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Asymmetric proximal motor neuropathy due to diabetes mellitus

MedGen UID:
75761
•Concept ID:
C0271674
•
Disease or Syndrome
Synonym: Asymmetric Diabetic Proximal Motor Neuropathy
SNOMED CT: Asymmetric diabetic proximal motor neuropathy (79554005); Asymmetric proximal motor neuropathy with diabetes mellitus (79554005); Asymmetric proximal motor neuropathy due to diabetes mellitus (79554005)

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Progress in the treatment of diabetic peripheral neuropathy.
Yang K, Wang Y, Li YW, Chen YG, Xing N, Lin HB, Zhou P, Yu XP
Biomed Pharmacother 2022 Apr;148:112717. Epub 2022 Feb 19 doi: 10.1016/j.biopha.2022.112717. PMID: 35193039
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024

Recent clinical studies

Etiology

Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL
Lancet Neurol 2022 Oct;21(10):922-936. doi: 10.1016/S1474-4422(22)00188-0. PMID: 36115364Free PMC Article
Progress in the treatment of diabetic peripheral neuropathy.
Yang K, Wang Y, Li YW, Chen YG, Xing N, Lin HB, Zhou P, Yu XP
Biomed Pharmacother 2022 Apr;148:112717. Epub 2022 Feb 19 doi: 10.1016/j.biopha.2022.112717. PMID: 35193039
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024
Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes.
Hicks CW, Selvin E
Curr Diab Rep 2019 Aug 27;19(10):86. doi: 10.1007/s11892-019-1212-8. PMID: 31456118Free PMC Article
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article

Diagnosis

Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Diabetic Gastroparesis.
Bharucha AE, Kudva YC, Prichard DO
Endocr Rev 2019 Oct 1;40(5):1318-1352. doi: 10.1210/er.2018-00161. PMID: 31081877Free PMC Article
Neuropathy and Diabetic Foot Syndrome.
Volmer-Thole M, Lobmann R
Int J Mol Sci 2016 Jun 10;17(6) doi: 10.3390/ijms17060917. PMID: 27294922Free PMC Article
Diabetic neuropathy.
Vinik AI, Nevoret ML, Casellini C, Parson H
Endocrinol Metab Clin North Am 2013 Dec;42(4):747-87. doi: 10.1016/j.ecl.2013.06.001. PMID: 24286949

Therapy

Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes.
Yang J, Yang X, Wu G, Huang F, Shi X, Wei W, Zhang Y, Zhang H, Cheng L, Yu L, Shang J, Lv Y, Wang X, Zhai R, Li P, Cui B, Fang Y, Deng X, Tang S, Wang L, Yuan Q, Zhao L, Zhang F, Zhang C, Yuan H
Cell Metab 2023 Sep 5;35(9):1548-1562.e7. Epub 2023 Jul 13 doi: 10.1016/j.cmet.2023.06.010. PMID: 37451270
Small Fiber Neuropathy.
Strand N, Wie C, Peck J, Maita M, Singh N, Dumbroff J, Tieppo Francio V, Murphy M, Chang K, Dickerson DM, Maloney J
Curr Pain Headache Rep 2022 Jun;26(6):429-438. Epub 2022 Apr 6 doi: 10.1007/s11916-022-01044-8. PMID: 35384587
Diabetic Peripheral Neuropathy: Diagnosis and Treatment.
Røikjer J, Mørch CD, Ejskjaer N
Curr Drug Saf 2021;16(1):2-16. doi: 10.2174/1574886315666200731173113. PMID: 32735526
Cardiac Autonomic Neuropathy in Diabetes Mellitus.
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Efficacy of α-lipoic acid in diabetic neuropathy.
Papanas N, Ziegler D
Expert Opin Pharmacother 2014 Dec;15(18):2721-31. Epub 2014 Nov 10 doi: 10.1517/14656566.2014.972935. PMID: 25381809

Prognosis

Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Study on Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus and Establishment of Prediction Model.
Wu B, Niu Z, Hu F
Diabetes Metab J 2021 Jul;45(4):526-538. Epub 2021 Jul 30 doi: 10.4093/dmj.2020.0100. PMID: 34352988Free PMC Article
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets.
Dewanjee S, Das S, Das AK, Bhattacharjee N, Dihingia A, Dua TK, Kalita J, Manna P
Eur J Pharmacol 2018 Aug 15;833:472-523. Epub 2018 Jun 30 doi: 10.1016/j.ejphar.2018.06.034. PMID: 29966615
Diabetic neuropathy: mechanisms, emerging treatments, and subtypes.
Albers JW, Pop-Busui R
Curr Neurol Neurosci Rep 2014 Aug;14(8):473. doi: 10.1007/s11910-014-0473-5. PMID: 24954624Free PMC Article
Vasculitic neuropathies.
Gwathmey KG, Burns TM, Collins MP, Dyck PJ
Lancet Neurol 2014 Jan;13(1):67-82. doi: 10.1016/S1474-4422(13)70236-9. PMID: 24331794

Clinical prediction guides

Prevalence and risk factors of diabetic peripheral neuropathy: A population-based cross-sectional study in China.
Wang W, Ji Q, Ran X, Li C, Kuang H, Yu X, Fang H, Yang J, Liu J, Xue Y, Feng B, Lei M, Zhu D
Diabetes Metab Res Rev 2023 Nov;39(8):e3702. Epub 2023 Jul 25 doi: 10.1002/dmrr.3702. PMID: 37490047
Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes.
Yang J, Yang X, Wu G, Huang F, Shi X, Wei W, Zhang Y, Zhang H, Cheng L, Yu L, Shang J, Lv Y, Wang X, Zhai R, Li P, Cui B, Fang Y, Deng X, Tang S, Wang L, Yuan Q, Zhao L, Zhang F, Zhang C, Yuan H
Cell Metab 2023 Sep 5;35(9):1548-1562.e7. Epub 2023 Jul 13 doi: 10.1016/j.cmet.2023.06.010. PMID: 37451270
Study on Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus and Establishment of Prediction Model.
Wu B, Niu Z, Hu F
Diabetes Metab J 2021 Jul;45(4):526-538. Epub 2021 Jul 30 doi: 10.4093/dmj.2020.0100. PMID: 34352988Free PMC Article
Cardiac Autonomic Neuropathy in Diabetes Mellitus.
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Diabetic neuropathy.
Said G
Handb Clin Neurol 2013;115:579-89. doi: 10.1016/B978-0-444-52902-2.00033-3. PMID: 23931803

Recent systematic reviews

Evidence-Based Treatment of Painful Diabetic Neuropathy: a Systematic Review.
D'Souza RS, Barman R, Joseph A, Abd-Elsayed A
Curr Pain Headache Rep 2022 Aug;26(8):583-594. Epub 2022 Jun 18 doi: 10.1007/s11916-022-01061-7. PMID: 35716275
Exercise and Neuropathy: Systematic Review with Meta-Analysis.
Streckmann F, Balke M, Cavaletti G, Toscanelli A, Bloch W, Décard BF, Lehmann HC, Faude O
Sports Med 2022 May;52(5):1043-1065. Epub 2021 Dec 29 doi: 10.1007/s40279-021-01596-6. PMID: 34964950
Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses.
Nanayakkara N, Curtis AJ, Heritier S, Gadowski AM, Pavkov ME, Kenealy T, Owens DR, Thomas RL, Song S, Wong J, Chan JC, Luk AO, Penno G, Ji L, Mohan V, Amutha A, Romero-Aroca P, Gasevic D, Magliano DJ, Teede HJ, Chalmers J, Zoungas S
Diabetologia 2021 Feb;64(2):275-287. Epub 2020 Dec 14 doi: 10.1007/s00125-020-05319-w. PMID: 33313987Free PMC Article
Prevention, assessment, diagnosis and management of diabetic foot based on clinical practice guidelines: A systematic review.
Pérez-Panero AJ, Ruiz-Muñoz M, Cuesta-Vargas AI, Gónzalez-Sánchez M
Medicine (Baltimore) 2019 Aug;98(35):e16877. doi: 10.1097/MD.0000000000016877. PMID: 31464916Free PMC Article
Prevention of foot ulcers in the at-risk patient with diabetes: a systematic review.
van Netten JJ, Price PE, Lavery LA, Monteiro-Soares M, Rasmussen A, Jubiz Y, Bus SA; International Working Group on the Diabetic Foot
Diabetes Metab Res Rev 2016 Jan;32 Suppl 1:84-98. doi: 10.1002/dmrr.2701. PMID: 26340966

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