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Acute monoblastic leukemia

MedGen UID:
141597
Concept ID:
C0457334
Neoplastic Process
Synonyms: Acute Monoblastic Leukemia; Acute Monoblastic Leukemia (FAB M5a); FAB M5A; FAB type M5a; French-American-British type M5a
SNOMED CT: French-American-British type M5a (278170009); FAB M5A (22331004); FAB type M5a (278170009)

Definition

An acute myeloid leukemia in which the monoblasts represent 80% or more of the total cellular population. (WHO, 2001) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Lampkin BC, Lange B, Bernstein I, Woods W, Odom L, Wells R, Ruymann F, Feig S, Miller L, Chard R
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McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Recent clinical studies

Therapy

Brierley CK, Eyre TA
Blood 2017 Jun 22;129(25):3396. doi: 10.1182/blood-2017-03-765776. PMID: 28642361
Prayongratana K, Kulpraneet M, Panichchob P, Tantisiriwat W
J Med Assoc Thai 2008 Apr;91(4):559-63. PMID: 18556867
Pawarode A, Baer MR, Padmanabhan S, Wallace PK, Barcos M, Sait SN, Block AW, Wetzler M, Battiwalla M
Leuk Lymphoma 2005 Dec;46(12):1813-8. doi: 10.1080/10428190500244258. PMID: 16263586
Müller CI, Trepel M, Kunzmann R, Lais A, Engelhardt R, Lübbert M
Eur J Haematol 2004 Jul;73(1):62-6. doi: 10.1111/j.1600-0609.2004.00248.x. PMID: 15182340
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Prognosis

Galland A, Gourain V, Habbas K, Güler Y, Martin E, Ebel C, Tavian M, Vallat L, Chenard MP, Mauvieux L, Freund JN, Duluc I, Domon-Dell C
Mol Oncol 2021 Sep;15(9):2318-2329. Epub 2021 Jun 26 doi: 10.1002/1878-0261.12982. PMID: 33960108Free PMC Article
Terao T, Matsue K
N Engl J Med 2021 Feb 18;384(7):650. doi: 10.1056/NEJMicm2026508. PMID: 33596359
Wu X, Du L, Wang X
Fetal Pediatr Pathol 2011;30(1):27-31. doi: 10.3109/15513815.2010.494701. PMID: 21204663
Sun T, Wu E
Am J Hematol 2001 Mar;66(3):207-12. doi: 10.1002/1096-8652(200103)66:3<207::aid-ajh1046>3.0.co;2-q. PMID: 11279628
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957

Clinical prediction guides

Yu J, Song F, Zhang M, Xiao P, Feng J, Hong R, Hu Y, Huang H, Wei G
Mol Biol Rep 2024 Apr 21;51(1):561. doi: 10.1007/s11033-024-09543-0. PMID: 38643442Free PMC Article
Sato S, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Tsushima H, Hata T, Moriuchi Y, Mishima H, Kinoshita A, Yoshiura KI, Miyazaki Y
Int J Hematol 2018 Aug;108(2):213-217. Epub 2018 Feb 7 doi: 10.1007/s12185-018-2419-1. PMID: 29417354
Xiao PF, Tao YF, Hu SY, Cao L, Lu J, Wang J, Feng X, Pan J, Chai YH
Pharmazie 2017 Mar 1;72(3):177-186. doi: 10.1691/ph.2017.6768. PMID: 29442054
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
Hecht F, Hecht BK, Morgan R, Sandberg AA, Link MP
Cancer Genet Cytogenet 1986 Mar 15;21(2):93-8. doi: 10.1016/0165-4608(86)90034-8. PMID: 2936445

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