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Asthma-related traits, susceptibility to, 7(ASRT7)

MedGen UID:
394362
Concept ID:
C2677770
Finding
Synonym: ASRT7
 
Gene (location): CHI3L1 (1q32.1)
 
Monarch Initiative: MONDO:0012771
OMIM®: 611960

Definition

Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. [from OMIM]

Recent clinical studies

Etiology

Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER
Allergy 2015 Oct;70(10):1309-18. Epub 2015 Jul 24 doi: 10.1111/all.12683. PMID: 26119467Free PMC Article
Martínez-Aguilar NE, Del Río-Navarro BE, Navarro-Olivos E, García-Ortíz H, Orozco L, Jiménez-Morales S
J Asthma 2015 Apr;52(3):232-9. Epub 2014 Oct 8 doi: 10.3109/02770903.2014.966913. PMID: 25233048
Thomsen SF, van der Sluis S, Kyvik KO, Backer V
Clin Respir J 2012 Oct;6(4):228-37. Epub 2011 Dec 14 doi: 10.1111/j.1752-699X.2011.00273.x. PMID: 22081985
Chen J, Deng Y, Zhao J, Luo Z, Peng W, Yang J, Ren L, Wang L, Fu Z, Yang X, Liu E
J Clin Immunol 2010 Jul;30(4):539-45. Epub 2010 May 2 doi: 10.1007/s10875-010-9391-8. PMID: 20437253
Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J
Science 2004 Apr 9;304(5668):300-4. doi: 10.1126/science.1090010. PMID: 15073379

Diagnosis

Thomsen SF, van der Sluis S, Kyvik KO, Backer V
Clin Respir J 2012 Oct;6(4):228-37. Epub 2011 Dec 14 doi: 10.1111/j.1752-699X.2011.00273.x. PMID: 22081985

Therapy

Thomsen SF, van der Sluis S, Kyvik KO, Backer V
Clin Respir J 2012 Oct;6(4):228-37. Epub 2011 Dec 14 doi: 10.1111/j.1752-699X.2011.00273.x. PMID: 22081985
Hersh CP, Soto-Quirós ME, Avila L, Lake SL, Liang C, Fournier E, Spesny M, Sylvia JS, Lazarus R, Hudson T, Verner A, Klanderman BJ, Freimer NB, Silverman EK, Celedón JC
Thorax 2007 Mar;62(3):224-30. Epub 2006 Nov 10 doi: 10.1136/thx.2006.067934. PMID: 17099076Free PMC Article

Prognosis

Thomsen SF, van der Sluis S, Kyvik KO, Backer V
Clin Respir J 2012 Oct;6(4):228-37. Epub 2011 Dec 14 doi: 10.1111/j.1752-699X.2011.00273.x. PMID: 22081985
Polvi A, Polvi T, Sevon P, Petäys T, Haahtela T, Laitinen LA, Kere J, Laitinen T
Eur J Hum Genet 2002 Oct;10(10):658-65. doi: 10.1038/sj.ejhg.5200861. PMID: 12357338

Clinical prediction guides

Hersh CP, Soto-Quirós ME, Avila L, Lake SL, Liang C, Fournier E, Spesny M, Sylvia JS, Lazarus R, Hudson T, Verner A, Klanderman BJ, Freimer NB, Silverman EK, Celedón JC
Thorax 2007 Mar;62(3):224-30. Epub 2006 Nov 10 doi: 10.1136/thx.2006.067934. PMID: 17099076Free PMC Article
Batra J, Sharma SK, Ghosh B
Pharmacogenomics 2006 Jul;7(5):673-82. doi: 10.2217/14622416.7.5.673. PMID: 16886893
Polvi A, Polvi T, Sevon P, Petäys T, Haahtela T, Laitinen LA, Kere J, Laitinen T
Eur J Hum Genet 2002 Oct;10(10):658-65. doi: 10.1038/sj.ejhg.5200861. PMID: 12357338
Laitinen T, Daly MJ, Rioux JD, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander ES, Laitinen LA, Hudson TJ, Kere J
Nat Genet 2001 May;28(1):87-91. doi: 10.1038/ng0501-87. PMID: 11326283

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