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Primary Malignant Neoplasm

MedGen UID:
227011
•Concept ID:
C1306459
•
Neoplastic Process
Synonym: Primary malignant neoplasm
SNOMED CT: Primary malignant neoplasm (372087000)

Definition

A malignant tumor at the original site of growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Malignant Neoplasm

Professional guidelines

PubMed

Excess Body Weight and the Risk of Second Primary Cancers Among Cancer Survivors.
Bodelon C, Sung H, Mitchell EL, Deubler EL, Newton CC, Jemal A, Teras LR, Patel AV
JAMA Netw Open 2024 Sep 3;7(9):e2433132. doi: 10.1001/jamanetworkopen.2024.33132. PMID: 39287946Free PMC Article
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
Current and future management strategies for relapsed or progressive hepatoblastoma.
Venkatramani R, Furman WL, Fuchs J, Warmann SW, Malogolowkin MH
Paediatr Drugs 2012 Aug 1;14(4):221-32. doi: 10.2165/11597740-000000000-00000. PMID: 22702740

Recent clinical studies

Etiology

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Obesity and Risk of Recurrence in Patients With Breast Cancer Treated With Aromatase Inhibitors.
Harborg S, Cronin-Fenton D, Jensen MR, Ahern TP, Ewertz M, Borgquist S
JAMA Netw Open 2023 Oct 2;6(10):e2337780. doi: 10.1001/jamanetworkopen.2023.37780. PMID: 37831449Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Diagnosis

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
Obesity and Risk of Recurrence in Patients With Breast Cancer Treated With Aromatase Inhibitors.
Harborg S, Cronin-Fenton D, Jensen MR, Ahern TP, Ewertz M, Borgquist S
JAMA Netw Open 2023 Oct 2;6(10):e2337780. doi: 10.1001/jamanetworkopen.2023.37780. PMID: 37831449Free PMC Article
GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma.
Mitchell B, Dhingra JK, Mahalingam M
Adv Anat Pathol 2016 Jul;23(4):244-71. doi: 10.1097/PAP.0000000000000113. PMID: 27145091

Therapy

Obesity and Risk of Recurrence in Patients With Breast Cancer Treated With Aromatase Inhibitors.
Harborg S, Cronin-Fenton D, Jensen MR, Ahern TP, Ewertz M, Borgquist S
JAMA Netw Open 2023 Oct 2;6(10):e2337780. doi: 10.1001/jamanetworkopen.2023.37780. PMID: 37831449Free PMC Article
GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
Chemotherapy of secondary leukemias.
Visani G, Pagano L, Pulsoni A, Tosi P, Piccaluga PP, Pastano R, Grafone T, Malagola M, Isidori A, Tura S
Leuk Lymphoma 2000 May;37(5-6):543-9. doi: 10.3109/10428190009058506. PMID: 11042514

Prognosis

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Second Primary Malignant Neoplasms and Survival in Adolescent and Young Adult Cancer Survivors.
Keegan THM, Bleyer A, Rosenberg AS, Li Q, Goldfarb M
JAMA Oncol 2017 Nov 1;3(11):1554-1557. doi: 10.1001/jamaoncol.2017.0465. PMID: 28426850Free PMC Article
Mesenchymal tumors of the liver.
Mani H, Van Thiel DH
Clin Liver Dis 2001 Feb;5(1):219-57, viii. doi: 10.1016/s1089-3261(05)70162-8. PMID: 11218917
Chemotherapy of secondary leukemias.
Visani G, Pagano L, Pulsoni A, Tosi P, Piccaluga PP, Pastano R, Grafone T, Malagola M, Isidori A, Tura S
Leuk Lymphoma 2000 May;37(5-6):543-9. doi: 10.3109/10428190009058506. PMID: 11042514

Clinical prediction guides

Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D, Yehia L, Dhawan A, Ni Y, Eng C
Cell Rep Med 2024 Feb 20;5(2):101384. Epub 2024 Jan 18 doi: 10.1016/j.xcrm.2023.101384. PMID: 38242121Free PMC Article
3D-printed hemipelvic prosthesis combined with a dual mobility bearing in patients with primary malignant neoplasm involving the acetabulum: clinical outcomes and finite element analysis.
Wang M, Liu T, Xu C, Liu C, Li B, Lian Q, Chen T, Qiao S, Wang Z
BMC Surg 2022 Oct 6;22(1):357. doi: 10.1186/s12893-022-01804-8. PMID: 36203147Free PMC Article
Nuclei detection in hepatocellular carcinoma and dysplastic liver nodules in histopathology images using bootstrap regression.
Kalinathan L, Kathavarayan RS, Kanmani M, Dinakaran N
Histol Histopathol 2020 Oct;35(10):1115-1123. Epub 2020 Jul 21 doi: 10.14670/HH-18-240. PMID: 32691405
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article

Recent systematic reviews

Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review.
Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML
JAMA Surg 2014 Apr;149(4):383-92. doi: 10.1001/jamasurg.2013.4059. PMID: 24477929Free PMC Article

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