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Age-related cortical cataract

MedGen UID:
853858
•Concept ID:
C2880562
•
Acquired Abnormality
HPO: HP:0011143

Definition

A type of age-related cataract that primarily affects the cortex of the lens. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Age-related cortical cataract

Professional guidelines

PubMed

NSAIDs and Corticosteroids for the Postoperative Management of Age-Related Cataract Surgery: A Systematic Review and Meta-analysis.
Haddad JE, Sabbakh NA, Macaron MM, Shaaban H, Bourdakos NE, Shi A, Saad B, Nakanishi H, Than CA, Daoud YJ
Am J Ophthalmol 2024 Apr;260:1-13. Epub 2023 Oct 4 doi: 10.1016/j.ajo.2023.09.027. PMID: 37797866
Associations of Polymorphisms in MTHFR Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis.
Wang XB, Qiao C, Wei L, Han YD, Cui NH, Huang ZL, Li ZH, Zheng F, Yan M
PLoS One 2015;10(12):e0145581. Epub 2015 Dec 21 doi: 10.1371/journal.pone.0145581. PMID: 26689687Free PMC Article
Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population.
Alberti G, Oguni M, Podgor M, Sperduto RD, Tomarev S, Grassi C, Williams S, Kaiser-Kupfer M, Maraini G, Hejtmancik JF
Invest Ophthalmol Vis Sci 1996 May;37(6):1167-73. PMID: 8631631

Recent clinical studies

Etiology

Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: A case-control study.
Fu Q, Qin Z, Yu J, Yu Y, Tang Q, Lyu D, Zhang L, Chen Z, Yao K
Medicine (Baltimore) 2016 Jun;95(25):e3869. doi: 10.1097/MD.0000000000003869. PMID: 27336873Free PMC Article
Glutathione S-transferases polymorphisms confer susceptibility to senile cortical cataract in the Han Chinese population.
Jiang Z, Liang K, Zhang Q, Tao L
Mol Vis 2012;18:1247-52. Epub 2012 May 11 PMID: 22665971Free PMC Article
EPHA2 is associated with age-related cortical cataract in mice and humans.
Jun G, Guo H, Klein BE, Klein R, Wang JJ, Mitchell P, Miao H, Lee KE, Joshi T, Buck M, Chugha P, Bardenstein D, Klein AP, Bailey-Wilson JE, Gong X, Spector TD, Andrew T, Hammond CJ, Elston RC, Iyengar SK, Wang B
PLoS Genet 2009 Jul;5(7):e1000584. Epub 2009 Jul 31 doi: 10.1371/journal.pgen.1000584. PMID: 19649315Free PMC Article
Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors.
Congdon N, Broman KW, Lai H, Munoz B, Bowie H, Gilbert D, Wojciechowski R, West SK
Ophthalmology 2005 Jan;112(1):73-7. doi: 10.1016/j.ophtha.2004.07.012. PMID: 15629823Free PMC Article
Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study.
Iyengar SK, Klein BE, Klein R, Jun G, Schick JH, Millard C, Liptak R, Russo K, Lee KE, Elston RC
Proc Natl Acad Sci U S A 2004 Oct 5;101(40):14485-90. Epub 2004 Sep 27 doi: 10.1073/pnas.0400778101. PMID: 15452352Free PMC Article

Diagnosis

The heritability of age-related cortical cataract: the twin eye study.
Hammond CJ, Duncan DD, Snieder H, de Lange M, West SK, Spector TD, Gilbert CE
Invest Ophthalmol Vis Sci 2001 Mar;42(3):601-5. PMID: 11222516

Therapy

CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract.
Liu J, Zhang J, Zhang G, Zhou T, Zou X, Guan H, Wang Y
Aging (Albany NY) 2021 Jan 28;13(4):5383-5402. doi: 10.18632/aging.202470. PMID: 33508783Free PMC Article
Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors.
Congdon N, Broman KW, Lai H, Munoz B, Bowie H, Gilbert D, Wojciechowski R, West SK
Ophthalmology 2005 Jan;112(1):73-7. doi: 10.1016/j.ophtha.2004.07.012. PMID: 15629823Free PMC Article
Temporal and spatial growth patterns in the normal and cataractous human lens.
Kwok LS, Coroneo MT
Exp Eye Res 2000 Sep;71(3):317-22. doi: 10.1006/exer.2000.0883. PMID: 10973740

Prognosis

Lens epithelial apoptosis and cell proliferation in human age-related cortical cataract.
Charakidas A, Kalogeraki A, Tsilimbaris M, Koukoulomatis P, Brouzas D, Delides G
Eur J Ophthalmol 2005 Mar-Apr;15(2):213-20. doi: 10.1177/112067210501500206. PMID: 15812762

Clinical prediction guides

CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract.
Liu J, Zhang J, Zhang G, Zhou T, Zou X, Guan H, Wang Y
Aging (Albany NY) 2021 Jan 28;13(4):5383-5402. doi: 10.18632/aging.202470. PMID: 33508783Free PMC Article
Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract.
Tu Y, Xie L, Chen L, Yuan Y, Qin B, Wang K, Zhu Q, Ji N, Zhu M, Guan H
Exp Eye Res 2020 Oct;199:108185. Epub 2020 Aug 22 doi: 10.1016/j.exer.2020.108185. PMID: 32841649
Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract.
Tan AG, Kifley A, Holliday EG, Klein BEK, Iyengar SK, Lee KE, Jun GR, Cumming RG, Zhao W, Wong TY, Cheng CY, Mitchell P, Wang JJ
Invest Ophthalmol Vis Sci 2018 Sep 4;59(11):4755-4762. doi: 10.1167/iovs.18-24353. PMID: 30267098
Association of EPHA2 polymorphisms and age-related cortical cataract in a Han Chinese population.
Tan W, Hou S, Jiang Z, Hu Z, Yang P, Ye J
Mol Vis 2011;17:1553-8. Epub 2011 Jun 9 PMID: 21686326Free PMC Article
The heritability of age-related cortical cataract: the twin eye study.
Hammond CJ, Duncan DD, Snieder H, de Lange M, West SK, Spector TD, Gilbert CE
Invest Ophthalmol Vis Sci 2001 Mar;42(3):601-5. PMID: 11222516

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