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Postmenopausal osteoporosis

MedGen UID:
10498
Concept ID:
C0029458
Disease or Syndrome
Synonyms: BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS; OSTEOPOROSIS, INVOLUTIONAL
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Postmenopausal osteoporosis (102447009); Type I osteoporosis (32369003); Type 1 osteoporosis (32369003); Menopausal osteoporosis (32369003)
 
Genes (locations): CALCR (7q21.3); COL1A1 (17q21.33); COL1A2 (7q21.3); LRP5 (11q13.2); PDLIM4 (5q31.1); VDR (12q13.11)
OMIM®: 166710

Definition

Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency. [from MeSH]

Clinical features

Generalized osteoporosis
MedGen UID:
14535
Concept ID:
C0029456
Disease or Syndrome
Osteoporosis makes your bones weak and more likely to break. Anyone can develop osteoporosis, but it is common in older women. As many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis. Risk factors include . - Getting older . - Being small and thin . - Having a family history of osteoporosis. - Taking certain medicines. - Being a white or Asian woman. - Having osteopenia, which is low bone density. Osteoporosis is a silent disease. You might not know you have it until you break a bone. A bone mineral density test is the best way to check your bone health. To keep bones strong, eat a diet rich in calcium and vitamin D, exercise and do not smoke. If needed, medicines can also help. . NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostmenopausal osteoporosis

Recent clinical studies

Etiology

Zhang Y, Liu H, Zhang C, Zhang T, Zhang B, Li L, Chen G, Fu D, Wang K
Sci Rep 2015 Nov 16;5:16783. doi: 10.1038/srep16783. PMID: 26568273Free PMC Article
Satpathy S, Patra A, Ahirwar B
J Complement Integr Med 2015 Dec;12(4):251-66. doi: 10.1515/jcim-2015-0034. PMID: 26215536
Tian J, Xu XJ, Shen L, Yang YP, Zhu R, Shuai B, Zhu XW, Li CG, Ma C, Lv L
J Huazhong Univ Sci Technolog Med Sci 2015 Apr;35(2):212-8. Epub 2015 Apr 16 doi: 10.1007/s11596-015-1413-6. PMID: 25877354
Zhang J, Fu Q, Ren Z, Wang Y, Wang C, Shen T, Wang G, Wu L
Gynecol Endocrinol 2015 Mar;31(3):183-90. Epub 2014 Nov 11 doi: 10.3109/09513590.2014.975683. PMID: 25384921
Li SM, Zhou DX, Liu MY
Int J Immunogenet 2014 Aug;41(4):324-9. Epub 2014 Jun 11 doi: 10.1111/iji.12130. PMID: 24917365

Diagnosis

Safer U, Safer VB, Demir SO, Yanikoglu I
Endocr Metab Immune Disord Drug Targets 2016;16(1):56-60. PMID: 27026340
Ma M, Chen X, Lu L, Yuan F, Zeng W, Luo S, Yin F, Cai J
Aging Clin Exp Res 2016 Dec;28(6):1067-1074. Epub 2015 Dec 16 doi: 10.1007/s40520-015-0509-y. PMID: 26676054
Liu HF, He HC, Yang L, Yang ZY, Yao K, Wu YC, Yang XB, He CQ
Trials 2015 Jun 10;16:265. doi: 10.1186/s13063-015-0780-4. PMID: 26058489Free PMC Article
Diab DL, Watts NB
Curr Opin Endocrinol Diabetes Obes 2013 Dec;20(6):501-9. doi: 10.1097/01.med.0000436194.10599.94. PMID: 24150190
Marozik P, Mosse I, Alekna V, Rudenko E, Tamulaitienė M, Ramanau H, Strazdienė V, Samokhovec V, Ameliyanovich M, Byshnev N, Gonchar A, Kundas L, Zhur K
Medicina (Kaunas) 2013;49(4):177-84. PMID: 23985982

Therapy

Mukherjee K, Chattopadhyay N
Biochem Pharmacol 2016 Oct 1;117:10-9. Epub 2016 Apr 19 doi: 10.1016/j.bcp.2016.04.010. PMID: 27106079
Ma M, Chen X, Lu L, Yuan F, Zeng W, Luo S, Yin F, Cai J
Aging Clin Exp Res 2016 Dec;28(6):1067-1074. Epub 2015 Dec 16 doi: 10.1007/s40520-015-0509-y. PMID: 26676054
Satpathy S, Patra A, Ahirwar B
J Complement Integr Med 2015 Dec;12(4):251-66. doi: 10.1515/jcim-2015-0034. PMID: 26215536
Jackson RD, Mysiw WJ
Semin Reprod Med 2014 Nov;32(6):454-62. Epub 2014 Oct 16 doi: 10.1055/s-0034-1384629. PMID: 25321423
Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS; Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators.
J Bone Miner Res 2012 Aug;27(8):1821-9. doi: 10.1002/jbmr.1602. PMID: 22437792

Prognosis

You L, Pan L, Chen L, Gu W, Chen J
Cell Physiol Biochem 2016;39(1):253-65. Epub 2016 Jun 24 doi: 10.1159/000445621. PMID: 27337099
Stuss M, Sewerynek E, Król I, Stępień-Kłos W, Jędrzejczyk S
Endokrynol Pol 2016;67(2):174-84. Epub 2016 Feb 17 doi: 10.5603/EP.a2016.0014. PMID: 26884284
Kaleta B, Walicka M, Sawicka A, Bogołowska-Stieblich A, Górski A, Łukaszkiewicz J, Marcinowska-Suchowierska E
Adv Clin Exp Med 2015 Mar-Apr;24(2):239-43. PMID: 25931355
Jackson RD, Mysiw WJ
Semin Reprod Med 2014 Nov;32(6):454-62. Epub 2014 Oct 16 doi: 10.1055/s-0034-1384629. PMID: 25321423
Huang S, Lin H, Zhu X, Chen X, Fan L, Liu C
Endokrynol Pol 2014;65(2):96-104. doi: 10.5603/EP.2014.0014. PMID: 24802732

Clinical prediction guides

Ma M, Chen X, Lu L, Yuan F, Zeng W, Luo S, Yin F, Cai J
Aging Clin Exp Res 2016 Dec;28(6):1067-1074. Epub 2015 Dec 16 doi: 10.1007/s40520-015-0509-y. PMID: 26676054
Tian J, Xu XJ, Shen L, Yang YP, Zhu R, Shuai B, Zhu XW, Li CG, Ma C, Lv L
J Huazhong Univ Sci Technolog Med Sci 2015 Apr;35(2):212-8. Epub 2015 Apr 16 doi: 10.1007/s11596-015-1413-6. PMID: 25877354
Zhang J, Fu Q, Ren Z, Wang Y, Wang C, Shen T, Wang G, Wu L
Gynecol Endocrinol 2015 Mar;31(3):183-90. Epub 2014 Nov 11 doi: 10.3109/09513590.2014.975683. PMID: 25384921
Jackson RD, Mysiw WJ
Semin Reprod Med 2014 Nov;32(6):454-62. Epub 2014 Oct 16 doi: 10.1055/s-0034-1384629. PMID: 25321423
Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS; Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators.
J Bone Miner Res 2012 Aug;27(8):1821-9. doi: 10.1002/jbmr.1602. PMID: 22437792

Recent systematic reviews

Hiligsmann M, Evers SM, Ben Sedrine W, Kanis JA, Ramaekers B, Reginster JY, Silverman S, Wyers CE, Boonen A
Pharmacoeconomics 2015 Mar;33(3):205-24. doi: 10.1007/s40273-014-0231-1. PMID: 25377850
Ohta H, Hamaya E, Taketsuna M, Sowa H
Curr Med Res Opin 2015 Jan;31(1):85-94. Epub 2014 Oct 28 doi: 10.1185/03007995.2014.975339. PMID: 25299349
Eriksen EF, Díez-Pérez A, Boonen S
Bone 2014 Jan;58:126-35. Epub 2013 Oct 9 doi: 10.1016/j.bone.2013.09.023. PMID: 24120384
Mendoza N, Sánchez-Borrego R, Villero J, Baró F, Calaf J, Cancelo MJ, Coronado P, Estévez A, Fernández-Moya JM, González S, Llaneza P, Neyro JL, del Pino J, Rodríguez E, Ruiz E, Cano A; Spanish Menopause Society.
Maturitas 2013 Sep;76(1):99-107. Epub 2013 Jul 1 doi: 10.1016/j.maturitas.2013.05.021. PMID: 23827473
OSHK Task Group for Formulation of 2013 OSHK Guideline for Clinical Management of Postmenopausal Osteoporosis in Hong Kong., Ip TP, Cheung SK, Cheung TC, Choi TC, Chow SL, Ho YY, Kan SY, Kung WC, Lee KK, Leung KL, Leung YY, Lo ST, Sy CT, Wong YW; Osteoporosis Society of Hong Kong.
Hong Kong Med J 2013 Apr;19 Suppl 2:1-40. PMID: 23535738

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