemlink D, Sonka K, Bachmann CG, Paulus W, Trenkwalder C, Oertel WH, Hornyak M, Teder-Laving M, Metspalu A, Hadjigeorgiou GM, Polo O, Fietze I, Ross OA, Wszolek Z, Butterworth AS, Soranzo N, Ouwehand WH, Roberts DJ, Danesh J, Allen RP, Earley CJ, Ondo WG, Xiong L, Montplaisir J, Gan-Or Z, Perola M, Vodicka P, Dina C, Franke A, Tittmann L, Stewart AFR, Shah SH, Gieger C, Peters A, Rouleau GA, Berger K, Oexle K, Di Angelantonio E, Hinds DA, Müller-Myhsok B, Winkelmann J; 23andMe Research Team.; DESIR study group.
Lancet Neurol 2017 Nov;16(11):898-907. doi: 10.1016/S1474-4422(17)30327-7. PMID: 29029846Free PMC Article
Per H, Gunay N, Ismailogullari S, Oztop DB, Gunay O
Brain Dev 2017 Feb;39(2):154-160. Epub 2016 Sep 22 doi: 10.1016/j.braindev.2016.08.011. PMID: 27666468
Yang Q, Li L, Chen Q, Foldvary-Schaefer N, Ondo WG, Wang QK
Sleep Med 2011 Sep;12(8):800-4. doi: 10.1016/j.sleep.2011.06.006. PMID: 21925394Free PMC Article
Xiong L, Montplaisir J, Desautels A, Barhdadi A, Turecki G, Levchenko A, Thibodeau P, Dubé MP, Gaspar C, Rouleau GA
Arch Neurol 2010 May;67(5):617-22. doi: 10.1001/archneurol.2010.67. PMID: 20457962
Winkelmann J
Curr Neurol Neurosci Rep 2008 May;8(3):211-6. PMID: 18541116

Diagnosis

Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, Dauvilliers Y, Stefani A, Högl B, Poewe W, Kemlink D, Sonka K, Bachmann CG, Paulus W, Trenkwalder C, Oertel WH, Hornyak M, Teder-Laving M, Metspalu A, Hadjigeorgiou GM, Polo O, Fietze I, Ross OA, Wszolek Z, Butterworth AS, Soranzo N, Ouwehand WH, Roberts DJ, Danesh J, Allen RP, Earley CJ, Ondo WG, Xiong L, Montplaisir J, Gan-Or Z, Perola M, Vodicka P, Dina C, Franke A, Tittmann L, Stewart AFR, Shah SH, Gieger C, Peters A, Rouleau GA, Berger K, Oexle K, Di Angelantonio E, Hinds DA, Müller-Myhsok B, Winkelmann J; 23andMe Research Team.; DESIR study group.
Lancet Neurol 2017 Nov;16(11):898-907. doi: 10.1016/S1474-4422(17)30327-7. PMID: 29029846Free PMC Article
Picchietti MA, Picchietti DL
Sleep Med 2010 Aug;11(7):643-51. doi: 10.1016/j.sleep.2009.11.014. PMID: 20620105
Xiong L, Montplaisir J, Desautels A, Barhdadi A, Turecki G, Levchenko A, Thibodeau P, Dubé MP, Gaspar C, Rouleau GA
Arch Neurol 2010 May;67(5):617-22. doi: 10.1001/archneurol.2010.67. PMID: 20457962
Xiong L, Catoire H, Dion P, Gaspar C, Lafrenière RG, Girard SL, Levchenko A, Rivière JB, Fiori L, St-Onge J, Bachand I, Thibodeau P, Allen R, Earley C, Turecki G, Montplaisir J, Rouleau GA
Hum Mol Genet 2009 Mar 15;18(6):1065-74. Epub 2009 Jan 6 doi: 10.1093/hmg/ddn443. PMID: 19126776Free PMC Article
Muhle H, Neumann A, Lohmann-Hedrich K, Lohnau T, Lu Y, Winkler S, Waltz S, Fischenbeck A, Kramer PL, Klein C, Stephani U
Mov Disord 2008 Jun 15;23(8):1113-21; quiz 1203. doi: 10.1002/mds.22016. PMID: 18381645

Therapy

Picchietti MA, Picchietti DL
Sleep Med 2010 Aug;11(7):643-51. doi: 10.1016/j.sleep.2009.11.014. PMID: 20620105
Stiasny-Kolster K, Trenkwalder C, Fogel W, Greulich W, Hahne M, Lachenmayer L, Oechsner M, Oertel WH
J Neurol 2004 Sep;251 Suppl 6:VI/39-43. PMID: 15675724
Akpinar S
Clin Neuropharmacol 1987;10(1):69-79. PMID: 3545461

Clinical prediction guides

Per H, Gunay N, Ismailogullari S, Oztop DB, Gunay O
Brain Dev 2017 Feb;39(2):154-160. Epub 2016 Sep 22 doi: 10.1016/j.braindev.2016.08.011. PMID: 27666468
Muhle H, Neumann A, Lohmann-Hedrich K, Lohnau T, Lu Y, Winkler S, Waltz S, Fischenbeck A, Kramer PL, Klein C, Stephani U
Mov Disord 2008 Jun 15;23(8):1113-21; quiz 1203. doi: 10.1002/mds.22016. PMID: 18381645
Pichler I, Marroni F, Volpato CB, Gusella JF, Klein C, Casari G, De Grandi A, Pramstaller PP
Am J Hum Genet 2006 Oct;79(4):716-23. Epub 2006 Aug 14 doi: 10.1086/507875. PMID: 16960808Free PMC Article
Vogl FD, Pichler I, Adel S, Pinggera GK, Bracco S, De Grandi A, Volpato CB, Aridon P, Mayer T, Meitinger T, Klein C, Casari G, Pramstaller PP
Mov Disord 2006 Aug;21(8):1189-95. doi: 10.1002/mds.20922. PMID: 16685686
Desautels A, Turecki G, Montplaisir J, Xiong L, Walters AS, Ehrenberg BL, Brisebois K, Desautels AK, Gingras Y, Johnson WG, Lugaresi E, Coccagna G, Picchietti DL, Lazzarini A, Rouleau GA
Arch Neurol 2005 Apr;62(4):591-6. doi: 10.1001/archneur.62.4.591. PMID: 15824258

Recent systematic reviews

Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, Dauvilliers Y, Stefani A, Högl B, Poewe W, Kemlink D, Sonka K, Bachmann CG, Paulus W, Trenkwalder C, Oertel WH, Hornyak M, Teder-Laving M, Metspalu A, Hadjigeorgiou GM, Polo O, Fietze I, Ross OA, Wszolek Z, Butterworth AS, Soranzo N, Ouwehand WH, Roberts DJ, Danesh J, Allen RP, Earley CJ, Ondo WG, Xiong L, Montplaisir J, Gan-Or Z, Perola M, Vodicka P, Dina C, Franke A, Tittmann L, Stewart AFR, Shah SH, Gieger C, Peters A, Rouleau GA, Berger K, Oexle K, Di Angelantonio E, Hinds DA, Müller-Myhsok B, Winkelmann J; 23andMe Research Team.; DESIR study group.
Lancet Neurol 2017 Nov;16(11):898-907. doi: 10.1016/S1474-4422(17)30327-7. PMID: 29029846Free PMC Article

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