U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancreatic cancer, susceptibility to, 1

MedGen UID:
339739
Concept ID:
C1847351
Finding
Synonyms: Pancreatic cancer 1; Pancreatic Cancer Susceptibility 1
 
Gene (location): PALLD (4q32.3)
 
Monarch Initiative: MONDO:0011739
OMIM®: 606856

Definition

Any familial pancreatic carcinoma in which the cause of the disease is a mutation in the PALLD gene. [from MONDO]

Clinical features

From HPO
Pancreatic adenocarcinoma
MedGen UID:
83800
Concept ID:
C0281361
Neoplastic Process
The presence of an adenocarcinoma of the pancreas.

Recent clinical studies

Etiology

Antwi SO, Rabe KG, Bamlet WR, Meyer M, Chandra S, Fagan SE, Hu C, Couch FJ, McWilliams RR, Oberg AL, Petersen GM
Cancer Epidemiol Biomarkers Prev 2022 Feb;31(2):372-381. Epub 2021 Nov 15 doi: 10.1158/1055-9965.EPI-21-0745. PMID: 34782396Free PMC Article
Liu D, Zhou D, Sun Y, Zhu J, Ghoneim D, Wu C, Yao Q, Gamazon ER, Cox NJ, Wu L
Cancer Res 2020 Oct 15;80(20):4346-4354. Epub 2020 Sep 9 doi: 10.1158/0008-5472.CAN-20-1353. PMID: 32907841Free PMC Article
Zhong J, Jermusyk A, Wu L, Hoskins JW, Collins I, Mocci E, Zhang M, Song L, Chung CC, Zhang T, Xiao W, Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt S, Borgida A, Bracci PM, Brais L, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Childs EJ, Cotterchio M, Du M, Duell EJ, Fuchs C, Gallinger S, Gaziano JM, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Haiman C, Hartge P, Hasan M, Helzlsouer KJ, Holly EA, Klein EA, Kogevinas M, Kurtz RJ, LeMarchand L, Malats N, Männistö S, Milne R, Neale RE, Ng K, Obazee O, Oberg AL, Orlow I, Patel AV, Peters U, Porta M, Rothman N, Scelo G, Sesso HD, Severi G, Sieri S, Silverman D, Sund M, Tjønneland A, Thornquist MD, Tobias GS, Trichopoulou A, Van Den Eeden SK, Visvanathan K, Wactawski-Wende J, Wentzensen N, White E, Yu H, Yuan C, Zeleniuch-Jacquotte A, Hoover R, Brown K, Kooperberg C, Risch HA, Jacobs EJ, Li D, Yu K, Shu XO, Chanock SJ, Wolpin BM, Stolzenberg-Solomon RZ, Chatterjee N, Klein AP, Smith JP, Kraft P, Shi J, Petersen GM, Zheng W, Amundadottir LT
J Natl Cancer Inst 2020 Oct 1;112(10):1003-1012. doi: 10.1093/jnci/djz246. PMID: 31917448Free PMC Article
Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA
J Clin Oncol 2019 Jan 10;37(2):153-164. Epub 2018 Nov 20 doi: 10.1200/JCO.18.01489. PMID: 30457921
Streicher SA, Klein AP, Olson SH, Amundadottir LT, DeWan AT, Zhao H, Risch HA
Cancer Epidemiol Biomarkers Prev 2017 Oct;26(10):1540-1548. Epub 2017 Jul 28 doi: 10.1158/1055-9965.EPI-17-0262. PMID: 28754795Free PMC Article

Diagnosis

Park JM, Mau CZ, Chen YC, Su YH, Chen HA, Huang SY, Chang JS, Chiu CF
Sci Rep 2021 Oct 28;11(1):21242. doi: 10.1038/s41598-021-00650-7. PMID: 34711879Free PMC Article
Wang Y, Yang G, You L, Yang J, Feng M, Qiu J, Zhao F, Liu Y, Cao Z, Zheng L, Zhang T, Zhao Y
Mol Cancer 2019 Dec 1;18(1):173. doi: 10.1186/s12943-019-1103-2. PMID: 31785619Free PMC Article
Luu HN, Huang JY, Wang R, Adams-Haduch J, Jin A, Koh WP, Yuan JM
PLoS One 2019;14(8):e0221697. Epub 2019 Aug 29 doi: 10.1371/journal.pone.0221697. PMID: 31465482Free PMC Article
Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA
J Clin Oncol 2019 Jan 10;37(2):153-164. Epub 2018 Nov 20 doi: 10.1200/JCO.18.01489. PMID: 30457921
Harashima N, Takenaga K, Akimoto M, Harada M
Oncotarget 2017 Jun 27;8(26):42887-42900. doi: 10.18632/oncotarget.17157. PMID: 28476028Free PMC Article

Therapy

Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Shao T, Kou J
Crit Rev Eukaryot Gene Expr 2021;31(2):17-23. doi: 10.1615/CritRevEukaryotGeneExpr.2021037540. PMID: 34347976
Rosato V, Negri E, Bosetti C, Malats N, Gomez-Rubio P, Consortium P, Maisonneuve P, Miller AB, Bueno-de-Mesquita HB, Baghurst PA, Zatonski W, Petersen GM, Scelo G, Holcatova I, Fabianova E, Serraino D, Olson SH, Vioque J, Lagiou P, Duell EJ, Boffetta P, La Vecchia C
Eur J Cancer Prev 2020 Sep;29(5):408-415. doi: 10.1097/CEJ.0000000000000572. PMID: 32740166
Langdon RJ, Richmond RC, Hemani G, Zheng J, Wade KH, Carreras-Torres R, Johansson M, Brennan P, Wootton RE, Munafo MR, Smith GD, Relton CL, Vincent EE, Martin RM, Haycock P
Cancer Epidemiol Biomarkers Prev 2019 Dec;28(12):2070-2078. Epub 2019 Jul 17 doi: 10.1158/1055-9965.EPI-19-0036. PMID: 31315910
Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand RE, Rustgi A, Olson SH, Stoffel E, Cote ML, Zogopoulos G, Potash JB, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M
Proc Natl Acad Sci U S A 2018 May 1;115(18):4767-4772. Epub 2018 Apr 18 doi: 10.1073/pnas.1720588115. PMID: 29669919Free PMC Article

Prognosis

Park JM, Mau CZ, Chen YC, Su YH, Chen HA, Huang SY, Chang JS, Chiu CF
Sci Rep 2021 Oct 28;11(1):21242. doi: 10.1038/s41598-021-00650-7. PMID: 34711879Free PMC Article
Liu D, Zhou D, Sun Y, Zhu J, Ghoneim D, Wu C, Yao Q, Gamazon ER, Cox NJ, Wu L
Cancer Res 2020 Oct 15;80(20):4346-4354. Epub 2020 Sep 9 doi: 10.1158/0008-5472.CAN-20-1353. PMID: 32907841Free PMC Article
Zhong J, Jermusyk A, Wu L, Hoskins JW, Collins I, Mocci E, Zhang M, Song L, Chung CC, Zhang T, Xiao W, Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt S, Borgida A, Bracci PM, Brais L, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Childs EJ, Cotterchio M, Du M, Duell EJ, Fuchs C, Gallinger S, Gaziano JM, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Haiman C, Hartge P, Hasan M, Helzlsouer KJ, Holly EA, Klein EA, Kogevinas M, Kurtz RJ, LeMarchand L, Malats N, Männistö S, Milne R, Neale RE, Ng K, Obazee O, Oberg AL, Orlow I, Patel AV, Peters U, Porta M, Rothman N, Scelo G, Sesso HD, Severi G, Sieri S, Silverman D, Sund M, Tjønneland A, Thornquist MD, Tobias GS, Trichopoulou A, Van Den Eeden SK, Visvanathan K, Wactawski-Wende J, Wentzensen N, White E, Yu H, Yuan C, Zeleniuch-Jacquotte A, Hoover R, Brown K, Kooperberg C, Risch HA, Jacobs EJ, Li D, Yu K, Shu XO, Chanock SJ, Wolpin BM, Stolzenberg-Solomon RZ, Chatterjee N, Klein AP, Smith JP, Kraft P, Shi J, Petersen GM, Zheng W, Amundadottir LT
J Natl Cancer Inst 2020 Oct 1;112(10):1003-1012. doi: 10.1093/jnci/djz246. PMID: 31917448Free PMC Article
Luu HN, Huang JY, Wang R, Adams-Haduch J, Jin A, Koh WP, Yuan JM
PLoS One 2019;14(8):e0221697. Epub 2019 Aug 29 doi: 10.1371/journal.pone.0221697. PMID: 31465482Free PMC Article
Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA
J Clin Oncol 2019 Jan 10;37(2):153-164. Epub 2018 Nov 20 doi: 10.1200/JCO.18.01489. PMID: 30457921

Clinical prediction guides

Antwi SO, Rabe KG, Bamlet WR, Meyer M, Chandra S, Fagan SE, Hu C, Couch FJ, McWilliams RR, Oberg AL, Petersen GM
Cancer Epidemiol Biomarkers Prev 2022 Feb;31(2):372-381. Epub 2021 Nov 15 doi: 10.1158/1055-9965.EPI-21-0745. PMID: 34782396Free PMC Article
Liu D, Zhou D, Sun Y, Zhu J, Ghoneim D, Wu C, Yao Q, Gamazon ER, Cox NJ, Wu L
Cancer Res 2020 Oct 15;80(20):4346-4354. Epub 2020 Sep 9 doi: 10.1158/0008-5472.CAN-20-1353. PMID: 32907841Free PMC Article
Zhong J, Jermusyk A, Wu L, Hoskins JW, Collins I, Mocci E, Zhang M, Song L, Chung CC, Zhang T, Xiao W, Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt S, Borgida A, Bracci PM, Brais L, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Childs EJ, Cotterchio M, Du M, Duell EJ, Fuchs C, Gallinger S, Gaziano JM, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Haiman C, Hartge P, Hasan M, Helzlsouer KJ, Holly EA, Klein EA, Kogevinas M, Kurtz RJ, LeMarchand L, Malats N, Männistö S, Milne R, Neale RE, Ng K, Obazee O, Oberg AL, Orlow I, Patel AV, Peters U, Porta M, Rothman N, Scelo G, Sesso HD, Severi G, Sieri S, Silverman D, Sund M, Tjønneland A, Thornquist MD, Tobias GS, Trichopoulou A, Van Den Eeden SK, Visvanathan K, Wactawski-Wende J, Wentzensen N, White E, Yu H, Yuan C, Zeleniuch-Jacquotte A, Hoover R, Brown K, Kooperberg C, Risch HA, Jacobs EJ, Li D, Yu K, Shu XO, Chanock SJ, Wolpin BM, Stolzenberg-Solomon RZ, Chatterjee N, Klein AP, Smith JP, Kraft P, Shi J, Petersen GM, Zheng W, Amundadottir LT
J Natl Cancer Inst 2020 Oct 1;112(10):1003-1012. doi: 10.1093/jnci/djz246. PMID: 31917448Free PMC Article
Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA
J Clin Oncol 2019 Jan 10;37(2):153-164. Epub 2018 Nov 20 doi: 10.1200/JCO.18.01489. PMID: 30457921
Harashima N, Takenaga K, Akimoto M, Harada M
Oncotarget 2017 Jun 27;8(26):42887-42900. doi: 10.18632/oncotarget.17157. PMID: 28476028Free PMC Article

Recent systematic reviews

Ye ZM, Li LJ, Luo MB, Qing HY, Zheng JH, Zhang C, Lu YX, Tang YM
Aging (Albany NY) 2020 Nov 20;12(24):25256-25274. doi: 10.18632/aging.104128. PMID: 33226370Free PMC Article
Li Y, Liu L, Huang Y, Zheng H, Li L
BMC Med Genet 2020 Feb 24;21(1):41. doi: 10.1186/s12881-020-0975-8. PMID: 32093636Free PMC Article
Cui JP, Lin MY, Liu ZH, Liu BL
Chin Med Sci J 2019 Sep 30;34(3):205-210. doi: 10.24920/003490. PMID: 31648673
Stoffel EM, McKernin SE, Brand R, Canto M, Goggins M, Moravek C, Nagarajan A, Petersen GM, Simeone DM, Yurgelun M, Khorana AA
J Clin Oncol 2019 Jan 10;37(2):153-164. Epub 2018 Nov 20 doi: 10.1200/JCO.18.01489. PMID: 30457921
Ciliberto D, Staropoli N, Chiellino S, Botta C, Tassone P, Tagliaferri P
Pancreatology 2016 Mar-Apr;16(2):249-58. Epub 2016 Jan 20 doi: 10.1016/j.pan.2016.01.003. PMID: 26852170

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center