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Scoliosis, isolated, susceptibility to, 2(IS2)

MedGen UID:
375871
Concept ID:
C1846366
Finding
Synonyms: IS2
 
OMIM®: 607354

Definition

Idiopathic scoliosis is a structurally fixed lateral curvature of the spine with a rotatory component. There is at least a 10 degree curvature as demonstrated by upright spine roentgenograms by the Cobb method (Weinstein, 1994). For a discussion of genetic heterogeneity of isolated scoliosis, see 181800. [from OMIM]

Additional description

From GHR
Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "S" or "C" shape; the bones of the spine are also slightly twisted or rotated.Adolescent idiopathic scoliosis appears during the adolescent growth spurt, a time when children are growing rapidly. In many cases the abnormal spinal curve is stable, although in some children the curve is progressive (meaning it becomes more severe over time). For unknown reasons, severe and progressive curves occur more frequently in girls than in boys. However, mild spinal curvature is equally common in girls and boys.Mild scoliosis generally does not cause pain, problems with movement, or difficulty breathing. It may only be diagnosed if it is noticed during a regular physical examination or a scoliosis screening at school. The most common signs of the condition include a tilt or unevenness (asymmetry) in the shoulders, hips, or waist, or having one leg that appears longer than the other. A small percentage of affected children develop more severe, pronounced spinal curvature.Scoliosis can occur as a feature of other conditions, including a variety of genetic syndromes. However, adolescent idiopathic scoliosis typically occurs by itself, without signs and symptoms affecting other parts of the body.  https://ghr.nlm.nih.gov/condition/adolescent-idiopathic-scoliosis

Recent clinical studies

Etiology

Buchan JG, Alvarado DM, Haller G, Aferol H, Miller NH, Dobbs MB, Gurnett CA
Clin Orthop Relat Res 2014 Oct;472(10):3216-25. Epub 2014 Jul 9 doi: 10.1007/s11999-014-3766-8. PMID: 25005481Free PMC Article

Diagnosis

Buchan JG, Alvarado DM, Haller G, Aferol H, Miller NH, Dobbs MB, Gurnett CA
Clin Orthop Relat Res 2014 Oct;472(10):3216-25. Epub 2014 Jul 9 doi: 10.1007/s11999-014-3766-8. PMID: 25005481Free PMC Article

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