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Coronary artery calcification

MedGen UID:
345985
Concept ID:
C1611184
Finding; Pathologic Function
Synonym: Calcification of coronary arteries
SNOMED CT: Calcification of coronary artery (445512009)
 
HPO: HP:0001717

Definition

An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a coronary artery. [from HPO]

Term Hierarchy

Conditions with this feature

Alkaptonuria
MedGen UID:
1413
Concept ID:
C0002066
Disease or Syndrome
Alkaptonuria is caused by deficiency of homogentisate 1,2-dioxygenase, an enzyme that converts homogentisic acid (HGA) to maleylacetoacetic acid in the tyrosine degradation pathway. The three major features of alkaptonuria are dark urine or urine that turns dark on standing, ochronosis (bluish-black pigmentation in connective tissue), and arthritis of the spine and larger joints. Ochronosis generally occurs after age 30 years; arthritis often begins in the third decade. Other manifestations can include pigment in the sclera, ear cartilage, and skin of the hands; aortic or mitral valve calcification or regurgitation and occasionally aortic dilatation; renal stones; prostate stones; and hypothyroidism.
Hereditary arterial and articular multiple calcification syndrome
MedGen UID:
347132
Concept ID:
C1859372
Disease or Syndrome
Adult-onset calcification of the lower extremity arteries (CALJA), including the iliac, femoral, and tibial arteries, and hand and foot capsule joints, is an autosomal recessive condition that represents only the second mendelian disorder of isolated calcification (see generalized arterial calcification of infancy (GACI), 208000). Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands (St. Hilaire et al., 2011).
Arterial calcification, generalized, of infancy, 2
MedGen UID:
477791
Concept ID:
C3276161
Disease or Syndrome
Generalized arterial calcification of infancy (GACI) is characterized by infantile onset of widespread arterial calcification and/or narrowing of large and medium-sized vessels resulting in cardiovascular findings (which can include heart failure, respiratory distress, edema, cyanosis, hypertension, and/or cardiomegaly). Additional findings can include typical skin and retinal manifestations of pseudoxanthoma elasticum (PXE), periarticular calcifications, development of rickets after infancy, cervical spine fusion, and hearing loss. While mortality in infancy is high, survival into the third and fourth decades has occurred.
Arterial calcification, generalized, of infancy, 1
MedGen UID:
1631685
Concept ID:
C4551985
Disease or Syndrome
Generalized arterial calcification of infancy (GACI) is characterized by infantile onset of widespread arterial calcification and/or narrowing of large and medium-sized vessels resulting in cardiovascular findings (which can include heart failure, respiratory distress, edema, cyanosis, hypertension, and/or cardiomegaly). Additional findings can include typical skin and retinal manifestations of pseudoxanthoma elasticum (PXE), periarticular calcifications, development of rickets after infancy, cervical spine fusion, and hearing loss. While mortality in infancy is high, survival into the third and fourth decades has occurred.

Professional guidelines

PubMed

Aengevaeren VL, Mosterd A, Sharma S, Prakken NHJ, Möhlenkamp S, Thompson PD, Velthuis BK, Eijsvogels TMH
Circulation 2020 Apr 21;141(16):1338-1350. Epub 2020 Apr 20 doi: 10.1161/CIRCULATIONAHA.119.044467. PMID: 32310695Free PMC Article
Cobin RH, Goodman NF; AACE Reproductive Endocrinology Scientific Committee
Endocr Pract 2017 Jul;23(7):869-880. doi: 10.4158/EP171828.PS. PMID: 28703650
Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, Grunberger G, Guerin CK, Bell DSH, Mechanick JI, Pessah-Pollack R, Wyne K, Smith D, Brinton EA, Fazio S, Davidson M
Endocr Pract 2017 Apr;23(Suppl 2):1-87. doi: 10.4158/EP171764.APPGL. PMID: 28437620

Recent clinical studies

Etiology

Wang J, Huang X, Fu C, Sheng Q, Liu P
Cardiovasc Diabetol 2022 Sep 16;21(1):187. doi: 10.1186/s12933-022-01615-4. PMID: 36114495Free PMC Article
Aengevaeren VL, Mosterd A, Sharma S, Prakken NHJ, Möhlenkamp S, Thompson PD, Velthuis BK, Eijsvogels TMH
Circulation 2020 Apr 21;141(16):1338-1350. Epub 2020 Apr 20 doi: 10.1161/CIRCULATIONAHA.119.044467. PMID: 32310695Free PMC Article
Shaikh K, Nakanishi R, Kim N, Budoff MJ
J Cardiovasc Comput Tomogr 2019 Nov-Dec;13(6):353-359. Epub 2018 Oct 2 doi: 10.1016/j.jcct.2018.10.002. PMID: 30322775
Mori H, Torii S, Kutyna M, Sakamoto A, Finn AV, Virmani R
JACC Cardiovasc Imaging 2018 Jan;11(1):127-142. doi: 10.1016/j.jcmg.2017.10.012. PMID: 29301708
Osawa K, Nakanishi R, Budoff M
Glob Heart 2016 Sep;11(3):287-293. doi: 10.1016/j.gheart.2016.08.001. PMID: 27741976Free PMC Article

Diagnosis

Calverley PMA, Walker PP
Respirology 2023 May;28(5):428-436. Epub 2023 Mar 15 doi: 10.1111/resp.14489. PMID: 36922031
Wang J, Huang X, Fu C, Sheng Q, Liu P
Cardiovasc Diabetol 2022 Sep 16;21(1):187. doi: 10.1186/s12933-022-01615-4. PMID: 36114495Free PMC Article
Sasaki KI, Fukumoto Y
J Cardiol 2022 May;79(5):596-604. Epub 2021 Dec 11 doi: 10.1016/j.jjcc.2021.10.013. PMID: 34906433
Huang X, D'Addabbo J, Nguyen PK
J Nucl Cardiol 2021 Oct;28(5):2215-2219. Epub 2020 Mar 13 doi: 10.1007/s12350-020-02058-8. PMID: 32170644Free PMC Article
Osawa K, Nakanishi R, Budoff M
Glob Heart 2016 Sep;11(3):287-293. doi: 10.1016/j.gheart.2016.08.001. PMID: 27741976Free PMC Article

Therapy

Sakaguchi Y
Clin Exp Nephrol 2022 May;26(5):379-384. Epub 2022 Jan 25 doi: 10.1007/s10157-022-02182-4. PMID: 35076791Free PMC Article
Isaka Y, Hamano T, Fujii H, Tsujimoto Y, Koiwa F, Sakaguchi Y, Tanaka R, Tomiyama N, Tatsugami F, Teramukai S
J Am Soc Nephrol 2021 Mar;32(3):723-735. Epub 2021 Feb 5 doi: 10.1681/ASN.2020050598. PMID: 33547218Free PMC Article
Rapa SF, Di Iorio BR, Campiglia P, Heidland A, Marzocco S
Int J Mol Sci 2019 Dec 30;21(1) doi: 10.3390/ijms21010263. PMID: 31906008Free PMC Article
Ali ZA, Nef H, Escaned J, Werner N, Banning AP, Hill JM, De Bruyne B, Montorfano M, Lefevre T, Stone GW, Crowley A, Matsumura M, Maehara A, Lansky AJ, Fajadet J, Di Mario C
Circ Cardiovasc Interv 2019 Oct;12(10):e008434. Epub 2019 Sep 25 doi: 10.1161/CIRCINTERVENTIONS.119.008434. PMID: 31553205
Mori H, Torii S, Kutyna M, Sakamoto A, Finn AV, Virmani R
JACC Cardiovasc Imaging 2018 Jan;11(1):127-142. doi: 10.1016/j.jcmg.2017.10.012. PMID: 29301708

Prognosis

Wang J, Huang X, Fu C, Sheng Q, Liu P
Cardiovasc Diabetol 2022 Sep 16;21(1):187. doi: 10.1186/s12933-022-01615-4. PMID: 36114495Free PMC Article
Shaikh K, Nakanishi R, Kim N, Budoff MJ
J Cardiovasc Comput Tomogr 2019 Nov-Dec;13(6):353-359. Epub 2018 Oct 2 doi: 10.1016/j.jcct.2018.10.002. PMID: 30322775
Mori H, Torii S, Kutyna M, Sakamoto A, Finn AV, Virmani R
JACC Cardiovasc Imaging 2018 Jan;11(1):127-142. doi: 10.1016/j.jcmg.2017.10.012. PMID: 29301708
Fernández-Friera L, Fuster V, López-Melgar B, Oliva B, García-Ruiz JM, Mendiguren J, Bueno H, Pocock S, Ibáñez B, Fernández-Ortiz A, Sanz J
J Am Coll Cardiol 2017 Dec 19;70(24):2979-2991. doi: 10.1016/j.jacc.2017.10.024. PMID: 29241485
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article

Clinical prediction guides

Moradi M, Rafiei E, Rasti S, Haghbin H
Emerg Radiol 2022 Dec;29(6):969-977. Epub 2022 Aug 4 doi: 10.1007/s10140-022-02082-w. PMID: 35922681Free PMC Article
Llewellyn O, Williams MC
Rofo 2022 Aug;194(8):833-840. Epub 2022 Mar 10 doi: 10.1055/a-1752-0577. PMID: 35272359
Manapragada PP, Aziz MU, Singh SP, Nath H
J Med Imaging Radiat Sci 2021 Nov;52(3S):S12-S18. Epub 2021 Aug 31 doi: 10.1016/j.jmir.2021.07.006. PMID: 34479829
Tsuda E, Singhal M
Int J Rheum Dis 2018 Jan;21(1):56-63. Epub 2017 Nov 8 doi: 10.1111/1756-185X.13210. PMID: 29115035
Nakahara T, Dweck MR, Narula N, Pisapia D, Narula J, Strauss HW
JACC Cardiovasc Imaging 2017 May;10(5):582-593. doi: 10.1016/j.jcmg.2017.03.005. PMID: 28473100

Recent systematic reviews

Shahraki MN, Jouabadi SM, Bos D, Stricker BH, Ahmadizar F
Curr Atheroscler Rep 2023 Nov;25(11):769-784. Epub 2023 Oct 5 doi: 10.1007/s11883-023-01151-w. PMID: 37796384Free PMC Article
Liang S, Wang C, Zhang J, Liu Z, Bai Y, Chen Z, Huang H, He Y
Cardiovasc Diabetol 2023 Jul 6;22(1):170. doi: 10.1186/s12933-023-01906-4. PMID: 37415168Free PMC Article
Abedi F, Sadeghi M, Omidkhoda N, Kelesidis T, Ramezani J, Samadi S, Mohammadpour AH
Lipids Health Dis 2023 May 8;22(1):60. doi: 10.1186/s12944-023-01827-x. PMID: 37158895Free PMC Article
Hao W, Wang X, Fan J, Zeng Y, Ai H, Nie S, Wei Y
Ann Med 2021 Dec;53(1):302-317. doi: 10.1080/07853890.2021.1875137. PMID: 33522282Free PMC Article
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article

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