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Abnormal liver function

MedGen UID:
39248
•Concept ID:
C0086565
•
Finding
Synonyms: Dysfunction, Liver; Dysfunctions, Liver; Liver Dysfunction; Liver Dysfunctions
SNOMED CT: Abnormal liver function (75183008); Abnormal hepatic function (75183008)

Definition

A finding that indicates abnormal liver function. [from NCI]

Recent clinical studies

Etiology

The Prevalence of Gastrointestinal Symptoms, Abnormal Liver Function, Digestive System Disease and Liver Disease in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Dong ZY, Xiang BJ, Jiang M, Sun MJ, Dai C
J Clin Gastroenterol 2021 Jan;55(1):67-76. doi: 10.1097/MCG.0000000000001424. PMID: 33116063Free PMC Article
Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations: Findings from two independent surveys.
Yu L, Cai Y, Qin R, Zhao B, Li X
Medicine (Baltimore) 2019 Dec;98(50):e18265. doi: 10.1097/MD.0000000000018265. PMID: 31852096Free PMC Article
Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study of Chinese population.
Song X, Gong W, Shen H, Li X, Ding L, Han L, Zhang H, Zhu B, Liu X
Biomarkers 2018 Mar;23(2):147-153. Epub 2017 Aug 14 doi: 10.1080/1354750X.2017.1360942. PMID: 28749186
Distribution of Diseases Causing Liver Function Test Abnormality in Children and Natural Recovery Time of the Abnormal Liver Function.
Jang M, Oh MS, Oh SC, Kang KS
J Korean Med Sci 2016 Nov;31(11):1784-1789. doi: 10.3346/jkms.2016.31.11.1784. PMID: 27709857Free PMC Article
Genetic Variations in the Promoter of the APE1 Gene Are Associated with DMF-Induced Abnormal Liver Function: A Case-Control Study in a Chinese Population.
Tong Z, Shen H, Yang D, Zhang F, Bai Y, Li Q, Shi J, Zhang H, Zhu B
Int J Environ Res Public Health 2016 Jul 25;13(8) doi: 10.3390/ijerph13080752. PMID: 27463724Free PMC Article

Diagnosis

The Prevalence of Gastrointestinal Symptoms, Abnormal Liver Function, Digestive System Disease and Liver Disease in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Dong ZY, Xiang BJ, Jiang M, Sun MJ, Dai C
J Clin Gastroenterol 2021 Jan;55(1):67-76. doi: 10.1097/MCG.0000000000001424. PMID: 33116063Free PMC Article
Prevalence of Abnormal Liver Function Tests in COVID-19 Patients at a Tertiary Care Centre.
Kaushik A, Wani SN, Baba MA, Agarwal AK
J Assoc Physicians India 2020 Aug;68(8):73-75. PMID: 32738845
Abnormal Liver Function Tests of Patients with Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis.
Xin S, Xu J, Yu Y
J Gastrointestin Liver Dis 2020 Jun 3;29(2):219-226. doi: 10.15403/jgld-2513. PMID: 32530989
Outcome of High Level Procalcitonin (PCT) without Evidence of Infection in Patients with End Stage Renal Disease (ESRD) Accompanied by Abnormal Liver Function: a Case Report.
Jin M, Liu J, Chen X, Zhao S, Xu C
Clin Lab 2020 Apr 1;66(4) doi: 10.7754/Clin.Lab.2019.190827. PMID: 32255308
Distribution of Diseases Causing Liver Function Test Abnormality in Children and Natural Recovery Time of the Abnormal Liver Function.
Jang M, Oh MS, Oh SC, Kang KS
J Korean Med Sci 2016 Nov;31(11):1784-1789. doi: 10.3346/jkms.2016.31.11.1784. PMID: 27709857Free PMC Article

Therapy

Abnormal Liver Function Tests of Patients with Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis.
Xin S, Xu J, Yu Y
J Gastrointestin Liver Dis 2020 Jun 3;29(2):219-226. doi: 10.15403/jgld-2513. PMID: 32530989
Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations: Findings from two independent surveys.
Yu L, Cai Y, Qin R, Zhao B, Li X
Medicine (Baltimore) 2019 Dec;98(50):e18265. doi: 10.1097/MD.0000000000018265. PMID: 31852096Free PMC Article
Catalase C-262T Polymorphism Is a Risk Factor for Valproic Acid-Induced Abnormal Liver Function in Chinese Patients With Epilepsy.
Ma L, Pan Y, Sun M, Shen H, Zhao L, Guo Y
Ther Drug Monit 2019 Feb;41(1):91-96. doi: 10.1097/FTD.0000000000000574. PMID: 30422963
Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study of Chinese population.
Song X, Gong W, Shen H, Li X, Ding L, Han L, Zhang H, Zhu B, Liu X
Biomarkers 2018 Mar;23(2):147-153. Epub 2017 Aug 14 doi: 10.1080/1354750X.2017.1360942. PMID: 28749186
Genetic Variations in the Promoter of the APE1 Gene Are Associated with DMF-Induced Abnormal Liver Function: A Case-Control Study in a Chinese Population.
Tong Z, Shen H, Yang D, Zhang F, Bai Y, Li Q, Shi J, Zhang H, Zhu B
Int J Environ Res Public Health 2016 Jul 25;13(8) doi: 10.3390/ijerph13080752. PMID: 27463724Free PMC Article

Prognosis

The Utility of Liver Biopsy in the Evaluation of Liver Disease and Abnormal Liver Function Tests.
Khalifa A, Lewin DN, Sasso R, Rockey DC
Am J Clin Pathol 2021 Jul 6;156(2):259-267. doi: 10.1093/ajcp/aqaa225. PMID: 33693456Free PMC Article
Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis.
Bertolini A, van de Peppel IP, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G
Hepatology 2020 Nov;72(5):1864-1872. Epub 2020 Oct 20 doi: 10.1002/hep.31480. PMID: 32702162Free PMC Article
Clinical epidemiological analyses of overweight/obesity and abnormal liver function contributing to prolonged hospitalization in patients infected with COVID-19.
Hu X, Pan X, Zhou W, Gu X, Shen F, Yang B, Hu Z
Int J Obes (Lond) 2020 Aug;44(8):1784-1789. Epub 2020 Jun 22 doi: 10.1038/s41366-020-0634-3. PMID: 32572128Free PMC Article
Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations: Findings from two independent surveys.
Yu L, Cai Y, Qin R, Zhao B, Li X
Medicine (Baltimore) 2019 Dec;98(50):e18265. doi: 10.1097/MD.0000000000018265. PMID: 31852096Free PMC Article
Factors for hepatitis B vaccination and abnormal liver function in Chinese patients with inflammatory bowel disease: a single center experience.
Leung WK, Liu KSh, Seto WK, Chan KH, Tong T, Yuen MF, Lai CL, Hung IF
J Dig Dis 2013 Nov;14(11):596-603. doi: 10.1111/1751-2980.12089. PMID: 23870196

Clinical prediction guides

Prevalence of Abnormal Liver Function Tests in COVID-19 Patients at a Tertiary Care Centre.
Kaushik A, Wani SN, Baba MA, Agarwal AK
J Assoc Physicians India 2020 Aug;68(8):73-75. PMID: 32738845
Abnormal liver function tests associated with severe rhabdomyolysis.
Lim AK
World J Gastroenterol 2020 Mar 14;26(10):1020-1028. doi: 10.3748/wjg.v26.i10.1020. PMID: 32205993Free PMC Article
Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations: Findings from two independent surveys.
Yu L, Cai Y, Qin R, Zhao B, Li X
Medicine (Baltimore) 2019 Dec;98(50):e18265. doi: 10.1097/MD.0000000000018265. PMID: 31852096Free PMC Article
Analysis of 15 patients with abnormal liver function as the first systemic lupus erythematosus symptom.
Gao Y, Li W, Meng QH, Liu HX, Zhu YK
Acta Gastroenterol Belg 2016 Sep-Dec;79(2):441-446. PMID: 28209103
Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes.
Kim JH, Lee MR, Hong YC
Environ Res 2016 May;147:324-30. Epub 2016 Feb 27 doi: 10.1016/j.envres.2016.02.026. PMID: 26922413

Recent systematic reviews

The Prevalence of Gastrointestinal Symptoms, Abnormal Liver Function, Digestive System Disease and Liver Disease in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Dong ZY, Xiang BJ, Jiang M, Sun MJ, Dai C
J Clin Gastroenterol 2021 Jan;55(1):67-76. doi: 10.1097/MCG.0000000000001424. PMID: 33116063Free PMC Article
Abnormal Liver Function Tests of Patients with Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis.
Xin S, Xu J, Yu Y
J Gastrointestin Liver Dis 2020 Jun 3;29(2):219-226. doi: 10.15403/jgld-2513. PMID: 32530989
Paracetamol versus placebo for knee and hip osteoarthritis.
Leopoldino AO, Machado GC, Ferreira PH, Pinheiro MB, Day R, McLachlan AJ, Hunter DJ, Ferreira ML
Cochrane Database Syst Rev 2019 Feb 25;2:CD013273. doi: 10.1002/14651858.CD013273. PMID: 30801133Free PMC Article
A systematic review of the prevalence of mildly abnormal liver function tests and associated health outcomes.
Radcke S, Dillon JF, Murray AL
Eur J Gastroenterol Hepatol 2015 Jan;27(1):1-7. doi: 10.1097/MEG.0000000000000233. PMID: 25380394
Antipsychotics and abnormal liver function tests: systematic review.
Marwick KF, Taylor M, Walker SW
Clin Neuropharmacol 2012 Sep-Oct;35(5):244-53. doi: 10.1097/WNF.0b013e31826818b6. PMID: 22986798

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