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Squamous cell carcinoma of the head and neck(HNSCC)

MedGen UID:
257911
Concept ID:
C1168401
Neoplastic Process
Synonyms: Carcinoma, squamous cell of head and neck; Head and neck squamous cell carcinoma; HNSCC; Squamous cell carcinoma, head and neck, somatic
SNOMED CT: Squamous cell carcinoma of head and neck (716659002)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Sources: HPO, OMIM
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
 
Genes (locations): ING1 (13q34); TNFRSF10B (8p21.3)
 
OMIM®: 275355

Definition

Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.\n\nHNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.\n\nHNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis. [from MedlinePlus Genetics]

Clinical features

From HPO
Squamous cell carcinoma
MedGen UID:
2874
Concept ID:
C0007137
Neoplastic Process
The presence of squamous cell carcinoma of the skin.
Squamous cell carcinoma
MedGen UID:
2874
Concept ID:
C0007137
Neoplastic Process
The presence of squamous cell carcinoma of the skin.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma of the head and neck
Follow this link to review classifications for Squamous cell carcinoma of the head and neck in Orphanet.

Recent clinical studies

Etiology

Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group.
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659

Diagnosis

Leung HW, Lang HC, Wang SY, Leung JH, Chan AL
Expert Rev Pharmacoecon Outcomes Res 2021 Jun;21(3):489-495. Epub 2021 Mar 17 doi: 10.1080/14737167.2021.1890585. PMID: 33729079
Reyes-Gibby CC, Wang J, Zhang L, Peterson CB, Do KA, Jenq RR, Shelburne S, Shah DP, Chambers MS, Hanna EY, Yeung SJ, Shete S
Cancer 2020 Dec 1;126(23):5124-5136. Epub 2020 Sep 5 doi: 10.1002/cncr.33161. PMID: 32888342Free PMC Article
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group.
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559

Therapy

Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group.
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659

Prognosis

Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J
Lancet Oncol 2015 Feb;16(2):208-20. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71198-2. PMID: 25596660
Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A
Lancet Oncol 2015 Feb;16(2):221-32. Epub 2015 Jan 15 doi: 10.1016/S1470-2045(14)71200-8. PMID: 25596659

Clinical prediction guides

Tanaka H, Takemoto N, Horie M, Takai E, Fukusumi T, Suzuki M, Eguchi H, Komukai S, Tatsumi M, Isohashi F, Ogawa K, Yachida S, Inohara H
Int J Cancer 2021 Feb 15;148(4):995-1005. Epub 2020 Sep 30 doi: 10.1002/ijc.33287. PMID: 32895945
Day D, Prawira A, Spreafico A, Waldron J, Karithanam R, Giuliani M, Weinreb I, Kim J, Cho J, Hope A, Bayley A, Ringash J, Bratman SV, Jang R, O'Sullivan B, Siu LL, Hansen AR
Oral Oncol 2020 Sep;108:104753. Epub 2020 May 25 doi: 10.1016/j.oraloncology.2020.104753. PMID: 32464516
Zhang S, Li G, Liu C, Lu S, Jing Q, Chen X, Zheng H, Ma H, Zhang D, Ren S, Shen Z, Wang Y, Lu Z, Huang D, Tan P, Chen J, Zhang X, Qiu Y, Liu Y
Cancer Sci 2020 Feb;111(2):356-368. Epub 2019 Dec 30 doi: 10.1111/cas.14259. PMID: 31778279Free PMC Article
Wu MP, Sethi RKV, Emerick KS
Laryngoscope 2020 Jan;130(1):108-114. Epub 2019 Mar 7 doi: 10.1002/lary.27881. PMID: 30843617
Montal R, Oliva M, Taberna M, De Avila L, Rovira A, Cos M, Mañós M, Navarro V, Nogués J, Lozano A, Rodríguez L, Vilajosana E, Vázquez S, Mesia R
Clin Transl Oncol 2016 Nov;18(11):1140-1146. Epub 2016 Mar 10 doi: 10.1007/s12094-016-1496-y. PMID: 26960559

Recent systematic reviews

Margalit DN, Sacco AG, Cooper JS, Ridge JA, Bakst RL, Beadle BM, Beitler JJ, Chang SS, Chen AM, Galloway TJ, Koyfman SA, Mita C, Robbins JR, Tsai CJ, Truong MT, Yom SS, Siddiqui F
Head Neck 2021 Jan;43(1):367-391. Epub 2020 Oct 23 doi: 10.1002/hed.26490. PMID: 33098180Free PMC Article
Bisheshar SK, De Ruiter EJ, Devriese LA, Willems SM
Oncoimmunology 2020;9(1):1747345. Epub 2020 Apr 23 doi: 10.1080/2162402X.2020.1747345. PMID: 32363116Free PMC Article
Galot R, Machiels JH
Cancer Treat Rev 2020 Apr;85:101992. Epub 2020 Feb 14 doi: 10.1016/j.ctrv.2020.101992. PMID: 32092618
Mohamed A, Twardy B, Zordok MA, Ashraf K, Alkhoder A, Schrapp K, Steuer C, Chen Z, Pakkala S, Pillai R, Trad Wadsworth J, Higgins K, Beitler JJ, Ramalingam SS, Owonikoko TK, Khuri FR, Shin DM, Behera M, Saba NF
Head Neck 2019 May;41(5):1490-1498. Epub 2019 Mar 5 doi: 10.1002/hed.25379. PMID: 30835900
Jerzak KJ, Delos Santos K, Saluja R, Lien K, Lee J, Chan KKW
Oral Oncol 2017 Aug;71:1-10. Epub 2017 Jun 3 doi: 10.1016/j.oraloncology.2017.05.011. PMID: 28688674

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