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Infantile eczema

MedGen UID:
43301
•Concept ID:
C0086196
•
Disease or Syndrome
Synonyms: Eczema, Infantile; Infantile Eczema
SNOMED CT: Infantile eczema (90823000)

Professional guidelines

PubMed

Parental issues in the treatment of chronic infantile eczema.
Koblenzer PJ
Dermatol Clin 1996 Jul;14(3):423-7. doi: 10.1016/s0733-8635(05)70369-7. PMID: 8818551
Hydrocortisone ointment in the treatment of infantile eczema.
HILL LW
N Engl J Med 1955 Jun 16;252(24):1038-9. doi: 10.1056/NEJM195506162522408. PMID: 14383959
Oral cortisone treatment of infantile eczema.
HILL LW
N Engl J Med 1953 Jun 18;248(25):1051-6. doi: 10.1056/NEJM195306182482503. PMID: 13054885

Recent clinical studies

Etiology

Maternal yogurt consumption during pregnancy and infantile eczema: a prospective cohort study.
Tan T, Xiao D, Li Q, Zhong C, Hu W, Guo J, Chen X, Zhang H, Lin L, Yang S, Xiong G, Yang H, Yang X, Hao L, Yang N
Food Funct 2023 Feb 21;14(4):1929-1936. doi: 10.1039/d2fo02064e. PMID: 36723007
The relationship between vitamin D levels in umbilical cord blood and infantile eczema.
Liu YY, Zhou XJ, Li YC
J Obstet Gynaecol 2022 Oct;42(7):2813-2817. Epub 2022 Aug 18 doi: 10.1080/01443615.2022.2109948. PMID: 35980725
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, Crozier SR, Inskip H, Cooper C, Harvey NC, Godfrey KM; MAVIDOS Trial Group
Br J Dermatol 2022 Nov;187(5):659-666. Epub 2022 Aug 3 doi: 10.1111/bjd.21721. PMID: 35763390Free PMC Article
Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies.
Haider S, Fontanella S, Ullah A, Turner S, Simpson A, Roberts G, Murray CS, Holloway JW, Curtin JA, Cullinan P, Arshad SH, Hurault G, Granell R, Custovic A; STELAR/UNICORN investigators
Am J Respir Crit Care Med 2022 Oct 15;206(8):950-960. doi: 10.1164/rccm.202110-2418OC. PMID: 35679320Free PMC Article
Association between sites and severity of eczema and the onset of cow's milk and egg allergy in children.
Kawada S, Futamura M, Hashimoto H, Ono M, Akita N, Sekimizu M, Hattori H, Goto M, Horibe K, Maeda N
PLoS One 2020;15(10):e0240980. Epub 2020 Oct 19 doi: 10.1371/journal.pone.0240980. PMID: 33075082Free PMC Article

Diagnosis

Maternal yogurt consumption during pregnancy and infantile eczema: a prospective cohort study.
Tan T, Xiao D, Li Q, Zhong C, Hu W, Guo J, Chen X, Zhang H, Lin L, Yang S, Xiong G, Yang H, Yang X, Hao L, Yang N
Food Funct 2023 Feb 21;14(4):1929-1936. doi: 10.1039/d2fo02064e. PMID: 36723007
Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta-analysis, and recommendation for uniform use of 'atopic dermatitis'.
Kantor R, Thyssen JP, Paller AS, Silverberg JI
Allergy 2016 Oct;71(10):1480-5. Epub 2016 Aug 3 doi: 10.1111/all.12982. PMID: 27392131Free PMC Article
Maternal consumption of dairy products, calcium, and vitamin D during pregnancy and infantile allergic disorders.
Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M
Ann Allergy Asthma Immunol 2014 Jul;113(1):82-7. doi: 10.1016/j.anai.2014.04.023. PMID: 24950846
Atopic dermatitis/atopic eczema.
Wallach D, Taïeb A
Chem Immunol Allergy 2014;100:81-96. Epub 2014 May 22 doi: 10.1159/000358606. PMID: 24925387
Food allergy testing in infantile eczema: a clinical approach and algorithm.
Newland K, Warren L, Gold M
Australas J Dermatol 2013 May;54(2):79-84. Epub 2012 Jun 12 doi: 10.1111/j.1440-0960.2012.00911.x. PMID: 22686941

Therapy

The relationship between vitamin D levels in umbilical cord blood and infantile eczema.
Liu YY, Zhou XJ, Li YC
J Obstet Gynaecol 2022 Oct;42(7):2813-2817. Epub 2022 Aug 18 doi: 10.1080/01443615.2022.2109948. PMID: 35980725
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, Crozier SR, Inskip H, Cooper C, Harvey NC, Godfrey KM; MAVIDOS Trial Group
Br J Dermatol 2022 Nov;187(5):659-666. Epub 2022 Aug 3 doi: 10.1111/bjd.21721. PMID: 35763390Free PMC Article
Outdoor environment, ozone, radionuclide-associated aerosols and incidences of infantile eczema in Minsk, Belarus.
Belugina IN, Yagovdik NZ, Belugina OS, Belugin SN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1977-1985. Epub 2018 May 29 doi: 10.1111/jdv.15063. PMID: 29730889
Vitamin D deficiency in mothers, neonates and children.
Elsori DH, Hammoud MS
J Steroid Biochem Mol Biol 2018 Jan;175:195-199. Epub 2017 Feb 5 doi: 10.1016/j.jsbmb.2017.01.023. PMID: 28179126
Evidence of preventive effect of probiotics and prebiotics for infantile eczema.
Eigenmann PA
Curr Opin Allergy Clin Immunol 2013 Aug;13(4):426-31. doi: 10.1097/ACI.0b013e3283630bad. PMID: 23799337

Prognosis

Breast milk flora plays an important role in infantile eczema: cohort study in Northeast China.
Wu Y, Zhou X, Zhang X, Niu H, Lyu L, Liang C, Chen S, Gong P, Pan J, Li Y, Jiang S, Han X, Zhang L
J Appl Microbiol 2021 Dec;131(6):2981-2993. Epub 2021 May 11 doi: 10.1111/jam.15076. PMID: 33735474
Outdoor environment, ozone, radionuclide-associated aerosols and incidences of infantile eczema in Minsk, Belarus.
Belugina IN, Yagovdik NZ, Belugina OS, Belugin SN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1977-1985. Epub 2018 May 29 doi: 10.1111/jdv.15063. PMID: 29730889
The temporal sequence of allergic sensitization and onset of infantile eczema.
Lowe AJ, Abramson MJ, Hosking CS, Carlin JB, Bennett CM, Dharmage SC, Hill DJ
Clin Exp Allergy 2007 Apr;37(4):536-42. doi: 10.1111/j.1365-2222.2007.02691.x. PMID: 17430350
Ten-year prognosis for generalized infantile eczema.
Linna O, Kokkonen J, Lahtela P, Tammela O
Acta Paediatr 1992 Dec;81(12):1013-6. doi: 10.1111/j.1651-2227.1992.tb12165.x. PMID: 1290844
Immunological aspects of human milk.
Chandra RK
Nutr Rev 1978 Sep;36(9):265-72. doi: 10.1111/j.1753-4887.1978.tb07393.x. PMID: 362248

Clinical prediction guides

The positive effect of mother-performed infant massage on infantile eczema and maternal mental state: A randomized controlled trial.
Lin L, Yu L, Zhang S, Liu J, Xiong Y
Front Public Health 2022;10:1068043. Epub 2023 Jan 11 doi: 10.3389/fpubh.2022.1068043. PMID: 36711419Free PMC Article
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, Crozier SR, Inskip H, Cooper C, Harvey NC, Godfrey KM; MAVIDOS Trial Group
Br J Dermatol 2022 Nov;187(5):659-666. Epub 2022 Aug 3 doi: 10.1111/bjd.21721. PMID: 35763390Free PMC Article
Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies.
Haider S, Fontanella S, Ullah A, Turner S, Simpson A, Roberts G, Murray CS, Holloway JW, Curtin JA, Cullinan P, Arshad SH, Hurault G, Granell R, Custovic A; STELAR/UNICORN investigators
Am J Respir Crit Care Med 2022 Oct 15;206(8):950-960. doi: 10.1164/rccm.202110-2418OC. PMID: 35679320Free PMC Article
Outdoor environment, ozone, radionuclide-associated aerosols and incidences of infantile eczema in Minsk, Belarus.
Belugina IN, Yagovdik NZ, Belugina OS, Belugin SN
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1977-1985. Epub 2018 May 29 doi: 10.1111/jdv.15063. PMID: 29730889
Atopic dermatitis in 2008.
Chan LS
Curr Dir Autoimmun 2008;10:76-118. doi: 10.1159/000131450. PMID: 18460882

Recent systematic reviews

What are the highest yielding search strategy terms for systematic reviews in atopic dermatitis? A systematic review.
Ayasse MT, Ahmed A, Espinosa ML, Walker CJ, Yousaf M, Thyssen JP, Silverberg JI
Arch Dermatol Res 2021 Nov;313(9):737-750. Epub 2020 Nov 22 doi: 10.1007/s00403-020-02165-z. PMID: 33221950
Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta-analysis, and recommendation for uniform use of 'atopic dermatitis'.
Kantor R, Thyssen JP, Paller AS, Silverberg JI
Allergy 2016 Oct;71(10):1480-5. Epub 2016 Aug 3 doi: 10.1111/all.12982. PMID: 27392131Free PMC Article
The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies.
Alduraywish SA, Lodge CJ, Campbell B, Allen KJ, Erbas B, Lowe AJ, Dharmage SC
Allergy 2016 Jan;71(1):77-89. Epub 2015 Nov 4 doi: 10.1111/all.12784. PMID: 26466117
Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis.
Zuccotti G, Meneghin F, Aceti A, Barone G, Callegari ML, Di Mauro A, Fantini MP, Gori D, Indrio F, Maggio L, Morelli L, Corvaglia L; Italian Society of Neonatology
Allergy 2015 Nov;70(11):1356-71. Epub 2015 Aug 13 doi: 10.1111/all.12700. PMID: 26198702

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