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Heart failure

MedGen UID:
6749
Concept ID:
C0018801
Disease or Syndrome
Synonyms: Cardiac Failure; Heart Failure
SNOMED CT: HF - Heart failure (84114007); Heart failure (84114007); Weak heart (84114007); Cardiac failure (84114007); Cardiac insufficiency (84114007)
 
Monarch Initiative: MONDO:0005252

Definition

Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. [from NCI]

Professional guidelines

PubMed

Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, Dixon DL, Fearon WF, Hess B, Johnson HM, Kazi DS, Kolte D, Kumbhani DJ, LoFaso J, Mahtta D, Mark DB, Minissian M, Navar AM, Patel AR, Piano MR, Rodriguez F, Talbot AW, Taqueti VR, Thomas RJ, van Diepen S, Wiggins B, Williams MS; Peer Review Committee Members
Circulation 2023 Aug 29;148(9):e9-e119. Epub 2023 Jul 20 doi: 10.1161/CIR.0000000000001168. PMID: 37471501
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e876-e894. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001062. PMID: 35363500
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e895-e1032. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001063. PMID: 35363499

Curated

UK NICE Guideline CG187, Acute heart failure: diagnosis and management, 2021

DailyMed Drug Label, CARVEDILOL, 2019

Recent clinical studies

Etiology

Kittleson MM
Ann Intern Med 2023 Dec;176(12):ITC177-ITC192. Epub 2023 Dec 12 doi: 10.7326/AITC202312190. PMID: 38079639
Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J, Drazner MH, Michael Felker G, Filippatos G, Fiuzat M, Fonarow GC, Gomez-Mesa JE, Heidenreich P, Imamura T, Jankowska EA, Januzzi J, Khazanie P, Kinugawa K, Lam CSP, Matsue Y, Metra M, Ohtani T, Francesco Piepoli M, Ponikowski P, Rosano GMC, Sakata Y, Seferović P, Starling RC, Teerlink JR, Vardeny O, Yamamoto K, Yancy C, Zhang J, Zieroth S
Eur J Heart Fail 2021 Mar;23(3):352-380. Epub 2021 Mar 3 doi: 10.1002/ejhf.2115. PMID: 33605000
Boorsma EM, Ter Maaten JM, Damman K, Dinh W, Gustafsson F, Goldsmith S, Burkhoff D, Zannad F, Udelson JE, Voors AA
Nat Rev Cardiol 2020 Oct;17(10):641-655. Epub 2020 May 15 doi: 10.1038/s41569-020-0379-7. PMID: 32415147
Chaudhry MA
Curr Hypertens Rev 2019;15(1):7. doi: 10.2174/157340211501190129144451. PMID: 30729894
Kurmani S, Squire I
Curr Heart Fail Rep 2017 Oct;14(5):385-392. doi: 10.1007/s11897-017-0351-y. PMID: 28785969Free PMC Article

Diagnosis

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
J Am Coll Cardiol 2022 May 3;79(17):e263-e421. Epub 2022 Apr 1 doi: 10.1016/j.jacc.2021.12.012. PMID: 35379503
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e876-e894. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001062. PMID: 35363500
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e895-e1032. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001063. PMID: 35363499
Snipelisky D, Chaudhry SP, Stewart GC
Card Electrophysiol Clin 2019 Mar;11(1):11-20. Epub 2018 Dec 24 doi: 10.1016/j.ccep.2018.11.001. PMID: 30717842
King M, Kingery J, Casey B
Am Fam Physician 2012 Jun 15;85(12):1161-8. PMID: 22962896

Therapy

Bartlett RH
Anesthesiology 2024 Mar 1;140(3):578-584. doi: 10.1097/ALN.0000000000004843. PMID: 38349754
Tromp J, Ferreira JP, Janwanishstaporn S, Shah M, Greenberg B, Zannad F, Lam CSP
Eur J Heart Fail 2019 Oct;21(10):1187-1196. Epub 2019 Aug 16 doi: 10.1002/ejhf.1585. PMID: 31419004
Trautmann SI, Kloss M, Auricchio A
Curr Cardiol Rep 2002 Sep;4(5):371-8. doi: 10.1007/s11886-002-0036-2. PMID: 12169233
Martinez-Castelao A
Curr Opin Investig Drugs 2002 Jan;3(1):89-95. PMID: 12054079
CONSENSUS Trial Study Group
N Engl J Med 1987 Jun 4;316(23):1429-35. doi: 10.1056/NEJM198706043162301. PMID: 2883575

Prognosis

Gouveia M, Ascenção R, Fiorentino F, Costa J, Caldeira D, Broeiro-Gonçalves P, Fonseca C, Borges M
ESC Heart Fail 2019 Apr;6(2):254-261. Epub 2019 Jan 8 doi: 10.1002/ehf2.12399. PMID: 30620150Free PMC Article
Akamizu T
Thyroid 2018 Jan;28(1):32-40. Epub 2017 Oct 5 doi: 10.1089/thy.2017.0243. PMID: 28899229Free PMC Article
Chioncel O, Lainscak M, Seferovic PM, Anker SD, Crespo-Leiro MG, Harjola VP, Parissis J, Laroche C, Piepoli MF, Fonseca C, Mebazaa A, Lund L, Ambrosio GA, Coats AJ, Ferrari R, Ruschitzka F, Maggioni AP, Filippatos G
Eur J Heart Fail 2017 Dec;19(12):1574-1585. Epub 2017 Apr 6 doi: 10.1002/ejhf.813. PMID: 28386917
Díez-López C, Lupón J, de Antonio M, Zamora E, Domingo M, Santesmases J, Troya MI, Boldó M, Bayes-Genis A
Rev Esp Cardiol (Engl Ed) 2016 Sep;69(9):820-6. Epub 2016 Jun 16 doi: 10.1016/j.rec.2016.02.028. PMID: 27318441
Sayago-Silva I, García-López F, Segovia-Cubero J
Rev Esp Cardiol (Engl Ed) 2013 Aug;66(8):649-56. Epub 2013 Jul 5 doi: 10.1016/j.rec.2013.03.012. PMID: 24776334

Clinical prediction guides

Arana-Achaga X, Goena-Vives C, Villanueva-Benito I, Solla-Ruiz I, Rengel Jimenez A, Gaspar TI, Urreta-Barallobre I, Barge-Caballero G, Seijas-Marcos S, Cabrera E, Garcia-Pavía P, Basurte Elorz MT, Ayestarán NM, Sierra LT, Robledo Iñarritu M, Lozano-Bahamonde A, Escolar-Perez V, Gómez-Ramírez C, Alzola E, Andrés RN, Francisco Matias JL, Limeres Freire J, Armengou Arxe A, Negre Busó M, Piqueras-Flores J, Martínez-Del Río J, Onaindia Gandarias JJ, Rodriguez Sanchez I, Querejeta Iraola R
JACC Cardiovasc Imaging 2023 Dec;16(12):1567-1580. Epub 2023 Jun 28 doi: 10.1016/j.jcmg.2023.05.002. PMID: 37389511
Liu C, Ferrari VA, Han Y
Curr Cardiol Rep 2021 Mar 8;23(4):35. doi: 10.1007/s11886-021-01464-9. PMID: 33686516Free PMC Article
Kobayashi M, Girerd N, Duarte K, Chouihed T, Chikamori T, Pitt B, Zannad F, Rossignol P
Clin Res Cardiol 2021 Aug;110(8):1159-1172. Epub 2021 Jan 6 doi: 10.1007/s00392-020-01794-8. PMID: 33409701
Sweitzer NK
Circ Heart Fail 2020 Feb;13(2):e006927. Epub 2020 Feb 14 doi: 10.1161/CIRCHEARTFAILURE.120.006927. PMID: 32059633
Guazzi M, Bandera F, Ozemek C, Systrom D, Arena R
J Am Coll Cardiol 2017 Sep 26;70(13):1618-1636. doi: 10.1016/j.jacc.2017.08.012. PMID: 28935040

Recent systematic reviews

Emmons-Bell S, Johnson C, Roth G
Heart 2022 Aug 11;108(17):1351-1360. doi: 10.1136/heartjnl-2021-320131. PMID: 35042750Free PMC Article
Schichtel M, Wee B, Perera R, Onakpoya I
J Gen Intern Med 2020 Mar;35(3):874-884. Epub 2019 Nov 12 doi: 10.1007/s11606-019-05482-w. PMID: 31720968Free PMC Article
Shaddy RE, George AT, Jaecklin T, Lochlainn EN, Thakur L, Agrawal R, Solar-Yohay S, Chen F, Rossano JW, Severin T, Burch M
Pediatr Cardiol 2018 Mar;39(3):415-436. Epub 2017 Dec 20 doi: 10.1007/s00246-017-1787-2. PMID: 29260263Free PMC Article
Cannon JA, Moffitt P, Perez-Moreno AC, Walters MR, Broomfield NM, McMurray JJV, Quinn TJ
J Card Fail 2017 Jun;23(6):464-475. Epub 2017 Apr 19 doi: 10.1016/j.cardfail.2017.04.007. PMID: 28433667
Cajita MI, Cajita TR, Han HR
J Cardiovasc Nurs 2016 Mar-Apr;31(2):121-30. doi: 10.1097/JCN.0000000000000229. PMID: 25569150Free PMC Article

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