U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uterine Corpus Undifferentiated Sarcoma

MedGen UID:
412175
Concept ID:
C2239246
Neoplastic Process
Synonyms: Endometrial stromal sarcoma, high grade; Endometrioid stromal sarcoma, high grade; High grade endometrial stromal sarcoma; Undifferentiated Uterine Sarcoma; Uterine Corpus Undifferentiated Endometrial Sarcoma
SNOMED CT: Endometrial stromal sarcoma, high grade (70555003); High grade endometrial stromal sarcoma (699358009); Endometrioid stromal sarcoma, high grade (70555003)

Definition

A rare, high grade sarcoma that arises from the endometrial stroma or myometrium without a specific type of differentiation. It was previously also known as high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. Undifferentiated uterine sarcoma has a worse prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine Corpus Undifferentiated Sarcoma

Professional guidelines

PubMed

Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750

Recent clinical studies

Etiology

Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Sangoi AR, Kshirsagar M, Horvai AE, Roma AA
Int J Gynecol Pathol 2017 Mar;36(2):140-145. doi: 10.1097/PGP.0000000000000301. PMID: 27294605
El-Fiky SM, Taha YM
Acta Histochem 1976;56(1):1-17. doi: 10.1016/S0065-1281(76)80022-0. PMID: 184637

Diagnosis

Moura MS, Costa J, Velasco V, Kommoss F, Oliva E, Le Loarer F, McCluggage WG, Razack R, Treilleux I, Mills A, Longacre T, Devouassoux-Shisheboran M, Hostein I, Azmani R, Blanchard L, Hartog C, Soubeyran I, Khalifa E, Croce S
Histopathology 2024 Feb;84(3):451-462. Epub 2023 Nov 21 doi: 10.1111/his.15082. PMID: 37988282
Niu S, Rivera-Colon G, Lucas E
Int J Gynecol Pathol 2023 Sep 1;42(5):460-465. Epub 2023 Jan 25 doi: 10.1097/PGP.0000000000000937. PMID: 36811835
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Kihara A, Amano Y, Fukushima N, Fujiwara H, Niki T
Histopathology 2022 Jul;81(1):108-118. Epub 2022 May 18 doi: 10.1111/his.14671. PMID: 35478361
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387

Prognosis

Niu S, Rivera-Colon G, Lucas E
Int J Gynecol Pathol 2023 Sep 1;42(5):460-465. Epub 2023 Jan 25 doi: 10.1097/PGP.0000000000000937. PMID: 36811835
Kihara A, Amano Y, Fukushima N, Fujiwara H, Niki T
Histopathology 2022 Jul;81(1):108-118. Epub 2022 May 18 doi: 10.1111/his.14671. PMID: 35478361
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Sangoi AR, Kshirsagar M, Horvai AE, Roma AA
Int J Gynecol Pathol 2017 Mar;36(2):140-145. doi: 10.1097/PGP.0000000000000301. PMID: 27294605
McCluggage WG
Adv Anat Pathol 2010 Mar;17(2):122-9. doi: 10.1097/PAP.0b013e3181cfe732. PMID: 20179434

Clinical prediction guides

Kihara A, Amano Y, Fukushima N, Fujiwara H, Niki T
Histopathology 2022 Jul;81(1):108-118. Epub 2022 May 18 doi: 10.1111/his.14671. PMID: 35478361
Choi S, Na K, Kim SW, Kim HS
Anticancer Res 2021 May;41(5):2719-2726. doi: 10.21873/anticanres.15053. PMID: 33952503
Vera AA, Guadarrama MB
Ann Diagn Pathol 2011 Oct;15(5):312-7. Epub 2011 Jun 8 doi: 10.1016/j.anndiagpath.2011.01.008. PMID: 21652246
El-Fiky SM, Taha YM
Acta Histochem 1976;56(1):1-17. doi: 10.1016/S0065-1281(76)80022-0. PMID: 184637

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...