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Hyperparathyroidism 2 with jaw tumors(HPT-JT; HRPT2)

MedGen UID:
310065
Concept ID:
C1704981
Disease or Syndrome
Synonyms: HYPERPARATHYROIDISM, FAMILIAL PRIMARY, WITH MULTIPLE OSSIFYING JAW FIBROMAS; Hyperparathyroidism-Jaw Tumor Syndrome; HYPERPARATHYROIDISM-JAW TUMOR SYNDROME, HEREDITARY
SNOMED CT: Hyperparathyroidism 2 (702378002); Hyperparathyroidism-jaw tumor syndrome (702378002); Familial primary hyperparathyroidism with multiple ossifying jaw fibromas (702378002); Familial cystic parathyroid adenomatosis (702378002)
 
Gene (location): CDC73 (1q31.2)
 
Monarch Initiative: MONDO:0007768
OMIM®: 145001
Orphanet: ORPHA99880

Definition

The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified. [from GeneReviews]

Additional descriptions

From OMIM
Hyperparathyroidism-2 with jaw tumors (HRPT2) is a rare autosomal dominant disorder characterized by synchronous or metachronous occurrence of primary hyperparathyroidism, ossifying fibroma of the maxilla and/or mandible, renal tumor, and uterine tumors. It is associated with increased risk of parathyroid cancer (summary by Shibata et al., 2015). For a discussion of genetic heterogeneity of hyperparathyroidism, see HRPT1 (145000).  http://www.omim.org/entry/145001
From MedlinePlus Genetics
Hyperparathyroidism-jaw tumor syndrome is a condition characterized by overactivity of the parathyroid glands (hyperparathyroidism). The four parathyroid glands are located in the neck and secrete a hormone that regulates the body's use of calcium. Hyperparathyroidism disrupts the normal balance of calcium in the blood, which can lead to kidney stones, thinning of the bones (osteoporosis), nausea, vomiting, high blood pressure (hypertension), weakness, and fatigue. About 95 percent of people with hyperparathyroidism-jaw tumor syndrome will develop hyperparathyroidism during their lifetime.

In people with hyperparathyroidism-jaw tumor syndrome, hyperparathyroidism is caused by tumors that form in the parathyroid glands. Typically, only one of the four parathyroid glands is affected, but in some people, tumors are found in more than one gland. The tumors are usually a noncancerous (benign) type of tumor called an adenoma. Approximately 15 percent of people with hyperparathyroidism-jaw tumor syndrome develop a cancerous tumor called parathyroid carcinoma. 

People with hyperparathyroidism-jaw tumor syndrome may also have a type of benign tumor called a fibroma in the jaw. Even though jaw tumors are specified in the name of this condition, it is estimated that only 11 to 40 percent of affected individuals have this symptom.

Other tumors, both benign and cancerous, are often seen in people with hyperparathyroidism-jaw tumor syndrome. For example, tumors of the uterus occur in up to 50 percent of people with this condition. Uterine tumors are typically benign, but they can cause heavy menstrual bleeding or other symptoms. The kidneys are affected in about 20 percent of people with hyperparathyroidism-jaw tumor syndrome. Benign kidney cysts are the most common kidney feature, but a rare cancerous tumor called Wilms tumor and other types of kidney tumor have also been found.

Regular medical screening may assist in the early detection of the features of hyperparathyroidism-jaw tumor syndrome.  https://medlineplus.gov/genetics/condition/hyperparathyroidism-jaw-tumor-syndrome

Clinical features

From HPO
Hamartoma
MedGen UID:
6713
Concept ID:
C0018552
Neoplastic Process
A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma.
Hypercalcemia
MedGen UID:
5686
Concept ID:
C0020437
Disease or Syndrome
An abnormally increased calcium concentration in the blood.
Hyperparathyroidism
MedGen UID:
6967
Concept ID:
C0020502
Disease or Syndrome
Excessive production of parathyroid hormone (PTH) by the parathyroid glands.
Polycystic kidney disease
MedGen UID:
9639
Concept ID:
C0022680
Disease or Syndrome
The presence of multiple cysts in both kidneys.
Nephroblastoma
MedGen UID:
10221
Concept ID:
C0027708
Neoplastic Process
The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children.
Parathyroid gland adenoma
MedGen UID:
75502
Concept ID:
C0262587
Neoplastic Process
A benign tumor of the parathyroid gland that can cause hyperparathyroidism.
Pancreatic adenocarcinoma
MedGen UID:
83800
Concept ID:
C0281361
Neoplastic Process
The presence of an adenocarcinoma of the pancreas.
Renal cortical adenoma
MedGen UID:
577332
Concept ID:
C0346253
Neoplastic Process
The presence of an adenoma in the cortex of the kidney.
Nephrolithiasis
MedGen UID:
98227
Concept ID:
C0392525
Disease or Syndrome
The presence of calculi (stones) in the kidneys.
Parathyroid carcinoma
MedGen UID:
146361
Concept ID:
C0687150
Neoplastic Process
The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified.
Papillary renal cell carcinoma
MedGen UID:
266300
Concept ID:
C1306837
Neoplastic Process
The presence of renal cell carcinoma in the renal papilla.
Hurthle cell thyroid adenoma
MedGen UID:
237009
Concept ID:
C1336750
Neoplastic Process
A kind of thyroid adenoma characterized by the presence of oxyphil cells.
Abnormality of the head
MedGen UID:
867438
Concept ID:
C4021812
Anatomical Abnormality
An abnormality of the head.
Recurrent pancreatitis
MedGen UID:
1639431
Concept ID:
C4551632
Disease or Syndrome
A recurrent form of pancreatitis.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperparathyroidism 2 with jaw tumors
Follow this link to review classifications for Hyperparathyroidism 2 with jaw tumors in Orphanet.

Professional guidelines

PubMed

Romanet P, Coppin L, Molin A, Santucci N, Le Bras M, Odou MF
Ann Endocrinol (Paris) 2025 Feb;86(1):101694. Epub 2025 Jan 14 doi: 10.1016/j.ando.2025.101694. PMID: 39818301
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Clark OH, Wilkes W, Siperstein AE, Duh QY
J Bone Miner Res 1991 Oct;6 Suppl 2:S135-42; discussion 151-2. doi: 10.1002/jbmr.5650061428. PMID: 1763665

Recent clinical studies

Etiology

Gheorghe AM, Sima OC, Florescu AF, Ciuche A, Nistor C, Sandru F, Carsote M
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Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Figueiredo AA, Saramago A, Cavaco BM, Simões-Pereira J, Leite V
J Endocrinol Invest 2023 Sep;46(9):1799-1806. Epub 2023 Feb 13 doi: 10.1007/s40618-023-02032-4. PMID: 36780067
Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM
Urology 2019 Feb;124:91-97. Epub 2018 Nov 16 doi: 10.1016/j.urology.2018.11.013. PMID: 30452964Free PMC Article
Wasserman JD, Tomlinson GE, Druker H, Kamihara J, Kohlmann WK, Kratz CP, Nathanson KL, Pajtler KW, Parareda A, Rednam SP, States LJ, Villani A, Walsh MF, Zelley K, Schiffman JD
Clin Cancer Res 2017 Jul 1;23(13):e123-e132. doi: 10.1158/1078-0432.CCR-17-0548. PMID: 28674121Free PMC Article

Diagnosis

English KA, Lines KE, Thakker RV
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Marini F, Giusti F, Iantomasi T, Brandi ML
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Salcuni AS, Cetani F, Guarnieri V, Nicastro V, Romagnoli E, de Martino D, Scillitani A, Cole DEC
Best Pract Res Clin Endocrinol Metab 2018 Dec;32(6):877-889. Epub 2018 Dec 1 doi: 10.1016/j.beem.2018.11.002. PMID: 30551989
Wasserman JD, Tomlinson GE, Druker H, Kamihara J, Kohlmann WK, Kratz CP, Nathanson KL, Pajtler KW, Parareda A, Rednam SP, States LJ, Villani A, Walsh MF, Zelley K, Schiffman JD
Clin Cancer Res 2017 Jul 1;23(13):e123-e132. doi: 10.1158/1078-0432.CCR-17-0548. PMID: 28674121Free PMC Article

Therapy

Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Che H, Breuil V, Cortet B, Paccou J, Thomas T, Chapuis L, Debiais F, Mehsen-Cetre N, Javier RM, Loiseau Peres S, Roux C, Briot K
Osteoporos Int 2019 Mar;30(3):555-563. Epub 2018 Dec 5 doi: 10.1007/s00198-018-4793-1. PMID: 30519756
Schweitzer DH
Obes Surg 2007 Nov;17(11):1510-6. doi: 10.1007/s11695-008-9431-0. PMID: 18219780
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Semin Dial 2003 Mar-Apr;16(2):140-7. doi: 10.1046/j.1525-139x.2003.160301.x. PMID: 12641878
Bendz H, Sjödin I, Toss G, Berglund K
J Intern Med 1996 Dec;240(6):357-65. doi: 10.1046/j.1365-2796.1996.28864000.x. PMID: 9010382

Prognosis

Gheorghe AM, Sima OC, Florescu AF, Ciuche A, Nistor C, Sandru F, Carsote M
Int J Mol Sci 2024 Feb 15;25(4) doi: 10.3390/ijms25042301. PMID: 38396977Free PMC Article
English KA, Lines KE, Thakker RV
Hormones (Athens) 2024 Mar;23(1):3-14. Epub 2023 Dec 1 doi: 10.1007/s42000-023-00508-9. PMID: 38038882Free PMC Article
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Mehta A, Patel D, Rosenberg A, Boufraqech M, Ellis RJ, Nilubol N, Quezado MM, Marx SJ, Simonds WF, Kebebew E
Surgery 2014 Dec;156(6):1315-24; discussion 1324-5. Epub 2014 Oct 16 doi: 10.1016/j.surg.2014.08.004. PMID: 25444225Free PMC Article
Bendz H, Sjödin I, Toss G, Berglund K
J Intern Med 1996 Dec;240(6):357-65. doi: 10.1046/j.1365-2796.1996.28864000.x. PMID: 9010382

Clinical prediction guides

Gheorghe AM, Sima OC, Florescu AF, Ciuche A, Nistor C, Sandru F, Carsote M
Int J Mol Sci 2024 Feb 15;25(4) doi: 10.3390/ijms25042301. PMID: 38396977Free PMC Article
Kim SY, Lee JY, Cho YJ, Jo KH, Kim ES, Han JH, Baek KH, Moon SD
Int J Mol Sci 2022 Jun 7;23(12) doi: 10.3390/ijms23126364. PMID: 35742816Free PMC Article
Verploegen MFA, Vargas-Poussou R, Walsh SB, Alpay H, Amouzegar A, Ariceta G, Atmis B, Bacchetta J, Bárány P, Baron S, Bayrakci US, Belge H, Besouw M, Blanchard A, Bökenkamp A, Boyer O, Burgmaier K, Calò LA, Decramer S, Devuyst O, van Dyck M, Ferraro PM, Fila M, Francisco T, Ghiggeri GM, Gondra L, Guarino S, Hooman N, Hoorn EJ, Houillier P, Kamperis K, Kari JA, Konrad M, Levtchenko E, Lucchetti L, Lugani F, Marzuillo P, Mohidin B, Neuhaus TJ, Osman A, Papizh S, Perelló M, Rookmaaker MB, Conti VS, Santos F, Sawaf G, Serdaroglu E, Szczepanska M, Taroni F, Topaloglu R, Trepiccione F, Vidal E, Wan ER, Weber L, Yildirim ZY, Yüksel S, Zlatanova G, Bockenhauer D, Emma F, Nijenhuis T
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Salcuni AS, Cetani F, Guarnieri V, Nicastro V, Romagnoli E, de Martino D, Scillitani A, Cole DEC
Best Pract Res Clin Endocrinol Metab 2018 Dec;32(6):877-889. Epub 2018 Dec 1 doi: 10.1016/j.beem.2018.11.002. PMID: 30551989
Tonelli F, Giudici F, Cavalli T, Brandi ML
Clinics (Sao Paulo) 2012;67 Suppl 1(Suppl 1):155-60. doi: 10.6061/clinics/2012(sup01)26. PMID: 22584722Free PMC Article

Recent systematic reviews

Evangelista L, Ravelli I, Magnani F, Iacobone M, Giraudo C, Camozzi V, Spimpolo A, Cecchin D
Ann Nucl Med 2020 Sep;34(9):601-619. Epub 2020 Aug 7 doi: 10.1007/s12149-020-01507-1. PMID: 32767248Free PMC Article

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