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Malignant lymphoma, large B-cell, diffuse

MedGen UID:
Concept ID:
Neoplastic Process
Synonym: Diffuse large B cell lymphoma
SNOMED CT: Diffuse malignant lymphoma - histiocytic (109969005); Diffuse malignant lymphoma - large cell (109969005); Malignant lymphoma - large cell cleaved and non-cleaved (109969005); Diffuse non-Hodgkin's lymphoma, large cell (clinical) (109969005); Diffuse non-Hodgkin's lymphoma, large cell (109969005); Diffuse non-Hodgkin lymphoma, large cell (109969005); Lymphoma, diffuse large B cell, non Hodgkins (109969005); DLBCL - diffuse large B cell lymphoma (109969005); Diffuse large B cell lymphoma (1172695008); Diffuse large B cell malignant lymphoma (1172695008); Large B-cell malignant lymphoma (1172695008); Large cell malignant lymphoma (1172695008); Centroblastic diffuse large B-cell malignant lymphoma (1172695008); Centroblastic diffuse malignant lymphoma (1172695008); Histiocytic malignant lymphoma (1172695008); Centroblastic malignant lymphoma (1172695008); Histiocytic diffuse malignant lymphoma (1172695008); Diffuse large cleaved cell malignant lymphoma (1172695008); Large noncleaved cell malignant lymphoma (1172695008); Noncleaved malignant lymphoma (1172695008); Diffuse large noncleaved cell malignant lymphoma (1172695008); Large cleaved cell and noncleaved cell malignant lymphoma (1172695008); Large cleaved cell malignant lymphoma (1172695008)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
Concept ID:
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
Concept ID:
Source: Orphanet
clinical entity without genetic inheritance.
Monarch Initiative: MONDO:0018905
Orphanet: ORPHA544


Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant lymphoma, large B-cell, diffuse
Follow this link to review classifications for Malignant lymphoma, large B-cell, diffuse in Orphanet.

Professional guidelines


Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159


NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

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    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.


    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

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