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Lung cancer

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
Synonyms: Lung cancer, somatic
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Autosomal recessive inheritance (HPO, OMIM, Orphanet)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); DLEC1 (3p22.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); RASSF1 (3p21.31); SLC22A18 (11p15.4)
OMIM®: 211980

Definition

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from OMIM]

Additional description

From GHR
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. Lung cancer may or may not cause signs or symptoms in its early stages. Some people with lung cancer have chest pain, frequent coughing, breathing problems, trouble swallowing or speaking, blood in the mucus, loss of appetite and weight loss, fatigue, or swelling in the face or neck. Lung cancer occurs most often in adults in their sixties or seventies. Most people who develop lung cancer have a history of long-term tobacco smoking; however, the condition can occur in people who have never smoked.Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent.Small cell lung cancer grows quickly and often spreads to other tissues (metastasizes), most commonly to the adrenal glands (small hormone-producing glands located on top of each kidney), liver, brain, and bones. In more than half of cases, the small cell lung cancer has spread beyond the lung at the time of diagnosis. After diagnosis, most people with small cell lung cancer survive for about one year; less than seven percent survive 5 years.Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. Adenocarcinoma arises from the cells that line the small air sacs (alveoli) located throughout the lungs. Squamous cell carcinoma arises from the squamous cells that line the passages leading from the windpipe to the lungs (bronchi). Large cell carcinoma describes non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. As the name suggests, the tumor cells are large when viewed under a microscope. The 5-year survival rate for people with non-small cell lung cancer is usually between 11 and 17 percent; it can be lower or higher depending on the subtype and stage of the cancer.  https://ghr.nlm.nih.gov/condition/lung-cancer

Clinical features

Alveolar cell carcinoma
MedGen UID:
2871
Concept ID:
C0007120
Neoplastic Process
Adenocarcinoma of the Bronchus.
Alveolar cell carcinoma
MedGen UID:
2871
Concept ID:
C0007120
Neoplastic Process
Adenocarcinoma of the Bronchus.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Leighl NB, Rekhtman N, Biermann WA, Huang J, Mino-Kenudson M, Ramalingam SS, West H, Whitlock S, Somerfield MR
J Clin Oncol 2014 Nov 10;32(32):3673-9. Epub 2014 Oct 13 doi: 10.1200/JCO.2014.57.3055. PMID: 25311215Free PMC Article
Kim H, Shim HS, Kim L, Kim TJ, Kwon KY, Lee GK, Chung JH; Korean Cardiopulmonary Pathology Study Group.
Korean J Pathol 2014 Feb;48(1):1-9. Epub 2014 Feb 25 doi: 10.4132/KoreanJPathol.2014.48.1.1. PMID: 24627688Free PMC Article
Shim HS, Chung JH, Kim L, Chang S, Kim WS, Lee GK, Jung SH, Jang SJ
Korean J Pathol 2013 Apr;47(2):100-6. Epub 2013 Apr 24 doi: 10.4132/KoreanJPathol.2013.47.2.100. PMID: 23667368Free PMC Article
Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M, College of American Pathologists International Association for the Study of Lung Cancer and Association for Molecular Pathology
J Mol Diagn 2013 Jul;15(4):415-53. Epub 2013 Apr 4 doi: 10.1016/j.jmoldx.2013.03.001. PMID: 23562183

External

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin

Suggested Reading

PubMed

Pasche B, Grant SC
JAMA 2014 May 21;311(19):1975-6. doi: 10.1001/jama.2014.3742. PMID: 24846033

Recent clinical studies

Etiology

van der Aalst CM, de Koning HJ
Lung Cancer 2016 Apr;94:96-101. Epub 2016 Feb 4 doi: 10.1016/j.lungcan.2016.02.001. PMID: 26973213
Menamin ÚC, Cardwell CR, Hughes CM, Murray LM
Lung Cancer 2016 Apr;94:35-9. Epub 2016 Jan 23 doi: 10.1016/j.lungcan.2016.01.012. PMID: 26973204
Yin Z, Cui Z, Ren Y, Xia L, Wang Q, Zhang Y, He Q, Zhou B
Lung Cancer 2016 Apr;94:15-21. Epub 2016 Jan 23 doi: 10.1016/j.lungcan.2016.01.013. PMID: 26973201
Schwarzkopf L, Wacker M, Holle R, Leidl R, Günster C, Adler JB, Huber RM
Lung Cancer 2015 Nov;90(2):274-80. Epub 2015 Sep 10 doi: 10.1016/j.lungcan.2015.09.005. PMID: 26384433
Chen G, Sun X, Ren H, Wan X, Huang H, Ma X, Ning B, Zou X, Hu W, Yang G
Lung Cancer 2015 Nov;90(2):155-60. Epub 2015 Aug 20 doi: 10.1016/j.lungcan.2015.08.006. PMID: 26314615

Diagnosis

van der Aalst CM, de Koning HJ
Lung Cancer 2016 Apr;94:96-101. Epub 2016 Feb 4 doi: 10.1016/j.lungcan.2016.02.001. PMID: 26973213
Menamin ÚC, Cardwell CR, Hughes CM, Murray LM
Lung Cancer 2016 Apr;94:35-9. Epub 2016 Jan 23 doi: 10.1016/j.lungcan.2016.01.012. PMID: 26973204
Schwarzkopf L, Wacker M, Holle R, Leidl R, Günster C, Adler JB, Huber RM
Lung Cancer 2015 Nov;90(2):274-80. Epub 2015 Sep 10 doi: 10.1016/j.lungcan.2015.09.005. PMID: 26384433
Kobayashi M, Nagashio R, Jiang SX, Saito K, Tsuchiya B, Ryuge S, Katono K, Nakashima H, Fukuda E, Goshima N, Satoh Y, Masuda N, Saegusa M, Sato Y
Lung Cancer 2015 Nov;90(2):342-5. Epub 2015 Aug 28 doi: 10.1016/j.lungcan.2015.08.015. PMID: 26344721
Wilson DO, Weissfeld J
Lung Cancer 2015 Jul;89(1):31-7. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.021. PMID: 25863905Free PMC Article

Therapy

van der Aalst CM, de Koning HJ
Lung Cancer 2016 Apr;94:96-101. Epub 2016 Feb 4 doi: 10.1016/j.lungcan.2016.02.001. PMID: 26973213
Menamin ÚC, Cardwell CR, Hughes CM, Murray LM
Lung Cancer 2016 Apr;94:35-9. Epub 2016 Jan 23 doi: 10.1016/j.lungcan.2016.01.012. PMID: 26973204
Schwarzkopf L, Wacker M, Holle R, Leidl R, Günster C, Adler JB, Huber RM
Lung Cancer 2015 Nov;90(2):274-80. Epub 2015 Sep 10 doi: 10.1016/j.lungcan.2015.09.005. PMID: 26384433
Kobayashi M, Nagashio R, Jiang SX, Saito K, Tsuchiya B, Ryuge S, Katono K, Nakashima H, Fukuda E, Goshima N, Satoh Y, Masuda N, Saegusa M, Sato Y
Lung Cancer 2015 Nov;90(2):342-5. Epub 2015 Aug 28 doi: 10.1016/j.lungcan.2015.08.015. PMID: 26344721
Chen G, Sun X, Ren H, Wan X, Huang H, Ma X, Ning B, Zou X, Hu W, Yang G
Lung Cancer 2015 Nov;90(2):155-60. Epub 2015 Aug 20 doi: 10.1016/j.lungcan.2015.08.006. PMID: 26314615

Prognosis

van der Aalst CM, de Koning HJ
Lung Cancer 2016 Apr;94:96-101. Epub 2016 Feb 4 doi: 10.1016/j.lungcan.2016.02.001. PMID: 26973213
Schwarzkopf L, Wacker M, Holle R, Leidl R, Günster C, Adler JB, Huber RM
Lung Cancer 2015 Nov;90(2):274-80. Epub 2015 Sep 10 doi: 10.1016/j.lungcan.2015.09.005. PMID: 26384433
Simmons CP, Koinis F, Fallon MT, Fearon KC, Bowden J, Solheim TS, Gronberg BH, McMillan DC, Gioulbasanis I, Laird BJ
Lung Cancer 2015 Jun;88(3):304-9. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.020. PMID: 25870155
Wilson DO, Weissfeld J
Lung Cancer 2015 Jul;89(1):31-7. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.021. PMID: 25863905Free PMC Article
Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL
Lung Cancer 2015 Jun;88(3):297-303. Epub 2015 Mar 20 doi: 10.1016/j.lungcan.2015.03.011. PMID: 25840848Free PMC Article

Clinical prediction guides

van der Aalst CM, de Koning HJ
Lung Cancer 2016 Apr;94:96-101. Epub 2016 Feb 4 doi: 10.1016/j.lungcan.2016.02.001. PMID: 26973213
Schwarzkopf L, Wacker M, Holle R, Leidl R, Günster C, Adler JB, Huber RM
Lung Cancer 2015 Nov;90(2):274-80. Epub 2015 Sep 10 doi: 10.1016/j.lungcan.2015.09.005. PMID: 26384433
Simmons CP, Koinis F, Fallon MT, Fearon KC, Bowden J, Solheim TS, Gronberg BH, McMillan DC, Gioulbasanis I, Laird BJ
Lung Cancer 2015 Jun;88(3):304-9. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.020. PMID: 25870155
Wilson DO, Weissfeld J
Lung Cancer 2015 Jul;89(1):31-7. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.021. PMID: 25863905Free PMC Article
Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL
Lung Cancer 2015 Jun;88(3):297-303. Epub 2015 Mar 20 doi: 10.1016/j.lungcan.2015.03.011. PMID: 25840848Free PMC Article

Recent systematic reviews

Brenner DR, Yannitsos DH, Farris MS, Johansson M, Friedenreich CM
Lung Cancer 2016 May;95:17-27. Epub 2016 Feb 4 doi: 10.1016/j.lungcan.2016.01.021. PMID: 27040847
Wang Y, Li F, Wang Z, Qiu T, Shen Y, Wang M
Lung Cancer 2015 May;88(2):124-30. Epub 2015 Feb 26 doi: 10.1016/j.lungcan.2015.02.015. PMID: 25747805
Yu Y, Liu H, Zheng S, Ding Z, Chen Z, Jin W, Wang L, Wang Z, Fei Y, Zhang S, Ying K, Zhang R
Lung Cancer 2014 Sep;85(3):351-60. Epub 2014 Jul 15 doi: 10.1016/j.lungcan.2014.07.004. PMID: 25064415
Smith BM, Pinto L, Ezer N, Sverzellati N, Muro S, Schwartzman K
Lung Cancer 2012 Jul;77(1):58-63. Epub 2012 Mar 20 doi: 10.1016/j.lungcan.2012.02.019. PMID: 22437042
Vansteenkiste J, Glaspy J, Henry D, Ludwig H, Pirker R, Tomita D, Collins H, Crawford J
Lung Cancer 2012 Jun;76(3):478-85. Epub 2012 Jan 25 doi: 10.1016/j.lungcan.2011.12.015. PMID: 22277104

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