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Left heart failure

MedGen UID:
7287
•Concept ID:
C0023212
•
Disease or Syndrome
Synonyms: Heart Failure, Left Sided; Heart Failure, Left-Sided; Left Sided Heart Failure; Left-Sided Heart Failure
SNOMED CT: LVF - Left ventricular failure (85232009); Left heart failure (85232009); Left ventricular failure (85232009); Left-sided heart failure (85232009)

Definition

Failure of adequate output by the left ventricle despite an increase in distending pressure and in end-diastolic volume, with dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeft heart failure

Professional guidelines

PubMed

Emergency Department Evaluation and Management of Patients with Left Ventricular Assist Devices.
Honasoge A, Hu KM
Emerg Med Clin North Am 2022 Nov;40(4):755-770. doi: 10.1016/j.emc.2022.06.011. PMID: 36396220
Atrial Fibrillation in Heart Failure: Left Atrial Appendage Management.
Ellis CR, Kanagasundram AN
Cardiol Clin 2019 May;37(2):241-249. Epub 2019 Feb 13 doi: 10.1016/j.ccl.2019.01.009. PMID: 30926025
Evaluation and Management of Pulmonary Hypertension in Kidney Transplant Candidates and Recipients: Concepts and Controversies.
Lentine KL, Villines TC, Axelrod D, Kaviratne S, Weir MR, Costa SP
Transplantation 2017 Jan;101(1):166-181. doi: 10.1097/TP.0000000000001043. PMID: 26985742

Recent clinical studies

Etiology

Left Heart Failure Caused by Capacity Overload in Peritoneal Dialysis Patients.
Zhang L, Zhang X, Xue S
Biomed Res Int 2022;2022:5422333. Epub 2022 May 14 doi: 10.1155/2022/5422333. PMID: 35607309Free PMC Article
Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction.
Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC
ESC Heart Fail 2021 Aug;8(4):2968-2981. Epub 2021 May 2 doi: 10.1002/ehf2.13386. PMID: 33934536Free PMC Article
Lung function and cardiovascular disease: A link.
Ramalho SHR, Shah AM
Trends Cardiovasc Med 2021 Feb;31(2):93-98. Epub 2020 Jan 3 doi: 10.1016/j.tcm.2019.12.009. PMID: 31932098Free PMC Article
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.
Zelt JGE, Chaudhary KR, Cadete VJ, Mielniczuk LM, Stewart DJ
Circ Res 2019 May 24;124(11):1551-1567. doi: 10.1161/CIRCRESAHA.118.313650. PMID: 31120820
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641

Diagnosis

Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart.
Alenezi F, Covington TA, Mukherjee M, Mathai SC, Yu PB, Rajagopal S
Circ Res 2022 Apr 29;130(9):1445-1465. Epub 2022 Apr 28 doi: 10.1161/CIRCRESAHA.121.319990. PMID: 35482838Free PMC Article
Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction.
Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC
ESC Heart Fail 2021 Aug;8(4):2968-2981. Epub 2021 May 2 doi: 10.1002/ehf2.13386. PMID: 33934536Free PMC Article
Lung function and cardiovascular disease: A link.
Ramalho SHR, Shah AM
Trends Cardiovasc Med 2021 Feb;31(2):93-98. Epub 2020 Jan 3 doi: 10.1016/j.tcm.2019.12.009. PMID: 31932098Free PMC Article
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.
Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D22-33. doi: 10.1016/j.jacc.2013.10.027. PMID: 24355638

Therapy

Left Heart Failure Caused by Capacity Overload in Peritoneal Dialysis Patients.
Zhang L, Zhang X, Xue S
Biomed Res Int 2022;2022:5422333. Epub 2022 May 14 doi: 10.1155/2022/5422333. PMID: 35607309Free PMC Article
Beta-blockers in pulmonary arterial hypertension: Time for a second thought?
Badagliacca R, Mercurio V, Romeo E, Correale M, Masarone D, Papa S, Tocchetti CG, Agostoni P; Members of the Study Group on Right and Left Heart Failure of the Italian Society of Cardiology
Vascul Pharmacol 2022 Jun;144:106974. Epub 2022 Mar 4 doi: 10.1016/j.vph.2022.106974. PMID: 35248781
Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction.
Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC
ESC Heart Fail 2021 Aug;8(4):2968-2981. Epub 2021 May 2 doi: 10.1002/ehf2.13386. PMID: 33934536Free PMC Article
Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions.
Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, Komarova YA, Malik AB
Proc Natl Acad Sci U S A 2019 Jun 25;116(26):12980-12985. Epub 2019 Jun 11 doi: 10.1073/pnas.1902165116. PMID: 31186359Free PMC Article
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.
Zelt JGE, Chaudhary KR, Cadete VJ, Mielniczuk LM, Stewart DJ
Circ Res 2019 May 24;124(11):1551-1567. doi: 10.1161/CIRCRESAHA.118.313650. PMID: 31120820

Prognosis

Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction.
Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC
ESC Heart Fail 2021 Aug;8(4):2968-2981. Epub 2021 May 2 doi: 10.1002/ehf2.13386. PMID: 33934536Free PMC Article
Lung function and cardiovascular disease: A link.
Ramalho SHR, Shah AM
Trends Cardiovasc Med 2021 Feb;31(2):93-98. Epub 2020 Jan 3 doi: 10.1016/j.tcm.2019.12.009. PMID: 31932098Free PMC Article
Right Heart Failure: A Hemodynamic Review.
El Hajj MC, Viray MC, Tedford RJ
Cardiol Clin 2020 May;38(2):161-173. Epub 2020 Feb 20 doi: 10.1016/j.ccl.2020.01.001. PMID: 32284094
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.
Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D22-33. doi: 10.1016/j.jacc.2013.10.027. PMID: 24355638

Clinical prediction guides

Beta-blockers in pulmonary arterial hypertension: Time for a second thought?
Badagliacca R, Mercurio V, Romeo E, Correale M, Masarone D, Papa S, Tocchetti CG, Agostoni P; Members of the Study Group on Right and Left Heart Failure of the Italian Society of Cardiology
Vascul Pharmacol 2022 Jun;144:106974. Epub 2022 Mar 4 doi: 10.1016/j.vph.2022.106974. PMID: 35248781
Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction.
Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC
ESC Heart Fail 2021 Aug;8(4):2968-2981. Epub 2021 May 2 doi: 10.1002/ehf2.13386. PMID: 33934536Free PMC Article
Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions.
Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, Komarova YA, Malik AB
Proc Natl Acad Sci U S A 2019 Jun 25;116(26):12980-12985. Epub 2019 Jun 11 doi: 10.1073/pnas.1902165116. PMID: 31186359Free PMC Article
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.
Zelt JGE, Chaudhary KR, Cadete VJ, Mielniczuk LM, Stewart DJ
Circ Res 2019 May 24;124(11):1551-1567. doi: 10.1161/CIRCRESAHA.118.313650. PMID: 31120820
Definitions and diagnosis of pulmonary hypertension.
Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB
J Am Coll Cardiol 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. PMID: 24355641

Recent systematic reviews

The association between pulmonary hypertension and stroke: A systematic review and meta-analysis.
Shah TG, Sutaria JM, Vyas MV
Int J Cardiol 2019 Nov 15;295:21-24. Epub 2019 Jul 31 doi: 10.1016/j.ijcard.2019.07.085. PMID: 31402157
Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.
Guay CA, Morin-Thibault LV, Bonnet S, Lacasse Y, Lambert C, Lega JC, Provencher S
PLoS One 2018;13(10):e0204610. Epub 2018 Oct 11 doi: 10.1371/journal.pone.0204610. PMID: 30307953Free PMC Article
WITHDRAWN: Diuretics for heart failure.
Faris RF, Flather M, Purcell H, Poole-Wilson PA, Coats AJ
Cochrane Database Syst Rev 2016 Apr 4;4(4):CD003838. doi: 10.1002/14651858.CD003838.pub4. PMID: 27040884Free PMC Article

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