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Abnormal esophagus physiology

MedGen UID:
1370638
•Concept ID:
C4476684
•
Finding
Synonyms: Abnormality of esophagus physiology; Abnormality of oesophagus physiology; Functional abnormality of the esophagus; Functional abnormality of the oesophagus
 
HPO: HP:0025270

Definition

Any physiological abnormality of the esophagus. [from HPO]

Professional guidelines

PubMed

Regurgitation, eructation, and supragastric belch: retrograde esophageal motility, disorders, and treatment.
Patel P, Layne S, Leiman DA
Curr Opin Gastroenterol 2024 Nov 1;40(6):442-448. Epub 2024 Aug 5 doi: 10.1097/MOG.0000000000001059. PMID: 39150445
Eosinophilic esophagitis: Pathophysiology, diagnosis, and management.
Vinit C, Dieme A, Courbage S, Dehaine C, Dufeu CM, Jacquemot S, Lajus M, Montigny L, Payen E, Yang DD, Dupont C
Arch Pediatr 2019 Apr;26(3):182-190. Epub 2019 Mar 1 doi: 10.1016/j.arcped.2019.02.005. PMID: 30827775
Diagnosis and Management of Laryngotracheoesophageal Cleft.
Sobol SE
Curr Probl Pediatr Adolesc Health Care 2018 Mar;48(3):82-84. doi: 10.1016/j.cppeds.2018.01.007. PMID: 29571545

Recent clinical studies

Etiology

Clinical Presentations and Diagnostic Imaging of VACTERL Association.
Tonni G, Koçak Ç, Grisolia G, Rizzo G, Araujo Júnior E, Werner H, Ruano R, Sepulveda W, Bonasoni MP, Lituania M; “International Perinatology Research Group (IPRG)”
Fetal Pediatr Pathol 2023 Aug;42(4):651-674. Epub 2023 May 17 doi: 10.1080/15513815.2023.2206905. PMID: 37195727
Normal and abnormal physiology, pharmacology, and anatomy of the gastroesophageal junction high-pressure zone.
Miller L, Vegesna A, Ruggieri M, Braverman A
Ann N Y Acad Sci 2016 Sep;1380(1):48-57. Epub 2016 Jul 28 doi: 10.1111/nyas.13168. PMID: 27467321
Oesophageal atresia.
Spitz L
Orphanet J Rare Dis 2007 May 11;2:24. doi: 10.1186/1750-1172-2-24. PMID: 17498283Free PMC Article
GERD pathogenesis, pathophysiology, and clinical manifestations.
Kahrilas PJ
Cleve Clin J Med 2003 Nov;70 Suppl 5:S4-19. doi: 10.3949/ccjm.70.suppl_5.s4. PMID: 14705378
Pharyngoesophageal pH monitoring.
Bardan E
Am J Med 2003 Aug 18;115 Suppl 3A:78S-80S. doi: 10.1016/s0002-9343(03)00202-x. PMID: 12928080

Diagnosis

Clinical Presentations and Diagnostic Imaging of VACTERL Association.
Tonni G, Koçak Ç, Grisolia G, Rizzo G, Araujo Júnior E, Werner H, Ruano R, Sepulveda W, Bonasoni MP, Lituania M; “International Perinatology Research Group (IPRG)”
Fetal Pediatr Pathol 2023 Aug;42(4):651-674. Epub 2023 May 17 doi: 10.1080/15513815.2023.2206905. PMID: 37195727
Developmental basis of trachea-esophageal birth defects.
Edwards NA, Shacham-Silverberg V, Weitz L, Kingma PS, Shen Y, Wells JM, Chung WK, Zorn AM
Dev Biol 2021 Sep;477:85-97. Epub 2021 May 21 doi: 10.1016/j.ydbio.2021.05.015. PMID: 34023332Free PMC Article
Oesophageal atresia.
van Lennep M, Singendonk MMJ, Dall'Oglio L, Gottrand F, Krishnan U, Terheggen-Lagro SWJ, Omari TI, Benninga MA, van Wijk MP
Nat Rev Dis Primers 2019 Apr 18;5(1):26. doi: 10.1038/s41572-019-0077-0. PMID: 31000707
Achalasia: a systematic review.
Pandolfino JE, Gawron AJ
JAMA 2015 May 12;313(18):1841-52. doi: 10.1001/jama.2015.2996. PMID: 25965233
VACTERL/VATER Association.
Solomon BD
Orphanet J Rare Dis 2011 Aug 16;6:56. doi: 10.1186/1750-1172-6-56. PMID: 21846383Free PMC Article

Therapy

Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis.
Hirano I, Dellon ES, Hamilton JD, Collins MH, Peterson K, Chehade M, Schoepfer AM, Safroneeva E, Rothenberg ME, Falk GW, Assouline-Dayan Y, Zhao Q, Chen Z, Swanson BN, Pirozzi G, Mannent L, Graham NMH, Akinlade B, Stahl N, Yancopoulos GD, Radin A
Gastroenterology 2020 Jan;158(1):111-122.e10. Epub 2019 Oct 5 doi: 10.1053/j.gastro.2019.09.042. PMID: 31593702
Pathophysiology of Eosinophilic Esophagitis.
O'Shea KM, Aceves SS, Dellon ES, Gupta SK, Spergel JM, Furuta GT, Rothenberg ME
Gastroenterology 2018 Jan;154(2):333-345. Epub 2017 Jul 27 doi: 10.1053/j.gastro.2017.06.065. PMID: 28757265Free PMC Article
Achalasia: a systematic review.
Pandolfino JE, Gawron AJ
JAMA 2015 May 12;313(18):1841-52. doi: 10.1001/jama.2015.2996. PMID: 25965233
Eosinophilic esophagitis.
Chan SK, Mahmoudi M
Compr Ther 2009 Fall-Winter;35(3-4):160-6. PMID: 20043612
Esophagopharyngeal reflux.
Belafsky PC, Rees CJ, Rodriguez K, Pryor JS, Katz PO
Otolaryngol Head Neck Surg 2008 Jan;138(1):57-61. doi: 10.1016/j.otohns.2007.09.006. PMID: 18164994

Prognosis

Lymphocytic Esophagitis: Current Understanding and Controversy.
Pittman ME
Am J Surg Pathol 2022 Jan 1;46(1):e55-e63. doi: 10.1097/PAS.0000000000001667. PMID: 33481383
Achalasia: a systematic review.
Pandolfino JE, Gawron AJ
JAMA 2015 May 12;313(18):1841-52. doi: 10.1001/jama.2015.2996. PMID: 25965233
VACTERL/VATER Association.
Solomon BD
Orphanet J Rare Dis 2011 Aug 16;6:56. doi: 10.1186/1750-1172-6-56. PMID: 21846383Free PMC Article
Esophagopharyngeal reflux.
Belafsky PC, Rees CJ, Rodriguez K, Pryor JS, Katz PO
Otolaryngol Head Neck Surg 2008 Jan;138(1):57-61. doi: 10.1016/j.otohns.2007.09.006. PMID: 18164994
GERD pathogenesis, pathophysiology, and clinical manifestations.
Kahrilas PJ
Cleve Clin J Med 2003 Nov;70 Suppl 5:S4-19. doi: 10.3949/ccjm.70.suppl_5.s4. PMID: 14705378

Clinical prediction guides

The functional substrate in patients with atrial fibrillation is predictive of recurrences after catheter ablation.
Frontera A, Villella F, Cristiano E, Comi F, Latini A, Ceriotti C, Galimberti P, Zachariah D, Pinna G, Taormina A, Vlachos K, Laredo M, Sánchez-Millán PJ, Penela D, Bernardini A, Bologna F, Giomi A, Augello G, Botto G, Tzeis S, Mazzone P
Heart Rhythm 2025 Jun;22(6):1401-1410. Epub 2024 Sep 13 doi: 10.1016/j.hrthm.2024.09.017. PMID: 39278611
Lymphocytic Esophagitis: Current Understanding and Controversy.
Pittman ME
Am J Surg Pathol 2022 Jan 1;46(1):e55-e63. doi: 10.1097/PAS.0000000000001667. PMID: 33481383
Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis.
Hirano I, Dellon ES, Hamilton JD, Collins MH, Peterson K, Chehade M, Schoepfer AM, Safroneeva E, Rothenberg ME, Falk GW, Assouline-Dayan Y, Zhao Q, Chen Z, Swanson BN, Pirozzi G, Mannent L, Graham NMH, Akinlade B, Stahl N, Yancopoulos GD, Radin A
Gastroenterology 2020 Jan;158(1):111-122.e10. Epub 2019 Oct 5 doi: 10.1053/j.gastro.2019.09.042. PMID: 31593702
Advances in the endoscopic evaluation of eosinophilic esophagitis.
Kia L, Hirano I
Curr Opin Gastroenterol 2016 Jul;32(4):325-31. doi: 10.1097/MOG.0000000000000278. PMID: 27054896Free PMC Article
Current knowledge on esophageal atresia.
Pinheiro PF, Simões e Silva AC, Pereira RM
World J Gastroenterol 2012 Jul 28;18(28):3662-72. doi: 10.3748/wjg.v18.i28.3662. PMID: 22851858Free PMC Article

Recent systematic reviews

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.
Gao S, Zhao ZY, Zhang ZY, Zhang Y, Wu R
Clin Transl Gastroenterol 2018 Nov 13;9(11):203. doi: 10.1038/s41424-018-0070-z. PMID: 30420592Free PMC Article
Presentation of oropharyngeal dysphagia and rehabilitative intervention following esophagectomy: a systematic review.
Kaneoka A, Yang S, Inokuchi H, Ueha R, Yamashita H, Nito T, Seto Y, Haga N
Dis Esophagus 2018 Aug 1;31(8) doi: 10.1093/dote/doy050. PMID: 29788321Free PMC Article
Challenges and limitations in the diagnosis of atrioesophageal fistula.
Ha FJ, Han HC, Sanders P, Teh AW, O'Donnell D, Farouque O, Lim HS
J Cardiovasc Electrophysiol 2018 Jun;29(6):861-871. Epub 2018 Apr 23 doi: 10.1111/jce.13494. PMID: 29603477
A systematic review with meta-analysis of the prevalence of gastroesophageal reflux in congenital diaphragmatic hernia pediatric survivors.
Arcos-Machancoses JV, Ruiz Hernández C, Martin de Carpi J, Pinillos Pisón S
Dis Esophagus 2018 Jun 1;31(6) doi: 10.1093/dote/dox158. PMID: 29444224
Achalasia: a systematic review.
Pandolfino JE, Gawron AJ
JAMA 2015 May 12;313(18):1841-52. doi: 10.1001/jama.2015.2996. PMID: 25965233

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