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Inflammatory bowel disease 14(IBD14)

MedGen UID:
436860
•Concept ID:
C2677100
•
Disease or Syndrome
Synonym: IBD14
 
Gene (location): IRF5 (7q32.1)
 
Monarch Initiative: MONDO:0012832
OMIM®: 612245

Definition

Any inflammatory bowel disease in which the cause of the disease is a mutation in the IRF5 gene. [from MONDO]

Professional guidelines

PubMed

Assessment of the Risk of Venous Thromboembolism in Nonhospitalized Patients With COVID-19.
Fang MC, Reynolds K, Tabada GH, Prasad PA, Sung SH, Parks AL, Garcia E, Portugal C, Fan D, Pai AP, Go AS
JAMA Netw Open 2023 Mar 1;6(3):e232338. doi: 10.1001/jamanetworkopen.2023.2338. PMID: 36912838Free PMC Article

Recent clinical studies

Etiology

Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
Cheng W, Liao Y, Mou R, Xiao X, Jia Y
Front Immunol 2023;14:1157313. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1157313. PMID: 37409117Free PMC Article
Systematic review with network meta-analysis: Risk of Herpes zoster with biological therapies and small molecules in inflammatory bowel disease.
Din S, Selinger CP, Black CJ, Ford AC
Aliment Pharmacol Ther 2023 Mar;57(6):666-675. Epub 2022 Dec 31 doi: 10.1111/apt.17379. PMID: 36585944
Dietary Interventions in Inflammatory Bowel Disease.
Godala M, Gaszyńska E, Zatorski H, Małecka-Wojciesko E
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204261. PMID: 36296945Free PMC Article
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.
Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN
Cell Host Microbe 2021 Aug 11;29(8):1294-1304.e4. Epub 2021 Jul 22 doi: 10.1016/j.chom.2021.06.019. PMID: 34297922Free PMC Article
Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L, Panés J, Sandborn WJ, Vermeire S, Danese S, Feagan BG, Colombel JF, Hanauer SB, Rycroft B
Clin Gastroenterol Hepatol 2016 Mar;14(3):348-354.e17. Epub 2015 Jun 11 doi: 10.1016/j.cgh.2015.06.001. PMID: 26071941

Diagnosis

Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.
Khrom M, Long M, Dube S, Robbins L, Botwin GJ, Yang S, Mengesha E, Li D, Naito T, Bonthala NN, Ha C, Melmed G, Rabizadeh S, Syal G, Vasiliauskas E, Ziring D, Brant SR, Cho J, Duerr RH, Rioux J, Schumm P, Silverberg M, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Xavier RJ, Kugathasan S, Hercules D, Targan SR, Sartor RB, Haritunians T, McGovern DPB
Gastroenterology 2024 Jul;167(2):315-332. Epub 2024 Mar 13 doi: 10.1053/j.gastro.2024.02.026. PMID: 38490347Free PMC Article
The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization.
Xu D, Chen Y, Gao X, Xie W, Wang Y, Shen J, Yang G, Xie B
Front Immunol 2023;14:1148107. Epub 2023 May 18 doi: 10.3389/fimmu.2023.1148107. PMID: 37275908Free PMC Article
Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.
Mörbe UM, Jørgensen PB, Fenton TM, von Burg N, Riis LB, Spencer J, Agace WW
Mucosal Immunol 2021 Jul;14(4):793-802. Epub 2021 Mar 22 doi: 10.1038/s41385-021-00389-4. PMID: 33753873
AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review.
Colombel JF, Shin A, Gibson PR
Clin Gastroenterol Hepatol 2019 Feb;17(3):380-390.e1. Epub 2018 Aug 9 doi: 10.1016/j.cgh.2018.08.001. PMID: 30099108Free PMC Article
Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L, Panés J, Sandborn WJ, Vermeire S, Danese S, Feagan BG, Colombel JF, Hanauer SB, Rycroft B
Clin Gastroenterol Hepatol 2016 Mar;14(3):348-354.e17. Epub 2015 Jun 11 doi: 10.1016/j.cgh.2015.06.001. PMID: 26071941

Therapy

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment.
Yan D, Ye S, He Y, Wang S, Xiao Y, Xiang X, Deng M, Luo W, Chen X, Wang X
Front Immunol 2023;14:1286667. Epub 2023 Oct 5 doi: 10.3389/fimmu.2023.1286667. PMID: 37868958Free PMC Article
Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
Cheng W, Liao Y, Mou R, Xiao X, Jia Y
Front Immunol 2023;14:1157313. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1157313. PMID: 37409117Free PMC Article
Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives.
Roy S, Dhaneshwar S
World J Gastroenterol 2023 Apr 14;29(14):2078-2100. doi: 10.3748/wjg.v29.i14.2078. PMID: 37122604Free PMC Article
Food Processing and Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Narula N, Chang NH, Mohammad D, Wong ECL, Ananthakrishnan AN, Chan SSM, Carbonnel F, Meyer A
Clin Gastroenterol Hepatol 2023 Sep;21(10):2483-2495.e1. Epub 2023 Jan 31 doi: 10.1016/j.cgh.2023.01.012. PMID: 36731590
Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease.
Baumgart DC, Le Berre C
N Engl J Med 2021 Sep 30;385(14):1302-1315. doi: 10.1056/NEJMra1907607. PMID: 34587387

Prognosis

Incidence of Inflammatory Bowel Disease in Urban China: A Nationwide Population-based Study.
Xu L, He B, Sun Y, Li J, Shen P, Hu L, Liu G, Wang J, Duan L, Zhan S, Wang S
Clin Gastroenterol Hepatol 2023 Dec;21(13):3379-3386.e29. Epub 2023 Sep 1 doi: 10.1016/j.cgh.2023.08.013. PMID: 37660767
Dietary Interventions in Inflammatory Bowel Disease.
Godala M, Gaszyńska E, Zatorski H, Małecka-Wojciesko E
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204261. PMID: 36296945Free PMC Article
Long-term safety of vedolizumab for inflammatory bowel disease.
Loftus EV Jr, Feagan BG, Panaccione R, Colombel JF, Sandborn WJ, Sands BE, Danese S, D'Haens G, Rubin DT, Shafran I, Parfionovas A, Rogers R, Lirio RA, Vermeire S
Aliment Pharmacol Ther 2020 Oct;52(8):1353-1365. Epub 2020 Sep 2 doi: 10.1111/apt.16060. PMID: 32876349Free PMC Article
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646
Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L, Panés J, Sandborn WJ, Vermeire S, Danese S, Feagan BG, Colombel JF, Hanauer SB, Rycroft B
Clin Gastroenterol Hepatol 2016 Mar;14(3):348-354.e17. Epub 2015 Jun 11 doi: 10.1016/j.cgh.2015.06.001. PMID: 26071941

Clinical prediction guides

Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease.
Chen J, Ruan X, Sun Y, Lu S, Hu S, Yuan S, Li X
EBioMedicine 2024 Jan;99:104934. Epub 2023 Dec 16 doi: 10.1016/j.ebiom.2023.104934. PMID: 38103512Free PMC Article
Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations.
He R, Zhao S, Cui M, Chen Y, Ma J, Li J, Wang X
Front Immunol 2023;14:1234535. Epub 2023 Oct 26 doi: 10.3389/fimmu.2023.1234535. PMID: 37954590Free PMC Article
Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
Cheng W, Liao Y, Mou R, Xiao X, Jia Y
Front Immunol 2023;14:1157313. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1157313. PMID: 37409117Free PMC Article
Lipids, lipid-lowering agents, and inflammatory bowel disease: a Mendelian randomization study.
Tao H, Yu Z, Dong Y, Liu L, Peng L, Chen X
Front Immunol 2023;14:1160312. Epub 2023 Jun 7 doi: 10.3389/fimmu.2023.1160312. PMID: 37350960Free PMC Article
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.
Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN
Cell Host Microbe 2021 Aug 11;29(8):1294-1304.e4. Epub 2021 Jul 22 doi: 10.1016/j.chom.2021.06.019. PMID: 34297922Free PMC Article

Recent systematic reviews

High-Fiber Diet and Crohn's Disease: Systematic Review and Meta-Analysis.
Serrano Fernandez V, Seldas Palomino M, Laredo-Aguilera JA, Pozuelo-Carrascosa DP, Carmona-Torres JM
Nutrients 2023 Jul 12;15(14) doi: 10.3390/nu15143114. PMID: 37513532Free PMC Article
Comparative efficacy and safety of biologic therapies for moderate-to-severe Crohn's disease: a systematic review and network meta-analysis.
Singh S, Murad MH, Fumery M, Sedano R, Jairath V, Panaccione R, Sandborn WJ, Ma C
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1002-1014. Epub 2021 Oct 22 doi: 10.1016/S2468-1253(21)00312-5. PMID: 34688373Free PMC Article
Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis.
Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC
Lancet Gastroenterol Hepatol 2021 May;6(5):359-370. Epub 2021 Mar 12 doi: 10.1016/S2468-1253(21)00014-5. PMID: 33721557
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646
ESPEN guideline: Clinical nutrition in inflammatory bowel disease.
Forbes A, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Bischoff SC
Clin Nutr 2017 Apr;36(2):321-347. Epub 2016 Dec 31 doi: 10.1016/j.clnu.2016.12.027. PMID: 28131521

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