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Prostate carcinoma

MedGen UID:
108657
Concept ID:
C0600139
Neoplastic Process
Synonyms: CA - Carcinoma of prostate; Cancer of Prostate; Cancer of the Prostate; Carcinoma of prostate; Carcinoma of Prostate; carcinoma of prostate; carcinoma of prostate gland; Carcinoma of the Prostate; carcinoma of the prostate; Prostate cancer; Prostate Cancer; Prostate Carcinoma; prostate carcinoma; prostate gland carcinoma
SNOMED CT: Prostate cancer (254900004); Carcinoma of prostate (254900004); CA - Carcinoma of prostate (254900004); Prostate carcinoma (254900004)

Definition

One of the most common malignant tumors afflicting men. The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate carcinoma

Recent clinical studies

Etiology

Plaza López PJ, Puertas E, Aguiló JJ, Suarez-Piñera M, Domenech B, Mestre-Fusco A, Casals J, Chicharo de Fleitas JR
Actas Urol Esp (Engl Ed) 2021 Jun;45(5):353-358. Epub 2021 May 14 doi: 10.1016/j.acuroe.2021.04.008. PMID: 34088434
Liu G, Tang T, Liu XP, Zhou ZH, Li FJ
Medicine (Baltimore) 2021 Apr 30;100(17):e25612. doi: 10.1097/MD.0000000000025612. PMID: 33907113Free PMC Article
McCarthy M, Francis R, Tang C, Watts J, Campbell A
Int J Radiat Oncol Biol Phys 2019 Jul 15;104(4):801-808. Epub 2019 Mar 16 doi: 10.1016/j.ijrobp.2019.03.014. PMID: 30890448
Liu H, Hou T, Ju W, Xing Y, Zhang X, Yang J
Mol Med Rep 2019 May;19(5):3882-3888. Epub 2019 Feb 27 doi: 10.3892/mmr.2019.9995. PMID: 30816534
Rynkiewicz NK, Fedele CG, Chiam K, Gupta R, Kench JG, Ooms LM, McLean CA, Giles GG, Horvath LG, Mitchell CA
Prostate 2015 Jan;75(1):92-102. Epub 2014 Oct 4 doi: 10.1002/pros.22895. PMID: 25284366

Diagnosis

Liu G, Tang T, Liu XP, Zhou ZH, Li FJ
Medicine (Baltimore) 2021 Apr 30;100(17):e25612. doi: 10.1097/MD.0000000000025612. PMID: 33907113Free PMC Article
Wu Z, Huang W, Chen Y, Chen B, Liu R, Bai P, Xing J
Cancer Biomark 2019;25(2):161-168. doi: 10.3233/CBM-182137. PMID: 31104008
McCarthy M, Francis R, Tang C, Watts J, Campbell A
Int J Radiat Oncol Biol Phys 2019 Jul 15;104(4):801-808. Epub 2019 Mar 16 doi: 10.1016/j.ijrobp.2019.03.014. PMID: 30890448
Liu H, Hou T, Ju W, Xing Y, Zhang X, Yang J
Mol Med Rep 2019 May;19(5):3882-3888. Epub 2019 Feb 27 doi: 10.3892/mmr.2019.9995. PMID: 30816534
Ren J, Yuan L, Wen G, Yang J
Acta Radiol 2016 Apr;57(4):487-93. Epub 2015 Apr 22 doi: 10.1177/0284185115581541. PMID: 25907118

Therapy

Liu G, Tang T, Liu XP, Zhou ZH, Li FJ
Medicine (Baltimore) 2021 Apr 30;100(17):e25612. doi: 10.1097/MD.0000000000025612. PMID: 33907113Free PMC Article
McCarthy M, Francis R, Tang C, Watts J, Campbell A
Int J Radiat Oncol Biol Phys 2019 Jul 15;104(4):801-808. Epub 2019 Mar 16 doi: 10.1016/j.ijrobp.2019.03.014. PMID: 30890448
Dalidovich TS, Hurski AL, Morozevich GE, Latysheva AS, Sushko TA, Strushkevich NV, Gilep AA, Misharin AY, Zhabinskii VN, Khripach VA
Steroids 2019 Jul;147:10-18. Epub 2018 Aug 25 doi: 10.1016/j.steroids.2018.08.004. PMID: 30149075
Buergy D, Schneiberg V, Schaefer J, Welzel G, Trojan L, Bolenz C, Wenz F
Health Qual Life Outcomes 2018 Jan 22;16(1):21. doi: 10.1186/s12955-018-0844-8. PMID: 29357874Free PMC Article
Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ
BMC Cancer 2017 Feb 24;17(1):158. doi: 10.1186/s12885-017-3134-7. PMID: 28235398Free PMC Article

Prognosis

Liu G, Tang T, Liu XP, Zhou ZH, Li FJ
Medicine (Baltimore) 2021 Apr 30;100(17):e25612. doi: 10.1097/MD.0000000000025612. PMID: 33907113Free PMC Article
Li G, Zhang Y, Mao J, Hu P, Chen Q, Ding W, Pu R
Gene 2019 Jul 30;707:224-230. Epub 2019 May 11 doi: 10.1016/j.gene.2019.05.026. PMID: 31085276
Liu H, Hou T, Ju W, Xing Y, Zhang X, Yang J
Mol Med Rep 2019 May;19(5):3882-3888. Epub 2019 Feb 27 doi: 10.3892/mmr.2019.9995. PMID: 30816534
Zhang X, Pan Y, Fu H, Zhang J
Med Sci Monit 2019 Feb 11;25:1122-1132. doi: 10.12659/MSM.912148. PMID: 30741252Free PMC Article
Rynkiewicz NK, Fedele CG, Chiam K, Gupta R, Kench JG, Ooms LM, McLean CA, Giles GG, Horvath LG, Mitchell CA
Prostate 2015 Jan;75(1):92-102. Epub 2014 Oct 4 doi: 10.1002/pros.22895. PMID: 25284366

Clinical prediction guides

Wu Z, Huang W, Chen Y, Chen B, Liu R, Bai P, Xing J
Cancer Biomark 2019;25(2):161-168. doi: 10.3233/CBM-182137. PMID: 31104008
Li G, Zhang Y, Mao J, Hu P, Chen Q, Ding W, Pu R
Gene 2019 Jul 30;707:224-230. Epub 2019 May 11 doi: 10.1016/j.gene.2019.05.026. PMID: 31085276
McCarthy M, Francis R, Tang C, Watts J, Campbell A
Int J Radiat Oncol Biol Phys 2019 Jul 15;104(4):801-808. Epub 2019 Mar 16 doi: 10.1016/j.ijrobp.2019.03.014. PMID: 30890448
Liu H, Hou T, Ju W, Xing Y, Zhang X, Yang J
Mol Med Rep 2019 May;19(5):3882-3888. Epub 2019 Feb 27 doi: 10.3892/mmr.2019.9995. PMID: 30816534
Rynkiewicz NK, Fedele CG, Chiam K, Gupta R, Kench JG, Ooms LM, McLean CA, Giles GG, Horvath LG, Mitchell CA
Prostate 2015 Jan;75(1):92-102. Epub 2014 Oct 4 doi: 10.1002/pros.22895. PMID: 25284366

Recent systematic reviews

Siepe G, Buwenge M, Nguyen NP, Macchia G, Deodato F, Cilla S, Mattiucci GC, Capocaccia I, Cammelli S, Guido A, Arcelli A, Ntreta M, Guerri S, Morganti AG
Anticancer Res 2018 Mar;38(3):1221-1230. doi: 10.21873/anticanres.12343. PMID: 29491044
Wu LM, Xu JR, Ye YQ, Lu Q, Hu JN
AJR Am J Roentgenol 2012 Jul;199(1):103-10. doi: 10.2214/AJR.11.7634. PMID: 22733900
Martino P, Scattoni V, Galosi AB, Consonni P, Trombetta C, Palazzo S, Maccagnano C, Liguori G, Valentino M, Battaglia M, Barozzi L
World J Urol 2011 Oct;29(5):595-605. Epub 2011 May 8 doi: 10.1007/s00345-011-0687-y. PMID: 21553276
de Vasconcelos Sobreira Guedes B, da Rocha AJ, Gama HP, da Silva CJ
Eur J Radiol 2011 Nov;80(2):236-40. Epub 2010 Jul 9 doi: 10.1016/j.ejrad.2010.06.007. PMID: 20619564
Dale W, Bilir P, Han M, Meltzer D
Cancer 2005 Aug 1;104(3):467-78. doi: 10.1002/cncr.21198. PMID: 15959911Free PMC Article

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