U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult fibrosarcoma

MedGen UID:
75840
Concept ID:
C0278595
Neoplastic Process
Synonyms: Adult Fibrosarcoma; adult fibrosarcoma; adult fibrosarcoma (disease); fibrosarcoma (disease) of adults
 
Monarch Initiative: MONDO:0002676

Definition

A malignant mesenchymal neoplasm composed of fibroblasts. It is characterized by collagen production and a herringbone architectural pattern. It is more commonly seen in middle-aged and older adults. It usually affects the deep soft tissues of extremities, trunk, head and neck. Adult fibrosarcomas may recur and metastasize to the lungs and bones. [from NCI]

Professional guidelines

PubMed

Martínez-Trufero J, Cruz Jurado J, Gómez-Mateo MC, Bernabeu D, Floría LJ, Lavernia J, Sebio A, García Del Muro X, Álvarez R, Correa R, Hernández-León CN, Marquina G, Hindi N, Redondo A, Martínez V, Asencio JM, Mata C, Valverde Morales CM, Martin-Broto J
Cancer Treat Rev 2021 Sep;99:102259. Epub 2021 Jul 11 doi: 10.1016/j.ctrv.2021.102259. PMID: 34311246

Recent clinical studies

Etiology

Martínez-Trufero J, Cruz Jurado J, Gómez-Mateo MC, Bernabeu D, Floría LJ, Lavernia J, Sebio A, García Del Muro X, Álvarez R, Correa R, Hernández-León CN, Marquina G, Hindi N, Redondo A, Martínez V, Asencio JM, Mata C, Valverde Morales CM, Martin-Broto J
Cancer Treat Rev 2021 Sep;99:102259. Epub 2021 Jul 11 doi: 10.1016/j.ctrv.2021.102259. PMID: 34311246
Wang H, Nie P, Dong C, Li J, Huang Y, Hao D, Xu W
Biomed Res Int 2018;2018:6075705. Epub 2018 Mar 6 doi: 10.1155/2018/6075705. PMID: 29693010Free PMC Article
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Zyluk A, Walaszek I, Grabarek J
Handchir Mikrochir Plast Chir 2012 Jun;44(3):171-4. Epub 2012 Jun 11 doi: 10.1055/s-0032-1312623. PMID: 22689150
Sheng WQ, Hashimoto H, Okamoto S, Ishida T, Meis-Kindblom JM, Kindblom LG, Hisaoka M
J Pathol 2001 May;194(1):88-94. doi: 10.1002/path.839. PMID: 11329146

Diagnosis

Martínez-Trufero J, Cruz Jurado J, Gómez-Mateo MC, Bernabeu D, Floría LJ, Lavernia J, Sebio A, García Del Muro X, Álvarez R, Correa R, Hernández-León CN, Marquina G, Hindi N, Redondo A, Martínez V, Asencio JM, Mata C, Valverde Morales CM, Martin-Broto J
Cancer Treat Rev 2021 Sep;99:102259. Epub 2021 Jul 11 doi: 10.1016/j.ctrv.2021.102259. PMID: 34311246
Wang H, Nie P, Dong C, Li J, Huang Y, Hao D, Xu W
Biomed Res Int 2018;2018:6075705. Epub 2018 Mar 6 doi: 10.1155/2018/6075705. PMID: 29693010Free PMC Article
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Folpe AL
Histopathology 2014 Jan;64(1):12-25. Epub 2013 Nov 22 doi: 10.1111/his.12282. PMID: 24266941
Iwasaki H, Enjoji M
Acta Pathol Jpn 1979 May;29(3):377-88. doi: 10.1111/j.1440-1827.1979.tb00195.x. PMID: 452901

Therapy

Dall'Igna P, De Corti F, Alaggio R, Cecchetto G
Eur J Pediatr Surg 2014 Dec;24(6):482-7. Epub 2014 Dec 5 doi: 10.1055/s-0034-1396422. PMID: 25478665

Prognosis

Jin Z, Tao S, Zhang C, Xu D, Zhu Z
Exp Cell Res 2022 Nov 1;420(1):113322. Epub 2022 Aug 28 doi: 10.1016/j.yexcr.2022.113322. PMID: 36037925
Xu J, Weisman P
Genes Chromosomes Cancer 2021 Jun;60(6):447-451. Epub 2020 Dec 28 doi: 10.1002/gcc.22929. PMID: 33342011
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Schmidt H, Taubert H, Würl P, Kappler M, Lange H, Bartel F, Bache M, Holzhausen HJ, Hinze R
Genes Chromosomes Cancer 2002 May;34(1):69-77. doi: 10.1002/gcc.10036. PMID: 11921284
Kihara S, Nehlsen-Cannarella N, Kirsch WM, Chase D, Garvin AJ
Am J Clin Pathol 1996 Oct;106(4):493-7. doi: 10.1093/ajcp/106.4.493. PMID: 8853038

Clinical prediction guides

Schmidt H, Taubert H, Würl P, Kappler M, Lange H, Bartel F, Bache M, Holzhausen HJ, Hinze R
Genes Chromosomes Cancer 2002 May;34(1):69-77. doi: 10.1002/gcc.10036. PMID: 11921284
Dubus P, Coindre JM, Groppi A, Jouan H, Ferrer J, Cohen C, Rivel J, Copin MC, Leroy JP, de Muret A, Merlio JP
J Pathol 2001 Jan;193(1):88-94. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH724>3.0.CO;2-S. PMID: 11169520

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...