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Solid tumor

MedGen UID:
124697
Concept ID:
C0280100
Neoplastic Process
Synonyms: Solid neoplasm; Solid tumors

Definition

A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. [from NCI]

Professional guidelines

PubMed

Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S
Mol Cancer 2023 Jan 30;22(1):20. doi: 10.1186/s12943-023-01723-z. PMID: 36717905Free PMC Article
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Dekkers JF, Alieva M, Cleven A, Keramati F, Wezenaar AKL, van Vliet EJ, Puschhof J, Brazda P, Johanna I, Meringa AD, Rebel HG, Buchholz MB, Barrera Román M, Zeeman AL, de Blank S, Fasci D, Geurts MH, Cornel AM, Driehuis E, Millen R, Straetemans T, Nicolasen MJT, Aarts-Riemens T, Ariese HCR, Johnson HR, van Ineveld RL, Karaiskaki F, Kopper O, Bar-Ephraim YE, Kretzschmar K, Eggermont AMM, Nierkens S, Wehrens EJ, Stunnenberg HG, Clevers H, Kuball J, Sebestyen Z, Rios AC
Nat Biotechnol 2023 Jan;41(1):60-69. Epub 2022 Jul 25 doi: 10.1038/s41587-022-01397-w. PMID: 35879361Free PMC Article
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Olalekan S, Xie B, Back R, Eckart H, Basu A
Cell Rep 2021 May 25;35(8):109165. doi: 10.1016/j.celrep.2021.109165. PMID: 34038734
Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K
Cancer Sci 2017 Mar;108(3):283-289. doi: 10.1111/cas.13155. PMID: 28064442Free PMC Article
McNeill KA
Neurol Clin 2016 Nov;34(4):981-998. doi: 10.1016/j.ncl.2016.06.014. PMID: 27720005

Diagnosis

Swanson K, Wu E, Zhang A, Alizadeh AA, Zou J
Cell 2023 Apr 13;186(8):1772-1791. Epub 2023 Mar 10 doi: 10.1016/j.cell.2023.01.035. PMID: 36905928
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Veeranarayanan S, Azam AH, Kiga K, Watanabe S, Cui L
Int J Mol Sci 2021 Dec 30;23(1) doi: 10.3390/ijms23010402. PMID: 35008840Free PMC Article
Rafael MS, Cohen-Gogo S, Irwin MS, Vali R, Shammas A, Morgenstern DA
PET Clin 2021 Jul;16(3):419-427. doi: 10.1016/j.cpet.2021.03.006. PMID: 34053585
Minakova E, Lang J
Neoreviews 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716. PMID: 33139509

Therapy

O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Jiang Z, Sun H, Yu J, Tian W, Song Y
J Hematol Oncol 2021 Oct 30;14(1):180. doi: 10.1186/s13045-021-01197-w. PMID: 34717705Free PMC Article
Drilon A, Jenkins C, Iyer S, Schoenfeld A, Keddy C, Davare MA
Nat Rev Clin Oncol 2021 Jan;18(1):35-55. Epub 2020 Aug 5 doi: 10.1038/s41571-020-0408-9. PMID: 32760015Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Guo R, Luo J, Chang J, Rekhtman N, Arcila M, Drilon A
Nat Rev Clin Oncol 2020 Sep;17(9):569-587. Epub 2020 Jun 8 doi: 10.1038/s41571-020-0377-z. PMID: 32514147Free PMC Article

Prognosis

O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, Stattin P, Van Poppel H, La Vecchia C
Eur Urol Oncol 2021 Dec;4(6):877-892. Epub 2021 Oct 26 doi: 10.1016/j.euo.2021.09.006. PMID: 34716119
McKay SL, Guo A, Pergam SA, Dooling K
Clin Infect Dis 2020 Oct 23;71(7):e125-e134. doi: 10.1093/cid/ciz1090. PMID: 31677266Free PMC Article
Newman EA, Abdessalam S, Aldrink JH, Austin M, Heaton TE, Bruny J, Ehrlich P, Dasgupta R, Baertschiger RM, Lautz TB, Rhee DS, Langham MR Jr, Malek MM, Meyers RL, Nathan JD, Weil BR, Polites S, Madonna MB; APSA Cancer committee
J Pediatr Surg 2019 Mar;54(3):383-389. Epub 2018 Sep 19 doi: 10.1016/j.jpedsurg.2018.09.004. PMID: 30305231
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Clinical prediction guides

Baeuerle PA, Wesche H
Curr Opin Oncol 2022 Sep 1;34(5):552-558. Epub 2022 Jul 28 doi: 10.1097/CCO.0000000000000869. PMID: 35880455Free PMC Article
Zhang L, Huang T, Xu F, Li S, Zheng S, Lyu J, Yin H
BMC Emerg Med 2022 Feb 11;22(1):26. doi: 10.1186/s12873-022-00582-z. PMID: 35148680Free PMC Article
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Minakova E, Lang J
Neoreviews 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716. PMID: 33139509
Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

Recent systematic reviews

Roche KN, Cooper D, Armstrong TS, King AL
Cancer Med 2023 Feb;12(3):3343-3364. Epub 2023 Jan 5 doi: 10.1002/cam4.5200. PMID: 36602400Free PMC Article
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
McKay SL, Guo A, Pergam SA, Dooling K
Clin Infect Dis 2020 Oct 23;71(7):e125-e134. doi: 10.1093/cid/ciz1090. PMID: 31677266Free PMC Article
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292
Wu P, Wu D, Li L, Chai Y, Huang J
PLoS One 2015;10(6):e0131403. Epub 2015 Jun 26 doi: 10.1371/journal.pone.0131403. PMID: 26114883Free PMC Article

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