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Liver cancer

MedGen UID:
87520
Concept ID:
C0345904
Neoplastic Process
Synonyms: Cancer of Liver; Cancer of the Liver; Cancer, Hepatic; Cancer, Hepatocellular; Cancer, Liver; Cancers, Hepatic; Cancers, Hepatocellular; Cancers, Liver; Hepatic Cancer; Hepatic Cancers; Hepatocellular Cancer; Hepatocellular Cancers; Liver Cancer; Liver Cancers
SNOMED CT: Malignant neoplasm of liver (93870000); CA - Liver cancer (93870000); Liver cancer (93870000); Malignant tumor of liver (93870000)
 
Monarch Initiative: MONDO:0002691
OMIM®: 114550

Definition

A primary or metastatic malignant neoplasm that affects the liver. [from NCI]

Professional guidelines

PubMed

Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J
J Hepatol 2022 Mar;76(3):681-693. Epub 2021 Nov 19 doi: 10.1016/j.jhep.2021.11.018. PMID: 34801630Free PMC Article
Anwanwan D, Singh SK, Singh S, Saikam V, Singh R
Biochim Biophys Acta Rev Cancer 2020 Jan;1873(1):188314. Epub 2019 Nov 1 doi: 10.1016/j.bbcan.2019.188314. PMID: 31682895Free PMC Article

Recent clinical studies

Etiology

Salazar J, Le A
Adv Exp Med Biol 2021;1311:127-136. doi: 10.1007/978-3-030-65768-0_9. PMID: 34014539Free PMC Article
Sohn W, Lee HW, Lee S, Lim JH, Lee MW, Park CH, Yoon SK
Clin Mol Hepatol 2021 Jan;27(1):157-174. Epub 2020 Nov 26 doi: 10.3350/cmh.2020.0176. PMID: 33238333Free PMC Article
Yang WS, Zeng XF, Liu ZN, Zhao QH, Tan YT, Gao J, Li HL, Xiang YB
Br J Nutr 2020 Aug 14;124(3):330-340. Epub 2020 Apr 1 doi: 10.1017/S0007114520001208. PMID: 32234090
Zhou Y, Li Y, Zhou T, Zheng J, Li S, Li HB
Nutrients 2016 Mar 10;8(3):156. doi: 10.3390/nu8030156. PMID: 26978396Free PMC Article
Li L, Wang H
Cancer Lett 2016 Sep 1;379(2):191-7. Epub 2015 Jul 23 doi: 10.1016/j.canlet.2015.07.018. PMID: 26213370

Diagnosis

Rumgay H, Arnold M, Ferlay J, Lesi O, Cabasag CJ, Vignat J, Laversanne M, McGlynn KA, Soerjomataram I
J Hepatol 2022 Dec;77(6):1598-1606. Epub 2022 Oct 5 doi: 10.1016/j.jhep.2022.08.021. PMID: 36208844Free PMC Article
Salazar J, Le A
Adv Exp Med Biol 2021;1311:127-136. doi: 10.1007/978-3-030-65768-0_9. PMID: 34014539Free PMC Article
Yang WS, Zeng XF, Liu ZN, Zhao QH, Tan YT, Gao J, Li HL, Xiang YB
Br J Nutr 2020 Aug 14;124(3):330-340. Epub 2020 Apr 1 doi: 10.1017/S0007114520001208. PMID: 32234090
Anwanwan D, Singh SK, Singh S, Saikam V, Singh R
Biochim Biophys Acta Rev Cancer 2020 Jan;1873(1):188314. Epub 2019 Nov 1 doi: 10.1016/j.bbcan.2019.188314. PMID: 31682895Free PMC Article
Wang FS, Fan JG, Zhang Z, Gao B, Wang HY
Hepatology 2014 Dec;60(6):2099-108. Epub 2014 Oct 29 doi: 10.1002/hep.27406. PMID: 25164003Free PMC Article

Therapy

Zhu AX, Abbas AR, de Galarreta MR, Guan Y, Lu S, Koeppen H, Zhang W, Hsu CH, He AR, Ryoo BY, Yau T, Kaseb AO, Burgoyne AM, Dayyani F, Spahn J, Verret W, Finn RS, Toh HC, Lujambio A, Wang Y
Nat Med 2022 Aug;28(8):1599-1611. Epub 2022 Jun 23 doi: 10.1038/s41591-022-01868-2. PMID: 35739268
Jin H, Shi Y, Lv Y, Yuan S, Ramirez CFA, Lieftink C, Wang L, Wang S, Wang C, Dias MH, Jochems F, Yang Y, Bosma A, Hijmans EM, de Groot MHP, Vegna S, Cui D, Zhou Y, Ling J, Wang H, Guo Y, Zheng X, Isima N, Wu H, Sun C, Beijersbergen RL, Akkari L, Zhou W, Zhai B, Qin W, Bernards R
Nature 2021 Jul;595(7869):730-734. Epub 2021 Jul 21 doi: 10.1038/s41586-021-03741-7. PMID: 34290403
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article
Xu F, Jin T, Zhu Y, Dai C
J Exp Clin Cancer Res 2018 May 29;37(1):110. doi: 10.1186/s13046-018-0777-4. PMID: 29843754Free PMC Article
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749

Prognosis

Rumgay H, Arnold M, Ferlay J, Lesi O, Cabasag CJ, Vignat J, Laversanne M, McGlynn KA, Soerjomataram I
J Hepatol 2022 Dec;77(6):1598-1606. Epub 2022 Oct 5 doi: 10.1016/j.jhep.2022.08.021. PMID: 36208844Free PMC Article
Siegel RL, Miller KD, Jemal A
CA Cancer J Clin 2020 Jan;70(1):7-30. Epub 2020 Jan 8 doi: 10.3322/caac.21590. PMID: 31912902
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
CA Cancer J Clin 2018 Nov;68(6):394-424. Epub 2018 Sep 12 doi: 10.3322/caac.21492. PMID: 30207593
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

Chen W, Zhang Z, Liu K, Jiang D, Sun X, Mao Y, Li S, Ye D
Biol Trace Elem Res 2023 Oct;201(10):4649-4656. Epub 2023 Jan 12 doi: 10.1007/s12011-023-03554-x. PMID: 36633787
Ding GY, Ma JQ, Yun JP, Chen X, Ling Y, Zhang S, Shi JY, Chang YQ, Ji Y, Wang XY, Tan WM, Yuan KF, Yan B, Zhang XM, Liang F, Zhou J, Fan J, Zeng Y, Cai MY, Gao Q
J Hepatol 2022 Mar;76(3):608-618. Epub 2021 Nov 15 doi: 10.1016/j.jhep.2021.10.030. PMID: 34793865
Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, D'Ambrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L
J Hepatol 2021 Apr;74(4):775-782. Epub 2020 Nov 25 doi: 10.1016/j.jhep.2020.11.024. PMID: 33248170Free PMC Article
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N
Cancer Cell 2019 Jun 10;35(6):932-947.e8. Epub 2019 May 23 doi: 10.1016/j.ccell.2019.04.007. PMID: 31130341Free PMC Article
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518

Recent systematic reviews

Sohn W, Lee HW, Lee S, Lim JH, Lee MW, Park CH, Yoon SK
Clin Mol Hepatol 2021 Jan;27(1):157-174. Epub 2020 Nov 26 doi: 10.3350/cmh.2020.0176. PMID: 33238333Free PMC Article
Lee KH, Seong HJ, Kim G, Jeong GH, Kim JY, Park H, Jung E, Kronbichler A, Eisenhut M, Stubbs B, Solmi M, Koyanagi A, Hong SH, Dragioti E, de Rezende LFM, Jacob L, Keum N, van der Vliet HJ, Cho E, Veronese N, Grosso G, Ogino S, Song M, Radua J, Jung SJ, Thompson T, Jackson SE, Smith L, Yang L, Oh H, Choi EK, Shin JI, Giovannucci EL, Gamerith G
Adv Nutr 2020 Sep 1;11(5):1134-1149. doi: 10.1093/advances/nmaa055. PMID: 32488249Free PMC Article
Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM
Cochrane Database Syst Rev 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. PMID: 29376219Free PMC Article
Schwingshackl L, Schwedhelm C, Galbete C, Hoffmann G
Nutrients 2017 Sep 26;9(10) doi: 10.3390/nu9101063. PMID: 28954418Free PMC Article
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D
Diabetes Care 2012 Nov;35(11):2402-11. doi: 10.2337/dc12-0336. PMID: 23093685Free PMC Article

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