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Squamous cell carcinoma of the head and neck(HNSCC)

MedGen UID:
257911
Concept ID:
C1168401
Neoplastic Process
Synonyms: Carcinoma, squamous cell of head and neck; Head and neck squamous cell carcinoma; HNSCC; Squamous cell carcinoma, head and neck, somatic
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Multifactorial inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Sources: HPO, Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
Autosomal recessive inheritance (HPO, OMIM, Orphanet)
not inherited (Orphanet)
SNOMED CT: Squamous cell carcinoma of head and neck (716659002)
 
Genes (locations): ING1 (13q34); PTEN (10q23.31); TNFRSF10B (8p21.3)
OMIM®: 275355
Orphanet: ORPHA67037

Definition

Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.HNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.HNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis.
[from GHR]

Clinical features

Squamous cell carcinoma
MedGen UID:
2874
Concept ID:
C0007137
Neoplastic Process
The presence of squamous cell carcinoma of the skin.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma of the head and neck
Follow this link to review classifications for Squamous cell carcinoma of the head and neck in Orphanet.

Recent clinical studies

Etiology

Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659
Machiels JP, Subramanian S, Ruzsa A, Repassy G, Lifirenko I, Flygare A, Sørensen P, Nielsen T, Lisby S, Clement PM
Lancet Oncol 2011 Apr;12(4):333-43. Epub 2011 Mar 4 doi: 10.1016/S1470-2045(11)70034-1. PMID: 21377930

Diagnosis

Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559
Young NR, Soneru C, Liu J, Grushko TA, Hardeman A, Olopade OI, Baum A, Solca F, Cohen EE
Target Oncol 2015 Dec;10(4):501-8. Epub 2015 Jan 6 doi: 10.1007/s11523-014-0353-6. PMID: 25559287Free PMC Article
Grünwald V, Keilholz U, Boehm A, Guntinas-Lichius O, Hennemann B, Schmoll HJ, Ivanyi P, Abbas M, Lehmann U, Koch A, Karch A, Zörner A, Gauler TC
Ann Oncol 2015 Mar;26(3):561-7. Epub 2014 Dec 19 doi: 10.1093/annonc/mdu571. PMID: 25527417
Chai RL, Rath TJ, Johnson JT, Ferris RL, Kubicek GJ, Duvvuri U, Branstetter BF 4th
JAMA Otolaryngol Head Neck Surg 2013 Nov;139(11):1187-94. doi: 10.1001/jamaoto.2013.4491. PMID: 24076619
Zhang H, Graham CM, Elci O, Griswold ME, Zhang X, Khan MA, Pitman K, Caudell JJ, Hamilton RD, Ganeshan B, Smith AD
Radiology 2013 Dec;269(3):801-9. Epub 2013 Oct 28 doi: 10.1148/radiol.13130110. PMID: 23912620

Therapy

Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659
Machiels JP, Subramanian S, Ruzsa A, Repassy G, Lifirenko I, Flygare A, Sørensen P, Nielsen T, Lisby S, Clement PM
Lancet Oncol 2011 Apr;12(4):333-43. Epub 2011 Mar 4 doi: 10.1016/S1470-2045(11)70034-1. PMID: 21377930

Prognosis

Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784
Strigari L, Pinnarò P, Carlini P, Torino F, Strolin S, Minosse S, Sanguineti G, Benassi M
Crit Rev Oncol Hematol 2016 Jun;102:101-10. Epub 2016 Apr 22 doi: 10.1016/j.critrevonc.2016.04.004. PMID: 27157527
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659

Clinical prediction guides

Specenier P, Vermorken J
Expert Opin Pharmacother 2016 Jun;17(9):1295-301. Epub 2016 May 19 doi: 10.1080/14656566.2016.1183647. PMID: 27160335
Strigari L, Pinnarò P, Carlini P, Torino F, Strolin S, Minosse S, Sanguineti G, Benassi M
Crit Rev Oncol Hematol 2016 Jun;102:101-10. Epub 2016 Apr 22 doi: 10.1016/j.critrevonc.2016.04.004. PMID: 27157527
Hsu CM, Lin PM, Lin HC, Lai CC, Yang CH, Lin SF, Yang MY
Anticancer Res 2016 May;36(5):2251-8. PMID: 27127130
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559
Chai RL, Rath TJ, Johnson JT, Ferris RL, Kubicek GJ, Duvvuri U, Branstetter BF 4th
JAMA Otolaryngol Head Neck Surg 2013 Nov;139(11):1187-94. doi: 10.1001/jamaoto.2013.4491. PMID: 24076619

Recent systematic reviews

Budach W, Bölke E, Kammers K, Gerber PA, Orth K, Gripp S, Matuschek C
Radiother Oncol 2016 Feb;118(2):238-43. Epub 2015 Nov 14 doi: 10.1016/j.radonc.2015.10.014. PMID: 26589131
Jiang Y, Zhu XD, Qu S, Li L, Zhou Z
Ear Nose Throat J 2015 Apr-May;94(4-5):E14-24. PMID: 25923280
Wang Z, Cui K, Xue Y, Tong F, Li S
Med Oncol 2015 May;32(5):164. Epub 2015 Apr 22 doi: 10.1007/s12032-015-0579-x. PMID: 25895596
Winquist E, Al-Rasheedy I, Nichols AC, Palma DA, Stitt L
Cancer Treat Rev 2014 Oct;40(9):1073-9. Epub 2014 Aug 27 doi: 10.1016/j.ctrv.2014.08.002. PMID: 25200522
Wang Y, Chu X, Meng X, Zou F
PLoS One 2013;8(10):e77898. Epub 2013 Oct 30 doi: 10.1371/journal.pone.0077898. PMID: 24205020Free PMC Article

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