Format

Send to:

Choose Destination

Heart failure

MedGen UID:
6749
Concept ID:
C0018801
Disease or Syndrome
Synonyms: Cardiac Failure; Heart Failure
SNOMED CT: HF - Heart failure (84114007); Heart failure (84114007); Weak heart (84114007); Cardiac failure (84114007); Cardiac insufficiency (84114007)

Definition

Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. [from NCI]

Recent clinical studies

Etiology

Seferović PM, Vardas P, Jankowska EA, Maggioni AP, Timmis A, Milinković I, Polovina M, Gale CP, Lund LH, Lopatin Y, Lainscak M, Savarese G, Huculeci R, Kazakiewicz D, Coats AJS; National Heart Failure Societies of the ESC member countries (see Appendix).
Eur J Heart Fail 2021 Jun;23(6):906-914. Epub 2021 Mar 13 doi: 10.1002/ejhf.2143. PMID: 33634931
Miró Ò, Rossello X, Platz E, Masip J, Gualandro DM, Peacock WF, Price S, Cullen L, DiSomma S, de Oliveira MT Jr, McMurray JJ, Martín-Sánchez FJ, Maisel AS, Vrints C, Cowie MR, Bueno H, Mebazaa A, Mueller C; Study Group on Acute Heart Failure of the Acute Cardiovascular Care Association of the European Society of Cardiology.
Eur Heart J Acute Cardiovasc Care 2020 Aug;9(5):375-398. doi: 10.1177/2048872620930889. PMID: 33191763Free PMC Article
Kapłon-Cieślicka A, Laroche C, Crespo-Leiro MG, Coats AJS, Anker SD, Filippatos G, Maggioni AP, Hage C, Lara-Padrón A, Fucili A, Drożdż J, Seferovic P, Rosano GMC, Mebazaa A, McDonagh T, Lainscak M, Ruschitzka F, Lund LH; Heart Failure Association (HFA) of the European Society of Cardiology (ESC) and the ESC Heart Failure Long-Term Registry Investigators.
ESC Heart Fail 2020 Oct;7(5):2098-2112. Epub 2020 Jul 2 doi: 10.1002/ehf2.12817. PMID: 32618139Free PMC Article
Anker MS, Bouleti C, Christodoulides T, Durante A, Gara E, Hadzibegovic S, Keramida K, Lena A, Massouh A, Milinkovic I, Nägele MP, Nossikoff A, Plácido R, Radovits T, Tolppanen H, Vergaro G, Wallner M, Welch S, Lopatin Y, Lainscak M, Mebazaa A, Coats AJS, Seferović PM, Jankowska EA; Heart Failure Association Committee on Heart Failure Specialists of Tomorrow of the European Society of Cardiology.
ESC Heart Fail 2020 Jun;7(3):873-877. Epub 2020 Apr 30 doi: 10.1002/ehf2.12674. PMID: 32352242Free PMC Article
Hashemi D, Blum M, Mende M, Störk S, Angermann CE, Pankuweit S, Tahirovic E, Wachter R, Pieske B, Edelmann F, Düngen HD; German Competence Network for Heart Failure.
ESC Heart Fail 2020 Jun;7(3):942-952. Epub 2020 Jan 30 doi: 10.1002/ehf2.12605. PMID: 32003157Free PMC Article

Diagnosis

Shoaib A, Van Spall HGC, Wu J, Cleland JGF, McDonagh TA, Rashid M, Mohamed MO, Ahmed FZ, Deanfield J, de Belder M, Gale CP, Mamas MA
Eur Heart J Qual Care Clin Outcomes 2021 Jul 21;7(4):378-387. doi: 10.1093/ehjqcco/qcab040. PMID: 34043762Free PMC Article
Seferović PM, Vardas P, Jankowska EA, Maggioni AP, Timmis A, Milinković I, Polovina M, Gale CP, Lund LH, Lopatin Y, Lainscak M, Savarese G, Huculeci R, Kazakiewicz D, Coats AJS; National Heart Failure Societies of the ESC member countries (see Appendix).
Eur J Heart Fail 2021 Jun;23(6):906-914. Epub 2021 Mar 13 doi: 10.1002/ejhf.2143. PMID: 33634931
Bader F, Manla Y, Atallah B, Starling RC
Heart Fail Rev 2021 Jan;26(1):1-10. doi: 10.1007/s10741-020-10008-2. PMID: 32720082Free PMC Article
Sciomer S, Moscucci F, Salvioni E, Marchese G, Bussotti M, Corrà U, Piepoli MF
Eur J Prev Cardiol 2020 Dec;27(2_suppl):46-51. doi: 10.1177/2047487320961980. PMID: 33238736Free PMC Article
Kapłon-Cieślicka A, Laroche C, Crespo-Leiro MG, Coats AJS, Anker SD, Filippatos G, Maggioni AP, Hage C, Lara-Padrón A, Fucili A, Drożdż J, Seferovic P, Rosano GMC, Mebazaa A, McDonagh T, Lainscak M, Ruschitzka F, Lund LH; Heart Failure Association (HFA) of the European Society of Cardiology (ESC) and the ESC Heart Failure Long-Term Registry Investigators.
ESC Heart Fail 2020 Oct;7(5):2098-2112. Epub 2020 Jul 2 doi: 10.1002/ehf2.12817. PMID: 32618139Free PMC Article

Therapy

DeVore AD, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Lewis EF, Butler J, Piña IL, Allen LA, Yancy CW, Cooper LB, Felker GM, Kaltenbach LA, McRae AT, Lanfear DE, Harrison RW, Disch M, Ariely D, Miller JM, Granger CB, Hernandez AF
JAMA 2021 Jul 27;326(4):314-323. doi: 10.1001/jama.2021.8844. PMID: 34313687Free PMC Article
Ma X, Li J, Ren X
Am J Emerg Med 2021 Sep;47:1-5. Epub 2021 Jan 16 doi: 10.1016/j.ajem.2021.01.032. PMID: 33744485
Abraham WT, Psotka MA, Fiuzat M, Filippatos G, Lindenfeld J, Mehran R, Ambardekar AV, Carson PE, Jacob R, Januzzi JL Jr, Konstam MA, Krucoff MW, Lewis EF, Piccini JP, Solomon SD, Stockbridge N, Teerlink JR, Unger EF, Zeitler EP, Anker SD, O'Connor CM
Eur J Heart Fail 2020 Dec;22(12):2175-2186. Epub 2020 Nov 13 doi: 10.1002/ejhf.2018. PMID: 33017862
Ibrahim NE, Piña IL, Camacho A, Bapat D, Felker GM, Maisel AS, Butler J, Prescott MF, Abbas CA, Solomon SD, Januzzi JL Jr; Prospective Study of Biomarkers, Symptom Improvement and Ventricular Remodeling During Entresto Therapy for Heart Failure (PROVE-HF) Study Investigators.
Circ Heart Fail 2020 Nov;13(11):e007829. Epub 2020 Oct 3 doi: 10.1161/CIRCHEARTFAILURE.120.007829. PMID: 33016100Free PMC Article
Mewton N, Girerd N, Boffa JJ, Courivaud C, Isnard R, Juillard L, Lamblin N, Legrand M, Logeart D, Mariat C, Meune E, Sabouret P, Sebbag L, Rossignol P
Arch Cardiovasc Dis 2020 Oct;113(10):660-670. Epub 2020 Jul 11 doi: 10.1016/j.acvd.2020.03.018. PMID: 32660835

Prognosis

Shoaib A, Van Spall HGC, Wu J, Cleland JGF, McDonagh TA, Rashid M, Mohamed MO, Ahmed FZ, Deanfield J, de Belder M, Gale CP, Mamas MA
Eur Heart J Qual Care Clin Outcomes 2021 Jul 21;7(4):378-387. doi: 10.1093/ehjqcco/qcab040. PMID: 34043762Free PMC Article
González-Pacheco H, Álvarez-Sangabriel A, Martínez-Sánchez C, Briseño-Cruz JL, Altamirano-Castillo A, Mendoza-García S, Manzur-Sandoval D, Amezcua-Guerra LM, Sandoval J, Bojalil R, Araiza-Garaygordobil D, Sierra-Lara D, Guiza-Sánchez CA, Gopar-Nieto R, Cruz-Rodríguez C, Valdivia-Nuño JJ, Salas-Teles B, Arias-Mendoza A
ESC Heart Fail 2021 Feb;8(1):423-437. Epub 2020 Nov 11 doi: 10.1002/ehf2.13092. PMID: 33179453Free PMC Article
Bader F, Manla Y, Atallah B, Starling RC
Heart Fail Rev 2021 Jan;26(1):1-10. doi: 10.1007/s10741-020-10008-2. PMID: 32720082Free PMC Article
Miró Ò, Rossello X, Platz E, Masip J, Gualandro DM, Peacock WF, Price S, Cullen L, DiSomma S, de Oliveira MT Jr, McMurray JJ, Martín-Sánchez FJ, Maisel AS, Vrints C, Cowie MR, Bueno H, Mebazaa A, Mueller C; Study Group on Acute Heart Failure of the Acute Cardiovascular Care Association of the European Society of Cardiology.
Eur Heart J Acute Cardiovasc Care 2020 Aug;9(5):375-398. doi: 10.1177/2048872620930889. PMID: 33191763Free PMC Article
Hashemi D, Blum M, Mende M, Störk S, Angermann CE, Pankuweit S, Tahirovic E, Wachter R, Pieske B, Edelmann F, Düngen HD; German Competence Network for Heart Failure.
ESC Heart Fail 2020 Jun;7(3):942-952. Epub 2020 Jan 30 doi: 10.1002/ehf2.12605. PMID: 32003157Free PMC Article

Clinical prediction guides

González-Pacheco H, Álvarez-Sangabriel A, Martínez-Sánchez C, Briseño-Cruz JL, Altamirano-Castillo A, Mendoza-García S, Manzur-Sandoval D, Amezcua-Guerra LM, Sandoval J, Bojalil R, Araiza-Garaygordobil D, Sierra-Lara D, Guiza-Sánchez CA, Gopar-Nieto R, Cruz-Rodríguez C, Valdivia-Nuño JJ, Salas-Teles B, Arias-Mendoza A
ESC Heart Fail 2021 Feb;8(1):423-437. Epub 2020 Nov 11 doi: 10.1002/ehf2.13092. PMID: 33179453Free PMC Article
Bader F, Manla Y, Atallah B, Starling RC
Heart Fail Rev 2021 Jan;26(1):1-10. doi: 10.1007/s10741-020-10008-2. PMID: 32720082Free PMC Article
Sciomer S, Moscucci F, Salvioni E, Marchese G, Bussotti M, Corrà U, Piepoli MF
Eur J Prev Cardiol 2020 Dec;27(2_suppl):46-51. doi: 10.1177/2047487320961980. PMID: 33238736Free PMC Article
Miró Ò, Rossello X, Platz E, Masip J, Gualandro DM, Peacock WF, Price S, Cullen L, DiSomma S, de Oliveira MT Jr, McMurray JJ, Martín-Sánchez FJ, Maisel AS, Vrints C, Cowie MR, Bueno H, Mebazaa A, Mueller C; Study Group on Acute Heart Failure of the Acute Cardiovascular Care Association of the European Society of Cardiology.
Eur Heart J Acute Cardiovasc Care 2020 Aug;9(5):375-398. doi: 10.1177/2048872620930889. PMID: 33191763Free PMC Article
Hashemi D, Blum M, Mende M, Störk S, Angermann CE, Pankuweit S, Tahirovic E, Wachter R, Pieske B, Edelmann F, Düngen HD; German Competence Network for Heart Failure.
ESC Heart Fail 2020 Jun;7(3):942-952. Epub 2020 Jan 30 doi: 10.1002/ehf2.12605. PMID: 32003157Free PMC Article

Recent systematic reviews

Zhao Q, Chen C, Zhang J, Ye Y, Fan X
Int J Nurs Stud 2021 Apr;116:103909. Epub 2021 Feb 25 doi: 10.1016/j.ijnurstu.2021.103909. PMID: 33642066
Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Gutierrez EJ, Yamin M, Siswanto BB, Virani SS
Am J Emerg Med 2021 Aug;46:204-211. Epub 2020 Jul 9 doi: 10.1016/j.ajem.2020.07.009. PMID: 33071085Free PMC Article
Santos GC, Liljeroos M, Dwyer AA, Jaques C, Girard J, Strömberg A, Hullin R, Schäfer-Keller P
Int J Nurs Stud 2021 Apr;116:103524. Epub 2020 Jan 10 doi: 10.1016/j.ijnurstu.2020.103524. PMID: 32063295
Miró Ò, Rossello X, Platz E, Masip J, Gualandro DM, Peacock WF, Price S, Cullen L, DiSomma S, de Oliveira MT Jr, McMurray JJ, Martín-Sánchez FJ, Maisel AS, Vrints C, Cowie MR, Bueno H, Mebazaa A, Mueller C; Study Group on Acute Heart Failure of the Acute Cardiovascular Care Association of the European Society of Cardiology.
Eur Heart J Acute Cardiovasc Care 2020 Aug;9(5):375-398. doi: 10.1177/2048872620930889. PMID: 33191763Free PMC Article
Tini G, Bertero E, Signori A, Sormani MP, Maack C, De Boer RA, Canepa M, Ameri P
J Am Heart Assoc 2020 Sep 15;9(18):e016309. Epub 2020 Aug 31 doi: 10.1161/JAHA.119.016309. PMID: 32862764Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center