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Lung carcinoma

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
Synonym: Lung cancer, somatic
 
Gene (location): FASLG (1q24.3)
 
Monarch Initiative: MONDO:0005138
OMIM®: 211980

Definition

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from OMIM]

Additional description

From MedlinePlus Genetics
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. Lung cancer may not cause signs or symptoms in its early stages. Some people with lung cancer have chest pain, frequent coughing, blood in the mucus, breathing problems, trouble swallowing or speaking, loss of appetite and weight loss, fatigue, or swelling in the face or neck. Additional symptoms can develop if the cancer spreads (metastasizes) into other tissues. Lung cancer occurs most often in adults in their sixties or seventies. Most people who develop lung cancer have a history of long-term tobacco smoking; however, the condition can occur in people who have never smoked.\n\nLung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent.\n\nSmall cell lung cancer grows quickly and in more than half of cases the cancer has spread beyond the lung by the time the condition is diagnosed. Small cell lung cancer often metastasizes, most commonly to the liver, brain, bones, and adrenal glands (small hormone-producing glands located on top of each kidney). After diagnosis, most people with small cell lung cancer survive for about 1 year; less than seven percent survive 5 years.\n\nNon-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. Adenocarcinoma arises from the cells that line the small air sacs (alveoli) located throughout the lungs. Squamous cell carcinoma arises from squamous cells that line the passages leading from the windpipe (trachea) to the lungs (bronchi). Large cell carcinoma arises from epithelial cells that line the lungs. Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. The 5-year survival rate for people with non-small cell lung cancer is usually between 11 and 17 percent; it can be lower or higher depending on the subtype and stage of the cancer.  https://medlineplus.gov/genetics/condition/lung-cancer

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Leighl NB, Rekhtman N, Biermann WA, Huang J, Mino-Kenudson M, Ramalingam SS, West H, Whitlock S, Somerfield MR
J Clin Oncol 2014 Nov 10;32(32):3673-9. Epub 2014 Oct 13 doi: 10.1200/JCO.2014.57.3055. PMID: 25311215Free PMC Article
Kim H, Shim HS, Kim L, Kim TJ, Kwon KY, Lee GK, Chung JH; Korean Cardiopulmonary Pathology Study Group.
Korean J Pathol 2014 Feb;48(1):1-9. Epub 2014 Feb 25 doi: 10.4132/KoreanJPathol.2014.48.1.1. PMID: 24627688Free PMC Article
Shim HS, Chung JH, Kim L, Chang S, Kim WS, Lee GK, Jung SH, Jang SJ
Korean J Pathol 2013 Apr;47(2):100-6. Epub 2013 Apr 24 doi: 10.4132/KoreanJPathol.2013.47.2.100. PMID: 23667368Free PMC Article
Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M, College of American Pathologists International Association for the Study of Lung Cancer and Association for Molecular Pathology
J Mol Diagn 2013 Jul;15(4):415-53. Epub 2013 Apr 4 doi: 10.1016/j.jmoldx.2013.03.001. PMID: 23562183

External

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin

Suggested Reading

PubMed

Pasche B, Grant SC
JAMA 2014 May 21;311(19):1975-6. doi: 10.1001/jama.2014.3742. PMID: 24846033

Recent clinical studies

Etiology

Voggel S, Abele M, Seitz C, Agaimy A, Vokuhl C, Dirksen U, Bier A, Flaadt T, Classen CF, Claviez A, Schneider DT, Brecht IB
Lung Cancer 2021 Oct;160:66-72. Epub 2021 Aug 11 doi: 10.1016/j.lungcan.2021.08.004. PMID: 34418863
Wang C, Tao X, Wei J
World J Surg Oncol 2021 Aug 16;19(1):244. doi: 10.1186/s12957-021-02346-8. PMID: 34399782Free PMC Article
Qin J, Xie F, Li C, Han N, Lu H
Pathol Oncol Res 2021;27:1609775. Epub 2021 Jun 18 doi: 10.3389/pore.2021.1609775. PMID: 34257619Free PMC Article
Aydın N, Çelik Ö, Aslan AF, Odabaş A, Dündar E, Şahin MC
Curr Med Imaging 2021;17(9):1137-1141. doi: 10.2174/1573405617666210204210500. PMID: 33563200
Mense ES, Smit AAJ, Crul M, Franssen EJF
J Clin Pharm Ther 2019 Apr;44(2):249-257. Epub 2018 Dec 21 doi: 10.1111/jcpt.12781. PMID: 30578577

Diagnosis

Voggel S, Abele M, Seitz C, Agaimy A, Vokuhl C, Dirksen U, Bier A, Flaadt T, Classen CF, Claviez A, Schneider DT, Brecht IB
Lung Cancer 2021 Oct;160:66-72. Epub 2021 Aug 11 doi: 10.1016/j.lungcan.2021.08.004. PMID: 34418863
Wang C, Tao X, Wei J
World J Surg Oncol 2021 Aug 16;19(1):244. doi: 10.1186/s12957-021-02346-8. PMID: 34399782Free PMC Article
Aydın N, Çelik Ö, Aslan AF, Odabaş A, Dündar E, Şahin MC
Curr Med Imaging 2021;17(9):1137-1141. doi: 10.2174/1573405617666210204210500. PMID: 33563200
Zhang T, Li Y, Zhang H, Wang X, Liu X, Li L
Adv Exp Med Biol 2020;1255:99-108. doi: 10.1007/978-981-15-4494-1_8. PMID: 32949393
Mense ES, Smit AAJ, Crul M, Franssen EJF
J Clin Pharm Ther 2019 Apr;44(2):249-257. Epub 2018 Dec 21 doi: 10.1111/jcpt.12781. PMID: 30578577

Therapy

Liau CS, Mogan P, Thomas W
J Steroid Biochem Mol Biol 2021 Apr;208:105786. Epub 2020 Nov 12 doi: 10.1016/j.jsbmb.2020.105786. PMID: 33189851
Ishiguro S, Upreti D, Robben N, Burghart R, Loyd M, Ogun D, Le T, Delzeit J, Nakashima A, Thakkar R, Nakashima A, Suzuki K, Comer J, Tamura M
Biomed Pharmacother 2020 Jul;127:110166. Epub 2020 Apr 28 doi: 10.1016/j.biopha.2020.110166. PMID: 32361165
Mense ES, Smit AAJ, Crul M, Franssen EJF
J Clin Pharm Ther 2019 Apr;44(2):249-257. Epub 2018 Dec 21 doi: 10.1111/jcpt.12781. PMID: 30578577
Jiang S, Liu X, Li D, Yan M, Ju C, Sun J, Jiang F
Technol Cancer Res Treat 2018 Jan 1;17:1533033818797587. doi: 10.1177/1533033818797587. PMID: 30198403Free PMC Article
Ichihara H, Kuwabara K, Matsumoto Y
Anticancer Res 2017 Nov;37(11):6133-6139. doi: 10.21873/anticanres.12062. PMID: 29061794

Prognosis

Voggel S, Abele M, Seitz C, Agaimy A, Vokuhl C, Dirksen U, Bier A, Flaadt T, Classen CF, Claviez A, Schneider DT, Brecht IB
Lung Cancer 2021 Oct;160:66-72. Epub 2021 Aug 11 doi: 10.1016/j.lungcan.2021.08.004. PMID: 34418863
Wang C, Tao X, Wei J
World J Surg Oncol 2021 Aug 16;19(1):244. doi: 10.1186/s12957-021-02346-8. PMID: 34399782Free PMC Article
Qin J, Xie F, Li C, Han N, Lu H
Pathol Oncol Res 2021;27:1609775. Epub 2021 Jun 18 doi: 10.3389/pore.2021.1609775. PMID: 34257619Free PMC Article
Dai J, Zhou N, Wu R, Du J, Miao S, Gong K, Yang L, Chen W, Li X, Li C, Wu Y
Pathol Oncol Res 2021;27:610159. Epub 2021 Mar 29 doi: 10.3389/pore.2021.610159. PMID: 34257576Free PMC Article
Mense ES, Smit AAJ, Crul M, Franssen EJF
J Clin Pharm Ther 2019 Apr;44(2):249-257. Epub 2018 Dec 21 doi: 10.1111/jcpt.12781. PMID: 30578577

Clinical prediction guides

Aydın N, Çelik Ö, Aslan AF, Odabaş A, Dündar E, Şahin MC
Curr Med Imaging 2021;17(9):1137-1141. doi: 10.2174/1573405617666210204210500. PMID: 33563200
Zhang T, Li Y, Zhang H, Wang X, Liu X, Li L
Adv Exp Med Biol 2020;1255:99-108. doi: 10.1007/978-981-15-4494-1_8. PMID: 32949393
Mense ES, Smit AAJ, Crul M, Franssen EJF
J Clin Pharm Ther 2019 Apr;44(2):249-257. Epub 2018 Dec 21 doi: 10.1111/jcpt.12781. PMID: 30578577
Zhou N, Yan HL
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6845-6852. doi: 10.26355/eurrev_201810_16153. PMID: 30402849
Ichihara H, Kuwabara K, Matsumoto Y
Anticancer Res 2017 Nov;37(11):6133-6139. doi: 10.21873/anticanres.12062. PMID: 29061794

Recent systematic reviews

Ijsseldijk MA, Shoni M, Siegert C, Wiering B, van Engelenburg AKC, Tsai TC, Ten Broek RPG, Lebenthal A
Clin Lung Cancer 2021 May;22(3):e235-e292. Epub 2020 May 7 doi: 10.1016/j.cllc.2020.04.017. PMID: 32912754
Liu J, Li C, Seery S, Yu J, Meng X
Oncoimmunology 2020;9(1):1746112. Epub 2020 Apr 7 doi: 10.1080/2162402X.2020.1746112. PMID: 32313723Free PMC Article
Xiao Z, Jiang Y, Wang CQ, Hu SS, Huang XR, Chen XF, Huang J, Shan LJ, Tang YH, Wang YH, Gong QH, Feng JH, Xiao X, Li XF
Pharmacol Res 2020 Mar;153:104637. Epub 2020 Jan 11 doi: 10.1016/j.phrs.2020.104637. PMID: 31935454
Zhou Y, Chen C, Zhang X, Fu S, Xue C, Ma Y, Fang W, Yang Y, Hou X, Huang Y, Zhao H, Hong S, Zhang L
J Immunother Cancer 2018 Dec 22;6(1):155. doi: 10.1186/s40425-018-0477-9. PMID: 30577837Free PMC Article
Mirrielees JA, Kapur JH, Szalkucki LM, Harter JM, Salkowski LR, Strigel RM, Traynor AM, Wilke LG
J Surg Res 2014 May 15;188(2):419-31. Epub 2014 Jan 24 doi: 10.1016/j.jss.2014.01.024. PMID: 24560348

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