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Mammary Neoplasms, Human

MedGen UID:
226225
•Concept ID:
C1257931
•
Neoplastic Process
Synonyms: Human Mammary Neoplasm; Human Mammary Neoplasms; Mammary Neoplasm, Human; Neoplasm, Human Mammary; Neoplasms, Human Mammary

Definition

Tumor or cancer of the human MAMMARY GLAND. [from MeSH]

Recent clinical studies

Etiology

Thirteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer.
Twigger AJ, Sumbal J, Bentires-Alj M, Howard BA
J Mammary Gland Biol Neoplasia 2022 Dec;27(3-4):233-239. Epub 2022 Oct 15 doi: 10.1007/s10911-022-09526-6. PMID: 36242657Free PMC Article
Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.
Miller JL, Bartlett AP, Harman RM, Majhi PD, Jerry DJ, Van de Walle GR
J Mammary Gland Biol Neoplasia 2022 Jun;27(2):185-210. Epub 2022 Jul 29 doi: 10.1007/s10911-022-09522-w. PMID: 35904679
Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.
Saeki K, Chang G, Kanaya N, Wu X, Wang J, Bernal L, Ha D, Neuhausen SL, Chen S
Commun Biol 2021 Jun 2;4(1):660. doi: 10.1038/s42003-021-02201-2. PMID: 34079055Free PMC Article
Cross-species oncogenic signatures of breast cancer in canine mammary tumors.
Kim TM, Yang IS, Seung BJ, Lee S, Kim D, Ha YJ, Seo MK, Kim KK, Kim HS, Cheong JH, Sur JH, Nam H, Kim S
Nat Commun 2020 Jul 17;11(1):3616. doi: 10.1038/s41467-020-17458-0. PMID: 32680987Free PMC Article
Androgen receptor and FOXA1 coexpression define a "luminal-AR" subtype of feline mammary carcinomas, spontaneous models of breast cancer.
Dagher E, Royer V, Buchet P, Abadie J, Loussouarn D, Campone M, Nguyen F
BMC Cancer 2019 Dec 30;19(1):1267. doi: 10.1186/s12885-019-6483-6. PMID: 31888566Free PMC Article

Diagnosis

Galectin-3 as a biomarker in breast neoplasms: Mechanisms and applications in patient care.
Niang DGM, Gaba FM, Diouf A, Hendricks J, Diallo RN, Niang MDS, Mbengue B, Dieye A
J Leukoc Biol 2022 Nov;112(5):1041-1052. Epub 2022 Sep 20 doi: 10.1002/JLB.5MR0822-673R. PMID: 36125083
Label-free isolation and cultivation of patient-matched human mammary epithelial and stromal cells from normal breast tissue.
Koch MK, Murekatete B, Hutmacher DW, Haupt LM, Bray LJ
Eur J Cell Biol 2021 Sep-Nov;100(7-8):151187. Epub 2021 Nov 22 doi: 10.1016/j.ejcb.2021.151187. PMID: 34837767
Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.
Park HM, Kim H, Kim DW, Yoon JH, Kim BG, Cho JY
BMB Rep 2020 Dec;53(12):664-669. PMID: 33298249Free PMC Article
A novel and cost-effective <i>ex vivo</i> orthotopic model for the study of human breast cancer in mouse mammary gland organ culture.
Gupta A, Gupta G, Mehta RR, Ivancic DZ, Walker RR, Patel JR, Gallegos KM, Davidson AM, Khan SA, Mehta RG, Tilghman SL
Biol Open 2020 May 29;9(5) doi: 10.1242/bio.051649. PMID: 32366373Free PMC Article
Comparison of metastatic neuroendocrine neoplasms to the breast and primary invasive mammary carcinomas with neuroendocrine differentiation.
Mohanty SK, Kim SA, DeLair DF, Bose S, Laury AR, Chopra S, Mertens RB, Dhall D
Mod Pathol 2016 Aug;29(8):788-98. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.69. PMID: 27125358

Therapy

Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC
Nat Commun 2021 Sep 10;12(1):5389. doi: 10.1038/s41467-021-25650-z. PMID: 34508101Free PMC Article
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer.
Duderstadt EL, McQuaide SA, Sanders MA, Samuelson DJ
Physiol Genomics 2021 Feb 1;53(2):61-68. Epub 2020 Dec 21 doi: 10.1152/physiolgenomics.00112.2020. PMID: 33346690Free PMC Article
Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer.
Citron F, Segatto I, Vinciguerra GLR, Musco L, Russo F, Mungo G, D'Andrea S, Mattevi MC, Perin T, Schiappacassi M, Massarut S, Marchini C, Amici A, Vecchione A, Baldassarre G, Belletti B
Cancer Res 2020 Mar 1;80(5):1064-1077. Epub 2019 Dec 20 doi: 10.1158/0008-5472.CAN-19-1793. PMID: 31862778
Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients.
Ávila-Gálvez MÁ, García-Villalba R, Martínez-Díaz F, Ocaña-Castillo B, Monedero-Saiz T, Torrecillas-Sánchez A, Abellán B, González-Sarrías A, Espín JC
Mol Nutr Food Res 2019 May;63(9):e1801239. Epub 2019 Feb 4 doi: 10.1002/mnfr.201801239. PMID: 30690879
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.
Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K
J Mammary Gland Biol Neoplasia 2016 Jun;21(1-2):9-17. Epub 2016 May 19 doi: 10.1007/s10911-016-9354-7. PMID: 27194029Free PMC Article

Prognosis

Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.
Miller JL, Bartlett AP, Harman RM, Majhi PD, Jerry DJ, Van de Walle GR
J Mammary Gland Biol Neoplasia 2022 Jun;27(2):185-210. Epub 2022 Jul 29 doi: 10.1007/s10911-022-09522-w. PMID: 35904679
Twelfth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer.
Charifou E, Traustadottir GA, Bentires-Alj M, Howard B, Van Keymeulen A
J Mammary Gland Biol Neoplasia 2021 Sep;26(3):221-226. Epub 2021 Aug 26 doi: 10.1007/s10911-021-09498-z. PMID: 34448098Free PMC Article
Cross-species oncogenic signatures of breast cancer in canine mammary tumors.
Kim TM, Yang IS, Seung BJ, Lee S, Kim D, Ha YJ, Seo MK, Kim KK, Kim HS, Cheong JH, Sur JH, Nam H, Kim S
Nat Commun 2020 Jul 17;11(1):3616. doi: 10.1038/s41467-020-17458-0. PMID: 32680987Free PMC Article
Androgen receptor and FOXA1 coexpression define a "luminal-AR" subtype of feline mammary carcinomas, spontaneous models of breast cancer.
Dagher E, Royer V, Buchet P, Abadie J, Loussouarn D, Campone M, Nguyen F
BMC Cancer 2019 Dec 30;19(1):1267. doi: 10.1186/s12885-019-6483-6. PMID: 31888566Free PMC Article
Comparison of metastatic neuroendocrine neoplasms to the breast and primary invasive mammary carcinomas with neuroendocrine differentiation.
Mohanty SK, Kim SA, DeLair DF, Bose S, Laury AR, Chopra S, Mertens RB, Dhall D
Mod Pathol 2016 Aug;29(8):788-98. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.69. PMID: 27125358

Clinical prediction guides

Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.
Miller JL, Bartlett AP, Harman RM, Majhi PD, Jerry DJ, Van de Walle GR
J Mammary Gland Biol Neoplasia 2022 Jun;27(2):185-210. Epub 2022 Jul 29 doi: 10.1007/s10911-022-09522-w. PMID: 35904679
A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans.
Ibrahim AM, Bilsland A, Rickelt S, Morris JS, Stein T
Breast Cancer Res 2021 Sep 26;23(1):90. doi: 10.1186/s13058-021-01470-3. PMID: 34565423Free PMC Article
Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
A novel and cost-effective <i>ex vivo</i> orthotopic model for the study of human breast cancer in mouse mammary gland organ culture.
Gupta A, Gupta G, Mehta RR, Ivancic DZ, Walker RR, Patel JR, Gallegos KM, Davidson AM, Khan SA, Mehta RG, Tilghman SL
Biol Open 2020 May 29;9(5) doi: 10.1242/bio.051649. PMID: 32366373Free PMC Article
Comparison of metastatic neuroendocrine neoplasms to the breast and primary invasive mammary carcinomas with neuroendocrine differentiation.
Mohanty SK, Kim SA, DeLair DF, Bose S, Laury AR, Chopra S, Mertens RB, Dhall D
Mod Pathol 2016 Aug;29(8):788-98. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.69. PMID: 27125358

Recent systematic reviews

Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.
Bodewes FTH, van Asselt AA, Dorrius MD, Greuter MJW, de Bock GH
Breast 2022 Dec;66:62-68. Epub 2022 Sep 26 doi: 10.1016/j.breast.2022.09.007. PMID: 36183671Free PMC Article
Global guidelines for breast cancer screening: A systematic review.
Ren W, Chen M, Qiao Y, Zhao F
Breast 2022 Aug;64:85-99. Epub 2022 Apr 19 doi: 10.1016/j.breast.2022.04.003. PMID: 35636342Free PMC Article
The Value of EphB2 Receptor and Cognate Ephrin Ligands in Prognostic and Predictive Assessments of Human Breast Cancer.
Ebrahim AS, Hailat Z, Bandyopadhyay S, Neill D, Kandouz M
Int J Mol Sci 2021 Jul 28;22(15) doi: 10.3390/ijms22158098. PMID: 34360867Free PMC Article
Digital breast tomosynthesis compared to diagnostic mammographic projections (including magnification) among women recalled at screening mammography: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC).
Canelo-Aybar C, Carrera L, Beltrán J, Posso M, Rigau D, Lebeau A, Gräwingholt A, Castells X, Langendam M, Pérez E, Giorgi Rossi P, Van Engen R, Parmelli E, Saz-Parkinson Z, Alonso-Coello P
Cancer Med 2021 Apr;10(7):2191-2204. Epub 2021 Mar 5 doi: 10.1002/cam4.3803. PMID: 33675147Free PMC Article
Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-analysis.
Piccoli GF, Mesquita LA, Stein C, Aziz M, Zoldan M, Degobi NAH, Spiazzi BF, Lopes Junior GL, Colpani V, Gerchman F
J Clin Endocrinol Metab 2021 Mar 8;106(3):912-921. doi: 10.1210/clinem/dgaa891. PMID: 33248445

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