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Precancerous condition

MedGen UID:
19442
Concept ID:
C0032927
Neoplastic Process
Synonyms: Condition, Precancerous; Conditions, Precancerous; Precancerous Condition; Precancerous Conditions
 
Monarch Initiative: MONDO:0021074

Definition

A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrecancerous condition

Professional guidelines

PubMed

Miller AC, Adjei S, Temiz LA, Tyring SK
Skin Therapy Lett 2022 Jul;27(4):4-7. PMID: 35857917
Ratcliffe EG, Jankowski JA
Pol Arch Intern Med 2019 Aug 29;129(7-8):516-525. Epub 2019 May 13 doi: 10.20452/pamw.14828. PMID: 31080232
Britton J, Keld R, Prasad N, Hamdy S, McLaughlin J, Ang Y
Lancet Gastroenterol Hepatol 2018 Jan;3(1):57-65. Epub 2017 Sep 29 doi: 10.1016/S2468-1253(17)30213-3. PMID: 28970029

Recent clinical studies

Etiology

Shuman JHB, Lin AS, Westland MD, Bryant KN, Piazuelo MB, Reyzer ML, Judd AM, McDonald WH, McClain MS, Schey KL, Algood HMS, Cover TL
mSystems 2024 Jan 23;9(1):e0109823. Epub 2023 Dec 7 doi: 10.1128/msystems.01098-23. PMID: 38059647Free PMC Article
Dal Buono A, Gaiani F, Poliani L, Laghi L
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101799. Epub 2022 Apr 4 doi: 10.1016/j.bpg.2022.101799. PMID: 35988962
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Rossin D, Calfapietra S, Sottero B, Poli G, Biasi F
Free Radic Biol Med 2017 Oct;111:186-195. Epub 2017 Jan 13 doi: 10.1016/j.freeradbiomed.2017.01.017. PMID: 28089726
Badreddine RJ, Wang KK
Nat Rev Gastroenterol Hepatol 2010 Jul;7(7):369-78. Epub 2010 Jun 1 doi: 10.1038/nrgastro.2010.78. PMID: 20517288

Diagnosis

Sugano K, Moss SF, Kuipers EJ
Gastroenterology 2023 Dec;165(6):1352-1366.e1. Epub 2023 Aug 29 doi: 10.1053/j.gastro.2023.08.028. PMID: 37652306
Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt AR, Schmitt-Graeff A, Kreisel W
World J Gastroenterol 2022 Nov 7;28(41):5893-5909. doi: 10.3748/wjg.v28.i41.5893. PMID: 36405107Free PMC Article
Dal Buono A, Gaiani F, Poliani L, Laghi L
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101799. Epub 2022 Apr 4 doi: 10.1016/j.bpg.2022.101799. PMID: 35988962
Rossin D, Calfapietra S, Sottero B, Poli G, Biasi F
Free Radic Biol Med 2017 Oct;111:186-195. Epub 2017 Jan 13 doi: 10.1016/j.freeradbiomed.2017.01.017. PMID: 28089726
Badreddine RJ, Wang KK
Nat Rev Gastroenterol Hepatol 2010 Jul;7(7):369-78. Epub 2010 Jun 1 doi: 10.1038/nrgastro.2010.78. PMID: 20517288

Therapy

Szasz A
Cells 2024 Jan 21;13(2) doi: 10.3390/cells13020197. PMID: 38275822Free PMC Article
Mehta CH, Paliwal S, Muttigi MS, Seetharam RN, Prasad ASB, Nayak Y, Acharya S, Nayak UY
Inflammopharmacology 2023 Oct;31(5):2349-2368. Epub 2023 Apr 27 doi: 10.1007/s10787-023-01212-1. PMID: 37106237Free PMC Article
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Rossin D, Calfapietra S, Sottero B, Poli G, Biasi F
Free Radic Biol Med 2017 Oct;111:186-195. Epub 2017 Jan 13 doi: 10.1016/j.freeradbiomed.2017.01.017. PMID: 28089726

Prognosis

Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt AR, Schmitt-Graeff A, Kreisel W
World J Gastroenterol 2022 Nov 7;28(41):5893-5909. doi: 10.3748/wjg.v28.i41.5893. PMID: 36405107Free PMC Article
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Britton J, Keld R, Prasad N, Hamdy S, McLaughlin J, Ang Y
Lancet Gastroenterol Hepatol 2018 Jan;3(1):57-65. Epub 2017 Sep 29 doi: 10.1016/S2468-1253(17)30213-3. PMID: 28970029
Zavoral M, Minarikova P, Zavada F, Salek C, Minarik M
World J Gastroenterol 2011 Jun 28;17(24):2897-908. doi: 10.3748/wjg.v17.i24.2897. PMID: 21734801Free PMC Article
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article

Clinical prediction guides

Szasz A
Cells 2024 Jan 21;13(2) doi: 10.3390/cells13020197. PMID: 38275822Free PMC Article
Moungthard H, Thinkhamrop K, Chamadol N, Laopaiboon V, Thinkhamrop B, Kelly M
Asian Pac J Cancer Prev 2023 Dec 1;24(12):4147-4154. doi: 10.31557/APJCP.2023.24.12.4147. PMID: 38156850Free PMC Article
Lin S, Zhang B, Lin Y, Lin Y, Zuo X
Front Cell Infect Microbiol 2022;12:767693. Epub 2022 Feb 14 doi: 10.3389/fcimb.2022.767693. PMID: 35237529Free PMC Article
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Britton J, Keld R, Prasad N, Hamdy S, McLaughlin J, Ang Y
Lancet Gastroenterol Hepatol 2018 Jan;3(1):57-65. Epub 2017 Sep 29 doi: 10.1016/S2468-1253(17)30213-3. PMID: 28970029

Recent systematic reviews

Saavedra JA, Novo DR, Mesko MF, Uchoa Vasconcellos AC, Duarte Da Silva K, Rojas Zuñiga G, Ramires RF, Tarquinio SBC
Asian Pac J Cancer Prev 2022 Mar 1;23(3):1031-1039. doi: 10.31557/APJCP.2022.23.3.1031. PMID: 35345377Free PMC Article
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Godos J, Bella F, Torrisi A, Sciacca S, Galvano F, Grosso G
J Hum Nutr Diet 2016 Dec;29(6):757-767. Epub 2016 Jul 14 doi: 10.1111/jhn.12395. PMID: 27412573
Nakajima S, Hattori T
Aliment Pharmacol Ther 2004 Jul;20 Suppl 1:54-61. doi: 10.1111/j.1365-2036.2004.01975.x. PMID: 15298606

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