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Abdominal symptom

MedGen UID:
488929
•Concept ID:
C0740651
•
Sign or Symptom
HPO: HP:0011458

Definition

A subjective manifestation of disease localized to the abdomen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbdominal symptom

Professional guidelines

PubMed

Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?
Fang XC, Fan WJ, Drossman DD, Han SM, Ke MY
World J Gastroenterol 2022 Sep 7;28(33):4861-4874. doi: 10.3748/wjg.v28.i33.4861. PMID: 36156921Free PMC Article
Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort study of diagnostic accuracy in primary care.
Holtedahl K, Borgquist L, Donker GA, Buntinx F, Weller D, Campbell C, Månsson J, Hammersley V, Braaten T, Parajuli R
BMC Fam Pract 2021 Jul 8;22(1):148. doi: 10.1186/s12875-021-01452-6. PMID: 34238248Free PMC Article

Recent clinical studies

Etiology

Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?
Fang XC, Fan WJ, Drossman DD, Han SM, Ke MY
World J Gastroenterol 2022 Sep 7;28(33):4861-4874. doi: 10.3748/wjg.v28.i33.4861. PMID: 36156921Free PMC Article
Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort study of diagnostic accuracy in primary care.
Holtedahl K, Borgquist L, Donker GA, Buntinx F, Weller D, Campbell C, Månsson J, Hammersley V, Braaten T, Parajuli R
BMC Fam Pract 2021 Jul 8;22(1):148. doi: 10.1186/s12875-021-01452-6. PMID: 34238248Free PMC Article
The nature and frequency of abdominal symptoms in cancer patients and their associations with time to help-seeking: evidence from a national audit of cancer diagnosis.
Koo MM, von Wagner C, Abel GA, McPhail S, Hamilton W, Rubin GP, Lyratzopoulos G
J Public Health (Oxf) 2018 Sep 1;40(3):e388-e395. doi: 10.1093/pubmed/fdx188. PMID: 29385513Free PMC Article
Symptomatic Diverticulosis Is Characterized By Loose Stools.
Järbrink-Sehgal ME, Andreasson A, Talley NJ, Agréus L, Song JY, Schmidt PT
Clin Gastroenterol Hepatol 2016 Dec;14(12):1763-1770.e1. Epub 2016 Jun 21 doi: 10.1016/j.cgh.2016.06.014. PMID: 27353142
The putative role of the intestinal microbiota in the irritable bowel syndrome.
Collins SM, Denou E, Verdu EF, Bercik P
Dig Liver Dis 2009 Dec;41(12):850-3. Epub 2009 Sep 8 doi: 10.1016/j.dld.2009.07.023. PMID: 19740713

Diagnosis

Gastrointestinal Kohlmeier-Degos disease: a narrative review.
Sattler SS, Magro CM, Shapiro L, Merves JF, Levy R, Veenstra J, Patel P
Orphanet J Rare Dis 2022 Apr 20;17(1):172. doi: 10.1186/s13023-022-02322-9. PMID: 35443671Free PMC Article
Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort study of diagnostic accuracy in primary care.
Holtedahl K, Borgquist L, Donker GA, Buntinx F, Weller D, Campbell C, Månsson J, Hammersley V, Braaten T, Parajuli R
BMC Fam Pract 2021 Jul 8;22(1):148. doi: 10.1186/s12875-021-01452-6. PMID: 34238248Free PMC Article
Falciform ligament hernia with specific abdominal symptom.
Baba K, Uemura K, Sumiyoshi T, Kobayashi T, Kondo Y, Tazuma S, Okano K, Muto T, Tatsumoto N, Takahashi S
Clin J Gastroenterol 2021 Apr;14(2):566-569. Epub 2021 Jan 15 doi: 10.1007/s12328-020-01323-0. PMID: 33449310
Global Reports of Intussusception in Infants With SARS-CoV-2 Infection.
Giovanni JE, Hrapcak S, Melgar M, Godfred-Cato S
Pediatr Infect Dis J 2021 Jan;40(1):e35-e36. doi: 10.1097/INF.0000000000002946. PMID: 33105341Free PMC Article
Bowel endometriosis.
Galazis N, Arul D, Wilson J, Pisal N
BMJ Case Rep 2014 Jan 10;2014 doi: 10.1136/bcr-2013-202140. PMID: 24414186Free PMC Article

Therapy

Tenapanor Improves Abdominal Symptoms Irrespective of Changes in Complete Spontaneous Bowel Movement Frequency in Adults with Irritable Bowel Syndrome with Constipation.
Brenner DM, Sayuk GS, Cash BD, Harris LA, Ahuja NK, Deutsch JK, Yang Y, Zhao S, Rosenbaum DP, Lembo AJ
Dig Dis 2025;43(2):146-157. Epub 2024 Dec 19 doi: 10.1159/000543166. PMID: 39701047Free PMC Article
Development and Validation of a Simple and Multifaceted Instrument, Chronic Constipation-Therapeutic Efficacy and Satisfaction Test, for the Clinical Evaluation of Patients with Chronic Constipation.
Nakada K, Nagahara A, Isshi K, Oshima T, Futagami S, Tanaka Y, Yamaguchi Y, Kuribayashi S, Arihiro S, Oshio A, Manabe N; CC-TEST Study Group
Digestion 2024;105(5):359-372. Epub 2024 Jun 13 doi: 10.1159/000539788. PMID: 38870916
Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis.
Lembo AJ, Chey WD, Harris LA, Frazier R, Brenner DM, Chang L, Lacy BE, Edelstein S, Yang Y, Zhao S, Rosenbaum DP
Am J Gastroenterol 2024 May 1;119(5):937-945. Epub 2024 Jan 31 doi: 10.14309/ajg.0000000000002685. PMID: 38294158Free PMC Article
Blueberries Improve Abdominal Symptoms, Well-Being and Functioning in Patients with Functional Gastrointestinal Disorders.
Wilder-Smith CH, Materna A, Olesen SS
Nutrients 2023 May 20;15(10) doi: 10.3390/nu15102396. PMID: 37242279Free PMC Article
STW 5 (Iberogast) Therapy in Gastrointestinal Functional Disorders.
Malfertheiner P
Dig Dis 2017;35 Suppl 1:25-29. Epub 2018 Feb 8 doi: 10.1159/000485410. PMID: 29421817

Prognosis

Longer term follow-up of abdominal symptoms (CFAbd-Score) after initiation of Elexacaftor / Tezacaftor / Ivacaftor in adults with cystic fibrosis.
Caley LR, Gillgrass L, Zagoya C, Saumtally H, Duckstein F, H W, Mainz JG, Peckham DG
J Cyst Fibros 2025 Jul;24(4):787-791. Epub 2025 Jan 14 doi: 10.1016/j.jcf.2025.01.010. PMID: 39814671
Motion-based camera localization system in colonoscopy videos.
Yao H, Stidham RW, Gao Z, Gryak J, Najarian K
Med Image Anal 2021 Oct;73:102180. Epub 2021 Jul 15 doi: 10.1016/j.media.2021.102180. PMID: 34303888
Psychometric Analysis of the Abdominal Score From the Diary for Irritable Bowel Syndrome Symptoms-Constipation Using Phase IIb Clinical Trial Data.
Coon CD, Hanlon J, Abel JL, Lundy JJ, Carson RT, Reasner DS
Value Health 2020 Mar;23(3):362-369. Epub 2020 Feb 20 doi: 10.1016/j.jval.2020.01.002. PMID: 32197732
Symptomatic Diverticulosis Is Characterized By Loose Stools.
Järbrink-Sehgal ME, Andreasson A, Talley NJ, Agréus L, Song JY, Schmidt PT
Clin Gastroenterol Hepatol 2016 Dec;14(12):1763-1770.e1. Epub 2016 Jun 21 doi: 10.1016/j.cgh.2016.06.014. PMID: 27353142
Association between sleep disturbances and abdominal symptoms.
Morito Y, Aimi M, Ishimura N, Shimura S, Mikami H, Okimoto E, Sato S, Ishihara S, Kushiyama Y, Katsube T, Adachi K, Kinoshita Y
Intern Med 2014;53(19):2179-83. doi: 10.2169/internalmedicine.53.2591. PMID: 25274228

Clinical prediction guides

Tenapanor Improves Abdominal Symptoms Irrespective of Changes in Complete Spontaneous Bowel Movement Frequency in Adults with Irritable Bowel Syndrome with Constipation.
Brenner DM, Sayuk GS, Cash BD, Harris LA, Ahuja NK, Deutsch JK, Yang Y, Zhao S, Rosenbaum DP, Lembo AJ
Dig Dis 2025;43(2):146-157. Epub 2024 Dec 19 doi: 10.1159/000543166. PMID: 39701047Free PMC Article
Development and Validation of a Simple and Multifaceted Instrument, Chronic Constipation-Therapeutic Efficacy and Satisfaction Test, for the Clinical Evaluation of Patients with Chronic Constipation.
Nakada K, Nagahara A, Isshi K, Oshima T, Futagami S, Tanaka Y, Yamaguchi Y, Kuribayashi S, Arihiro S, Oshio A, Manabe N; CC-TEST Study Group
Digestion 2024;105(5):359-372. Epub 2024 Jun 13 doi: 10.1159/000539788. PMID: 38870916
Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis.
Lembo AJ, Chey WD, Harris LA, Frazier R, Brenner DM, Chang L, Lacy BE, Edelstein S, Yang Y, Zhao S, Rosenbaum DP
Am J Gastroenterol 2024 May 1;119(5):937-945. Epub 2024 Jan 31 doi: 10.14309/ajg.0000000000002685. PMID: 38294158Free PMC Article
Blueberries Improve Abdominal Symptoms, Well-Being and Functioning in Patients with Functional Gastrointestinal Disorders.
Wilder-Smith CH, Materna A, Olesen SS
Nutrients 2023 May 20;15(10) doi: 10.3390/nu15102396. PMID: 37242279Free PMC Article
Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?
Fang XC, Fan WJ, Drossman DD, Han SM, Ke MY
World J Gastroenterol 2022 Sep 7;28(33):4861-4874. doi: 10.3748/wjg.v28.i33.4861. PMID: 36156921Free PMC Article

Recent systematic reviews

Clinical characteristics and outcomes of patients with mpox during the 2022 mpox outbreak compared with those before the outbreak: A systematic review and meta-analysis.
Cho W, Park S, Kim HJ, Lee M, Choi YS, Yeo SG, Lee J, Koyanagi A, Jacob L, Smith L, Rahmati M, Ahmad S, Fond G, Boyer L, Rhee SY, Lee SW, Shin JI, Woo HG, Yon DK
Rev Med Virol 2024 Jan;34(1):e2508. doi: 10.1002/rmv.2508. PMID: 38282393

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