U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Diabetic peripheral neuropathy

MedGen UID:
677006
•Concept ID:
C0740447
•
Disease or Syndrome
Synonym: Peripheral neuropathy due to diabetes mellitus
SNOMED CT: Diabetic peripheral neuropathy (424736006); Peripheral neuropathy due to diabetes mellitus (424736006)

Professional guidelines

PubMed

Progress in the treatment of diabetic peripheral neuropathy.
Yang K, Wang Y, Li YW, Chen YG, Xing N, Lin HB, Zhou P, Yu XP
Biomed Pharmacother 2022 Apr;148:112717. Epub 2022 Feb 19 doi: 10.1016/j.biopha.2022.112717. PMID: 35193039
Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024

Recent clinical studies

Etiology

Diabetes Physical Examination.
Malik A, Ananthakrishnan S
Med Clin North Am 2022 May;106(3):483-494. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2021.12.007. PMID: 35491068
Progress in the treatment of diabetic peripheral neuropathy.
Yang K, Wang Y, Li YW, Chen YG, Xing N, Lin HB, Zhou P, Yu XP
Biomed Pharmacother 2022 Apr;148:112717. Epub 2022 Feb 19 doi: 10.1016/j.biopha.2022.112717. PMID: 35193039
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024
Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes.
Hicks CW, Selvin E
Curr Diab Rep 2019 Aug 27;19(10):86. doi: 10.1007/s11892-019-1212-8. PMID: 31456118Free PMC Article
Diabetic neuropathy: clinical manifestations and current treatments.
Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL
Lancet Neurol 2012 Jun;11(6):521-34. Epub 2012 May 16 doi: 10.1016/S1474-4422(12)70065-0. PMID: 22608666Free PMC Article

Diagnosis

Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL
Lancet Neurol 2022 Oct;21(10):922-936. doi: 10.1016/S1474-4422(22)00188-0. PMID: 36115364Free PMC Article
Diabetes Physical Examination.
Malik A, Ananthakrishnan S
Med Clin North Am 2022 May;106(3):483-494. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2021.12.007. PMID: 35491068
Metabolic syndrome and peripheral neuropathy.
Kazamel M, Stino AM, Smith AG
Muscle Nerve 2021 Mar;63(3):285-293. Epub 2020 Oct 24 doi: 10.1002/mus.27086. PMID: 33098165
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024
Peripheral Neuropathy.
Barrell K, Smith AG
Med Clin North Am 2019 Mar;103(2):383-397. Epub 2018 Dec 17 doi: 10.1016/j.mcna.2018.10.006. PMID: 30704689

Therapy

Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy.
Jang HN, Oh TJ
Diabetes Metab J 2023 Nov;47(6):743-756. Epub 2023 Sep 6 doi: 10.4093/dmj.2023.0018. PMID: 37670573Free PMC Article
Diabetic Peripheral Neuropathy: Diagnosis and Treatment.
Røikjer J, Mørch CD, Ejskjaer N
Curr Drug Saf 2021;16(1):2-16. doi: 10.2174/1574886315666200731173113. PMID: 32735526
The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials).
Seyedizadeh SH, Cheragh-Birjandi S, Hamedi Nia MR
J Diabetes Res 2020;2020:6978128. Epub 2020 Mar 6 doi: 10.1155/2020/6978128. PMID: 32215272Free PMC Article
Hand and foot exercises for diabetic peripheral neuropathy: A randomized controlled trial.
Win MMTM, Fukai K, Nyunt HH, Linn KZ
Nurs Health Sci 2020 Jun;22(2):416-426. Epub 2019 Dec 26 doi: 10.1111/nhs.12676. PMID: 31876991
Peripheral Neuropathy.
Barrell K, Smith AG
Med Clin North Am 2019 Mar;103(2):383-397. Epub 2018 Dec 17 doi: 10.1016/j.mcna.2018.10.006. PMID: 30704689

Prognosis

Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL
Lancet Neurol 2022 Oct;21(10):922-936. doi: 10.1016/S1474-4422(22)00188-0. PMID: 36115364Free PMC Article
Progress in the treatment of diabetic peripheral neuropathy.
Yang K, Wang Y, Li YW, Chen YG, Xing N, Lin HB, Zhou P, Yu XP
Biomed Pharmacother 2022 Apr;148:112717. Epub 2022 Feb 19 doi: 10.1016/j.biopha.2022.112717. PMID: 35193039
Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Metabolic syndrome and peripheral neuropathy.
Kazamel M, Stino AM, Smith AG
Muscle Nerve 2021 Mar;63(3):285-293. Epub 2020 Oct 24 doi: 10.1002/mus.27086. PMID: 33098165
Neuropathic pain in the general population: a systematic review of epidemiological studies.
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734

Clinical prediction guides

Study on Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus and Establishment of Prediction Model.
Wu B, Niu Z, Hu F
Diabetes Metab J 2021 Jul;45(4):526-538. Epub 2021 Jul 30 doi: 10.4093/dmj.2020.0100. PMID: 34352988Free PMC Article
Gene therapy for diabetic peripheral neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor.
Kessler JA, Shaibani A, Sang CN, Christiansen M, Kudrow D, Vinik A, Shin N; VM202 study group
Clin Transl Sci 2021 May;14(3):1176-1184. Epub 2021 Feb 2 doi: 10.1111/cts.12977. PMID: 33465273Free PMC Article
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
Hand and foot exercises for diabetic peripheral neuropathy: A randomized controlled trial.
Win MMTM, Fukai K, Nyunt HH, Linn KZ
Nurs Health Sci 2020 Jun;22(2):416-426. Epub 2019 Dec 26 doi: 10.1111/nhs.12676. PMID: 31876991
Effect of lifestyle interventions on diabetic peripheral neuropathy in patients with type 2 diabetes, result of a randomized clinical trial.
Ghavami H, Radfar M, Soheily S, Shamsi SA, Khalkhali HR
Agri 2018 Oct;30(4):165-170. doi: 10.5505/agri.2018.45477. PMID: 30403270

Recent systematic reviews

Exercise and Neuropathy: Systematic Review with Meta-Analysis.
Streckmann F, Balke M, Cavaletti G, Toscanelli A, Bloch W, Décard BF, Lehmann HC, Faude O
Sports Med 2022 May;52(5):1043-1065. Epub 2021 Dec 29 doi: 10.1007/s40279-021-01596-6. PMID: 34964950
Footwear and insole design features for offloading the diabetic at risk foot-A systematic review and meta-analyses.
Collings R, Freeman J, Latour JM, Paton J
Endocrinol Diabetes Metab 2021 Jan;4(1):e00132. Epub 2020 Apr 11 doi: 10.1002/edm2.132. PMID: 33532602Free PMC Article
Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Sawangjit R, Thongphui S, Chaichompu W, Phumart P
J Altern Complement Med 2020 Dec;26(12):1117-1129. Epub 2020 Jul 21 doi: 10.1089/acm.2020.0068. PMID: 32716261
Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia.
Lunn MP, Hughes RA, Wiffen PJ
Cochrane Database Syst Rev 2014 Jan 3;2014(1):CD007115. doi: 10.1002/14651858.CD007115.pub3. PMID: 24385423Free PMC Article
Neuropathic pain in the general population: a systematic review of epidemiological studies.
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...