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Perianal Intraepithelial Neoplasia

MedGen UID:
272309
•Concept ID:
C1332271
•
Neoplastic Process
Synonyms: Anal Margin Bowen Disease; Anal Margin Bowen's Disease; Anal Margin Intraepithelial Neoplasia; Anal Margin Squamous Dysplasia; Bowen Disease; Perianal Skin Bowen Disease; Perianal Skin Bowen's Disease; Perianal Squamous Dysplasia; Perianal Squamous Intraepithelial Neoplasia

Definition

A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerianal Intraepithelial Neoplasia

Professional guidelines

PubMed

Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata.
Coremans G, Margaritis V, Snoeck R, Wyndaele J, De Clercq E, Geboes K
Dis Colon Rectum 2003 Aug;46(8):1103-8; discussion 1108-9. doi: 10.1007/s10350-004-7287-5. PMID: 12907906
Current management of perianal intraepithelial neoplasia.
Branum GD
Obstet Gynecol Clin North Am 2001 Dec;28(4):703-10. doi: 10.1016/s0889-8545(05)70230-8. PMID: 11766146

Recent clinical studies

Etiology

Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women.
Stier EA, Goldstone SE, Einstein MH, Jay N, Berry JM, Wilkin T, Lee JY, Darragh TM, Da Costa M, Panther L, Aboulafia D, Palefsky JM
AIDS 2013 Feb 20;27(4):545-51. doi: 10.1097/QAD.0b013e32835a9b16. PMID: 23032420Free PMC Article
Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women.
Dedes KJ, Beneder C, Samartzis N, Muller MD, Fink D, Fehr MK
J Reprod Med 2008 Dec;53(12):947-51. PMID: 19160654
Prevalence of perianal intraepithelial neoplasia in HIV-infected patients referred for high-resolution anoscopy.
Nahas CS, Lin O, Weiser MR, Temple LK, Wong WD, Stier EA
Dis Colon Rectum 2006 Oct;49(10):1581-6. doi: 10.1007/s10350-006-0658-3. PMID: 16977374
Vulvar, vaginal, and perianal intraepithelial neoplasia in women with or at risk for human immunodeficiency virus.
Jamieson DJ, Paramsothy P, Cu-Uvin S, Duerr A; HIV Epidemiology Research Study Group
Obstet Gynecol 2006 May;107(5):1023-8. doi: 10.1097/01.AOG.0000210237.80211.ff. PMID: 16648406
Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata.
Coremans G, Margaritis V, Snoeck R, Wyndaele J, De Clercq E, Geboes K
Dis Colon Rectum 2003 Aug;46(8):1103-8; discussion 1108-9. doi: 10.1007/s10350-004-7287-5. PMID: 12907906

Diagnosis

A Rare Case of Varicella Zoster Infection in Hemorrhoids in a Patient With Inflammatory Bowel Disease.
Siatecka H, Al-Awami S, Siddiqi A, Diwan AH
Am J Dermatopathol 2024 Mar 1;46(3):159-161. doi: 10.1097/DAD.0000000000002626. PMID: 38354383
S1 guideline: anal intraepithelial neoplasia (AIN) and perianal intraepithelial neoplasia (PAIN).
Hartschuh W, Breitkopf C, Lenhard B, Wienert V, Mlitz H, Furtwängler A
J Dtsch Dermatol Ges 2011 Mar;9(3):256-8. Epub 2011 Jan 5 doi: 10.1111/j.1610-0387.2011.07428.x. PMID: 21208377
Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women.
Dedes KJ, Beneder C, Samartzis N, Muller MD, Fink D, Fehr MK
J Reprod Med 2008 Dec;53(12):947-51. PMID: 19160654
Prevalence of perianal intraepithelial neoplasia in HIV-infected patients referred for high-resolution anoscopy.
Nahas CS, Lin O, Weiser MR, Temple LK, Wong WD, Stier EA
Dis Colon Rectum 2006 Oct;49(10):1581-6. doi: 10.1007/s10350-006-0658-3. PMID: 16977374

Therapy

Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women.
Stier EA, Goldstone SE, Einstein MH, Jay N, Berry JM, Wilkin T, Lee JY, Darragh TM, Da Costa M, Panther L, Aboulafia D, Palefsky JM
AIDS 2013 Feb 20;27(4):545-51. doi: 10.1097/QAD.0b013e32835a9b16. PMID: 23032420Free PMC Article
Clinical responses to Cidofovir applied topically to women with high grade vulval intraepithelial neoplasia.
Tristram A, Fiander A
Gynecol Oncol 2005 Dec;99(3):652-5. Epub 2005 Sep 16 doi: 10.1016/j.ygyno.2005.07.127. PMID: 16169066
Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata.
Coremans G, Margaritis V, Snoeck R, Wyndaele J, De Clercq E, Geboes K
Dis Colon Rectum 2003 Aug;46(8):1103-8; discussion 1108-9. doi: 10.1007/s10350-004-7287-5. PMID: 12907906

Prognosis

Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women.
Stier EA, Goldstone SE, Einstein MH, Jay N, Berry JM, Wilkin T, Lee JY, Darragh TM, Da Costa M, Panther L, Aboulafia D, Palefsky JM
AIDS 2013 Feb 20;27(4):545-51. doi: 10.1097/QAD.0b013e32835a9b16. PMID: 23032420Free PMC Article
Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women.
Dedes KJ, Beneder C, Samartzis N, Muller MD, Fink D, Fehr MK
J Reprod Med 2008 Dec;53(12):947-51. PMID: 19160654
Vulvar, vaginal, and perianal intraepithelial neoplasia in women with or at risk for human immunodeficiency virus.
Jamieson DJ, Paramsothy P, Cu-Uvin S, Duerr A; HIV Epidemiology Research Study Group
Obstet Gynecol 2006 May;107(5):1023-8. doi: 10.1097/01.AOG.0000210237.80211.ff. PMID: 16648406

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