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Transitional cell carcinoma of the bladder

MedGen UID:
76013
Concept ID:
C0279680
Neoplastic Process
Synonym: Transitional cell bladder carcinoma
SNOMED CT: Transitional cell carcinoma of bladder (255109008); TCC - Transitional cell carcinoma of bladder (255109008)
 
HPO: HP:0006740

Definition

The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransitional cell carcinoma of the bladder

Conditions with this feature

Urinary bladder cancer
MedGen UID:
14150
Concept ID:
C0005684
Neoplastic Process
A primary or metastatic malignant neoplasm involving the bladder.
Colorectal cancer
MedGen UID:
3170
Concept ID:
C0009402
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
Cowden syndrome
MedGen UID:
5420
Concept ID:
C0018553
Neoplastic Process
Cowden syndrome-1 is a hamartomatous disorder characterized by macrocephaly, facial trichilemmomas, acral keratoses, papillomatous papules, and an increased risk for the development of breast, thyroid, and endometrial carcinoma. Bannayan-Riley-Ruvalcaba syndrome (BRRS), previously thought be distinct, shared clinical characteristics with Cowden syndrome, such as hamartomatous polyps of the gastrointestinal tract, mucocutaneous lesions, and increased risk of developing neoplasms, but had the additional features of developmental delay, macrocephaly, lipomas, hemangiomas, and pigmented speckled macules of the glans penis in males. Because features of BRRS and Cowden syndrome have been found in individuals within the same family with the same PTEN mutation, Cowden syndrome-1 and BRRS are considered to be the same disorder with variable expression and age-related penetrance (summary by Marsh et al., 1999, Lachlan et al., 2007, and Blumenthal and Dennis, 2008). Approximately 80% of patients reported with Cowden syndrome and 60% with BRSS have PTEN mutations (Blumenthal and Dennis, 2008). Some patients with Cowden syndrome may have immune system defects resulting in increased susceptibility to infections (summary by Browning et al., 2015).
Lhermitte-Duclos disease
MedGen UID:
140251
Concept ID:
C0391826
Neoplastic Process
A very rare disorder characterized by abnormal development and enlargement of the cerebellum, and an increased intracranial pressure.
Carcinoma of colon
MedGen UID:
147065
Concept ID:
C0699790
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
Cerebelloparenchymal Disorder VI
MedGen UID:
331813
Concept ID:
C1834711
Disease or Syndrome
Cerebellar Granule Cell Hypertrophy and Megalencephaly
MedGen UID:
371886
Concept ID:
C1834712
Disease or Syndrome
PTEN hamartoma tumor syndrome with granular cell tumor
MedGen UID:
400984
Concept ID:
C1866376
Neoplastic Process
Proteus-like syndrome
MedGen UID:
356222
Concept ID:
C1866398
Disease or Syndrome
Proteus like syndrome describes patients who do not meet the diagnostic criteria for Proteus syndrome but who share a multitude of characteristic clinical features of the disease. The prevalence is unknown. The main clinical features include skeletal overgrowth, hamartomatous overgrowth of multiple tissues, cerebriform connective tissue nevi, vascular malformations and linear epidermal nevi. Mutations in the PTEN gene are found in 50% of Proteus-like syndrome cases, making them a part of the PTEN hamartoma syndrome group.
PTEN hamartoma tumor syndrome
MedGen UID:
368366
Concept ID:
C1959582
Neoplastic Process
The PTEN hamartoma tumor syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and PTEN-related Proteus-like syndrome. CS is a multiple hamartoma syndrome with a high risk for benign and malignant tumors of the thyroid, breast, kidney, and endometrium. Affected individuals usually have macrocephaly, trichilemmomas, and papillomatous papules, and present by the late 20s. The lifetime risk of developing breast cancer is 85%, with an average age of diagnosis between 38 and 46 years. The lifetime risk for thyroid cancer (usually follicular, rarely papillary, but never medullary thyroid cancer) is approximately 35%. The lifetime risk for renal cell cancer (predominantly of papillary histology) is 34%. The risk for endometrial cancer may approach 28%. BRRS is a congenital disorder characterized by macrocephaly, intestinal hamartomatous polyposis, lipomas, and pigmented macules of the glans penis. PS is a complex, highly variable disorder involving congenital malformations and hamartomatous overgrowth of multiple tissues, as well as connective tissue nevi, epidermal nevi, and hyperostoses. Proteus-like syndrome is undefined but refers to individuals with significant clinical features of PS who do not meet the diagnostic criteria for PS.
Cowden syndrome 5
MedGen UID:
767432
Concept ID:
C3554518
Disease or Syndrome
Cowden syndrome 6
MedGen UID:
767433
Concept ID:
C3554519
Disease or Syndrome

Recent clinical studies

Etiology

Tschirdewahn S, Harke NN, Hirner L, Stagge E, Hadaschik B, Eisenhardt A
World J Urol 2020 Jun;38(6):1509-1515. Epub 2019 Aug 30 doi: 10.1007/s00345-019-02926-0. PMID: 31471739
Mukherjee P, George AJP, Yadav BK, Jeyaseelan L, Kumar RM, Mukha RP, Chandrasingh J, Kumar S, Kekre NS, Devasia A
Urology 2019 Jun;128:55-61. Epub 2019 Feb 26 doi: 10.1016/j.urology.2019.01.039. PMID: 30822478
Kelly JD, Tan WS, Porta N, Mostafid H, Huddart R, Protheroe A, Bogle R, Blazeby J, Palmer A, Cresswell J, Johnson M, Brough R, Madaan S, Andrews S, Cruickshank C, Burnett S, Maynard L, Hall E; BOXIT Investigators.
Eur Urol 2019 Apr;75(4):593-601. Epub 2018 Sep 29 doi: 10.1016/j.eururo.2018.09.020. PMID: 30279015
Hess J, Stelmach P, Eisenhardt A, Rübben H, Reis H, Schmid KW, Bachmann HS
J Cancer Res Clin Oncol 2017 Sep;143(9):1659-1670. Epub 2017 Apr 17 doi: 10.1007/s00432-017-2404-8. PMID: 28417194
Grimm T, Buchner A, Schneevoigt B, Kretschmer A, Apfelbeck M, Grabbert M, Jokisch JF, Stief CG, Karl A
World J Urol 2016 May;34(5):703-8. Epub 2015 Sep 16 doi: 10.1007/s00345-015-1680-7. PMID: 26376992

Diagnosis

Khurram R, Khurram A, Chaudhary K
BMJ Case Rep 2020 Jun 28;13(6) doi: 10.1136/bcr-2020-235084. PMID: 32595116Free PMC Article
Tschirdewahn S, Harke NN, Hirner L, Stagge E, Hadaschik B, Eisenhardt A
World J Urol 2020 Jun;38(6):1509-1515. Epub 2019 Aug 30 doi: 10.1007/s00345-019-02926-0. PMID: 31471739
Mukherjee P, George AJP, Yadav BK, Jeyaseelan L, Kumar RM, Mukha RP, Chandrasingh J, Kumar S, Kekre NS, Devasia A
Urology 2019 Jun;128:55-61. Epub 2019 Feb 26 doi: 10.1016/j.urology.2019.01.039. PMID: 30822478
Al-Husseini MJ, Kunbaz A, Saad AM, Santos JV, Salahia S, Iqbal M, Alahdab F
BMC Cancer 2019 Jan 10;19(1):46. doi: 10.1186/s12885-019-5267-3. PMID: 30630456Free PMC Article
Hu X, Ruan Y, Cheng F, Yu W, Zhang X, Larré S
Int J Urol 2011 Sep;18(9):630-7. Epub 2011 Jun 14 doi: 10.1111/j.1442-2042.2011.02793.x. PMID: 21672035

Therapy

Tschirdewahn S, Harke NN, Hirner L, Stagge E, Hadaschik B, Eisenhardt A
World J Urol 2020 Jun;38(6):1509-1515. Epub 2019 Aug 30 doi: 10.1007/s00345-019-02926-0. PMID: 31471739
Mukherjee P, George AJP, Yadav BK, Jeyaseelan L, Kumar RM, Mukha RP, Chandrasingh J, Kumar S, Kekre NS, Devasia A
Urology 2019 Jun;128:55-61. Epub 2019 Feb 26 doi: 10.1016/j.urology.2019.01.039. PMID: 30822478
Kelly JD, Tan WS, Porta N, Mostafid H, Huddart R, Protheroe A, Bogle R, Blazeby J, Palmer A, Cresswell J, Johnson M, Brough R, Madaan S, Andrews S, Cruickshank C, Burnett S, Maynard L, Hall E; BOXIT Investigators.
Eur Urol 2019 Apr;75(4):593-601. Epub 2018 Sep 29 doi: 10.1016/j.eururo.2018.09.020. PMID: 30279015
Apoznański W, Rysiakiewicz J, Polok M, Rysiakiewicz K, Siekanowicz P, Hilger T, Zagierski J, Hilger M, Nowak I, Kolęda P, Szydełko T
Adv Clin Exp Med 2015 May-Jun;24(3):505-9. doi: 10.17219/acem/36600. PMID: 26467141
Halpenny D, Salati U, Torregiani WC, Browne R
JBR-BTR 2013 Sep-Oct;96(5):282-5. doi: 10.5334/jbr-btr.402. PMID: 24479287

Prognosis

Khurram R, Khurram A, Chaudhary K
BMJ Case Rep 2020 Jun 28;13(6) doi: 10.1136/bcr-2020-235084. PMID: 32595116Free PMC Article
Tschirdewahn S, Harke NN, Hirner L, Stagge E, Hadaschik B, Eisenhardt A
World J Urol 2020 Jun;38(6):1509-1515. Epub 2019 Aug 30 doi: 10.1007/s00345-019-02926-0. PMID: 31471739
Mukherjee P, George AJP, Yadav BK, Jeyaseelan L, Kumar RM, Mukha RP, Chandrasingh J, Kumar S, Kekre NS, Devasia A
Urology 2019 Jun;128:55-61. Epub 2019 Feb 26 doi: 10.1016/j.urology.2019.01.039. PMID: 30822478
Grimm T, Buchner A, Schneevoigt B, Kretschmer A, Apfelbeck M, Grabbert M, Jokisch JF, Stief CG, Karl A
World J Urol 2016 May;34(5):703-8. Epub 2015 Sep 16 doi: 10.1007/s00345-015-1680-7. PMID: 26376992
Hu X, Ruan Y, Cheng F, Yu W, Zhang X, Larré S
Int J Urol 2011 Sep;18(9):630-7. Epub 2011 Jun 14 doi: 10.1111/j.1442-2042.2011.02793.x. PMID: 21672035

Clinical prediction guides

Al-Husseini MJ, Kunbaz A, Saad AM, Santos JV, Salahia S, Iqbal M, Alahdab F
BMC Cancer 2019 Jan 10;19(1):46. doi: 10.1186/s12885-019-5267-3. PMID: 30630456Free PMC Article
Candido S, Di Maso M, Serraino D, McCubrey JA, Bortolus R, Zanin M, Battiston M, Salemi R, Libra M, Polesel J
Tumour Biol 2016 Jul;37(7):9855-63. Epub 2016 Jan 26 doi: 10.1007/s13277-016-4872-x. PMID: 26810191
Apoznański W, Rysiakiewicz J, Polok M, Rysiakiewicz K, Siekanowicz P, Hilger T, Zagierski J, Hilger M, Nowak I, Kolęda P, Szydełko T
Adv Clin Exp Med 2015 May-Jun;24(3):505-9. doi: 10.17219/acem/36600. PMID: 26467141
Temraz S, Mukherji D, Farhat ZA, Nasr R, Charafeddine M, Shahait M, Wehbe MR, Ghaida RA, Gheida IA, Shamseddine A
BMC Urol 2014 Sep 19;14:76. doi: 10.1186/1471-2490-14-76. PMID: 25234356Free PMC Article
Hu X, Ruan Y, Cheng F, Yu W, Zhang X, Larré S
Int J Urol 2011 Sep;18(9):630-7. Epub 2011 Jun 14 doi: 10.1111/j.1442-2042.2011.02793.x. PMID: 21672035

Recent systematic reviews

Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413
Advanced Bladder Cancer (ABC) Meta-analysis Collaboration.
Cochrane Database Syst Rev 2006 Apr 19;(2):CD006018. doi: 10.1002/14651858.CD006018. PMID: 16625650
Advanced Bladder Cancer Overview Collaboration.
Cochrane Database Syst Rev 2005 Apr 18;(2):CD005246. doi: 10.1002/14651858.CD005246. PMID: 15846746
Winquist E, Kirchner TS, Segal R, Chin J, Lukka H; Genitourinary Cancer Disease Site Group, Cancer Care Ontario Program in Evidence-based Care Practice Guidelines Initiative.
J Urol 2004 Feb;171(2 Pt 1):561-9. doi: 10.1097/01.ju.0000090967.08622.33. PMID: 14713760

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