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Chronic myelomonocytic leukemia(CMML)

MedGen UID:
44125
Concept ID:
C0023480
Neoplastic Process
Synonym: CMML
SNOMED CT: Chronic myelomonocytic leukemia (128831004); Chronic myelomonocytic leukemia (127225006)
 
HPO: HP:0012325
OMIM®: 607785
Orphanet: ORPHA98823

Definition

A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic myelomonocytic leukemia
Follow this link to review classifications for Chronic myelomonocytic leukemia in Orphanet.

Recent clinical studies

Etiology

Tremblay D, Rippel N, Feld J, El Jamal SM, Mascarenhas J
Oncologist 2021 May;26(5):406-421. Epub 2021 Apr 21 doi: 10.1002/onco.13769. PMID: 33792103Free PMC Article
Hunter A, Padron E
Curr Hematol Malig Rep 2021 Jun;16(3):247-255. Epub 2021 Mar 3 doi: 10.1007/s11899-021-00613-9. PMID: 33660195
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Courville EL, Wu Y, Kourda J, Roth CG, Brockmann J, Muzikansky A, Fathi AT, de Leval L, Orazi A, Hasserjian RP
Mod Pathol 2013 Jun;26(6):751-61. Epub 2013 Jan 11 doi: 10.1038/modpathol.2012.218. PMID: 23307061
Zandberg DP, Huang TY, Ke X, Baer MR, Gore SD, Smith SW, Davidoff AJ
Haematologica 2013 Apr;98(4):584-90. Epub 2012 Nov 9 doi: 10.3324/haematol.2012.062547. PMID: 23144192Free PMC Article

Diagnosis

Tremblay D, Rippel N, Feld J, El Jamal SM, Mascarenhas J
Oncologist 2021 May;26(5):406-421. Epub 2021 Apr 21 doi: 10.1002/onco.13769. PMID: 33792103Free PMC Article
Hunter A, Padron E
Curr Hematol Malig Rep 2021 Jun;16(3):247-255. Epub 2021 Mar 3 doi: 10.1007/s11899-021-00613-9. PMID: 33660195
Chapman J, Geyer JT, Khanlari M, Moul A, Casas C, Connor ST, Fan YS, Watts JM, Swords RT, Vega F, Orazi A
Mod Pathol 2018 Mar;31(3):429-441. Epub 2017 Dec 1 doi: 10.1038/modpathol.2017.148. PMID: 29192651
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Courville EL, Wu Y, Kourda J, Roth CG, Brockmann J, Muzikansky A, Fathi AT, de Leval L, Orazi A, Hasserjian RP
Mod Pathol 2013 Jun;26(6):751-61. Epub 2013 Jan 11 doi: 10.1038/modpathol.2012.218. PMID: 23307061

Therapy

Ma L, Jiang L, Yang W, Luo Y, Mei C, Zhou X, Xu G, Xu W, Ye L, Ren Y, Lu C, Lin P, Jin J, Tong H
Cancer Med 2021 Mar;10(5):1715-1725. Epub 2021 Feb 8 doi: 10.1002/cam4.3774. PMID: 33559357Free PMC Article
Montalban-Bravo G, Darbaniyan F, Kanagal-Shamanna R, Ganan-Gomez I, Class CA, Sasaki K, Naqvi K, Wei Y, Yang H, Soltysiak KA, Chien KS, Bueso-Ramos C, Do KA, Kantarjian H, Garcia-Manero G
Leuk Res 2021 Feb;101:106511. Epub 2021 Jan 19 doi: 10.1016/j.leukres.2021.106511. PMID: 33517186
Zhao M, Yang C, Chai S, Yuan Y, Zhang J, Cao P, Wang Y, Xiao X, Wu K, Yan H, Liu J, Sun S
Phytother Res 2021 Apr;35(4):2157-2170. Epub 2020 Dec 4 doi: 10.1002/ptr.6968. PMID: 33274566
Ramos Perez J, Montalban-Bravo G
Expert Opin Emerg Drugs 2020 Dec;25(4):515-529. Epub 2020 Dec 13 doi: 10.1080/14728214.2020.1854224. PMID: 33280448
Krecak I, Medic MG, Gveric-Krecak V, Roncevic P, Bašić Kinda S, Babel J, Radonic R
Acta Clin Belg 2020 Oct;75(5):357-361. Epub 2019 Apr 22 doi: 10.1080/17843286.2019.1608395. PMID: 31007140

Prognosis

Tremblay D, Rippel N, Feld J, El Jamal SM, Mascarenhas J
Oncologist 2021 May;26(5):406-421. Epub 2021 Apr 21 doi: 10.1002/onco.13769. PMID: 33792103Free PMC Article
Hunter A, Padron E
Curr Hematol Malig Rep 2021 Jun;16(3):247-255. Epub 2021 Mar 3 doi: 10.1007/s11899-021-00613-9. PMID: 33660195
Chapman J, Geyer JT, Khanlari M, Moul A, Casas C, Connor ST, Fan YS, Watts JM, Swords RT, Vega F, Orazi A
Mod Pathol 2018 Mar;31(3):429-441. Epub 2017 Dec 1 doi: 10.1038/modpathol.2017.148. PMID: 29192651
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Courville EL, Wu Y, Kourda J, Roth CG, Brockmann J, Muzikansky A, Fathi AT, de Leval L, Orazi A, Hasserjian RP
Mod Pathol 2013 Jun;26(6):751-61. Epub 2013 Jan 11 doi: 10.1038/modpathol.2012.218. PMID: 23307061

Clinical prediction guides

González JS, Perusini MA, Basquiera AL, Alfonso G, Fantl D, Lima WM, Nucifora E, Lazzarino C, Novoa V, de Andrade Silva MC, Larripa IB, Rocha V, Arbelbide J, Velloso EDRP, Belli CB
Ann Hematol 2021 Jun;100(6):1439-1449. Epub 2021 May 1 doi: 10.1007/s00277-021-04539-3. PMID: 33932168
Tremblay D, Rippel N, Feld J, El Jamal SM, Mascarenhas J
Oncologist 2021 May;26(5):406-421. Epub 2021 Apr 21 doi: 10.1002/onco.13769. PMID: 33792103Free PMC Article
Ma L, Jiang L, Yang W, Luo Y, Mei C, Zhou X, Xu G, Xu W, Ye L, Ren Y, Lu C, Lin P, Jin J, Tong H
Cancer Med 2021 Mar;10(5):1715-1725. Epub 2021 Feb 8 doi: 10.1002/cam4.3774. PMID: 33559357Free PMC Article
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Courville EL, Wu Y, Kourda J, Roth CG, Brockmann J, Muzikansky A, Fathi AT, de Leval L, Orazi A, Hasserjian RP
Mod Pathol 2013 Jun;26(6):751-61. Epub 2013 Jan 11 doi: 10.1038/modpathol.2012.218. PMID: 23307061

Recent systematic reviews

Xu R, Li M, Wu P, Deng C, Geng S, Huang X, Weng J, Du X
Hematology 2021 Dec;26(1):312-320. doi: 10.1080/16078454.2021.1875600. PMID: 33706667
Kunacheewa C, Thongthang P, Ungprasert P, Utchariyaprasit E, Owattanapanich W
Hematology 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425. PMID: 31221030
Bell JA, Galaznik A, Huelin R, Stokes M, Guo Y, Fram RJ, Faller DV
Clin Lymphoma Myeloma Leuk 2018 Apr;18(4):e157-e166. Epub 2018 Feb 8 doi: 10.1016/j.clml.2018.02.001. PMID: 29475821
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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