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Aldosterone-producing adrenal cortex adenoma

MedGen UID:
353374
Concept ID:
C1706762
Neoplastic Process
Synonyms: adrenocortical carcinoma with pure aldosterone hypersecretion; Adrenocortical carcinoma with pure aldosterone hypersecretion; Aldosterone Producing Adrenal Cortex Adenoma; aldosterone producing adrenal cortex adenoma; Aldosterone Producing Adrenal Cortical Adenoma; aldosterone producing adrenal cortical adenoma; Aldosterone-Producing Adrenal Cortex Adenoma; aldosterone-producing adrenal cortex adenoma; APAC; Pure aldosterone-producing adrenocortical carcinoma; Pure aldosterone-secreting adrenocortical carcinoma; Pure APAC
 
Monarch Initiative: MONDO:0016505
Orphanet: ORPHA231625

Definition

An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation). [from MedlinePlus Genetics]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAldosterone-producing adrenal cortex adenoma

Recent clinical studies

Etiology

Zhang C, Wu L, Jiang L, Su T, Zhou W, Zhong X, Xie J, Sun F, Zhu Y, Jiang Y, Wang W
Endocr Pract 2021 Jul;27(7):736-742. Epub 2021 Jan 19 doi: 10.1016/j.eprac.2021.01.007. PMID: 33678553
Chang YY, Tsai CH, Peng SY, Chen ZW, Chang CC, Lee BC, Liao CW, Pan CT, Chen YL, Lin LC, Chang YR, Peng KY, Chou CH, Wu VC, Hung CS, Lin YH; TAIPAI Study Group.
Hypertension 2021 Jan;77(1):114-125. Epub 2020 Nov 30 doi: 10.1161/HYPERTENSIONAHA.120.15679. PMID: 33249859
Wang F, Ma X, Tong A, Zhang Y, Wen J, Li Y
Front Endocrinol (Lausanne) 2020;11:260. Epub 2020 Apr 28 doi: 10.3389/fendo.2020.00260. PMID: 32411097Free PMC Article
De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC
Hypertension 2020 Apr;75(4):1034-1044. Epub 2020 Mar 2 doi: 10.1161/HYPERTENSIONAHA.119.14177. PMID: 32114847Free PMC Article
Tezuka Y, Yamazaki Y, Kitada M, Morimoto R, Kudo M, Seiji K, Takase K, Kawasaki Y, Mitsuzuka K, Ito A, Nishikawa J, Asai N, Nakamura Y, Gomez-Sanchez CE, Ito S, Dezawa M, Sasano H, Satoh F
Hypertension 2019 Jun;73(6):1283-1290. doi: 10.1161/HYPERTENSIONAHA.118.12064. PMID: 31006333Free PMC Article

Diagnosis

Chen S, Liu H, Luo P, Yu Y
Endocr J 2021 Mar 28;68(3):299-306. Epub 2020 Oct 23 doi: 10.1507/endocrj.EJ20-0395. PMID: 33100281
Komada H, Hirota Y, So A, Nakamura T, Okuno Y, Fukuoka H, Iguchi G, Takahashi Y, Sakaguchi K, Ogawa W
Diabetes Metab 2020 Jun;46(3):236-242. Epub 2019 Oct 31 doi: 10.1016/j.diabet.2019.10.002. PMID: 31676325
Leung HT, Woo YC, Fong CHY, Tan KCB, Lau EYF, Chan KW, Leung JYY
J Endocrinol Invest 2020 Mar;43(3):347-355. Epub 2019 Sep 16 doi: 10.1007/s40618-019-01114-6. PMID: 31529391
Kitawaki Y, Nakamura Y, Kubota-Nakayama F, Yamazaki Y, Miki Y, Hata S, Ise K, Kikuchi K, Morimoto R, Satoh F, Sasano H
Hum Pathol 2018 Jul;77:88-97. Epub 2018 Mar 27 doi: 10.1016/j.humpath.2018.03.016. PMID: 29596893
Nakamura Y, Yamazaki Y, Tezuka Y, Satoh F, Sasano H
Tohoku J Exp Med 2016 Nov;240(3):183-190. doi: 10.1620/tjem.240.183. PMID: 27853054

Therapy

Kishimoto S, Oki K, Maruhashi T, Kajikawa M, Hashimoto H, Takaeko Y, Harada T, Yamaji T, Han Y, Kihara Y, Chayama K, Goto C, Yusoff FM, Nakashima A, Higashi Y
J Clin Endocrinol Metab 2020 Nov 1;105(11) doi: 10.1210/clinem/dgaa561. PMID: 32818224
Inoue K, Yamazaki Y, Kitamoto T, Hirose R, Saito J, Omura M, Sasano H, Nishikawa T
J Clin Endocrinol Metab 2018 Sep 1;103(9):3477-3485. doi: 10.1210/jc.2018-00738. PMID: 30020487
Heinze B, Fuss CT, Mulatero P, Beuschlein F, Reincke M, Mustafa M, Schirbel A, Deutschbein T, Williams TA, Rhayem Y, Quinkler M, Rayes N, Monticone S, Wild V, Gomez-Sanchez CE, Reis AC, Petersenn S, Wester HJ, Kropf S, Fassnacht M, Lang K, Herrmann K, Buck AK, Bluemel C, Hahner S
Hypertension 2018 Feb;71(2):317-325. Epub 2017 Dec 26 doi: 10.1161/HYPERTENSIONAHA.117.09975. PMID: 29279316
Park KS, Kim JH, Ku EJ, Hong AR, Moon MK, Choi SH, Shin CS, Kim SW, Kim SY
Eur J Endocrinol 2015 Jun;172(6):725-31. Epub 2015 Mar 12 doi: 10.1530/EJE-15-0074. PMID: 25766046
Karagüzel G, Bahat E, Imamoğlu M, Ahmetoğlu A, Yildiz K, Okten A
J Pediatr Endocrinol Metab 2009 Nov;22(11):1087-90. doi: 10.1515/jpem.2009.22.11.1087. PMID: 20101896

Prognosis

Zhang C, Wu L, Jiang L, Su T, Zhou W, Zhong X, Xie J, Sun F, Zhu Y, Jiang Y, Wang W
Endocr Pract 2021 Jul;27(7):736-742. Epub 2021 Jan 19 doi: 10.1016/j.eprac.2021.01.007. PMID: 33678553
Chen S, Liu H, Luo P, Yu Y
Endocr J 2021 Mar 28;68(3):299-306. Epub 2020 Oct 23 doi: 10.1507/endocrj.EJ20-0395. PMID: 33100281
Wang F, Ma X, Tong A, Zhang Y, Wen J, Li Y
Front Endocrinol (Lausanne) 2020;11:260. Epub 2020 Apr 28 doi: 10.3389/fendo.2020.00260. PMID: 32411097Free PMC Article
De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC
Hypertension 2020 Apr;75(4):1034-1044. Epub 2020 Mar 2 doi: 10.1161/HYPERTENSIONAHA.119.14177. PMID: 32114847Free PMC Article
Leung HT, Woo YC, Fong CHY, Tan KCB, Lau EYF, Chan KW, Leung JYY
J Endocrinol Invest 2020 Mar;43(3):347-355. Epub 2019 Sep 16 doi: 10.1007/s40618-019-01114-6. PMID: 31529391

Clinical prediction guides

Zhang C, Wu L, Jiang L, Su T, Zhou W, Zhong X, Xie J, Sun F, Zhu Y, Jiang Y, Wang W
Endocr Pract 2021 Jul;27(7):736-742. Epub 2021 Jan 19 doi: 10.1016/j.eprac.2021.01.007. PMID: 33678553
Chang YY, Tsai CH, Peng SY, Chen ZW, Chang CC, Lee BC, Liao CW, Pan CT, Chen YL, Lin LC, Chang YR, Peng KY, Chou CH, Wu VC, Hung CS, Lin YH; TAIPAI Study Group.
Hypertension 2021 Jan;77(1):114-125. Epub 2020 Nov 30 doi: 10.1161/HYPERTENSIONAHA.120.15679. PMID: 33249859
Chen S, Liu H, Luo P, Yu Y
Endocr J 2021 Mar 28;68(3):299-306. Epub 2020 Oct 23 doi: 10.1507/endocrj.EJ20-0395. PMID: 33100281
De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC
Hypertension 2020 Apr;75(4):1034-1044. Epub 2020 Mar 2 doi: 10.1161/HYPERTENSIONAHA.119.14177. PMID: 32114847Free PMC Article
Leung HT, Woo YC, Fong CHY, Tan KCB, Lau EYF, Chan KW, Leung JYY
J Endocrinol Invest 2020 Mar;43(3):347-355. Epub 2019 Sep 16 doi: 10.1007/s40618-019-01114-6. PMID: 31529391

Recent systematic reviews

Velema MS, de Nooijer AH, Burgers VWG, Hermus ARMM, Timmers HJLM, Lenders JWM, Husson O, Deinum J
Horm Metab Res 2017 Dec;49(12):943-950. Epub 2017 Dec 4 doi: 10.1055/s-0043-121706. PMID: 29202493

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