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Metastasis

MedGen UID:
45032
•Concept ID:
C0027627
•
Neoplastic Process
Synonyms: Metastase; Metastases; Metastases, Neoplasm; Metastasis, Neoplasm; Neoplasm Metastases; Neoplasm Metastasis

Definition

The spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastasis

Recent clinical studies

Etiology

The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma.
Mooney CP, Clark JR, Shannon K, Palme CE, Ebrahimi A, Gao K, Ch'ng S, Elliott M, Gupta R, Low TH
Head Neck 2021 Sep;43(9):2705-2711. Epub 2021 May 21 doi: 10.1002/hed.26744. PMID: 34019319
Predicting Nonsentinel Lymph Node Metastasis in Breast Cancer: A Multicenter Retrospective Study.
Mikami Y, Yamada A, Suzuki C, Adachi S, Harada F, Yamamoto S, Shimada K, Sugae S, Narui K, Chishima T, Ishikawa T, Ichikawa Y, Endo I
J Surg Res 2021 Aug;264:45-50. Epub 2021 Mar 20 doi: 10.1016/j.jss.2021.01.047. PMID: 33752166
The middle rectal artery detected by contrast-enhanced magnetic resonance imaging predicts lateral lymph node metastasis in lower rectal cancer.
Iwasa Y, Koyama F, Marugami N, Kuge H, Nakamoto T, Obara S, Nishiwada S, Takei T, Sadamitsu T, Yamauchi S, Kichikawa K, Sho M
Int J Colorectal Dis 2021 Aug;36(8):1677-1684. Epub 2021 Feb 22 doi: 10.1007/s00384-021-03887-w. PMID: 33616737Free PMC Article
Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer.
Kim DH, Kim SW, Hwang SH
Laryngoscope 2021 Sep;131(9):1990-1996. Epub 2021 Jan 25 doi: 10.1002/lary.29426. PMID: 33493364
Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer.
Park SB, Hwang KT, Chung CK, Roy D, Yoo C
Clin Exp Metastasis 2020 Dec;37(6):657-674. Epub 2020 Oct 20 doi: 10.1007/s10585-020-10060-0. PMID: 33083937

Diagnosis

Humeral metastasis as the only recurrence of a 5-year resected gastrointestinal stromal tumor: a case report.
Braunstein C, Sirveaux F, Kalbacher E, Aubry S, Delroeux D, Hubert P, Marie B, Meynard G, Mihai I, Chaigneau L
J Med Case Rep 2021 Aug 18;15(1):428. doi: 10.1186/s13256-021-02962-8. PMID: 34404447Free PMC Article
Prognostic analysis of 152 patients with distant metastasis after intensity-modulated radiotherapy for nasopharyngeal carcinoma.
Yang H, Liu C, Luo S, Ma R, Zhou Y, Yin Y, Zhao L, Shi M
Ann Palliat Med 2021 Jun;10(6):6824-6832. Epub 2021 Jun 16 doi: 10.21037/apm-21-1279. PMID: 34154349
Predicting Nonsentinel Lymph Node Metastasis in Breast Cancer: A Multicenter Retrospective Study.
Mikami Y, Yamada A, Suzuki C, Adachi S, Harada F, Yamamoto S, Shimada K, Sugae S, Narui K, Chishima T, Ishikawa T, Ichikawa Y, Endo I
J Surg Res 2021 Aug;264:45-50. Epub 2021 Mar 20 doi: 10.1016/j.jss.2021.01.047. PMID: 33752166
The middle rectal artery detected by contrast-enhanced magnetic resonance imaging predicts lateral lymph node metastasis in lower rectal cancer.
Iwasa Y, Koyama F, Marugami N, Kuge H, Nakamoto T, Obara S, Nishiwada S, Takei T, Sadamitsu T, Yamauchi S, Kichikawa K, Sho M
Int J Colorectal Dis 2021 Aug;36(8):1677-1684. Epub 2021 Feb 22 doi: 10.1007/s00384-021-03887-w. PMID: 33616737Free PMC Article
Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer.
Kim DH, Kim SW, Hwang SH
Laryngoscope 2021 Sep;131(9):1990-1996. Epub 2021 Jan 25 doi: 10.1002/lary.29426. PMID: 33493364

Therapy

Humeral metastasis as the only recurrence of a 5-year resected gastrointestinal stromal tumor: a case report.
Braunstein C, Sirveaux F, Kalbacher E, Aubry S, Delroeux D, Hubert P, Marie B, Meynard G, Mihai I, Chaigneau L
J Med Case Rep 2021 Aug 18;15(1):428. doi: 10.1186/s13256-021-02962-8. PMID: 34404447Free PMC Article
Tumor spread or siege immunity: dissemination to distant metastasis or not.
Bindea G, Mlecnik B, Galon J
Oncoimmunology 2021 Apr 25;10(1):1919377. doi: 10.1080/2162402X.2021.1919377. PMID: 33996269Free PMC Article
Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer.
Zhang KL, Zhu WW, Wang SH, Gao C, Pan JJ, Du ZG, Lu L, Jia HL, Dong QZ, Chen JH, Lu M, Qin LX
Theranostics 2021;11(13):6560-6572. Epub 2021 Apr 27 doi: 10.7150/thno.55609. PMID: 33995676Free PMC Article
The middle rectal artery detected by contrast-enhanced magnetic resonance imaging predicts lateral lymph node metastasis in lower rectal cancer.
Iwasa Y, Koyama F, Marugami N, Kuge H, Nakamoto T, Obara S, Nishiwada S, Takei T, Sadamitsu T, Yamauchi S, Kichikawa K, Sho M
Int J Colorectal Dis 2021 Aug;36(8):1677-1684. Epub 2021 Feb 22 doi: 10.1007/s00384-021-03887-w. PMID: 33616737Free PMC Article
miRNA for the assessment of lymph node metastasis in patients with oral squamous cell carcinoma: Systematic review and metanalysis.
Jadhav KB, Nagraj SK, Arora S
J Oral Pathol Med 2021 Apr;50(4):345-352. Epub 2021 Jan 7 doi: 10.1111/jop.13134. PMID: 33220092

Prognosis

The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma.
Mooney CP, Clark JR, Shannon K, Palme CE, Ebrahimi A, Gao K, Ch'ng S, Elliott M, Gupta R, Low TH
Head Neck 2021 Sep;43(9):2705-2711. Epub 2021 May 21 doi: 10.1002/hed.26744. PMID: 34019319
Predicting Nonsentinel Lymph Node Metastasis in Breast Cancer: A Multicenter Retrospective Study.
Mikami Y, Yamada A, Suzuki C, Adachi S, Harada F, Yamamoto S, Shimada K, Sugae S, Narui K, Chishima T, Ishikawa T, Ichikawa Y, Endo I
J Surg Res 2021 Aug;264:45-50. Epub 2021 Mar 20 doi: 10.1016/j.jss.2021.01.047. PMID: 33752166
Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer.
Kim DH, Kim SW, Hwang SH
Laryngoscope 2021 Sep;131(9):1990-1996. Epub 2021 Jan 25 doi: 10.1002/lary.29426. PMID: 33493364
Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer.
Park SB, Hwang KT, Chung CK, Roy D, Yoo C
Clin Exp Metastasis 2020 Dec;37(6):657-674. Epub 2020 Oct 20 doi: 10.1007/s10585-020-10060-0. PMID: 33083937
Regulation of breast cancer metastasis signaling by miRNAs.
Petri BJ, Klinge CM
Cancer Metastasis Rev 2020 Sep;39(3):837-886. doi: 10.1007/s10555-020-09905-7. PMID: 32577859Free PMC Article

Clinical prediction guides

Predicting Nonsentinel Lymph Node Metastasis in Breast Cancer: A Multicenter Retrospective Study.
Mikami Y, Yamada A, Suzuki C, Adachi S, Harada F, Yamamoto S, Shimada K, Sugae S, Narui K, Chishima T, Ishikawa T, Ichikawa Y, Endo I
J Surg Res 2021 Aug;264:45-50. Epub 2021 Mar 20 doi: 10.1016/j.jss.2021.01.047. PMID: 33752166
The middle rectal artery detected by contrast-enhanced magnetic resonance imaging predicts lateral lymph node metastasis in lower rectal cancer.
Iwasa Y, Koyama F, Marugami N, Kuge H, Nakamoto T, Obara S, Nishiwada S, Takei T, Sadamitsu T, Yamauchi S, Kichikawa K, Sho M
Int J Colorectal Dis 2021 Aug;36(8):1677-1684. Epub 2021 Feb 22 doi: 10.1007/s00384-021-03887-w. PMID: 33616737Free PMC Article
Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer.
Kim DH, Kim SW, Hwang SH
Laryngoscope 2021 Sep;131(9):1990-1996. Epub 2021 Jan 25 doi: 10.1002/lary.29426. PMID: 33493364
Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer.
Park SB, Hwang KT, Chung CK, Roy D, Yoo C
Clin Exp Metastasis 2020 Dec;37(6):657-674. Epub 2020 Oct 20 doi: 10.1007/s10585-020-10060-0. PMID: 33083937
A systems biology approach to discovering pathway signaling dysregulation in metastasis.
Clarke R, Kraikivski P, Jones BC, Sevigny CM, Sengupta S, Wang Y
Cancer Metastasis Rev 2020 Sep;39(3):903-918. Epub 2020 Aug 10 doi: 10.1007/s10555-020-09921-7. PMID: 32776157Free PMC Article

Recent systematic reviews

miRNA for the assessment of lymph node metastasis in patients with oral squamous cell carcinoma: Systematic review and metanalysis.
Jadhav KB, Nagraj SK, Arora S
J Oral Pathol Med 2021 Apr;50(4):345-352. Epub 2021 Jan 7 doi: 10.1111/jop.13134. PMID: 33220092
Type 2 Diabetes Mellitus Induced Paracrine Effects on Breast Cancer Metastasis Through Extracellular Vesicles Derived from Human Mesenchymal Stem Cells.
Khanh VC, Fukushige M, Moriguchi K, Yamashita T, Osaka M, Hiramatsu Y, Ohneda O
Stem Cells Dev 2020 Nov 1;29(21):1382-1394. Epub 2020 Oct 5 doi: 10.1089/scd.2020.0126. PMID: 32900278
Risk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies.
Xu W, He Y, Wang Y, Li X, Young J, Ioannidis JPA, Dunlop MG, Theodoratou E
BMC Med 2020 Jun 26;18(1):172. doi: 10.1186/s12916-020-01618-6. PMID: 32586325Free PMC Article
Prognostic factors for overall survival in patients with spinal metastasis secondary to prostate cancer: a systematic review and meta-analysis.
Gao ZY, Zhang T, Zhang H, Pang CG, Jiang WX
BMC Musculoskelet Disord 2020 Jun 17;21(1):388. doi: 10.1186/s12891-020-03412-0. PMID: 32552816Free PMC Article
A systematic review: Role of systemic therapy on treatment and prevention of brain metastasis in renal cell carcinoma.
Yekedüz E, Arzu Yaşar H, Utkan G, Ürün Y
J Oncol Pharm Pract 2020 Jun;26(4):972-981. Epub 2020 Feb 25 doi: 10.1177/1078155220905648. PMID: 32098554

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