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Hyperalgesia

MedGen UID:
6961
Concept ID:
C0020429
Sign or Symptom
Synonyms: Hyperalgesias; Hyperalgesic Sensation; Hyperalgesic Sensations; Hyperalgia; Sensation, Hyperalgesic; Sensations, Hyperalgesic
SNOMED CT: Hyperalgia (55406008); Increased sensitivity to painful stimulus (55406008); Hyperalgesia (55406008); Hyperpathia (55406008)

Definition

Abnormally increased pain sense. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperalgesia

Recent clinical studies

Etiology

Wu Z, Yu J, Lin Q, Li H, Zhang T, Tan H, Lin W, Cao L
Anesth Analg 2021 Feb 1;132(2):320-328. doi: 10.1213/ANE.0000000000005003. PMID: 32639389
Xue Y, Wei SQ, Wang PX, Wang WY, Liu EQ, Traub RJ, Cao DY
Neuroscience 2020 Aug 1;440:196-209. Epub 2020 Jun 1 doi: 10.1016/j.neuroscience.2020.05.044. PMID: 32497757
You DS, Hahn HA, Welsh TH, Meagher MW
Alcohol Alcohol 2020 Oct 20;55(6):608-615. doi: 10.1093/alcalc/agaa035. PMID: 32476005Free PMC Article
Leuchtweis J, Segond von Banchet G, Eitner A, Ebbinghaus M, Schaible HG
Pain 2020 Jul;161(7):1571-1583. doi: 10.1097/j.pain.0000000000001852. PMID: 32149861
Madden VJ, Bedwell GJ, Chikezie PC, Rice ASC, Kamerman PR
Syst Rev 2019 Aug 19;8(1):208. doi: 10.1186/s13643-019-1120-7. PMID: 31426841Free PMC Article

Diagnosis

Wu Z, Yu J, Lin Q, Li H, Zhang T, Tan H, Lin W, Cao L
Anesth Analg 2021 Feb 1;132(2):320-328. doi: 10.1213/ANE.0000000000005003. PMID: 32639389
Xue Y, Wei SQ, Wang PX, Wang WY, Liu EQ, Traub RJ, Cao DY
Neuroscience 2020 Aug 1;440:196-209. Epub 2020 Jun 1 doi: 10.1016/j.neuroscience.2020.05.044. PMID: 32497757
You DS, Hahn HA, Welsh TH, Meagher MW
Alcohol Alcohol 2020 Oct 20;55(6):608-615. doi: 10.1093/alcalc/agaa035. PMID: 32476005Free PMC Article
Geers AL, Close S, Caplandies FC, Vogel CL, Murray AB, Pertiwi Y, Handley IM, Vase L
Pain 2019 Oct;160(10):2290-2297. doi: 10.1097/j.pain.0000000000001618. PMID: 31107412
Wheeler DW, Bhatia A, Mani V, Kinna S, Bell A, Boyle Y, Chizh BA, Menon DK, Lee MC
J Pain 2019 Oct;20(10):1199-1208. Epub 2019 Apr 18 doi: 10.1016/j.jpain.2019.03.012. PMID: 31005594

Therapy

Wu Z, Yu J, Lin Q, Li H, Zhang T, Tan H, Lin W, Cao L
Anesth Analg 2021 Feb 1;132(2):320-328. doi: 10.1213/ANE.0000000000005003. PMID: 32639389
Springborg AD, Jensen EK, Kreilgaard M, Petersen MA, Papathanasiou T, Lund TM, Taylor BK, Werner MU
PLoS One 2020;15(11):e0242169. Epub 2020 Nov 12 doi: 10.1371/journal.pone.0242169. PMID: 33180816Free PMC Article
Arout CA, Petrakis IL, Ralevski E, Acampora G, Koretski J, DeNegre D, Newcomb J, Perrino AC
Pain Med 2020 Nov 1;21(11):2823-2829. doi: 10.1093/pm/pnaa037. PMID: 32249311
Geers AL, Close S, Caplandies FC, Vogel CL, Murray AB, Pertiwi Y, Handley IM, Vase L
Pain 2019 Oct;160(10):2290-2297. doi: 10.1097/j.pain.0000000000001618. PMID: 31107412
Hooten WM, Hu D, Cunningham JM, Black JL 3rd
Mol Pain 2019 Jan-Dec;15:1744806919848929. doi: 10.1177/1744806919848929. PMID: 31041874Free PMC Article

Prognosis

You DS, Hahn HA, Welsh TH, Meagher MW
Alcohol Alcohol 2020 Oct 20;55(6):608-615. doi: 10.1093/alcalc/agaa035. PMID: 32476005Free PMC Article
Leuchtweis J, Segond von Banchet G, Eitner A, Ebbinghaus M, Schaible HG
Pain 2020 Jul;161(7):1571-1583. doi: 10.1097/j.pain.0000000000001852. PMID: 32149861
Wheeler DW, Bhatia A, Mani V, Kinna S, Bell A, Boyle Y, Chizh BA, Menon DK, Lee MC
J Pain 2019 Oct;20(10):1199-1208. Epub 2019 Apr 18 doi: 10.1016/j.jpain.2019.03.012. PMID: 31005594
Yang M, Zhang H, Yue R, Shi Q, Bian Y
J Tradit Chin Med 2018 Oct;38(5):698-704. PMID: 32185986
Toriyama T, Horiuchi T, Hongo K
J Headache Pain 2017 Dec 28;18(1):117. doi: 10.1186/s10194-017-0824-0. PMID: 29285568Free PMC Article

Clinical prediction guides

Schneider AH, Machado CC, Veras FP, Maganin AGM, de Souza FFL, Barroso LC, de Oliveira RDR, Alves-Filho JC, Cunha TM, Fukada SY, Louzada-Júnior P, da Silva TA, Cunha FQ
Rheumatology (Oxford) 2021 Jul 1;60(7):3461-3473. doi: 10.1093/rheumatology/keaa794. PMID: 33367912
Wu Z, Yu J, Lin Q, Li H, Zhang T, Tan H, Lin W, Cao L
Anesth Analg 2021 Feb 1;132(2):320-328. doi: 10.1213/ANE.0000000000005003. PMID: 32639389
Springborg AD, Jensen EK, Kreilgaard M, Petersen MA, Papathanasiou T, Lund TM, Taylor BK, Werner MU
PLoS One 2020;15(11):e0242169. Epub 2020 Nov 12 doi: 10.1371/journal.pone.0242169. PMID: 33180816Free PMC Article
Leuchtweis J, Segond von Banchet G, Eitner A, Ebbinghaus M, Schaible HG
Pain 2020 Jul;161(7):1571-1583. doi: 10.1097/j.pain.0000000000001852. PMID: 32149861
Hansen MS, Becerra L, Dahl JB, Borsook D, Mårtensson J, Christensen A, Nybing JD, Havsteen I, Boesen M, Asghar MS
Brain Struct Funct 2019 Apr;224(3):1119-1139. Epub 2019 Jan 10 doi: 10.1007/s00429-018-01819-z. PMID: 30631932

Recent systematic reviews

Madden VJ, Bedwell GJ, Chikezie PC, Rice ASC, Kamerman PR
Syst Rev 2019 Aug 19;8(1):208. doi: 10.1186/s13643-019-1120-7. PMID: 31426841Free PMC Article
Higgins C, Smith BH, Matthews K
Br J Anaesth 2019 Jun;122(6):e114-e126. Epub 2018 Oct 25 doi: 10.1016/j.bja.2018.09.019. PMID: 30915985
Yang DZ, Sin B, Beckhusen J, Xia D, Khaimova R, Iliev I
Am J Ther 2019 May/Jun;26(3):e397-e405. doi: 10.1097/MJT.0000000000000734. PMID: 29726847
Madden VJ, Harvie DS, Parker R, Jensen KB, Vlaeyen JW, Moseley GL, Stanton TR
Pain Med 2016 Jun;17(6):1094-111. Epub 2015 Dec 14 doi: 10.1093/pm/pnv044. PMID: 26814278
Katz NP, Paillard FC, Edwards RR
Anesthesiology 2015 Mar;122(3):677-85. doi: 10.1097/ALN.0000000000000530. PMID: 25437498

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