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Squamous cell carcinoma of the head and neck(HNSCC)

MedGen UID:
257911
Concept ID:
C1168401
Neoplastic Process
Synonyms: Carcinoma, squamous cell of head and neck; Head and neck squamous cell carcinoma; HNSCC; Squamous cell carcinoma, head and neck, somatic
SNOMED CT: Squamous cell carcinoma of head and neck (716659002)
 
Genes (locations): ING1 (13q34); TNFRSF10B (8p21.3)
 
Monarch Initiative: MONDO:0010150
OMIM®: 275355

Definition

Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.\n\nHNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.\n\nHNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis. [from MedlinePlus Genetics]

Clinical features

From HPO
Squamous cell carcinoma
MedGen UID:
2874
Concept ID:
C0007137
Neoplastic Process
The presence of squamous cell carcinoma of the skin.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma of the head and neck
Follow this link to review classifications for Squamous cell carcinoma of the head and neck in Orphanet.

Recent clinical studies

Etiology

Zwaan I, Soror T, Bruchhage KL, Hakim SG, Schild SE, Rades D
Anticancer Res 2023 Feb;43(2):795-800. doi: 10.21873/anticanres.16220. PMID: 36697066
Nishimura A, Yokota T, Hamauchi S, Onozawa Y, Shirasu H, Kawabata T, Ogawa H, Onoe T, Iida Y, Mukaigawa T, Yasui H
Int J Clin Oncol 2021 Oct;26(10):1822-1830. Epub 2021 Jun 21 doi: 10.1007/s10147-021-01965-1. PMID: 34152533
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group.
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article

Diagnosis

Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Leung HW, Lang HC, Wang SY, Leung JH, Chan AL
Expert Rev Pharmacoecon Outcomes Res 2021 Jun;21(3):489-495. Epub 2021 Mar 17 doi: 10.1080/14737167.2021.1890585. PMID: 33729079
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group.
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559

Therapy

Zwaan I, Soror T, Bruchhage KL, Hakim SG, Schild SE, Rades D
Anticancer Res 2023 Feb;43(2):795-800. doi: 10.21873/anticanres.16220. PMID: 36697066
Leung HW, Lang HC, Wang SY, Leung JH, Chan AL
Expert Rev Pharmacoecon Outcomes Res 2021 Jun;21(3):489-495. Epub 2021 Mar 17 doi: 10.1080/14737167.2021.1890585. PMID: 33729079
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group.
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article

Prognosis

Nishimura A, Yokota T, Hamauchi S, Onozawa Y, Shirasu H, Kawabata T, Ogawa H, Onoe T, Iida Y, Mukaigawa T, Yasui H
Int J Clin Oncol 2021 Oct;26(10):1822-1830. Epub 2021 Jun 21 doi: 10.1007/s10147-021-01965-1. PMID: 34152533
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659

Clinical prediction guides

Ota Y, Kodaira T, Fujii H, Shimokawa M, Yokota T, Nakashima T, Monden N, Homma A, Ueda S, Akimoto T
Int J Clin Oncol 2022 Nov;27(11):1675-1683. Epub 2022 Aug 24 doi: 10.1007/s10147-022-02228-3. PMID: 36001247
Ibarra AMC, Cecatto RB, Motta LJ, Dos Santos Franco AL, de Fátima Teixeira da Silva D, Nunes FD, Hamblin MR, Rodrigues MFSD
Lasers Med Sci 2022 Apr;37(3):1441-1470. Epub 2021 Dec 2 doi: 10.1007/s10103-021-03462-3. PMID: 34855034
León X, García J, López M, Holgado A, Llansana A, Quer M
Acta Otorrinolaringol Esp (Engl Ed) 2021 Nov-Dec;72(6):359-369. doi: 10.1016/j.otoeng.2020.08.007. PMID: 34844674
Tanaka H, Takemoto N, Horie M, Takai E, Fukusumi T, Suzuki M, Eguchi H, Komukai S, Tatsumi M, Isohashi F, Ogawa K, Yachida S, Inohara H
Int J Cancer 2021 Feb 15;148(4):995-1005. Epub 2020 Sep 30 doi: 10.1002/ijc.33287. PMID: 32895945
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559

Recent systematic reviews

Costantino A, Canali L, Festa BM, Spriano G, Mercante G, De Virgilio A
Head Neck 2022 Oct;44(10):2288-2300. Epub 2022 Jun 17 doi: 10.1002/hed.27121. PMID: 35713173
Margalit DN, Sacco AG, Cooper JS, Ridge JA, Bakst RL, Beadle BM, Beitler JJ, Chang SS, Chen AM, Galloway TJ, Koyfman SA, Mita C, Robbins JR, Tsai CJ, Truong MT, Yom SS, Siddiqui F
Head Neck 2021 Jan;43(1):367-391. Epub 2020 Oct 23 doi: 10.1002/hed.26490. PMID: 33098180Free PMC Article
Galot R, Machiels JH
Cancer Treat Rev 2020 Apr;85:101992. Epub 2020 Feb 14 doi: 10.1016/j.ctrv.2020.101992. PMID: 32092618
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Jerzak KJ, Delos Santos K, Saluja R, Lien K, Lee J, Chan KKW
Oral Oncol 2017 Aug;71:1-10. Epub 2017 Jun 3 doi: 10.1016/j.oraloncology.2017.05.011. PMID: 28688674

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