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primary malignant neoplasm

MedGen UID:
227011
•Concept ID:
C1306459
•
Neoplastic Process
Synonyms: Cancer; Cancer morphology; Malignancy; Malignant neoplasm; Malignant neoplasm, primary; Malignant tumor morphology; Neoplasm, malignant; Neoplasm, malignant (primary); Primary Malignant Neoplasm; Primary malignant neoplasm; Tumor, malignant; Unclassified tumor, malignant
SNOMED CT: Primary malignant neoplasm (372087000); Malignant tumor morphology (86049000); Cancer morphology (86049000); Neoplasm, malignant (86049000); Malignancy (86049000); Cancer (86049000); Unclassified tumor, malignant (86049000); Tumor, malignant (86049000); Malignant neoplasm (86049000); Malignant neoplasm, primary (86049000); Neoplasm, malignant (primary) (86049000)

Definition

A malignant tumor at the original site of growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVprimary malignant neoplasm

Recent clinical studies

Etiology

Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Multiple primary malignant neoplasm in patients with laryngeal carcinoma.
Esposito ED, Bevilacqua L, Guadagno MT
J Surg Oncol 2000 May;74(1):83-6. doi: 10.1002/1096-9098(200005)74:1<83::aid-jso18>3.0.co;2-q. PMID: 10861616
Primary malignant neoplasm of the female urethra.
Ampil FL
Obstet Gynecol 1985 Dec;66(6):799-804. PMID: 3934611
Prostate cancer and the multiple primary malignant neoplasm syndrome.
Ray P, Guinan P, Sharifi R, Mouli K, Shaw M
Prostate 1983;4(5):513-22. doi: 10.1002/pros.2990040510. PMID: 6684282

Diagnosis

High-throughput microRNA profile in adult and pediatric primary glioblastomas: the role of miR-10b-5p and miR-630 in the tumor aggressiveness.
Junior LGD, Baroni M, Lira RCP, Teixeira S, Fedatto PF, Silveira VS, Suazo VK, Veronez LC, Panepucci RA, Antônio DSM, Yunes JA, Brandalise SR, Dos Santos Aguiar S, Neder L, de Oliveira RS, Machado HR, Carlotti CG Jr, Tone LG, Valera ET, Scrideli CA
Mol Biol Rep 2020 Sep;47(9):6949-6959. Epub 2020 Sep 4 doi: 10.1007/s11033-020-05754-3. PMID: 32888124
GammaTile<sup>®</sup>: Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Primary malignant neoplasm of the female urethra.
Ampil FL
Obstet Gynecol 1985 Dec;66(6):799-804. PMID: 3934611

Therapy

Graphene Oxide Loaded with Protocatechuic Acid and Chlorogenic Acid Dual Drug Nanodelivery System for Human Hepatocellular Carcinoma Therapeutic Application.
Buskaran K, Hussein MZ, Moklas MAM, Masarudin MJ, Fakurazi S
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115786. PMID: 34071389Free PMC Article
GammaTile<sup>®</sup>: Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Intravitreal bevacizumab in treatment of iris metastasis from primary lung carcinoma.
Raval V, Saldanha M, Mittal R, Das T
BMJ Case Rep 2019 Sep 8;12(9) doi: 10.1136/bcr-2019-231097. PMID: 31501176Free PMC Article
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Complications Following Stereotactic Needle Biopsy of Intracranial Tumors.
Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI
World Neurosurg 2015 Oct;84(4):1084-9. Epub 2015 May 22 doi: 10.1016/j.wneu.2015.05.025. PMID: 26008141

Prognosis

High-throughput microRNA profile in adult and pediatric primary glioblastomas: the role of miR-10b-5p and miR-630 in the tumor aggressiveness.
Junior LGD, Baroni M, Lira RCP, Teixeira S, Fedatto PF, Silveira VS, Suazo VK, Veronez LC, Panepucci RA, Antônio DSM, Yunes JA, Brandalise SR, Dos Santos Aguiar S, Neder L, de Oliveira RS, Machado HR, Carlotti CG Jr, Tone LG, Valera ET, Scrideli CA
Mol Biol Rep 2020 Sep;47(9):6949-6959. Epub 2020 Sep 4 doi: 10.1007/s11033-020-05754-3. PMID: 32888124
GammaTile<sup>®</sup>: Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Complications Following Stereotactic Needle Biopsy of Intracranial Tumors.
Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI
World Neurosurg 2015 Oct;84(4):1084-9. Epub 2015 May 22 doi: 10.1016/j.wneu.2015.05.025. PMID: 26008141
Multiple primary malignant neoplasm in patients with laryngeal carcinoma.
Esposito ED, Bevilacqua L, Guadagno MT
J Surg Oncol 2000 May;74(1):83-6. doi: 10.1002/1096-9098(200005)74:1<83::aid-jso18>3.0.co;2-q. PMID: 10861616

Clinical prediction guides

High-throughput microRNA profile in adult and pediatric primary glioblastomas: the role of miR-10b-5p and miR-630 in the tumor aggressiveness.
Junior LGD, Baroni M, Lira RCP, Teixeira S, Fedatto PF, Silveira VS, Suazo VK, Veronez LC, Panepucci RA, Antônio DSM, Yunes JA, Brandalise SR, Dos Santos Aguiar S, Neder L, de Oliveira RS, Machado HR, Carlotti CG Jr, Tone LG, Valera ET, Scrideli CA
Mol Biol Rep 2020 Sep;47(9):6949-6959. Epub 2020 Sep 4 doi: 10.1007/s11033-020-05754-3. PMID: 32888124
Incidence of second primary malignant neoplasm in Malwa region of central India.
Naik A, Bhandari V, Saadvik RY, Gupta KL, Kausar M, Batra M
J Cancer Res Ther 2018 Jul-Sep;14(5):999-1004. doi: 10.4103/0973-1482.183560. PMID: 30197338
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.
Adjei Boakye E, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF
JAMA Otolaryngol Head Neck Surg 2018 Aug 1;144(8):727-737. doi: 10.1001/jamaoto.2018.0993. PMID: 30027284Free PMC Article
Multiple primary malignant neoplasm in patients with laryngeal carcinoma.
Esposito ED, Bevilacqua L, Guadagno MT
J Surg Oncol 2000 May;74(1):83-6. doi: 10.1002/1096-9098(200005)74:1<83::aid-jso18>3.0.co;2-q. PMID: 10861616
Primary malignant neoplasm of the female urethra.
Ampil FL
Obstet Gynecol 1985 Dec;66(6):799-804. PMID: 3934611

Recent systematic reviews

Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review.
Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML
JAMA Surg 2014 Apr;149(4):383-92. doi: 10.1001/jamasurg.2013.4059. PMID: 24477929Free PMC Article

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