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Prostate neoplasm

MedGen UID:
18697
Concept ID:
C0033578
Neoplastic Process
Synonyms: Neoplasm, Prostate; Neoplasm, Prostatic; Neoplasms, Prostate; Neoplasms, Prostatic; Prostate Neoplasm; Prostate Neoplasms; Prostatic Neoplasm; Prostatic Neoplasms
SNOMED CT: Tumor of prostate (126906006); NGP - New growth of prostate (126906006); Neoplasm of prostate (126906006)
 
HPO: HP:0100787
Monarch Initiative: MONDO:0021259

Definition

A benign, borderline, or malignant neoplasm that affects the prostate gland. Representative examples include benign prostate phyllodes tumor, prostatic intraepithelial neoplasia, prostate carcinoma, and prostate sarcoma. [from NCI]

Conditions with this feature

Li-Fraumeni syndrome 1
MedGen UID:
322656
Concept ID:
C1835398
Disease or Syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and adult-onset malignancies. The lifetime risk of cancer in individuals with LFS is =70% for men and =90% for women. Five cancer types account for the majority of LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, osteosarcomas, and soft-tissue sarcomas. LFS is associated with an increased risk of several additional cancers including leukemia, lymphoma, gastrointestinal cancers, cancers of head and neck, kidney, larynx, lung, skin (e.g., melanoma), ovary, pancreas, prostate, testis, and thyroid. Individuals with LFS are at increased risk for cancer in childhood and young adulthood; survivors are at increased risk for multiple primary cancers.

Professional guidelines

PubMed

Sciarra A, Frisenda M, Bevilacqua G, Gentilucci A, Cattarino S, Mariotti G, Del Giudice F, Di Pierro GB, Viscuso P, Casale P, Chung BI, Autorino R, Crivellaro S, Salciccia S
Int J Mol Sci 2022 Dec 30;24(1) doi: 10.3390/ijms24010674. PMID: 36614122Free PMC Article
Alwhaibi A, Alsanea S, Almadi B, Al-Sabhan J, Alosaimi FD
Aging Male 2022 Dec;25(1):101-124. doi: 10.1080/13685538.2022.2053954. PMID: 35343371
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Prostate Cancer, 2024

Recent clinical studies

Etiology

Alwhaibi A, Alsanea S, Almadi B, Al-Sabhan J, Alosaimi FD
Aging Male 2022 Dec;25(1):101-124. doi: 10.1080/13685538.2022.2053954. PMID: 35343371
Lenfant L, Barret E, Rouprêt M, Rozet F, Ploussard G, Mozer P; Cancerology Committee of Association Française d'Urologie (CCAFU)
Eur Urol 2022 Jul;82(1):3-5. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.046. PMID: 35216857
Montaño JJ, Barceló A, Franch P, Galceran J, Ameijide A, Pons J, Ramos M
Int J Environ Res Public Health 2021 Oct 24;18(21) doi: 10.3390/ijerph182111156. PMID: 34769675Free PMC Article
Al Qadire M, Alkhalaileh M, ALBashtawy M
Clin Nurs Res 2019 Nov;28(8):992-1008. Epub 2018 Feb 9 doi: 10.1177/1054773818757311. PMID: 29426230
Monni F, Fontanella P, Grasso A, Wiklund P, Ou YC, Randazzo M, Rocco B, Montanari E, Bianchi G
Minerva Urol Nefrol 2017 Dec;69(6):567-578. Epub 2017 May 8 doi: 10.23736/S0393-2249.17.02819-3. PMID: 28488844

Diagnosis

Lenfant L, Barret E, Rouprêt M, Rozet F, Ploussard G, Mozer P; Cancerology Committee of Association Française d'Urologie (CCAFU)
Eur Urol 2022 Jul;82(1):3-5. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.046. PMID: 35216857
Montaño JJ, Barceló A, Franch P, Galceran J, Ameijide A, Pons J, Ramos M
Int J Environ Res Public Health 2021 Oct 24;18(21) doi: 10.3390/ijerph182111156. PMID: 34769675Free PMC Article
Huang SM, Yin L, Yue JL, Li YF, Yang Y, Lin ZC
Medicine (Baltimore) 2018 Dec;97(50):e13344. doi: 10.1097/MD.0000000000013344. PMID: 30557983Free PMC Article
Monni F, Fontanella P, Grasso A, Wiklund P, Ou YC, Randazzo M, Rocco B, Montanari E, Bianchi G
Minerva Urol Nefrol 2017 Dec;69(6):567-578. Epub 2017 May 8 doi: 10.23736/S0393-2249.17.02819-3. PMID: 28488844
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Therapy

Alwhaibi A, Alsanea S, Almadi B, Al-Sabhan J, Alosaimi FD
Aging Male 2022 Dec;25(1):101-124. doi: 10.1080/13685538.2022.2053954. PMID: 35343371
Miura N, Pradere B, Mori K, Mostafaei H, Quhal F, Misrai V, D'Andrea D, Albisinni S, Papalia R, Saika T, Scarpa RM, Shariat SF, Esperto F
Minerva Urol Nefrol 2020 Oct;72(5):531-542. Epub 2020 Jun 16 doi: 10.23736/S0393-2249.20.03779-0. PMID: 32550632
Maggi M, Gentilucci A, Salciccia S, Gatto A, Gentile V, Colarieti A, Von Heland M, Busetto GM, Del Giudice F, Sciarra A
Andrologia 2019 Feb;51(1):e13157. Epub 2018 Oct 3 doi: 10.1111/and.13157. PMID: 30281167
Al Qadire M, Alkhalaileh M, ALBashtawy M
Clin Nurs Res 2019 Nov;28(8):992-1008. Epub 2018 Feb 9 doi: 10.1177/1054773818757311. PMID: 29426230
Sciarra A, Abrahamsson PA, Brausi M, Galsky M, Mottet N, Sartor O, Tammela TL, Calais da Silva F
Eur Urol 2013 Nov;64(5):722-30. Epub 2013 Apr 19 doi: 10.1016/j.eururo.2013.04.020. PMID: 23628492

Prognosis

Sciarra A, Frisenda M, Bevilacqua G, Gentilucci A, Cattarino S, Mariotti G, Del Giudice F, Di Pierro GB, Viscuso P, Casale P, Chung BI, Autorino R, Crivellaro S, Salciccia S
Int J Mol Sci 2022 Dec 30;24(1) doi: 10.3390/ijms24010674. PMID: 36614122Free PMC Article
Montaño JJ, Barceló A, Franch P, Galceran J, Ameijide A, Pons J, Ramos M
Int J Environ Res Public Health 2021 Oct 24;18(21) doi: 10.3390/ijerph182111156. PMID: 34769675Free PMC Article
Al Qadire M, Alkhalaileh M, ALBashtawy M
Clin Nurs Res 2019 Nov;28(8):992-1008. Epub 2018 Feb 9 doi: 10.1177/1054773818757311. PMID: 29426230
Monni F, Fontanella P, Grasso A, Wiklund P, Ou YC, Randazzo M, Rocco B, Montanari E, Bianchi G
Minerva Urol Nefrol 2017 Dec;69(6):567-578. Epub 2017 May 8 doi: 10.23736/S0393-2249.17.02819-3. PMID: 28488844
Schmidt-Hansen M, Hoskin P, Kirkbride P, Hasler E, Bromham N
Clin Oncol (R Coll Radiol) 2014 Oct;26(10):e21-46. Epub 2014 Jul 21 doi: 10.1016/j.clon.2014.06.016. PMID: 25059922

Clinical prediction guides

Alwhaibi A, Alsanea S, Almadi B, Al-Sabhan J, Alosaimi FD
Aging Male 2022 Dec;25(1):101-124. doi: 10.1080/13685538.2022.2053954. PMID: 35343371
Montaño JJ, Barceló A, Franch P, Galceran J, Ameijide A, Pons J, Ramos M
Int J Environ Res Public Health 2021 Oct 24;18(21) doi: 10.3390/ijerph182111156. PMID: 34769675Free PMC Article
Al Qadire M, Alkhalaileh M, ALBashtawy M
Clin Nurs Res 2019 Nov;28(8):992-1008. Epub 2018 Feb 9 doi: 10.1177/1054773818757311. PMID: 29426230
Monni F, Fontanella P, Grasso A, Wiklund P, Ou YC, Randazzo M, Rocco B, Montanari E, Bianchi G
Minerva Urol Nefrol 2017 Dec;69(6):567-578. Epub 2017 May 8 doi: 10.23736/S0393-2249.17.02819-3. PMID: 28488844
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Recent systematic reviews

Holmes A, Kelly BD, Perera M, Eapen RS, Bolton DM, Lawrentschuk N
World J Urol 2021 Feb;39(2):297-306. Epub 2020 Jun 4 doi: 10.1007/s00345-020-03265-1. PMID: 32500304
Miura N, Pradere B, Mori K, Mostafaei H, Quhal F, Misrai V, D'Andrea D, Albisinni S, Papalia R, Saika T, Scarpa RM, Shariat SF, Esperto F
Minerva Urol Nefrol 2020 Oct;72(5):531-542. Epub 2020 Jun 16 doi: 10.23736/S0393-2249.20.03779-0. PMID: 32550632
Eissa A, Elsherbiny A, Coelho RF, Rassweiler J, Davis JW, Porpiglia F, Patel VR, Prandini N, Micali S, Sighinolfi MC, Puliatti S, Rocco B, Bianchi G
Minerva Urol Nefrol 2018 Oct;70(5):462-478. Epub 2018 Apr 17 doi: 10.23736/S0393-2249.18.03081-3. PMID: 29664244
Monni F, Fontanella P, Grasso A, Wiklund P, Ou YC, Randazzo M, Rocco B, Montanari E, Bianchi G
Minerva Urol Nefrol 2017 Dec;69(6):567-578. Epub 2017 May 8 doi: 10.23736/S0393-2249.17.02819-3. PMID: 28488844
Schmidt-Hansen M, Hoskin P, Kirkbride P, Hasler E, Bromham N
Clin Oncol (R Coll Radiol) 2014 Oct;26(10):e21-46. Epub 2014 Jul 21 doi: 10.1016/j.clon.2014.06.016. PMID: 25059922

Supplemental Content

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    Clinical resources

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Prostate Cancer, 2024

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