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Abnormal CSF lactate concentration

MedGen UID:
868264
•Concept ID:
C4022656
•
Finding
Synonym: Abnormal CSF lactate level
 
HPO: HP:0030085

Definition

Abnormal concentration of lactate in the cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Treatment of Kearns-Sayre syndrome with coenzyme Q10.
Ogasahara S, Nishikawa Y, Yorifuji S, Soga F, Nakamura Y, Takahashi M, Hashimoto S, Kono N, Tarui S
Neurology 1986 Jan;36(1):45-53. doi: 10.1212/wnl.36.1.45. PMID: 3941783

Recent clinical studies

Etiology

Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage: A Multicenter Retrospective Study.
Taccone FS, Badenes R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa IA, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F
J Neurosurg Anesthesiol 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707
Developmental outcomes and prevalence of SLC2A1 variants in young infants with hypoglycorrhachia.
Yu WH, Chen LW, Wang ST, Tu YF, Huang CC
Brain Dev 2019 Nov;41(10):854-861. Epub 2019 Jul 17 doi: 10.1016/j.braindev.2019.07.004. PMID: 31326153
Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081

Diagnosis

Broadband Infrared Spectroscopy for Non-Contact Measurement of Neurological Disease Biomarkers in Cerebrospinal Fluid.
Horosh M, Feldman H, Yablonovich A, Firer MA, Abookasis D
Appl Spectrosc 2017 Mar;71(3):496-506. Epub 2016 Oct 1 doi: 10.1177/0003702816665125. PMID: 27634889
Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
Glut1 deficiency syndrome and erythrocyte glucose uptake assay.
Yang H, Wang D, Engelstad K, Bagay L, Wei Y, Rotstein M, Aggarwal V, Levy B, Ma L, Chung WK, De Vivo DC
Ann Neurol 2011 Dec;70(6):996-1005. doi: 10.1002/ana.22640. PMID: 22190371
1H magnetic resonance spectroscopy in human hydrocephalus.
Braun KP, Gooskens RH, Vandertop WP, Tulleken CA, van der Grond J
J Magn Reson Imaging 2003 Mar;17(3):291-9. doi: 10.1002/jmri.10270. PMID: 12594718

Therapy

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status.
Dumbuya JS, Chen L, Wu JY, Wang B
J Neuroinflammation 2021 Feb 21;18(1):55. doi: 10.1186/s12974-021-02084-4. PMID: 33612099Free PMC Article
Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081
Tardive dyskinesia and substrates of energy metabolism in CSF.
Goff DC, Tsai G, Beal MF, Coyle JT
Am J Psychiatry 1995 Dec;152(12):1730-6. doi: 10.1176/ajp.152.12.1730. PMID: 8526238
Treatment of Kearns-Sayre syndrome with coenzyme Q10.
Ogasahara S, Nishikawa Y, Yorifuji S, Soga F, Nakamura Y, Takahashi M, Hashimoto S, Kono N, Tarui S
Neurology 1986 Jan;36(1):45-53. doi: 10.1212/wnl.36.1.45. PMID: 3941783

Prognosis

Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage: A Multicenter Retrospective Study.
Taccone FS, Badenes R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa IA, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F
J Neurosurg Anesthesiol 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707
Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081

Clinical prediction guides

Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage: A Multicenter Retrospective Study.
Taccone FS, Badenes R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa IA, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F
J Neurosurg Anesthesiol 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707
Developmental outcomes and prevalence of SLC2A1 variants in young infants with hypoglycorrhachia.
Yu WH, Chen LW, Wang ST, Tu YF, Huang CC
Brain Dev 2019 Nov;41(10):854-861. Epub 2019 Jul 17 doi: 10.1016/j.braindev.2019.07.004. PMID: 31326153
Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Glut1 deficiency syndrome and erythrocyte glucose uptake assay.
Yang H, Wang D, Engelstad K, Bagay L, Wei Y, Rotstein M, Aggarwal V, Levy B, Ma L, Chung WK, De Vivo DC
Ann Neurol 2011 Dec;70(6):996-1005. doi: 10.1002/ana.22640. PMID: 22190371
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081

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