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Idiopathic membranous glomerulonephritis

MedGen UID:
39226
•Concept ID:
C0086445
•
Disease or Syndrome
Synonyms: Glomerulonephritides, Idiopathic Membranous; Glomerulonephritis, Idiopathic Membranous; Idiopathic Membranous Glomerulonephritides; Idiopathic Membranous Glomerulonephritis; Idiopathic Membranous Nephropathy; Membranous Glomerulonephritides, Idiopathic; Membranous Glomerulonephritis, Idiopathic; Membranous Nephropathy, Idiopathic; Nephropathy, Idiopathic Membranous
SNOMED CT: Idiopathic membranous glomerulonephritis (722119002); Idiopathic membranous nephropathy (722119002)
 
Monarch Initiative: MONDO:0013860
Orphanet: ORPHA97560

Definition

Glomerulonephritis with electron dense deposits in the glomerular basement membrane; after exclusion of membranous nephropathy caused by malignancy, systemic lupus erythematosus, drugs, or infection. Includes membranous nephropathy associated with autoantibodies to the phospholipase A2 receptor1. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic membranous glomerulonephritis

Professional guidelines

PubMed

Membranous glomerulonephritis: treatment response and outcome in children.
Valentini RP, Mattoo TK, Kapur G, Imam A
Pediatr Nephrol 2009 Feb;24(2):301-8. Epub 2008 Oct 10 doi: 10.1007/s00467-008-1005-9. PMID: 18846392
Conservative versus immunosuppressive treatment of patients with idiopathic membranous nephropathy.
Torres A, Domínguez-Gil B, Carreño A, Hernández E, Morales E, Segura J, González E, Praga M
Kidney Int 2002 Jan;61(1):219-27. doi: 10.1046/j.1523-1755.2002.00124.x. PMID: 11786104
Treatment of aggressive idiopathic membranous glomerulonephritis.
Winearls CG, Sanderson F
Q J Med 1994 Apr;87(4):199-201. PMID: 8208909

Recent clinical studies

Etiology

Establishment of Galectin-3 Time-resolved Fluoroimmunoassay and its Application in Idiopathic Membranous Nephropathy.
Yu X, Chen L, Lin B, Zhang L, Yang X, Liu X, Xia P, Liu Y, Zheng S, Zhou X, Wang Y, Qin Y, Wang L, Hu Z, He Q, Huang B
J Fluoresc 2022 Mar;32(2):629-636. Epub 2022 Jan 13 doi: 10.1007/s10895-022-02888-4. PMID: 35025017
Recurrent glomerulonephritis after kidney transplantation: a practical approach.
De Souza L, Prunster J, Chan D, Chakera A, Lim WH
Curr Opin Organ Transplant 2021 Aug 1;26(4):360-380. doi: 10.1097/MOT.0000000000000887. PMID: 34039882
Recurrent and de novo Glomerulonephritis After Kidney Transplantation.
Lim WH, Shingde M, Wong G
Front Immunol 2019;10:1944. Epub 2019 Aug 14 doi: 10.3389/fimmu.2019.01944. PMID: 31475005Free PMC Article
Membranous glomerulonephritis and malignancy.
Burstein DM, Korbet SM, Schwartz MM
Am J Kidney Dis 1993 Jul;22(1):5-10. doi: 10.1016/s0272-6386(12)70160-9. PMID: 8322793
The therapy of idiopathic membranous glomerulonephritis.
Glassock RJ
Semin Nephrol 1991 Mar;11(2):138-47. PMID: 2034923

Diagnosis

Establishment of Galectin-3 Time-resolved Fluoroimmunoassay and its Application in Idiopathic Membranous Nephropathy.
Yu X, Chen L, Lin B, Zhang L, Yang X, Liu X, Xia P, Liu Y, Zheng S, Zhou X, Wang Y, Qin Y, Wang L, Hu Z, He Q, Huang B
J Fluoresc 2022 Mar;32(2):629-636. Epub 2022 Jan 13 doi: 10.1007/s10895-022-02888-4. PMID: 35025017
Recurrent glomerulonephritis after kidney transplantation: a practical approach.
De Souza L, Prunster J, Chan D, Chakera A, Lim WH
Curr Opin Organ Transplant 2021 Aug 1;26(4):360-380. doi: 10.1097/MOT.0000000000000887. PMID: 34039882
Enigma (partially) resolved: phospholipase A2 receptor is the cause of "idiopathic" membranous glomerulonephritis.
Truong LD, Seshan SV
Am J Physiol Renal Physiol 2015 Dec 15;309(12):F1000-2. Epub 2015 Sep 23 doi: 10.1152/ajprenal.00264.2015. PMID: 26400544
Membranous glomerulonephritis and malignancy.
Burstein DM, Korbet SM, Schwartz MM
Am J Kidney Dis 1993 Jul;22(1):5-10. doi: 10.1016/s0272-6386(12)70160-9. PMID: 8322793
Membranous glomerulonephritis.
Harrison DJ, Thomson D, MacDonald MK
J Clin Pathol 1986 Feb;39(2):167-71. doi: 10.1136/jcp.39.2.167. PMID: 3950037Free PMC Article

Therapy

Recurrent glomerulonephritis after kidney transplantation: a practical approach.
De Souza L, Prunster J, Chan D, Chakera A, Lim WH
Curr Opin Organ Transplant 2021 Aug 1;26(4):360-380. doi: 10.1097/MOT.0000000000000887. PMID: 34039882
Recurrent and de novo Glomerulonephritis After Kidney Transplantation.
Lim WH, Shingde M, Wong G
Front Immunol 2019;10:1944. Epub 2019 Aug 14 doi: 10.3389/fimmu.2019.01944. PMID: 31475005Free PMC Article
Pre- and Posttransplant Refractory Idiopathic Membranous Glomerulonephritis: The Forgotten Potential Culprit.
Barbari A
Exp Clin Transplant 2017 Oct;15(5):483-489. Epub 2017 Aug 28 doi: 10.6002/ect.2017.0185. PMID: 28847264
Idiopathic membranous glomerulonephritis.
Cattran DC
Kidney Int 2001 May;59(5):1983-94. doi: 10.1046/j.1523-1755.2001.0590051983.x. PMID: 11318974
The therapy of idiopathic membranous glomerulonephritis.
Glassock RJ
Semin Nephrol 1991 Mar;11(2):138-47. PMID: 2034923

Prognosis

The Role of IgG4 in Autoimmunity and Rheumatic Diseases.
Maslinska M, Dmowska-Chalaba J, Jakubaszek M
Front Immunol 2021;12:787422. Epub 2022 Jan 25 doi: 10.3389/fimmu.2021.787422. PMID: 35145508Free PMC Article
Recurrent glomerulonephritis after kidney transplantation: a practical approach.
De Souza L, Prunster J, Chan D, Chakera A, Lim WH
Curr Opin Organ Transplant 2021 Aug 1;26(4):360-380. doi: 10.1097/MOT.0000000000000887. PMID: 34039882
Recurrent and de novo Glomerulonephritis After Kidney Transplantation.
Lim WH, Shingde M, Wong G
Front Immunol 2019;10:1944. Epub 2019 Aug 14 doi: 10.3389/fimmu.2019.01944. PMID: 31475005Free PMC Article
Pre- and Posttransplant Refractory Idiopathic Membranous Glomerulonephritis: The Forgotten Potential Culprit.
Barbari A
Exp Clin Transplant 2017 Oct;15(5):483-489. Epub 2017 Aug 28 doi: 10.6002/ect.2017.0185. PMID: 28847264
Idiopathic membranous glomerulonephritis.
Cattran DC
Kidney Int 2001 May;59(5):1983-94. doi: 10.1046/j.1523-1755.2001.0590051983.x. PMID: 11318974

Clinical prediction guides

Establishment of Galectin-3 Time-resolved Fluoroimmunoassay and its Application in Idiopathic Membranous Nephropathy.
Yu X, Chen L, Lin B, Zhang L, Yang X, Liu X, Xia P, Liu Y, Zheng S, Zhou X, Wang Y, Qin Y, Wang L, Hu Z, He Q, Huang B
J Fluoresc 2022 Mar;32(2):629-636. Epub 2022 Jan 13 doi: 10.1007/s10895-022-02888-4. PMID: 35025017
Recurrent and de novo Glomerulonephritis After Kidney Transplantation.
Lim WH, Shingde M, Wong G
Front Immunol 2019;10:1944. Epub 2019 Aug 14 doi: 10.3389/fimmu.2019.01944. PMID: 31475005Free PMC Article
Pre- and Posttransplant Refractory Idiopathic Membranous Glomerulonephritis: The Forgotten Potential Culprit.
Barbari A
Exp Clin Transplant 2017 Oct;15(5):483-489. Epub 2017 Aug 28 doi: 10.6002/ect.2017.0185. PMID: 28847264
Enigma (partially) resolved: phospholipase A2 receptor is the cause of "idiopathic" membranous glomerulonephritis.
Truong LD, Seshan SV
Am J Physiol Renal Physiol 2015 Dec 15;309(12):F1000-2. Epub 2015 Sep 23 doi: 10.1152/ajprenal.00264.2015. PMID: 26400544
Membranous glomerulonephritis.
Harrison DJ, Thomson D, MacDonald MK
J Clin Pathol 1986 Feb;39(2):167-71. doi: 10.1136/jcp.39.2.167. PMID: 3950037Free PMC Article

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