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Unipolar Depression

MedGen UID:
22552
Concept ID:
C0041696
Mental or Behavioral Dysfunction
Synonyms: Depression, Unipolar; Depressions, Unipolar; Unipolar Depressions
 
OMIM®: 608516

Definition

A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts. [from NCI]

Professional guidelines

PubMed

Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article
Dubovsky SL, Ghosh BM, Serotte JC, Cranwell V
Psychother Psychosom 2021;90(3):160-177. Epub 2020 Nov 9 doi: 10.1159/000511348. PMID: 33166960
Selph SS, McDonagh MS
Am Fam Physician 2019 Nov 15;100(10):609-617. PMID: 31730312

Recent clinical studies

Etiology

Jefsen OH, Erlangsen A, Nordentoft M, Hjorthøj C
JAMA Psychiatry 2023 Aug 1;80(8):803-810. doi: 10.1001/jamapsychiatry.2023.1256. PMID: 37223912Free PMC Article
Siegel-Ramsay JE, Bertocci MA, Wu B, Phillips ML, Strakowski SM, Almeida JRC
Bipolar Disord 2022 Aug;24(5):474-498. Epub 2022 Jan 30 doi: 10.1111/bdi.13176. PMID: 35060259
McIntyre RS, Calabrese JR
Curr Med Res Opin 2019 Nov;35(11):1993-2005. Epub 2019 Aug 5 doi: 10.1080/03007995.2019.1636017. PMID: 31311335
Hirschfeld RM
J Affect Disord 2014 Dec;169 Suppl 1:S12-6. doi: 10.1016/S0165-0327(14)70004-7. PMID: 25533909
Phillips ML, Kupfer DJ
Lancet 2013 May 11;381(9878):1663-71. doi: 10.1016/S0140-6736(13)60989-7. PMID: 23663952Free PMC Article

Diagnosis

Jefsen OH, Erlangsen A, Nordentoft M, Hjorthøj C
JAMA Psychiatry 2023 Aug 1;80(8):803-810. doi: 10.1001/jamapsychiatry.2023.1256. PMID: 37223912Free PMC Article
Siegel-Ramsay JE, Bertocci MA, Wu B, Phillips ML, Strakowski SM, Almeida JRC
Bipolar Disord 2022 Aug;24(5):474-498. Epub 2022 Jan 30 doi: 10.1111/bdi.13176. PMID: 35060259
McIntyre RS, Calabrese JR
Curr Med Res Opin 2019 Nov;35(11):1993-2005. Epub 2019 Aug 5 doi: 10.1080/03007995.2019.1636017. PMID: 31311335
Han KM, De Berardis D, Fornaro M, Kim YK
Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 20;91:20-27. Epub 2018 Mar 28 doi: 10.1016/j.pnpbp.2018.03.022. PMID: 29601896
Phillips ML, Kupfer DJ
Lancet 2013 May 11;381(9878):1663-71. doi: 10.1016/S0140-6736(13)60989-7. PMID: 23663952Free PMC Article

Therapy

Ekstrand J, Fattah C, Persson M, Cheng T, Nordanskog P, Åkeson J, Tingström A, Lindström MB, Nordenskjöld A, Movahed Rad P
Int J Neuropsychopharmacol 2022 May 27;25(5):339-349. doi: 10.1093/ijnp/pyab088. PMID: 35020871Free PMC Article
Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article
Kvam S, Kleppe CL, Nordhus IH, Hovland A
J Affect Disord 2016 Sep 15;202:67-86. Epub 2016 May 20 doi: 10.1016/j.jad.2016.03.063. PMID: 27253219
Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA
J Affect Disord 2015 Jul 15;180:179-84. Epub 2015 Mar 31 doi: 10.1016/j.jad.2015.03.021. PMID: 25911132
Hirschfeld RM
J Affect Disord 2014 Dec;169 Suppl 1:S12-6. doi: 10.1016/S0165-0327(14)70004-7. PMID: 25533909

Prognosis

Gukasyan N, Davis AK, Barrett FS, Cosimano MP, Sepeda ND, Johnson MW, Griffiths RR
J Psychopharmacol 2022 Feb;36(2):151-158. doi: 10.1177/02698811211073759. PMID: 35166158Free PMC Article
Gollan JK, Yang A, Ciolino JD, Sit D, Wisner KL
Psychiatry Res 2021 Dec;306:114274. Epub 2021 Nov 9 doi: 10.1016/j.psychres.2021.114274. PMID: 34837882
Benasi G, Fava GA, Guidi J
Psychother Psychosom 2021;90(6):365-372. Epub 2021 Jul 20 doi: 10.1159/000517953. PMID: 34350890
Dubovsky SL, Ghosh BM, Serotte JC, Cranwell V
Psychother Psychosom 2021;90(3):160-177. Epub 2020 Nov 9 doi: 10.1159/000511348. PMID: 33166960
Taiminen T
Duodecim 2017;133(1):52-60. PMID: 29199810

Clinical prediction guides

Morcos N, Strominger J
J ECT 2022 Dec 1;38(4):224-229. Epub 2022 Apr 14 doi: 10.1097/YCT.0000000000000853. PMID: 35462391
Gukasyan N, Davis AK, Barrett FS, Cosimano MP, Sepeda ND, Johnson MW, Griffiths RR
J Psychopharmacol 2022 Feb;36(2):151-158. doi: 10.1177/02698811211073759. PMID: 35166158Free PMC Article
Ekstrand J, Fattah C, Persson M, Cheng T, Nordanskog P, Åkeson J, Tingström A, Lindström MB, Nordenskjöld A, Movahed Rad P
Int J Neuropsychopharmacol 2022 May 27;25(5):339-349. doi: 10.1093/ijnp/pyab088. PMID: 35020871Free PMC Article
Baptist J, Thompson DE, Spencer C, Mowla MR, Love HA, Su Y
Psychiatry Res 2021 Feb;296:113696. Epub 2020 Dec 29 doi: 10.1016/j.psychres.2020.113696. PMID: 33387752
Oudart E, Hanak C, Ammendola S
Psychiatr Danub 2020 Sep;32(Suppl 1):188-193. PMID: 32890388

Recent systematic reviews

Yildiz A, Siafis S, Mavridis D, Vieta E, Leucht S
Lancet Psychiatry 2023 Sep;10(9):693-705. doi: 10.1016/S2215-0366(23)00199-2. PMID: 37595997
Siegel-Ramsay JE, Bertocci MA, Wu B, Phillips ML, Strakowski SM, Almeida JRC
Bipolar Disord 2022 Aug;24(5):474-498. Epub 2022 Jan 30 doi: 10.1111/bdi.13176. PMID: 35060259
Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article
Dean RL, Hurducas C, Hawton K, Spyridi S, Cowen PJ, Hollingsworth S, Marquardt T, Barnes A, Smith R, McShane R, Turner EH, Cipriani A
Cochrane Database Syst Rev 2021 Sep 12;9(9):CD011612. doi: 10.1002/14651858.CD011612.pub3. PMID: 34510411Free PMC Article
Rosenblat JD, Carvalho AF, Li M, Lee Y, Subramanieapillai M, McIntyre RS
J Clin Psychiatry 2019 Apr 16;80(3) doi: 10.4088/JCP.18r12475. PMID: 30995364

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