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Gestational diabetes

MedGen UID:
38815
Concept ID:
C0085207
Disease or Syndrome
Synonyms: Diabetes mellitus, gestational; Maternal diabetes
SNOMED CT: Gestational diabetes (11687002); Maternal gestational diabetes mellitus (11687002); Diabetes mellitus arising in pregnancy (11687002); Gestational diabetes mellitus (11687002); GDM - gestational diabetes mellitus (11687002)
 
HPO: HP:0009800
Monarch Initiative: MONDO:0005406

Definition

Gestational diabetes is a disorder characterized by abnormally high levels of blood glucose (also called blood sugar) during pregnancy. Affected women do not have diabetes before they are pregnant, and most of these women go back to being nondiabetic soon after the baby is born. The disease has a 30 to 70 percent chance of recurring in subsequent pregnancies. Additionally, about half of women with gestational diabetes develop another form of diabetes, known as type 2 diabetes, within a few years after their pregnancy.

Gestational diabetes is often discovered during the second trimester of pregnancy. Most affected women have no symptoms, and the disease is discovered through routine screening at their obstetrician's office. If untreated, gestational diabetes increases the risk of pregnancy-associated high blood pressure (called preeclampsia) and early (premature) delivery of the baby.

Babies of mothers with gestational diabetes tend to be large (macrosomia), which can cause complications during birth. Infants whose mothers have gestational diabetes are also more likely to develop dangerously low blood glucose levels soon after birth. Later in life, these individuals have an increased risk of developing obesity, heart disease, and type 2 diabetes. [from MedlinePlus Genetics]

Professional guidelines

PubMed

Echouffo-Tcheugui JB, Perreault L, Ji L, Dagogo-Jack S
JAMA 2023 Apr 11;329(14):1206-1216. doi: 10.1001/jama.2023.4063. PMID: 37039787
Lende M, Rijhsinghani A
Int J Environ Res Public Health 2020 Dec 21;17(24) doi: 10.3390/ijerph17249573. PMID: 33371325Free PMC Article
Obstet Gynecol 2018 Feb;131(2):e49-e64. doi: 10.1097/AOG.0000000000002501. PMID: 29370047

Curated

UK NICE Guideline NG3, Diabetes in pregnancy: management from preconception to the postnatal period

Recent clinical studies

Etiology

Sweeting A, Hannah W, Backman H, Catalano P, Feghali M, Herman WH, Hivert MF, Immanuel J, Meek C, Oppermann ML, Nolan CJ, Ram U, Schmidt MI, Simmons D, Chivese T, Benhalima K
Lancet 2024 Jul 13;404(10448):175-192. Epub 2024 Jun 20 doi: 10.1016/S0140-6736(24)00825-0. PMID: 38909620
Champion ML, Battarbee AN, Biggio JR, Casey BM, Harper LM
Am J Obstet Gynecol MFM 2022 May;4(3):100609. Epub 2022 Mar 7 doi: 10.1016/j.ajogmf.2022.100609. PMID: 35272093Free PMC Article
Chatzakis C, Cavoretto P, Sotiriadis A
Curr Pharm Des 2021;27(36):3833-3840. doi: 10.2174/1381612827666210125155428. PMID: 33550962
Lende M, Rijhsinghani A
Int J Environ Res Public Health 2020 Dec 21;17(24) doi: 10.3390/ijerph17249573. PMID: 33371325Free PMC Article
Hernandez TL, Mande A, Barbour LA
Diabetes Res Clin Pract 2018 Nov;145:39-50. Epub 2018 Apr 19 doi: 10.1016/j.diabres.2018.04.004. PMID: 29679625Free PMC Article

Diagnosis

Sweeting A, Hannah W, Backman H, Catalano P, Feghali M, Herman WH, Hivert MF, Immanuel J, Meek C, Oppermann ML, Nolan CJ, Ram U, Schmidt MI, Simmons D, Chivese T, Benhalima K
Lancet 2024 Jul 13;404(10448):175-192. Epub 2024 Jun 20 doi: 10.1016/S0140-6736(24)00825-0. PMID: 38909620
Moholdt T
Nutrients 2023 May 10;15(10) doi: 10.3390/nu15102251. PMID: 37242134Free PMC Article
Lende M, Rijhsinghani A
Int J Environ Res Public Health 2020 Dec 21;17(24) doi: 10.3390/ijerph17249573. PMID: 33371325Free PMC Article
Obstet Gynecol 2018 Feb;131(2):e49-e64. doi: 10.1097/AOG.0000000000002501. PMID: 29370047
Mack LR, Tomich PG
Obstet Gynecol Clin North Am 2017 Jun;44(2):207-217. doi: 10.1016/j.ogc.2017.02.002. PMID: 28499531

Therapy

Pérez-López FR, Pilz S, Chedraui P
Curr Opin Obstet Gynecol 2020 Oct;32(5):316-321. doi: 10.1097/GCO.0000000000000641. PMID: 32487800
Davenport MH, Ruchat SM, Poitras VJ, Jaramillo Garcia A, Gray CE, Barrowman N, Skow RJ, Meah VL, Riske L, Sobierajski F, James M, Kathol AJ, Nuspl M, Marchand AA, Nagpal TS, Slater LG, Weeks A, Adamo KB, Davies GA, Barakat R, Mottola MF
Br J Sports Med 2018 Nov;52(21):1367-1375. doi: 10.1136/bjsports-2018-099355. PMID: 30337463
Yamamoto JM, Kellett JE, Balsells M, García-Patterson A, Hadar E, Solà I, Gich I, van der Beek EM, Castañeda-Gutiérrez E, Heinonen S, Hod M, Laitinen K, Olsen SF, Poston L, Rueda R, Rust P, van Lieshout L, Schelkle B, Murphy HR, Corcoy R
Diabetes Care 2018 Jul;41(7):1346-1361. doi: 10.2337/dc18-0102. PMID: 29934478
Shepherd E, Gomersall JC, Tieu J, Han S, Crowther CA, Middleton P
Cochrane Database Syst Rev 2017 Nov 13;11(11):CD010443. doi: 10.1002/14651858.CD010443.pub3. PMID: 29129039Free PMC Article
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article

Prognosis

Lende M, Rijhsinghani A
Int J Environ Res Public Health 2020 Dec 21;17(24) doi: 10.3390/ijerph17249573. PMID: 33371325Free PMC Article
Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL
BMJ 2020 May 13;369:m1361. doi: 10.1136/bmj.m1361. PMID: 32404325Free PMC Article
Genco RJ, Graziani F, Hasturk H
Periodontol 2000 2020 Jun;83(1):59-65. doi: 10.1111/prd.12271. PMID: 32385875
Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A, Manolis A
Curr Vasc Pharmacol 2020;18(2):104-109. doi: 10.2174/1570161117666190405165911. PMID: 30961501
Spaight C, Gross J, Horsch A, Puder JJ
Endocr Dev 2016;31:163-78. Epub 2016 Jan 19 doi: 10.1159/000439413. PMID: 26824237

Clinical prediction guides

Yang MN, Zhang L, Wang WJ, Huang R, He H, Zheng T, Zhang GH, Fang F, Cheng J, Li F, Ouyang F, Li J, Zhang J, Luo ZC
BMC Pregnancy Childbirth 2024 Sep 16;24(1):601. doi: 10.1186/s12884-024-06651-4. PMID: 39285345Free PMC Article
Nayak SS, Kuriyakose D, Polisetty LD, Patil AA, Ameen D, Bonu R, Shetty SP, Biswas P, Ulrich MT, Letafatkar N, Habibi A, Keivanlou MH, Nobakht S, Alotaibi A, Hassanipour S, Amini-Salehi E
Cardiovasc Diabetol 2024 Aug 23;23(1):310. doi: 10.1186/s12933-024-02392-y. PMID: 39180024Free PMC Article
Leonard SA, Kennedy CJ, Carmichael SL, Lyell DJ, Main EK
Obstet Gynecol 2020 Sep;136(3):440-449. doi: 10.1097/AOG.0000000000004022. PMID: 32769656Free PMC Article
Lorenzo-Almorós A, Hang T, Peiró C, Soriano-Guillén L, Egido J, Tuñón J, Lorenzo Ó
Cardiovasc Diabetol 2019 Oct 30;18(1):140. doi: 10.1186/s12933-019-0935-9. PMID: 31666083Free PMC Article
Appelman Y, van Rijn BB, Ten Haaf ME, Boersma E, Peters SA
Atherosclerosis 2015 Jul;241(1):211-8. Epub 2015 Jan 28 doi: 10.1016/j.atherosclerosis.2015.01.027. PMID: 25670232

Recent systematic reviews

Malaza N, Masete M, Adam S, Dias S, Nyawo T, Pheiffer C
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710846. PMID: 36078559Free PMC Article
Keating N, Coveney C, McAuliffe FM, Higgins MF
Int J Environ Res Public Health 2022 Aug 30;19(17) doi: 10.3390/ijerph191710791. PMID: 36078508Free PMC Article
Karavasileiadou S, Almegwely W, Alanazi A, Alyami H, Chatzimichailidou S
Glob Health Action 2022 Dec 31;15(1):2087298. doi: 10.1080/16549716.2022.2087298. PMID: 35867537Free PMC Article
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728Free PMC Article
Mijatovic-Vukas J, Capling L, Cheng S, Stamatakis E, Louie J, Cheung NW, Markovic T, Ross G, Senior A, Brand-Miller JC, Flood VM
Nutrients 2018 May 30;10(6) doi: 10.3390/nu10060698. PMID: 29849003Free PMC Article

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    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Guideline NG3, Diabetes in pregnancy: management from preconception to the postnatal period

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