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Lung adenocarcinoma

MedGen UID:
57744
Concept ID:
C0152013
Neoplastic Process
Synonyms: Adenocarcinoma of lung; Adenocarcinoma of lung, somatic
SNOMED CT: Adenocarcinoma of lung (254626006)
 
HPO: HP:0030078
OMIM®: 211980

Definition

A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor. [from NCI]

Conditions with this feature

Lung cancer
MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
A primary or metastatic malignant neoplasm involving the lung.
Lung carcinoma
MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008).
Li-Fraumeni syndrome 1
MedGen UID:
322656
Concept ID:
C1835398
Disease or Syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and adult-onset malignancies. The lifetime risk of cancer in individuals with LFS is =70% for men and =90% for women. Five cancer types account for the majority of LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, osteosarcomas, and soft-tissue sarcomas. LFS is associated with an increased risk of several additional cancers including leukemia, lymphoma, gastrointestinal cancers, cancers of head and neck, kidney, larynx, lung, skin (e.g., melanoma), ovary, pancreas, prostate, testis, and thyroid. Individuals with LFS are at increased risk for cancer in childhood and young adulthood; survivors are at increased risk for multiple primary cancers.
Tumor susceptibility linked to germline BAP1 mutations
MedGen UID:
482122
Concept ID:
C3280492
Disease or Syndrome
BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical Spitz tumors), and the following cancers, in descending order of frequency: uveal (eye) melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), renal cell carcinoma (RCC), and basal cell carcinoma (BCC). Hepatocellular carcinoma, cholangiocarcinoma, and meningioma may also be associated with BAP1-TPDS. Affected individuals can have more than one type of primary cancer. In general, the median age of onset of these tumors is younger than in the general population. UM tends to be a more aggressive class 2 tumor with higher risk for metastasis and reduced survival compared to UM occurring in the general population. Due to the limited number of families reported to date, the penetrance, natural history, and frequencies of BAP1-associated tumors are yet to be determined. Other suspected but unconfirmed tumors in BAP1-TPDS include (in alphabetic order): breast cancer, neuroendocrine carcinoma, non-small-cell lung adenocarcinoma, thyroid cancer, and urinary bladder cancer.
Fanconi renotubular syndrome 5
MedGen UID:
1711127
Concept ID:
C5394473
Disease or Syndrome
Fanconi renotubular syndrome-5 (FRTS5) is a mitochondrial disorder characterized by proximal renotubular dysfunction from birth, followed by progressive kidney disease and pulmonary fibrosis. It occurs only in individuals of Acadian descent (Crocker et al., 1997 and Hartmannova et al., 2016). For a discussion of genetic heterogeneity of Fanconi renotubular syndrome, see FRTS1 (134600).

Professional guidelines

PubMed

Leighl NB, Rekhtman N, Biermann WA, Huang J, Mino-Kenudson M, Ramalingam SS, West H, Whitlock S, Somerfield MR
J Clin Oncol 2014 Nov 10;32(32):3673-9. Epub 2014 Oct 13 doi: 10.1200/JCO.2014.57.3055. PMID: 25311215Free PMC Article
Kim H, Shim HS, Kim L, Kim TJ, Kwon KY, Lee GK, Chung JH; Korean Cardiopulmonary Pathology Study Group.
Korean J Pathol 2014 Feb;48(1):1-9. Epub 2014 Feb 25 doi: 10.4132/KoreanJPathol.2014.48.1.1. PMID: 24627688Free PMC Article
Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M, College of American Pathologists International Association for the Study of Lung Cancer and Association for Molecular Pathology
J Mol Diagn 2013 Jul;15(4):415-53. Epub 2013 Apr 4 doi: 10.1016/j.jmoldx.2013.03.001. PMID: 23562183

External

EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer

Recent clinical studies

Etiology

Chen S, Han F, Huang D, Meng J, Chu J, Wang M, Wang P
J Transl Med 2021 Aug 9;19(1):337. doi: 10.1186/s12967-021-02971-7. PMID: 34372869Free PMC Article
Zhou LM, Yuan LL, Gao Y, Liu XS, Dai Q, Yang JW, Pei ZJ
Eur J Nucl Med Mol Imaging 2021 Mar;48(3):904-912. Epub 2020 Aug 27 doi: 10.1007/s00259-020-05005-4. PMID: 32856112
Deng S, Zhang Z, Lu X, Zhou Q, Xia S, Li M
Aging (Albany NY) 2020 Oct 28;12(20):20413-20431. doi: 10.18632/aging.103836. PMID: 33115964Free PMC Article
Zengin T, Önal-Süzek T
BMC Bioinformatics 2020 Sep 30;21(Suppl 14):368. doi: 10.1186/s12859-020-03691-3. PMID: 32998690Free PMC Article
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626

Diagnosis

Chen S, Han F, Huang D, Meng J, Chu J, Wang M, Wang P
J Transl Med 2021 Aug 9;19(1):337. doi: 10.1186/s12967-021-02971-7. PMID: 34372869Free PMC Article
Lou L, Wang J, Lv F, Wang G, Li Y, Xing L, Shen H, Zhang X
Cell Oncol (Dordr) 2021 Feb;44(1):109-133. Epub 2020 Sep 7 doi: 10.1007/s13402-020-00556-y. PMID: 32894437
Zhou LM, Yuan LL, Gao Y, Liu XS, Dai Q, Yang JW, Pei ZJ
Eur J Nucl Med Mol Imaging 2021 Mar;48(3):904-912. Epub 2020 Aug 27 doi: 10.1007/s00259-020-05005-4. PMID: 32856112
Deng S, Zhang Z, Lu X, Zhou Q, Xia S, Li M
Aging (Albany NY) 2020 Oct 28;12(20):20413-20431. doi: 10.18632/aging.103836. PMID: 33115964Free PMC Article
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626

Therapy

Liu J, Hao J, Niu Y, Wu X
J Cancer Res Clin Oncol 2021 Jul;147(7):2079-2092. Epub 2021 Apr 2 doi: 10.1007/s00432-020-03488-0. PMID: 33797608
Oktay E, Oflazoglu U, Varol Y, Tanriverdi O, Mermur N, Arda HU, Demir L, Keskin O, Ahmadli T, Somali I, Oztop I, Meydan N
J Cancer Res Ther 2020 Jul-Sep;16(4):737-744. doi: 10.4103/jcrt.JCRT_1404_16. PMID: 32930112
Xiao J, Chen X, Lu X, Xie M, He B, He S, You S, Chen Q
Thorac Cancer 2020 Aug;11(8):2209-2223. Epub 2020 Jun 11 doi: 10.1111/1759-7714.13528. PMID: 32529777Free PMC Article
Huang Z, Gao Y, Hou D
Hum Cell 2020 Jul;33(3):850-858. Epub 2020 May 25 doi: 10.1007/s13577-020-00373-3. PMID: 32452013
Dong Y, Yang W, Wang J, Zhao J, Qiang Y, Zhao Z, Kazihise NGF, Cui Y, Yang X, Liu S
BMC Bioinformatics 2019 Nov 14;20(1):578. doi: 10.1186/s12859-019-3172-z. PMID: 31726986Free PMC Article

Prognosis

Lv D, Luo X, Chen Z, Liu J, Liu M, Li Y, Huang S, Tang M, Yang L, Lu L, Jiang J, Zhou Q, Xie F, Zhong C, Li L, Chen L
Life Sci 2021 Sep 15;281:119763. Epub 2021 Jun 26 doi: 10.1016/j.lfs.2021.119763. PMID: 34186050
Lou L, Wang J, Lv F, Wang G, Li Y, Xing L, Shen H, Zhang X
Cell Oncol (Dordr) 2021 Feb;44(1):109-133. Epub 2020 Sep 7 doi: 10.1007/s13402-020-00556-y. PMID: 32894437
Zhou LM, Yuan LL, Gao Y, Liu XS, Dai Q, Yang JW, Pei ZJ
Eur J Nucl Med Mol Imaging 2021 Mar;48(3):904-912. Epub 2020 Aug 27 doi: 10.1007/s00259-020-05005-4. PMID: 32856112
Xu Y, Wu H, Wu L, Xu L, Li J, Wang Q, Pu X
Int J Biol Macromol 2020 Dec 1;164:1294-1303. Epub 2020 Jul 19 doi: 10.1016/j.ijbiomac.2020.07.172. PMID: 32698071
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626

Clinical prediction guides

Lv D, Luo X, Chen Z, Liu J, Liu M, Li Y, Huang S, Tang M, Yang L, Lu L, Jiang J, Zhou Q, Xie F, Zhong C, Li L, Chen L
Life Sci 2021 Sep 15;281:119763. Epub 2021 Jun 26 doi: 10.1016/j.lfs.2021.119763. PMID: 34186050
Lou L, Wang J, Lv F, Wang G, Li Y, Xing L, Shen H, Zhang X
Cell Oncol (Dordr) 2021 Feb;44(1):109-133. Epub 2020 Sep 7 doi: 10.1007/s13402-020-00556-y. PMID: 32894437
Zhou LM, Yuan LL, Gao Y, Liu XS, Dai Q, Yang JW, Pei ZJ
Eur J Nucl Med Mol Imaging 2021 Mar;48(3):904-912. Epub 2020 Aug 27 doi: 10.1007/s00259-020-05005-4. PMID: 32856112
Xu Y, Wu H, Wu L, Xu L, Li J, Wang Q, Pu X
Int J Biol Macromol 2020 Dec 1;164:1294-1303. Epub 2020 Jul 19 doi: 10.1016/j.ijbiomac.2020.07.172. PMID: 32698071
Chen C, Tian X, Zhao X, Ren L
Curr Probl Cancer 2020 Dec;44(6):100584. Epub 2020 May 21 doi: 10.1016/j.currproblcancer.2020.100584. PMID: 32475626

Recent systematic reviews

Chen D, Mao Y, Ding Q, Wang W, Zhu F, Chen C, Chen Y
Eur J Cardiothorac Surg 2020 Nov 1;58(5):888-898. doi: 10.1093/ejcts/ezaa172. PMID: 32596715
Li F, Yang L, Zhao Y, Yuan L, Wang S, Mao Y
Int J Surg 2019 Dec;72:175-184. Epub 2019 Nov 9 doi: 10.1016/j.ijsu.2019.10.047. PMID: 31715310
Jiang L, Mino-Kenudson M, Roden AC, Rosell R, Molina MÁ, Flores RM, Pilz LR, Brunelli A, Venuta F, He J; AME Lung Cancer Collaborative Group.
Eur J Surg Oncol 2019 May;45(5):870-876. Epub 2019 Feb 16 doi: 10.1016/j.ejso.2019.02.006. PMID: 30833014
Miyahara N, Nii K, Benazzo A, Hoda MA, Iwasaki A, Klepetko W, Klikovits T, Hoetzenecker K
Eur J Surg Oncol 2019 Jul;45(7):1156-1162. Epub 2019 Feb 4 doi: 10.1016/j.ejso.2019.01.220. PMID: 30772108
Roca E, Gurizzan C, Amoroso V, Vermi W, Ferrari V, Berruti A
Cancer Treat Rev 2017 Sep;59:117-122. Epub 2017 Jul 31 doi: 10.1016/j.ctrv.2017.07.007. PMID: 28806542

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