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Nonarteritic anterior ischemic optic neuropathy, susceptibility to(NAION)

MedGen UID:
338294
•Concept ID:
C1847711
•
Finding
Synonyms: NAION; NAION, SUSCEPTIBILITY TO; OPTIC NEUROPATHY, ANTERIOR ISCHEMIC, SUSCEPTIBILITY TO
 
Gene (location): GP1BA (17p13.2)
 
Monarch Initiative: MONDO:0009789
OMIM®: 258660

Clinical features

From HPO
Nonarteritic anterior ischemic optic neuropathy
MedGen UID:
338887
•Concept ID:
C1852242
•
Disease or Syndrome
An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disk or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates.
See: Feature record | Search on this feature

Recent clinical studies

Etiology

Genetic polymorphisms of apolipoprotein E in nonarteritic anterior ischemic optic neuropathy.
Chou Y, Sun Z, Wang Y, Wang Y, Ma J, Zhang D, Zhong Y
Graefes Arch Clin Exp Ophthalmol 2022 Aug;260(8):2717-2726. Epub 2022 Mar 8 doi: 10.1007/s00417-022-05616-7. PMID: 35258716
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy.
Chen T, Ma J, Shan G, Zhong Y
Exp Eye Res 2018 Sep;174:147-151. Epub 2018 May 21 doi: 10.1016/j.exer.2018.05.021. PMID: 29792847
Ocular Manifestations of Obstructive Sleep Apnea.
Santos M, Hofmann RJ
J Clin Sleep Med 2017 Nov 15;13(11):1345-1348. doi: 10.5664/jcsm.6812. PMID: 28942764Free PMC Article
Glutathione-S-Transferase Deletions and Non-arteritic Anterior Ischemic Optic Neuropathy.
Wan W, Peng T, Jin X, Li Q, Zhang F, Zheng G, Lv Y, Wan G, Zhu Y
Mol Neurobiol 2016 May;53(4):2361-7. Epub 2015 May 20 doi: 10.1007/s12035-015-9185-3. PMID: 25990411
Non-arteritic anterior ischaemic optic neuropathy: a review and update.
Kerr NM, Chew SS, Danesh-Meyer HV
J Clin Neurosci 2009 Aug;16(8):994-1000. doi: 10.1016/j.jocn.2009.04.002. PMID: 19596112

Diagnosis

Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis.
Khalili MR, Bremner F, Tabrizi R, Bashi A
Eur J Ophthalmol 2023 Jan;33(1):530-545. Epub 2022 Jul 17 doi: 10.1177/11206721221113681. PMID: 35844139
Rapidly Sequential Vision Loss From Posterior Ischemic Optic Neuropathy Due to Methicillin-Susceptible Staphylococcus Aureus Bacteremia.
Aldrees SS, Micieli JA
J Neuroophthalmol 2020 Sep;40(3):420-422. doi: 10.1097/WNO.0000000000000850. PMID: 31609844
The immunopathology of giant cell arteritis: diagnostic and therapeutic implications.
Weyand CM, Liao YJ, Goronzy JJ
J Neuroophthalmol 2012 Sep;32(3):259-65. doi: 10.1097/WNO.0b013e318268aa9b. PMID: 22914691Free PMC Article
Non-arteritic anterior ischaemic optic neuropathy: a review and update.
Kerr NM, Chew SS, Danesh-Meyer HV
J Clin Neurosci 2009 Aug;16(8):994-1000. doi: 10.1016/j.jocn.2009.04.002. PMID: 19596112
Determining whether delayed nonarteritic ischemic optic neuropathy associated with cataract extraction is a true entity.
Nguyen LT, Taravella MJ, Pelak VS
J Cataract Refract Surg 2006 Dec;32(12):2105-9. doi: 10.1016/j.jcrs.2006.08.028. PMID: 17137991

Therapy

Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis.
Khalili MR, Bremner F, Tabrizi R, Bashi A
Eur J Ophthalmol 2023 Jan;33(1):530-545. Epub 2022 Jul 17 doi: 10.1177/11206721221113681. PMID: 35844139
Ocular Complications in the Prone Position in the Critical Care Setting: The COVID-19 Pandemic.
Sanghi P, Malik M, Hossain IT, Manzouri B
J Intensive Care Med 2021 Mar;36(3):361-372. Epub 2020 Sep 28 doi: 10.1177/0885066620959031. PMID: 32985317
Rapidly Sequential Vision Loss From Posterior Ischemic Optic Neuropathy Due to Methicillin-Susceptible Staphylococcus Aureus Bacteremia.
Aldrees SS, Micieli JA
J Neuroophthalmol 2020 Sep;40(3):420-422. doi: 10.1097/WNO.0000000000000850. PMID: 31609844
Determining whether delayed nonarteritic ischemic optic neuropathy associated with cataract extraction is a true entity.
Nguyen LT, Taravella MJ, Pelak VS
J Cataract Refract Surg 2006 Dec;32(12):2105-9. doi: 10.1016/j.jcrs.2006.08.028. PMID: 17137991
Perioperative posterior ischemic optic neuropathy: review of the literature.
Buono LM, Foroozan R
Surv Ophthalmol 2005 Jan-Feb;50(1):15-26. doi: 10.1016/j.survophthal.2004.10.005. PMID: 15621075

Prognosis

Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis.
Khalili MR, Bremner F, Tabrizi R, Bashi A
Eur J Ophthalmol 2023 Jan;33(1):530-545. Epub 2022 Jul 17 doi: 10.1177/11206721221113681. PMID: 35844139
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy.
Chen T, Ma J, Shan G, Zhong Y
Exp Eye Res 2018 Sep;174:147-151. Epub 2018 May 21 doi: 10.1016/j.exer.2018.05.021. PMID: 29792847
Transient cortical blindness as a complication of posterior spinal surgery in a pediatric patient.
Nathan ST, Jain V, Lykissas MG, Crawford AH, West CE
J Pediatr Orthop B 2013 Sep;22(5):416-9. doi: 10.1097/BPB.0b013e32835ec658. PMID: 23407429
Non-arteritic anterior ischaemic optic neuropathy: a review and update.
Kerr NM, Chew SS, Danesh-Meyer HV
J Clin Neurosci 2009 Aug;16(8):994-1000. doi: 10.1016/j.jocn.2009.04.002. PMID: 19596112
Perioperative posterior ischemic optic neuropathy: review of the literature.
Buono LM, Foroozan R
Surv Ophthalmol 2005 Jan-Feb;50(1):15-26. doi: 10.1016/j.survophthal.2004.10.005. PMID: 15621075

Clinical prediction guides

Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis.
Khalili MR, Bremner F, Tabrizi R, Bashi A
Eur J Ophthalmol 2023 Jan;33(1):530-545. Epub 2022 Jul 17 doi: 10.1177/11206721221113681. PMID: 35844139
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy.
Chen T, Ma J, Shan G, Zhong Y
Exp Eye Res 2018 Sep;174:147-151. Epub 2018 May 21 doi: 10.1016/j.exer.2018.05.021. PMID: 29792847
Glutathione-S-Transferase Deletions and Non-arteritic Anterior Ischemic Optic Neuropathy.
Wan W, Peng T, Jin X, Li Q, Zhang F, Zheng G, Lv Y, Wan G, Zhu Y
Mol Neurobiol 2016 May;53(4):2361-7. Epub 2015 May 20 doi: 10.1007/s12035-015-9185-3. PMID: 25990411

Recent systematic reviews

Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis.
Khalili MR, Bremner F, Tabrizi R, Bashi A
Eur J Ophthalmol 2023 Jan;33(1):530-545. Epub 2022 Jul 17 doi: 10.1177/11206721221113681. PMID: 35844139

Supplemental Content

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