Format

Send to:

Choose Destination

Parkinson disease 16(PARK16)

MedGen UID:
442620
Concept ID:
C2751012
Disease or Syndrome
Synonyms: PARK16
 
OMIM®: 613164

Disease characteristics

Excerpted from the GeneReview: Parkinson Disease Overview
Parkinsonism refers to all clinical states characterized by tremor, muscle rigidity, slowed movement (bradykinesia) and often postural instability. Parkinson disease is the primary and most common form of parkinsonism. Psychiatric manifestations, which include depression and visual hallucinations, are common but not uniformly present. Dementia eventually occurs in at least 20% of cases. The most common sporadic form of Parkinson disease manifests around age 60; however, young-onset and even juvenile presentations are seen. [from GeneReviews]
Full text of GeneReview (by section):
Summary  |  Definition  |  Causes  |  Evaluation Strategy  |  Genetic Counseling  |  Resources  |  Management  |  References  |  Chapter Notes
Authors:
Janice Farlow  |  Nathan D Pankratz  |  Joanne Wojcieszek, et. al.   view full author information

Additional description

From GHR
Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.Parkinson disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.Generally, Parkinson disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson disease.  https://ghr.nlm.nih.gov/condition/parkinson-disease

Recent clinical studies

Etiology

Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Nakamura Y; Fukuoka Kinki Parkinson's Disease Study Group.
J Neurol Sci 2016 Mar 15;362:47-52. Epub 2016 Jan 14 doi: 10.1016/j.jns.2016.01.021. PMID: 26944116
Xia H, Luo Q, Li XX, Yang XL
Genet Mol Res 2015 Apr 10;14(2):2978-85. doi: 10.4238/2015.April.10.7. PMID: 25966061
Pihlstrøm L, Rengmark A, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Dietrichs E, Toft M
J Hum Genet 2015 Jul;60(7):357-62. Epub 2015 Apr 9 doi: 10.1038/jhg.2015.34. PMID: 25855069
Zhou LL, Zhang X, Bao QQ, Liu RP, Gong MY, Mao GY, Zou M, Zhu JH
J Clin Neurosci 2014 Jun;21(6):1029-32. Epub 2013 Nov 14 doi: 10.1016/j.jocn.2013.09.015. PMID: 24373818
Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR
Neurobiol Aging 2013 Oct;34(10):2442.e5-9. Epub 2013 Jun 5 doi: 10.1016/j.neurobiolaging.2013.04.028. PMID: 23747047

Diagnosis

Zhou LL, Zhang X, Bao QQ, Liu RP, Gong MY, Mao GY, Zou M, Zhu JH
J Clin Neurosci 2014 Jun;21(6):1029-32. Epub 2013 Nov 14 doi: 10.1016/j.jocn.2013.09.015. PMID: 24373818
Peeraully T, Tan EK
Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S63-5. doi: 10.1016/S1353-8020(11)70021-9. PMID: 22166457

Clinical prediction guides

Zhou LL, Zhang X, Bao QQ, Liu RP, Gong MY, Mao GY, Zou M, Zhu JH
J Clin Neurosci 2014 Jun;21(6):1029-32. Epub 2013 Nov 14 doi: 10.1016/j.jocn.2013.09.015. PMID: 24373818
MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD, Marder KS, Honig LS, Clark LN, Small SA, Abeliovich A
Neuron 2013 Feb 6;77(3):425-39. doi: 10.1016/j.neuron.2012.11.033. PMID: 23395371Free PMC Article

Recent systematic reviews

Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR
Neurobiol Aging 2013 Oct;34(10):2442.e5-9. Epub 2013 Jun 5 doi: 10.1016/j.neurobiolaging.2013.04.028. PMID: 23747047

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center