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Mammary Neoplasms, Human

MedGen UID:
226225
•Concept ID:
C1257931
•
Neoplastic Process
Synonyms: Human Mammary Neoplasm; Human Mammary Neoplasms; Mammary Neoplasm, Human; Neoplasm, Human Mammary; Neoplasms, Human Mammary

Definition

Tumor or cancer of the human MAMMARY GLAND. [from MeSH]

Recent clinical studies

Etiology

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.
Saeki K, Chang G, Kanaya N, Wu X, Wang J, Bernal L, Ha D, Neuhausen SL, Chen S
Commun Biol 2021 Jun 2;4(1):660. doi: 10.1038/s42003-021-02201-2. PMID: 34079055Free PMC Article
Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
Cross-species oncogenic signatures of breast cancer in canine mammary tumors.
Kim TM, Yang IS, Seung BJ, Lee S, Kim D, Ha YJ, Seo MK, Kim KK, Kim HS, Cheong JH, Sur JH, Nam H, Kim S
Nat Commun 2020 Jul 17;11(1):3616. doi: 10.1038/s41467-020-17458-0. PMID: 32680987Free PMC Article
Androgen receptor and FOXA1 coexpression define a "luminal-AR" subtype of feline mammary carcinomas, spontaneous models of breast cancer.
Dagher E, Royer V, Buchet P, Abadie J, Loussouarn D, Campone M, Nguyen F
BMC Cancer 2019 Dec 30;19(1):1267. doi: 10.1186/s12885-019-6483-6. PMID: 31888566Free PMC Article
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.
Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K
J Mammary Gland Biol Neoplasia 2016 Jun;21(1-2):9-17. Epub 2016 May 19 doi: 10.1007/s10911-016-9354-7. PMID: 27194029Free PMC Article

Diagnosis

Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.
Park HM, Kim H, Kim DW, Yoon JH, Kim BG, Cho JY
BMB Rep 2020 Dec;53(12):664-669. PMID: 33298249Free PMC Article
A novel and cost-effective <i>ex vivo</i> orthotopic model for the study of human breast cancer in mouse mammary gland organ culture.
Gupta A, Gupta G, Mehta RR, Ivancic DZ, Walker RR, Patel JR, Gallegos KM, Davidson AM, Khan SA, Mehta RG, Tilghman SL
Biol Open 2020 May 29;9(5) doi: 10.1242/bio.051649. PMID: 32366373Free PMC Article
Benign Fibromyxoid Lesion of the Breast: A Distinct Entity From Benign Spindle Cell Tumors of the Mammary Stroma?
Schwartz CJ, Schandl CA, Morse J, Ralston J, Rapkiewicz A, Darvishian F
Int J Surg Pathol 2018 Sep;26(6):488-493. Epub 2018 Mar 19 doi: 10.1177/1066896918763901. PMID: 29552929
Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors.
Nguyen F, Peña L, Ibisch C, Loussouarn D, Gama A, Rieder N, Belousov A, Campone M, Abadie J
Breast Cancer Res Treat 2018 Feb;167(3):635-648. Epub 2017 Oct 30 doi: 10.1007/s10549-017-4548-2. PMID: 29086231Free PMC Article
Comparison of metastatic neuroendocrine neoplasms to the breast and primary invasive mammary carcinomas with neuroendocrine differentiation.
Mohanty SK, Kim SA, DeLair DF, Bose S, Laury AR, Chopra S, Mertens RB, Dhall D
Mod Pathol 2016 Aug;29(8):788-98. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.69. PMID: 27125358

Therapy

Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer.
Citron F, Segatto I, Vinciguerra GLR, Musco L, Russo F, Mungo G, D'Andrea S, Mattevi MC, Perin T, Schiappacassi M, Massarut S, Marchini C, Amici A, Vecchione A, Baldassarre G, Belletti B
Cancer Res 2020 Mar 1;80(5):1064-1077. Epub 2019 Dec 20 doi: 10.1158/0008-5472.CAN-19-1793. PMID: 31862778
Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients.
Ávila-Gálvez MÁ, García-Villalba R, Martínez-Díaz F, Ocaña-Castillo B, Monedero-Saiz T, Torrecillas-Sánchez A, Abellán B, González-Sarrías A, Espín JC
Mol Nutr Food Res 2019 May;63(9):e1801239. Epub 2019 Feb 4 doi: 10.1002/mnfr.201801239. PMID: 30690879
Stromal PTEN determines mammary epithelial response to radiotherapy.
Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC
Nat Commun 2018 Jul 17;9(1):2783. doi: 10.1038/s41467-018-05266-6. PMID: 30018330Free PMC Article
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.
Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K
J Mammary Gland Biol Neoplasia 2016 Jun;21(1-2):9-17. Epub 2016 May 19 doi: 10.1007/s10911-016-9354-7. PMID: 27194029Free PMC Article
A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
Harman RM, Curtis TM, Argyle DJ, Coonrod SA, Van de Walle GR
J Mammary Gland Biol Neoplasia 2016 Jun;21(1-2):51-66. Epub 2016 Mar 22 doi: 10.1007/s10911-016-9350-y. PMID: 27002722

Prognosis

Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
Cross-species oncogenic signatures of breast cancer in canine mammary tumors.
Kim TM, Yang IS, Seung BJ, Lee S, Kim D, Ha YJ, Seo MK, Kim KK, Kim HS, Cheong JH, Sur JH, Nam H, Kim S
Nat Commun 2020 Jul 17;11(1):3616. doi: 10.1038/s41467-020-17458-0. PMID: 32680987Free PMC Article
Androgen receptor and FOXA1 coexpression define a "luminal-AR" subtype of feline mammary carcinomas, spontaneous models of breast cancer.
Dagher E, Royer V, Buchet P, Abadie J, Loussouarn D, Campone M, Nguyen F
BMC Cancer 2019 Dec 30;19(1):1267. doi: 10.1186/s12885-019-6483-6. PMID: 31888566Free PMC Article
Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance.
Abadie J, Nguyen F, Loussouarn D, Peña L, Gama A, Rieder N, Belousov A, Bemelmans I, Jaillardon L, Ibisch C, Campone M
Breast Cancer Res Treat 2018 Jan;167(2):459-468. Epub 2017 Oct 23 doi: 10.1007/s10549-017-4542-8. PMID: 29063312Free PMC Article
Comparison of metastatic neuroendocrine neoplasms to the breast and primary invasive mammary carcinomas with neuroendocrine differentiation.
Mohanty SK, Kim SA, DeLair DF, Bose S, Laury AR, Chopra S, Mertens RB, Dhall D
Mod Pathol 2016 Aug;29(8):788-98. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.69. PMID: 27125358

Clinical prediction guides

Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses.
Taurin S, Alkhalifa H
Neoplasia 2020 Dec;22(12):663-678. Epub 2020 Oct 23 doi: 10.1016/j.neo.2020.09.009. PMID: 33142233Free PMC Article
A novel and cost-effective <i>ex vivo</i> orthotopic model for the study of human breast cancer in mouse mammary gland organ culture.
Gupta A, Gupta G, Mehta RR, Ivancic DZ, Walker RR, Patel JR, Gallegos KM, Davidson AM, Khan SA, Mehta RG, Tilghman SL
Biol Open 2020 May 29;9(5) doi: 10.1242/bio.051649. PMID: 32366373Free PMC Article
Benign Fibromyxoid Lesion of the Breast: A Distinct Entity From Benign Spindle Cell Tumors of the Mammary Stroma?
Schwartz CJ, Schandl CA, Morse J, Ralston J, Rapkiewicz A, Darvishian F
Int J Surg Pathol 2018 Sep;26(6):488-493. Epub 2018 Mar 19 doi: 10.1177/1066896918763901. PMID: 29552929
Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance.
Abadie J, Nguyen F, Loussouarn D, Peña L, Gama A, Rieder N, Belousov A, Bemelmans I, Jaillardon L, Ibisch C, Campone M
Breast Cancer Res Treat 2018 Jan;167(2):459-468. Epub 2017 Oct 23 doi: 10.1007/s10549-017-4542-8. PMID: 29063312Free PMC Article
Comparison of metastatic neuroendocrine neoplasms to the breast and primary invasive mammary carcinomas with neuroendocrine differentiation.
Mohanty SK, Kim SA, DeLair DF, Bose S, Laury AR, Chopra S, Mertens RB, Dhall D
Mod Pathol 2016 Aug;29(8):788-98. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.69. PMID: 27125358

Recent systematic reviews

The Value of EphB2 Receptor and Cognate Ephrin Ligands in Prognostic and Predictive Assessments of Human Breast Cancer.
Ebrahim AS, Hailat Z, Bandyopadhyay S, Neill D, Kandouz M
Int J Mol Sci 2021 Jul 28;22(15) doi: 10.3390/ijms22158098. PMID: 34360867Free PMC Article
Digital breast tomosynthesis compared to diagnostic mammographic projections (including magnification) among women recalled at screening mammography: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC).
Canelo-Aybar C, Carrera L, Beltrán J, Posso M, Rigau D, Lebeau A, Gräwingholt A, Castells X, Langendam M, Pérez E, Giorgi Rossi P, Van Engen R, Parmelli E, Saz-Parkinson Z, Alonso-Coello P
Cancer Med 2021 Apr;10(7):2191-2204. Epub 2021 Mar 5 doi: 10.1002/cam4.3803. PMID: 33675147Free PMC Article
Can supplementary contrast-enhanced MRI of the breast avoid needle biopsies in suspicious microcalcifications seen on mammography? A systematic review and meta-analysis.
Fueger BJ, Clauser P, Kapetas P, Pötsch N, Helbich TH, Baltzer PAT
Breast 2021 Apr;56:53-60. Epub 2021 Feb 15 doi: 10.1016/j.breast.2021.02.002. PMID: 33618160Free PMC Article
Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - A systematic review and meta-analysis.
Davey MG, Davey CM, Ryan ÉJ, Lowery AJ, Kerin MJ
Breast 2021 Apr;56:26-34. Epub 2021 Feb 4 doi: 10.1016/j.breast.2021.02.001. PMID: 33582622Free PMC Article
Older women's experience with breast cancer treatment: A systematic review of qualitative literature.
Angarita FA, Zhang Y, Elmi M, Look Hong NJ
Breast 2020 Dec;54:293-302. Epub 2020 Nov 16 doi: 10.1016/j.breast.2020.11.009. PMID: 33242756Free PMC Article

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