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Primary Malignant Neoplasm

MedGen UID:
227011
•Concept ID:
C1306459
•
Neoplastic Process
Synonyms: Cancer; Cancer morphology; Malignancy; Malignant neoplasm; Malignant neoplasm, primary; Malignant tumor morphology; Neoplasm, malignant; Neoplasm, malignant (primary); Primary malignant neoplasm; Tumor, malignant; Unclassified tumor, malignant
SNOMED CT: Primary malignant neoplasm (372087000); Malignant tumor morphology (86049000); Cancer morphology (86049000); Neoplasm, malignant (86049000); Malignancy (86049000); Cancer (86049000); Unclassified tumor, malignant (86049000); Tumor, malignant (86049000); Malignant neoplasm (86049000); Malignant neoplasm, primary (86049000); Neoplasm, malignant (primary) (86049000)

Definition

A malignant tumor at the original site of growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Malignant Neoplasm

Recent clinical studies

Etiology

Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Multiple primary malignant neoplasm in patients with laryngeal carcinoma.
Esposito ED, Bevilacqua L, Guadagno MT
J Surg Oncol 2000 May;74(1):83-6. doi: 10.1002/1096-9098(200005)74:1<83::aid-jso18>3.0.co;2-q. PMID: 10861616
Primary malignant neoplasm of the female urethra.
Ampil FL
Obstet Gynecol 1985 Dec;66(6):799-804. PMID: 3934611
Prostate cancer and the multiple primary malignant neoplasm syndrome.
Ray P, Guinan P, Sharifi R, Mouli K, Shaw M
Prostate 1983;4(5):513-22. doi: 10.1002/pros.2990040510. PMID: 6684282

Diagnosis

Advanced thymic lymphoepithelioma-like carcinoma with bone marrow metastases treated by immunotherapy combined with antiangiogenesis therapy: a case report.
Li YJ, Li YW, Cui GH, Li SH, Deng YW, Lu D
Anticancer Drugs 2022 Aug 1;33(7):686-690. Epub 2022 Jun 21 doi: 10.1097/CAD.0000000000001293. PMID: 35324515
Risk Factors of Young-Onset Colorectal Cancer: Analysis of a Large Population-Based Registry.
Danial D, Youssef ED, Maryam BM, Mohammad A, Moein BM, Liliane D
Can J Gastroenterol Hepatol 2022;2022:3582443. Epub 2022 Feb 16 doi: 10.1155/2022/3582443. PMID: 35223684Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Primary malignant neoplasm of the female urethra.
Ampil FL
Obstet Gynecol 1985 Dec;66(6):799-804. PMID: 3934611

Therapy

Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19.
Schmidt AL, Tucker MD, Bakouny Z, Labaki C, Hsu CY, Shyr Y, Armstrong AJ, Beer TM, Bijjula RR, Bilen MA, Connell CF, Dawsey SJ, Faller B, Gao X, Gartrell BA, Gill D, Gulati S, Halabi S, Hwang C, Joshi M, Khaki AR, Menon H, Morris MJ, Puc M, Russell KB, Shah NJ, Sharifi N, Shaya J, Schweizer MT, Steinharter J, Wulff-Burchfield EM, Xu W, Zhu J, Mishra S, Grivas P, Rini BI, Warner JL, Zhang T, Choueiri TK, Gupta S, McKay RR
JAMA Netw Open 2021 Nov 1;4(11):e2134330. doi: 10.1001/jamanetworkopen.2021.34330. PMID: 34767021Free PMC Article
Graphene Oxide Loaded with Protocatechuic Acid and Chlorogenic Acid Dual Drug Nanodelivery System for Human Hepatocellular Carcinoma Therapeutic Application.
Buskaran K, Hussein MZ, Moklas MAM, Masarudin MJ, Fakurazi S
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115786. PMID: 34071389Free PMC Article
GammaTile<sup>®</sup>: Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Complications Following Stereotactic Needle Biopsy of Intracranial Tumors.
Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI
World Neurosurg 2015 Oct;84(4):1084-9. Epub 2015 May 22 doi: 10.1016/j.wneu.2015.05.025. PMID: 26008141

Prognosis

Nuclei detection in hepatocellular carcinoma and dysplastic liver nodules in histopathology images using bootstrap regression.
Kalinathan L, Kathavarayan RS, Kanmani M, Dinakaran N
Histol Histopathol 2020 Oct;35(10):1115-1123. Epub 2020 Jul 21 doi: 10.14670/HH-18-240. PMID: 32691405
GammaTile<sup>®</sup>: Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Complications Following Stereotactic Needle Biopsy of Intracranial Tumors.
Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI
World Neurosurg 2015 Oct;84(4):1084-9. Epub 2015 May 22 doi: 10.1016/j.wneu.2015.05.025. PMID: 26008141
Multiple primary malignant neoplasm in patients with laryngeal carcinoma.
Esposito ED, Bevilacqua L, Guadagno MT
J Surg Oncol 2000 May;74(1):83-6. doi: 10.1002/1096-9098(200005)74:1<83::aid-jso18>3.0.co;2-q. PMID: 10861616

Clinical prediction guides

Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19.
Schmidt AL, Tucker MD, Bakouny Z, Labaki C, Hsu CY, Shyr Y, Armstrong AJ, Beer TM, Bijjula RR, Bilen MA, Connell CF, Dawsey SJ, Faller B, Gao X, Gartrell BA, Gill D, Gulati S, Halabi S, Hwang C, Joshi M, Khaki AR, Menon H, Morris MJ, Puc M, Russell KB, Shah NJ, Sharifi N, Shaya J, Schweizer MT, Steinharter J, Wulff-Burchfield EM, Xu W, Zhu J, Mishra S, Grivas P, Rini BI, Warner JL, Zhang T, Choueiri TK, Gupta S, McKay RR
JAMA Netw Open 2021 Nov 1;4(11):e2134330. doi: 10.1001/jamanetworkopen.2021.34330. PMID: 34767021Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Multiple primary malignant neoplasm in patients with laryngeal carcinoma.
Esposito ED, Bevilacqua L, Guadagno MT
J Surg Oncol 2000 May;74(1):83-6. doi: 10.1002/1096-9098(200005)74:1<83::aid-jso18>3.0.co;2-q. PMID: 10861616
Primary malignant neoplasm of the female urethra.
Ampil FL
Obstet Gynecol 1985 Dec;66(6):799-804. PMID: 3934611

Recent systematic reviews

Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review.
Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML
JAMA Surg 2014 Apr;149(4):383-92. doi: 10.1001/jamasurg.2013.4059. PMID: 24477929Free PMC Article

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