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Thyrotoxic periodic paralysis

MedGen UID:: 120639
•Concept ID:: C0268446
•: Disease or Syndrome

Synonyms:	Hashitoxic periodic paralysis; Thyrotoxic hypokalemic periodic paralysis; thyrotoxic hypokalemic periodic paralysis; thyrotoxic periodic paralysis
SNOMED CT:	Thyrotoxic periodic paralysis (30967002); Hashitoxic periodic paralysis (30967002)
Modes of inheritance:	Non-Mendelian inheritance MedGen UID: 109109 •Concept ID: C0600599 • Genetic Function Source: Orphanet A mode of inheritance that depends on genetic determinants in more than one gene. Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Non-Mendelian inheritance (Orphanet) Not genetically inherited (Orphanet)

Monarch Initiative:	MONDO:0019201
OMIM® Phenotypic series:	PS188580
Orphanet:	ORPHA79102

Definition

Thyrotoxic periodic paralysis (TPP) is a rare neurological disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state. [from ORDO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThyrotoxic periodic paralysis

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system physiology
    - Abnormal central motor function
      - Paralysis
        Periodic paralysis
        Thyrotoxic periodic paralysis

Follow this link to review classifications for Thyrotoxic periodic paralysis in Orphanet.

Professional guidelines

PubMed

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.

Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916

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Recent clinical studies

Etiology

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.

Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916

Periodic paralysis.

Fialho D, Griggs RC, Matthews E
Handb Clin Neurol 2018;148:505-520. doi: 10.1016/B978-0-444-64076-5.00032-6. PMID: 29478596

Thyrotoxic periodic paralysis: clinical and molecular aspects.

Falhammar H, Thorén M, Calissendorff J
Endocrine 2013 Apr;43(2):274-84. Epub 2012 Aug 24 doi: 10.1007/s12020-012-9777-x. PMID: 22918841

Mechanism of thyrotoxic periodic paralysis.

Lin SH, Huang CL
J Am Soc Nephrol 2012 Jun;23(6):985-8. Epub 2012 Mar 29 doi: 10.1681/ASN.2012010046. PMID: 22460532 Free PMC Article

Thyrotoxic periodic paralysis.

Lin SH
Mayo Clin Proc 2005 Jan;80(1):99-105. doi: 10.1016/S0025-6196(11)62965-0. PMID: 15667036

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Diagnosis

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.

Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916

Thyrotoxic Periodic Paralysis.

Fralick M, Sarma S
N Engl J Med 2021 May 13;384(19):e71. Epub 2021 May 8 doi: 10.1056/NEJMicm2030770. PMID: 33983691

Thyrotoxic periodic paralysis: A retrospective, observational study from India.

Verma V, Kumar Y, Kotwal N, Upreti V, Hari Kumar KVS, Singh Y, Menon AS
Indian J Med Res 2020 Jan;151(1):42-46. doi: 10.4103/ijmr.IJMR_335_18. PMID: 32134013 Free PMC Article

Thyrotoxic Periodic Paralysis: A Concise Review of the Literature.

Chaudhry MA, Wayangankar S
Curr Rheumatol Rev 2016;12(3):190-194. doi: 10.2174/1573397112666160404124822. PMID: 27041083

Thyrotoxic periodic paralysis.

Lin SH
Mayo Clin Proc 2005 Jan;80(1):99-105. doi: 10.1016/S0025-6196(11)62965-0. PMID: 15667036

See all (166)

Therapy

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.

Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916

Thyrotoxic Periodic Paralysis.

Fralick M, Sarma S
N Engl J Med 2021 May 13;384(19):e71. Epub 2021 May 8 doi: 10.1056/NEJMicm2030770. PMID: 33983691

Sudden flaccid paralysis.

Tariq M, Peshin R, Ellis O, Grover K
BMJ Case Rep 2015 Jan 7;2015 doi: 10.1136/bcr-2014-206872. PMID: 25566931 Free PMC Article

Mechanism of thyrotoxic periodic paralysis.

Lin SH, Huang CL
J Am Soc Nephrol 2012 Jun;23(6):985-8. Epub 2012 Mar 29 doi: 10.1681/ASN.2012010046. PMID: 22460532 Free PMC Article

Analytic review: thyrotoxic periodic paralysis: a review.

Pothiwala P, Levine SN
J Intensive Care Med 2010 Mar-Apr;25(2):71-7. Epub 2010 Jan 19 doi: 10.1177/0885066609358849. PMID: 20089526

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Prognosis

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.

Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916

Unique Presentation of Thyrotoxic Periodic Paralysis With Urticarial Dermographia.

Minns RM, Barranco-Trabi JJ, Siemann DN, Chamas A, Shin T
Mil Med 2023 Aug 29;188(9-10):e3252-e3255. doi: 10.1093/milmed/usac342. PMID: 36383068

Thyrotoxic Periodic Paralysis: A Concise Review of the Literature.

Chaudhry MA, Wayangankar S
Curr Rheumatol Rev 2016;12(3):190-194. doi: 10.2174/1573397112666160404124822. PMID: 27041083

Thyroid disease and the nervous system.

Wood-Allum CA, Shaw PJ
Handb Clin Neurol 2014;120:703-35. doi: 10.1016/B978-0-7020-4087-0.00048-6. PMID: 24365348

Mechanism of thyrotoxic periodic paralysis.

Lin SH, Huang CL
J Am Soc Nephrol 2012 Jun;23(6):985-8. Epub 2012 Mar 29 doi: 10.1681/ASN.2012010046. PMID: 22460532 Free PMC Article

See all (24)

Clinical prediction guides

Thyrotoxic periodic paralysis associated with lactic metabolic acidosis: Case report of an African man and review of literature.

Allard M, Barrallier M, Pisaroni H, Fichet M, De La Vergne De Cerval M, Pflaum R, Poisson A, Derrien C, Bonnet F, Vaduva P
Ann Endocrinol (Paris) 2023 Aug;84(4):440-445. Epub 2023 Feb 8 doi: 10.1016/j.ando.2023.01.007. PMID: 36758896

Thyrotoxic Periodic Paralysis and Complicated Thyrotoxicosis, Two Presentations of Hyperthyroidism with Notable Differences in their Clinical Manifestations: An Experience from a Tertiary Care Hospital in the United States.

Rivas AM, Thavaraputta S, Orellana-Barrios MA, Payne JD, Sotello D, Vinan-Vega M, Lado-Abeal J
Endocr Pract 2020 Jul;26(7):699-706. Epub 2020 Nov 24 doi: 10.4158/EP-2019-0454. PMID: 33471637

Thyrotoxic periodic paralysis: A retrospective, observational study from India.

Verma V, Kumar Y, Kotwal N, Upreti V, Hari Kumar KVS, Singh Y, Menon AS
Indian J Med Res 2020 Jan;151(1):42-46. doi: 10.4103/ijmr.IJMR_335_18. PMID: 32134013 Free PMC Article

Is thyrotoxic periodic paralysis a disease caused by muscle membrane dysfunction?

Son YR, Kim NH, Kim DG, Park KS
Muscle Nerve 2017 Oct;56(4):780-786. Epub 2017 Mar 21 doi: 10.1002/mus.25532. PMID: 28006864

Clinical features and recovery patterns of acquired non-thyrotoxic hypokalemic paralysis.

Hiraga A, Kamitsukasa I, Kojima K, Kuwabara S
J Neurol Sci 2012 Feb 15;313(1-2):42-5. Epub 2011 Oct 13 doi: 10.1016/j.jns.2011.09.034. PMID: 22000401

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Thyrotoxic periodic paralysis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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