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Opsoclonus-myoclonus syndrome

MedGen UID:
97955
•Concept ID:
C0393626
•
Disease or Syndrome
Synonyms: Dancing eyes-dancing feet syndrome; Infantile polymyoclonus; Kinsbourne syndrome
SNOMED CT: Opsoclonus-myoclonus syndrome (230350000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015247
Orphanet: ORPHA1183

Definition

Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Opsoclonus-myoclonus syndrome

Professional guidelines

PubMed

Opsoclonus-myoclonus Syndrome with Neuroblastoma in Children and their Anaesthetic Management.
Gupta A, Kundal R, Pandey M
J Coll Physicians Surg Pak 2022 Aug;32(8):1086-1088. doi: 10.29271/jcpsp.2022.08.1086. PMID: 35932142
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318

Recent clinical studies

Etiology

Immune-mediated ataxias: Guide to clinicians.
Meira AT, de Moraes MPM, Ferreira MG, Franklin GL, Rezende Filho FM, Teive HAG, Barsottini OGP, Pedroso JL
Parkinsonism Relat Disord 2023 Dec;117:105861. Epub 2023 Sep 20 doi: 10.1016/j.parkreldis.2023.105861. PMID: 37748994
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318
Immune-mediated ataxias.
Joubert B, Rostásy K, Honnorat J
Handb Clin Neurol 2018;155:313-332. doi: 10.1016/B978-0-444-64189-2.00021-4. PMID: 29891069
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527

Diagnosis

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Opsoclonus-myoclonus-ataxia syndrome in children.
Bhatia P, Heim J, Cornejo P, Kane L, Santiago J, Kruer MC
J Neurol 2022 Feb;269(2):750-757. Epub 2021 Mar 29 doi: 10.1007/s00415-021-10536-3. PMID: 33779841
Update on opsoclonus-myoclonus syndrome in adults.
Oh SY, Kim JS, Dieterich M
J Neurol 2019 Jun;266(6):1541-1548. Epub 2018 Nov 27 doi: 10.1007/s00415-018-9138-7. PMID: 30483882
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527

Therapy

Opsoclonus myoclonus induced by lamotrigine toxicity.
Zouari R, Bouchaala W, Nsir SB, Kamoun F, Triki C
Seizure 2021 Oct;91:247-250. Epub 2021 Jun 29 doi: 10.1016/j.seizure.2021.06.021. PMID: 34243055
NK Cell-mediated Neuroblastoma Cell Lysis is Enhanced by IgG From Patients With Pediatric Opsoclonus-Myoclonus Syndrome.
Zar T, Tschernatsch M, Hero B, Lang B, Preissner KT, Blaes F
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e176-e179. doi: 10.1097/MPH.0000000000001953. PMID: 33060390
Opsoclonus-myoclonus syndrome.
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330
Opsoclonus myoclonus syndrome associated with GQ1b antibodies.
Morales-Briceño H, Rodríguez-Violante M, Cervantes-Arriaga A, Irani SR, Lees AJ, Silveira-Moriyama L
Mov Disord 2012 Nov;27(13):1615-6. doi: 10.1002/mds.25169. PMID: 23192922
Rituximab.
Borker A, Choudhary N
Indian Pediatr 2011 Aug;48(8):627-32. doi: 10.1007/s13312-011-0098-6. PMID: 21918268

Prognosis

Opsoclonus-Myoclonus-Ataxia Syndrome Due to Covid-19.
Adamaszek M, Langner S, Mehrholz J, Heiinrich A
Cerebellum 2024 Jun;23(3):1245-1248. Epub 2023 Oct 9 doi: 10.1007/s12311-023-01610-9. PMID: 37814146
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Opsoclonus-myoclonus syndrome.
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527

Clinical prediction guides

Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome.
Hero B, Clement N, Øra I, Pierron G, Lapouble E, Theissen J, Pasqualini C, Valteau-Couanet D, Plantaz D, Michon J, Delattre O, Tardieu M, Schleiermacher G
J Pediatr Hematol Oncol 2018 Mar;40(2):93-98. doi: 10.1097/MPH.0000000000000976. PMID: 29135842
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527
Paraneoplastic neurological disorders.
Blaes F, Tschernatsch M
Expert Rev Neurother 2010 Oct;10(10):1559-68. doi: 10.1586/ern.10.134. PMID: 20925471
Symptomatic myoclonus.
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775
Opsoclonus-myoclonus syndrome in acute cerebellar ataxia--clinical and electrophysiological observations of an adult case--.
Tamura K, Kuroiwa Y
Folia Psychiatr Neurol Jpn 1971;25(2):129-35. doi: 10.1111/j.1440-1819.1971.tb01495.x. PMID: 5171903

Recent systematic reviews

Drug- and Toxin-Induced Opsoclonus - a Systematized Review, including a Case Report on Amantadine-Induced Opsoclonus in Multiple System Atrophy.
Cannilla H, Messe M, Girardin F, Borruat FX, Bally JF
Tremor Other Hyperkinet Mov (N Y) 2024;14:23. Epub 2024 May 8 doi: 10.5334/tohm.832. PMID: 38737300Free PMC Article
Covid-19 vaccines and neurological complications: a systematic review.
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Systematic review of immunoglobulin use in paediatric neurological and neurodevelopmental disorders.
Gadian J, Kirk E, Holliday K, Lim M, Absoud M
Dev Med Child Neurol 2017 Feb;59(2):136-144. Epub 2016 Nov 30 doi: 10.1111/dmcn.13349. PMID: 27900773
Antineuronal Nuclear Autoantibody Type 1/Anti-Hu-Associated Opsoclonus Myoclonus and Epilepsia Partialis Continua: Case Report and Literature Review.
Sweeney M, Sweney M, Soldán MM, Clardy SL
Pediatr Neurol 2016 Dec;65:86-89. Epub 2016 Sep 2 doi: 10.1016/j.pediatrneurol.2016.08.024. PMID: 27707529
Cognitive and psychiatric phenotypes of movement disorders in children: a systematic review.
Ben-Pazi H, Jaworowski S, Shalev RS
Dev Med Child Neurol 2011 Dec;53(12):1077-84. Epub 2011 Sep 27 doi: 10.1111/j.1469-8749.2011.04134.x. PMID: 21950517

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