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Ovarian carcinoma

MedGen UID:
1648335
Concept ID:
C4721610
Neoplastic Process
Synonyms: Cancer, Epithelial Ovarian; Cancer, Ovarian Epithelial; Cancers, Epithelial Ovarian; Cancers, Ovarian Epithelial; Carcinoma, Epithelial Ovarian; Carcinoma, Ovarian Epithelial; Carcinomas, Epithelial Ovarian; Carcinomas, Ovarian Epithelial; Epithelial Cancer, Ovarian; Epithelial Cancers, Ovarian; Epithelial Carcinoma, Ovarian; Epithelial Carcinomas, Ovarian; Epithelial Ovarian Cancer; Epithelial Ovarian Cancers; Epithelial Ovarian Carcinoma; Epithelial Ovarian Carcinomas; Ovarian Cancer, Epithelial; Ovarian Cancers, Epithelial; Ovarian Carcinoma, Epithelial; Ovarian Carcinomas, Epithelial; Ovarian Epithelial Cancer; Ovarian Epithelial Cancers; Ovarian Epithelial Carcinoma; Ovarian Epithelial Carcinomas
 
HPO: HP:0025318
Monarch Initiative: MONDO:0005140

Definition

A malignant neoplasm originating from the surface ovarian epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Ovarian carcinoma

Conditions with this feature

Gorlin syndrome
MedGen UID:
2554
Concept ID:
C0004779
Neoplastic Process
Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by the development of multiple jaw keratocysts, frequently beginning in the second decade of life, and/or basal cell carcinomas (BCCs) usually from the third decade onward. Approximately 60% of individuals have a recognizable appearance with macrocephaly, frontal bossing, coarse facial features, and facial milia. Most individuals have skeletal anomalies (e.g., bifid ribs, wedge-shaped vertebrae). Ectopic calcification, particularly in the falx, is present in more than 90% of affected individuals by age 20 years. Cardiac and ovarian fibromas occur in approximately 2% and 20% of individuals respectively. Approximately 5% of all children with NBCCS develop medulloblastoma (primitive neuroectodermal tumor), generally the desmoplastic subtype. The risk of developing medulloblastoma is substantially higher in individuals with an SUFU pathogenic variant (33%) than in those with a PTCH1 pathogenic variant (<2%). Peak incidence is at age one to two years. Life expectancy in NBCCS is not significantly different from average.
PTEN hamartoma tumor syndrome
MedGen UID:
368366
Concept ID:
C1959582
Disease or Syndrome
The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and PTEN-related Proteus-like syndrome. CS is a multiple hamartoma syndrome with a high risk for benign and malignant tumors of the thyroid, breast, kidney, and endometrium. Affected individuals usually have macrocephaly, trichilemmomas, and papillomatous papules, and present by the late 20s. The lifetime risk of developing breast cancer is 85%, with an average age of diagnosis between 38 and 46 years. The lifetime risk for thyroid cancer (usually follicular, rarely papillary, but never medullary thyroid cancer) is approximately 35%. The lifetime risk for renal cell cancer (predominantly of papillary histology) is 34%. The risk for endometrial cancer may approach 28%. BRRS is a congenital disorder characterized by macrocephaly, intestinal hamartomatous polyposis, lipomas, and pigmented macules of the glans penis. PS is a complex, highly variable disorder involving congenital malformations and hamartomatous overgrowth of multiple tissues, as well as connective tissue nevi, epidermal nevi, and hyperostoses. Proteus-like syndrome is undefined but refers to individuals with significant clinical features of PS who do not meet the diagnostic criteria for PS.
Breast-ovarian cancer, familial, susceptibility to, 3
MedGen UID:
462009
Concept ID:
C3150659
Finding
Any hereditary breast ovarian cancer syndrome in which the cause of the disease is a mutation in the RAD51C gene.

Recent clinical studies

Etiology

Li Y, Huo FF, Wen YY, Jiang M
Biomed Res Int 2021;2021:6680036. Epub 2021 Apr 30 doi: 10.1155/2021/6680036. PMID: 33997040Free PMC Article
Leenen S, Hermens M, de Vos van Steenwijk PJ, Bekkers RLM, van Esch EMG
Cancer Immunol Immunother 2021 Jul;70(7):1821-1829. Epub 2021 Jan 7 doi: 10.1007/s00262-020-02831-1. PMID: 33411080
Abou-El-Naga AM, Abo El-Khair SM, Mahmoud AZ, Hamza M, Elshazli RM
J Biochem Mol Toxicol 2021 Feb;35(2):e22637. Epub 2020 Sep 30 doi: 10.1002/jbt.22637. PMID: 32997381
Chen J, Chen K, Zhou Z, Huang L, Cai Y, Tu H, Zhang X
Curr Probl Cancer 2020 Oct;44(5):100555. Epub 2020 Jan 28 doi: 10.1016/j.currproblcancer.2020.100555. PMID: 32057463
Babay W, Ben Yahia H, Boujelbene N, Zidi N, Laaribi AB, Kacem D, Ben Ghorbel R, Boudabous A, Ouzari HI, Rizzo R, Rebmann V, Mrad K, Zidi I
Hum Immunol 2018 Jun;79(6):463-470. Epub 2018 Mar 2 doi: 10.1016/j.humimm.2018.02.012. PMID: 29499226

Diagnosis

Liu P, Chen R, Zhang X, Fu R, Tao L, Jia W
BMC Genomics 2022 Jan 13;23(1):51. doi: 10.1186/s12864-021-08265-y. PMID: 35026984Free PMC Article
Srivastava A, Gupta A, Patidar S
Clin Transl Oncol 2021 Oct;23(10):1967-1978. Epub 2021 Apr 11 doi: 10.1007/s12094-021-02604-x. PMID: 33840014
An H, Wang Y, Wong EMF, Lyu S, Han L, Perucho JAU, Cao P, Lee EYP
Eur Radiol 2021 Jul;31(7):5050-5058. Epub 2021 Jan 6 doi: 10.1007/s00330-020-07565-3. PMID: 33409777
Abou-El-Naga AM, Abo El-Khair SM, Mahmoud AZ, Hamza M, Elshazli RM
J Biochem Mol Toxicol 2021 Feb;35(2):e22637. Epub 2020 Sep 30 doi: 10.1002/jbt.22637. PMID: 32997381
Hollis RL, Carmichael J, Meynert AM, Churchman M, Hallas-Potts A, Rye T, MacKean M, Nussey F, Semple CA, Herrington CS, Gourley C
Am J Obstet Gynecol 2019 Sep;221(3):245.e1-245.e15. Epub 2019 May 2 doi: 10.1016/j.ajog.2019.04.035. PMID: 31055034Free PMC Article

Therapy

Xu X, Zhu L, Long L
Medicine (Baltimore) 2021 Oct 15;100(41):e27395. doi: 10.1097/MD.0000000000027395. PMID: 34731110Free PMC Article
Rango E, D'Antona L, Iovenitti G, Brai A, Mancini A, Zamperini C, Trivisani CI, Marianelli S, Fallacara AL, Molinari A, Cianciusi A, Schenone S, Perrotti N, Dreassi E, Botta M
Eur J Med Chem 2021 Nov 5;223:113653. Epub 2021 Jun 17 doi: 10.1016/j.ejmech.2021.113653. PMID: 34161866
An H, Wang Y, Wong EMF, Lyu S, Han L, Perucho JAU, Cao P, Lee EYP
Eur Radiol 2021 Jul;31(7):5050-5058. Epub 2021 Jan 6 doi: 10.1007/s00330-020-07565-3. PMID: 33409777
Johnson KE, Popratiloff A, Fan Y, McDonald S, Godleski JJ
Gynecol Oncol 2020 Nov;159(2):527-533. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.09.028. PMID: 32977988
Guo L, Zhang Y, Yang Z, Peng H, Wei R, Wang C, Feng M
ACS Nano 2019 Feb 26;13(2):1078-1096. Epub 2019 Jan 4 doi: 10.1021/acsnano.8b08872. PMID: 30608136

Prognosis

Liu P, Chen R, Zhang X, Fu R, Tao L, Jia W
BMC Genomics 2022 Jan 13;23(1):51. doi: 10.1186/s12864-021-08265-y. PMID: 35026984Free PMC Article
Babay W, Boujelbene N, Ben Yahia H, Bortolotti D, Zemni I, Ouzari HI, Chelbi H, Mezlini A, Rizzo R, Zidi I
HLA 2021 Oct;98(4):357-365. Epub 2021 Jul 26 doi: 10.1111/tan.14374. PMID: 34272932
Li Y, Huo FF, Wen YY, Jiang M
Biomed Res Int 2021;2021:6680036. Epub 2021 Apr 30 doi: 10.1155/2021/6680036. PMID: 33997040Free PMC Article
Chen J, Chen K, Zhou Z, Huang L, Cai Y, Tu H, Zhang X
Curr Probl Cancer 2020 Oct;44(5):100555. Epub 2020 Jan 28 doi: 10.1016/j.currproblcancer.2020.100555. PMID: 32057463
Hollis RL, Carmichael J, Meynert AM, Churchman M, Hallas-Potts A, Rye T, MacKean M, Nussey F, Semple CA, Herrington CS, Gourley C
Am J Obstet Gynecol 2019 Sep;221(3):245.e1-245.e15. Epub 2019 May 2 doi: 10.1016/j.ajog.2019.04.035. PMID: 31055034Free PMC Article

Clinical prediction guides

Liu P, Chen R, Zhang X, Fu R, Tao L, Jia W
BMC Genomics 2022 Jan 13;23(1):51. doi: 10.1186/s12864-021-08265-y. PMID: 35026984Free PMC Article
Rango E, D'Antona L, Iovenitti G, Brai A, Mancini A, Zamperini C, Trivisani CI, Marianelli S, Fallacara AL, Molinari A, Cianciusi A, Schenone S, Perrotti N, Dreassi E, Botta M
Eur J Med Chem 2021 Nov 5;223:113653. Epub 2021 Jun 17 doi: 10.1016/j.ejmech.2021.113653. PMID: 34161866
Li Y, Huo FF, Wen YY, Jiang M
Biomed Res Int 2021;2021:6680036. Epub 2021 Apr 30 doi: 10.1155/2021/6680036. PMID: 33997040Free PMC Article
Chen J, Chen K, Zhou Z, Huang L, Cai Y, Tu H, Zhang X
Curr Probl Cancer 2020 Oct;44(5):100555. Epub 2020 Jan 28 doi: 10.1016/j.currproblcancer.2020.100555. PMID: 32057463
Babay W, Ben Yahia H, Boujelbene N, Zidi N, Laaribi AB, Kacem D, Ben Ghorbel R, Boudabous A, Ouzari HI, Rizzo R, Rebmann V, Mrad K, Zidi I
Hum Immunol 2018 Jun;79(6):463-470. Epub 2018 Mar 2 doi: 10.1016/j.humimm.2018.02.012. PMID: 29499226

Recent systematic reviews

Witjes VM, van Bommel MHD, Ligtenberg MJL, Vos JR, Mourits MJE, Ausems MGEM, de Hullu JA, Bosse T, Hoogerbrugge N
Gynecol Oncol 2022 Jan;164(1):221-230. Epub 2021 Oct 23 doi: 10.1016/j.ygyno.2021.10.072. PMID: 34702566
van de Vorst REWM, Hoogendam JP, van der Aa MA, Witteveen PO, Zweemer RP, Gerestein CG
Gynecol Oncol 2021 Jun;161(3):876-883. Epub 2021 Apr 10 doi: 10.1016/j.ygyno.2021.04.007. PMID: 33849726
Voutsadakis IA
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:172-178. Epub 2020 Nov 12 doi: 10.1016/j.ejogrb.2020.11.021. PMID: 33246201
Goulding EA, Simcock B, McLachlan J, van der Griend R, Sykes P
Aust N Z J Obstet Gynaecol 2020 Feb;60(1):27-33. Epub 2019 Dec 17 doi: 10.1111/ajo.13105. PMID: 31849044
Xiao Y, Xie S, Zhang N, Wang J, Lv C, Guo J, Yang Q
Gynecol Obstet Invest 2018;83(3):209-219. Epub 2017 Dec 21 doi: 10.1159/000485618. PMID: 29402804

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