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Thrombotic disease

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
Synonyms: Blood clot; Blood clots; Thrombosis; Thrombotic disorder
SNOMED CT: Thrombotic disorder (118927008); Thrombosis (439127006); Thrombosis (264579008)
 
Monarch Initiative: MONDO:0000831

Definition

The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury. [from NCI]

Recent clinical studies

Etiology

Ten Cate V, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS
Chest 2020 Jul;158(1):341-349. Epub 2020 Mar 23 doi: 10.1016/j.chest.2020.01.055. PMID: 32217063
Panova-Noeva M, Eggebrecht L, Prochaska JH, Wild PS
Hamostaseologie 2019 Jun;39(2):152-163. Epub 2019 Feb 5 doi: 10.1055/s-0038-1677520. PMID: 30722070
Liang S, Zhang Y, Gao X, Zhao H, Di B, Sheng Q, Liu R
Angiology 2019 Jan;70(1):62-68. Epub 2018 Jun 21 doi: 10.1177/0003319718782807. PMID: 29929375
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G
J Exp Med 2017 Jul 3;214(7):2121-2138. Epub 2017 May 31 doi: 10.1084/jem.20161070. PMID: 28566277Free PMC Article
Zhao L, Li C, Yin Q, Zhang Q, Shao R, Fang Y
Thromb Res 2014 Nov;134(5):1057-65. Epub 2014 Jul 17 doi: 10.1016/j.thromres.2014.07.014. PMID: 25081832

Diagnosis

van Dam LF, Kroft LJM, van der Wal LI, Cannegieter SC, Eikenboom J, de Jonge E, Huisman MV, Klok FA
Thromb Res 2020 Sep;193:86-89. Epub 2020 Jun 6 doi: 10.1016/j.thromres.2020.06.010. PMID: 32531548Free PMC Article
Ten Cate V, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS
Chest 2020 Jul;158(1):341-349. Epub 2020 Mar 23 doi: 10.1016/j.chest.2020.01.055. PMID: 32217063
Panova-Noeva M, Eggebrecht L, Prochaska JH, Wild PS
Hamostaseologie 2019 Jun;39(2):152-163. Epub 2019 Feb 5 doi: 10.1055/s-0038-1677520. PMID: 30722070
Liang S, Zhang Y, Gao X, Zhao H, Di B, Sheng Q, Liu R
Angiology 2019 Jan;70(1):62-68. Epub 2018 Jun 21 doi: 10.1177/0003319718782807. PMID: 29929375
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G
J Exp Med 2017 Jul 3;214(7):2121-2138. Epub 2017 May 31 doi: 10.1084/jem.20161070. PMID: 28566277Free PMC Article

Therapy

Ten Cate V, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS
Chest 2020 Jul;158(1):341-349. Epub 2020 Mar 23 doi: 10.1016/j.chest.2020.01.055. PMID: 32217063
Yap HY, Loa J, Tosenovsky PJ, Lee SQ, Chong TT, Tang TY
Phlebology 2020 Sep;35(8):545-547. Epub 2020 Jan 28 doi: 10.1177/0268355520901661. PMID: 31992130
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304
Liang S, Zhang Y, Gao X, Zhao H, Di B, Sheng Q, Liu R
Angiology 2019 Jan;70(1):62-68. Epub 2018 Jun 21 doi: 10.1177/0003319718782807. PMID: 29929375
Flaumenhaft R, Furie B, Zwicker JI
Arterioscler Thromb Vasc Biol 2015 Jan;35(1):16-23. Epub 2014 Aug 7 doi: 10.1161/ATVBAHA.114.303410. PMID: 25104801Free PMC Article

Prognosis

Ten Cate V, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T, Rapp S, Arnold N, Lackner KJ, Konstantinides S, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS
Chest 2020 Jul;158(1):341-349. Epub 2020 Mar 23 doi: 10.1016/j.chest.2020.01.055. PMID: 32217063
Isordia-Salas I, Martínez-Marino M, Alberti-Minutti P, Ricardo-Moreno MT, Castro-Calvo R, Santiago-Germán D, Alvarado-Moreno JA, Calleja-Carreño C, Hernández-Juárez J, Leaños-Miranda A, Majluf-Cruz A
Dis Markers 2019;2019:3745735. Epub 2019 Oct 30 doi: 10.1155/2019/3745735. PMID: 31781299Free PMC Article
Jovanovic L, Subota V, Stavric M, Subotic B, Dzudovic B, Novicic N, Matijasevic J, Miric M, Salinger S, Markovic-Nikolic N, Nikolic M, Miloradovic V, Kos L, Kovacevic-Preradovic T, Marinkovic J, Kocev N, Obradovic S
Clin Chim Acta 2019 May;492:78-83. Epub 2019 Feb 12 doi: 10.1016/j.cca.2019.02.008. PMID: 30768927
Panova-Noeva M, Eggebrecht L, Prochaska JH, Wild PS
Hamostaseologie 2019 Jun;39(2):152-163. Epub 2019 Feb 5 doi: 10.1055/s-0038-1677520. PMID: 30722070
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G
J Exp Med 2017 Jul 3;214(7):2121-2138. Epub 2017 May 31 doi: 10.1084/jem.20161070. PMID: 28566277Free PMC Article

Clinical prediction guides

van Dam LF, Kroft LJM, van der Wal LI, Cannegieter SC, Eikenboom J, de Jonge E, Huisman MV, Klok FA
Thromb Res 2020 Sep;193:86-89. Epub 2020 Jun 6 doi: 10.1016/j.thromres.2020.06.010. PMID: 32531548Free PMC Article
Jovanovic L, Subota V, Stavric M, Subotic B, Dzudovic B, Novicic N, Matijasevic J, Miric M, Salinger S, Markovic-Nikolic N, Nikolic M, Miloradovic V, Kos L, Kovacevic-Preradovic T, Marinkovic J, Kocev N, Obradovic S
Clin Chim Acta 2019 May;492:78-83. Epub 2019 Feb 12 doi: 10.1016/j.cca.2019.02.008. PMID: 30768927
Panova-Noeva M, Eggebrecht L, Prochaska JH, Wild PS
Hamostaseologie 2019 Jun;39(2):152-163. Epub 2019 Feb 5 doi: 10.1055/s-0038-1677520. PMID: 30722070
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G
J Exp Med 2017 Jul 3;214(7):2121-2138. Epub 2017 May 31 doi: 10.1084/jem.20161070. PMID: 28566277Free PMC Article
Martin-Fernandez L, Marco P, Corrales I, Pérez R, Ramírez L, López S, Vidal F, Soria JM
Sci Rep 2016 Dec 15;6:39255. doi: 10.1038/srep39255. PMID: 27976734Free PMC Article

Recent systematic reviews

Rodriguez JJ, Munoz OC, Porres-Aguilar M, Mukherjee D
Cardiovasc Hematol Disord Drug Targets 2021;21(1):23-29. doi: 10.2174/1871529X21666210315123347. PMID: 33719953
Bashar K, Shalan A, Sharafat Ali S, Tang T, Tiwari A
Vasa 2021 Jan;50(1):22-29. Epub 2020 Oct 13 doi: 10.1024/0301-1526/a000911. PMID: 33047662
Zhang Y, Zhang Z, Shu S, Niu W, Xie W, Wan J, Zhai Z, Wang C
J Thromb Thrombolysis 2021 Feb;51(2):359-369. doi: 10.1007/s11239-020-02203-7. PMID: 32623564
Klein SK, Slim EJ, de Kruif MD, Keller TT, ten Cate H, van Gorp EC, Brandjes DP
Neth J Med 2005 Apr;63(4):129-36. PMID: 15869040
Bijsterveld NR, Hettiarachchi R, Peters R, Prins MH, Levi M, Büller HR
Thromb Haemost 1999 Sep;82 Suppl 1:139-47. PMID: 10695506

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