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Sarcoma, Experimental

MedGen UID:
20652
•Concept ID:
C0036216
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Sarcoma; Experimental Sarcomas; Sarcomas, Experimental

Definition

Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcoma, Experimental

Professional guidelines

PubMed

4-amino-2-phenyl-6-(p-fluorophenyl)-5-carbonitrile-pyrimidine-bis-substituted-loaded liposomes as promising system for cancer treatment.
Oliveira JV, Almeida GC, Nogueira MCBL, Aguiar Júnior FCA, Melo AO, Silva TDS, Santos NPS, Magalhães NSS, Melo SJ, Falcão EPS
An Acad Bras Cienc 2023;95(suppl 1):e20211078. Epub 2023 Jul 10 doi: 10.1590/0001-3765202320211078. PMID: 37436228
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article

Recent clinical studies

Etiology

Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101).
Carmagnani Pestana R, Moyers JT, Roszik J, Sen S, Hong DS, Naing A, Herzog CE, Fu S, Piha-Paul SA, Rodon J, Yap TA, Karp DD, Tsimberidou AM, Pant S, Zarzour MA, Ratan R, Ravi V, Benjamin RS, Lazar AJ, Wang WL, Daw N, Gill JB, Harrison DJ, Lewis VO, Roland CL, Patel SR, Livingston JA, Somaiah N, Ludwig JA, Conley AP, Hamerschlak N, Gorlick R, Meric-Bernstam F, Subbiah V
Clin Cancer Res 2023 May 1;29(9):1708-1718. doi: 10.1158/1078-0432.CCR-22-3629. PMID: 37058010Free PMC Article
The anticancer peptide RT53 induces immunogenic cell death.
Pasquereau-Kotula E, Habault J, Kroemer G, Poyet JL
PLoS One 2018;13(8):e0201220. Epub 2018 Aug 6 doi: 10.1371/journal.pone.0201220. PMID: 30080874Free PMC Article
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article
The high mobility group protein, HMGI-C.
Goodwin G
Int J Biochem Cell Biol 1998 Jul;30(7):761-6. doi: 10.1016/s1357-2725(98)00016-8. PMID: 9722980
Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.
Epstein AL, Levy R, Kim H, Henle W, Henle G, Kaplan HS
Cancer 1978 Nov;42(5):2379-91. doi: 10.1002/1097-0142(197811)42:5<2379::aid-cncr2820420539>3.0.co;2-4. PMID: 214220

Diagnosis

Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma.
Mooney B, Negri GL, Shyp T, Delaidelli A, Zhang HF, Spencer Miko SE, Weiner AK, Radaoui AB, Shraim R, Lizardo MM, Hughes CS, Li A, El-Naggar AM, Rouleau M, Li W, Dimitrov DS, Kurmasheva RT, Houghton PJ, Diskin SJ, Maris JM, Morin GB, Sorensen PH
Clin Cancer Res 2024 Mar 1;30(5):1022-1037. doi: 10.1158/1078-0432.CCR-23-2187. PMID: 37812652Free PMC Article
Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101).
Carmagnani Pestana R, Moyers JT, Roszik J, Sen S, Hong DS, Naing A, Herzog CE, Fu S, Piha-Paul SA, Rodon J, Yap TA, Karp DD, Tsimberidou AM, Pant S, Zarzour MA, Ratan R, Ravi V, Benjamin RS, Lazar AJ, Wang WL, Daw N, Gill JB, Harrison DJ, Lewis VO, Roland CL, Patel SR, Livingston JA, Somaiah N, Ludwig JA, Conley AP, Hamerschlak N, Gorlick R, Meric-Bernstam F, Subbiah V
Clin Cancer Res 2023 May 1;29(9):1708-1718. doi: 10.1158/1078-0432.CCR-22-3629. PMID: 37058010Free PMC Article
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article
Cytogenetic and experimental models.
Fletcher J
Curr Opin Oncol 1992 Aug;4(4):659-66. doi: 10.1097/00001622-199208000-00010. PMID: 1511022
Cell cycle analysis using flow cytometry.
Gray JW, Dolbeare F, Pallavicini MG, Beisker W, Waldman F
Int J Radiat Biol Relat Stud Phys Chem Med 1986 Feb;49(2):237-55. doi: 10.1080/09553008514552531. PMID: 3510993

Therapy

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Dendritic cell immunotherapy in soft tissue sarcoma.
Indelicato DJ, Finkelstein SE
Immunotherapy 2012 Oct;4(10):1023-9. doi: 10.2217/imt.12.106. PMID: 23148754
Cell cycle analysis using flow cytometry.
Gray JW, Dolbeare F, Pallavicini MG, Beisker W, Waldman F
Int J Radiat Biol Relat Stud Phys Chem Med 1986 Feb;49(2):237-55. doi: 10.1080/09553008514552531. PMID: 3510993
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
Rosenberg SA, Spiess P, Lafreniere R
Science 1986 Sep 19;233(4770):1318-21. doi: 10.1126/science.3489291. PMID: 3489291
Carcinogenesis and aging.
Anisimov VN
Adv Cancer Res 1983;40:365-424. doi: 10.1016/s0065-230x(08)60684-3. PMID: 6419551

Prognosis

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article
Establishment of a synovial sarcoma model in athymic nude mice.
Steinstraesser L, Hauk J, Jacobsen F, Stricker I, Steinau HU, Al-Benna S
In Vivo 2011 Mar-Apr;25(2):165-9. PMID: 21471530
Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma.
Fuchs B, Inwards CY, Janknecht R
Clin Cancer Res 2004 Feb 15;10(4):1344-53. doi: 10.1158/1078-0432.ccr-03-0038. PMID: 14977835
Cytogenetic and experimental models.
Fletcher J
Curr Opin Oncol 1992 Aug;4(4):659-66. doi: 10.1097/00001622-199208000-00010. PMID: 1511022

Clinical prediction guides

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ
J Immunother Cancer 2017 Dec 19;5(1):98. doi: 10.1186/s40425-017-0305-7. PMID: 29254507Free PMC Article
p53: functions, mutations and sarcomas.
Hung J, Anderson R
Acta Orthop Scand Suppl 1997 Feb;273:68-73. doi: 10.1080/17453674.1997.11744705. PMID: 9057590
Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines.
Shyam K, Penketh PG, Loomis RH, Rose WC, Sartorelli AC
J Med Chem 1996 Feb 2;39(3):796-801. doi: 10.1021/jm9505021. PMID: 8576923
Reverse transformation of multidrug-resistant cells.
Biedler JL, Spengler BA
Cancer Metastasis Rev 1994 Jun;13(2):191-207. doi: 10.1007/BF00689636. PMID: 7923550

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